Lonza's approach to improving bioavailability with PBBM

With so many molecules entering the pharma development pipeline nowadays being poorly soluble, finding a dosage form that gives adequate bioavailability can be a real challenge. It’s something the Lonza team in Bend, Oregon has put a real focus on in recent years. They use tools such as physiologically based biopharmaceutics modeling, or PBBM, to help them find alternative solid forms with better solubility. PBBM software, such as GastroPlus® from Simulations Plus, Inc., allows them to simulate the interplay of a molecule’s physio-chemical, metabolism and excretion properties with the target physiology and formulation attributes. Combining these with carefully selected in vitro measurements, they can evaluate the likelihood that an enabled solid form will be successful, cutting down the number of experiments they have to run. Josh Marsh and Abhijeet Sinha, two of the Bend team, are giving a webinar that will look into this important topic in much more detail. It’s happening on Thursday, 5 June at 16:00 CEST/10:00 EDT, and is free to attend. Please register at https://bit.ly/4k3LOD4 and join them to find out more about how Lonza searches for the best enabled solid forms. #SFS #PBBM #AdvancedSynthesis #CDMO #Lonza