PCR’s Post

Session Wrap-Up – Meet the Expert: Implementing Guidelines for ATTR-CM Diagnosis and Management We’ve just concluded an insightful case-based discussion with Prof. Olivier Lairez and Dr. Ahmad Masri at #eSPACEHF2025. The experts walked through key diagnostic steps for cardiac amyloidosis, from recognizing red flags on ECG, ECHO, and CMR to interpreting 99mTc-DPD/PYP/HMDP scintigraphy and haematologic testing to differentiate between AL and ATTR amyloidosis. They also discussed MGUS prevalence across age groups and the impact of beta-blocker therapy on survival in patients with reduced LVEF. Watch on demand: https://lnkd.in/gTjppWHA AstraZeneca #eSPACEHF2025 #HeartFailure #ATTRCM #CardiologyEducation #MeetTheExpert

Another Complex PCI Performed During the #حملة_شفاء_وتعافي Campaign A 65-year-old patient presented with crescendo angina. He has a known history of complex coronary artery disease and underwent multiple PCIs (RCA, IM, CX, and marginal branch) 5 years ago. Coronary angiography revealed a chronic total occlusion (CTO) of the circumflex artery (CX) due to in-stent occlusion, along with in-stent restenosis in the marginal branch. There was also a bifurcation lesion (CX/Marginal) classified as Medina 1-1-1, in a left-dominant coronary system. After several attempts, we successfully crossed the CTO segment using the #Gaia III wire and #side branch technique, followed by #anchoring and multiple balloon dilatations. Stenting was then performed, including bifurcation stenting using the #TAP technique ( unfortunately #DCB was not available) achieving a good final result.

𝐒𝐭𝐮𝐝𝐲 𝐒𝐮𝐠𝐠𝐞𝐬𝐭𝐬 𝐭𝐡𝐚𝐭 𝐚 𝐂𝐓-𝐅𝐢𝐫𝐬𝐭 𝐒𝐭𝐫𝐚𝐭𝐞𝐠𝐲 𝐢𝐬 𝐚 𝐁𝐞𝐭𝐭𝐞𝐫 𝐁𝐞𝐭 𝐟𝐨𝐫 𝐁𝐮𝐝𝐠𝐞𝐭, 𝐂𝐨𝐦𝐩𝐚𝐫𝐞𝐝 𝐭𝐨 𝐈𝐂𝐀 A new cost-utility analysis of the 2016 CAD-MAN trial, which randomized patients with suspected coronary artery disease to a cardiac CT scan (using an #AquilionONE system) or invasive coronary angiography (ICA), shows that a CT-first approach is just as safe as ICA — but far more cost-effective. Some key takeaways: - 𝟖𝟔% 𝐟𝐞𝐰𝐞𝐫 𝐢𝐧𝐯𝐚𝐬𝐢𝐯𝐞 𝐚𝐧𝐠𝐢𝐨𝐠𝐫𝐚𝐩𝐡𝐢𝐞𝐬 𝐧𝐞𝐞𝐝𝐞𝐝 (only 14% vs 100%) - 𝟓𝟕% 𝐥𝐨𝐰𝐞𝐫 𝐢𝐧𝐢𝐭𝐢𝐚𝐥 𝐦𝐚𝐧𝐚𝐠𝐞𝐦𝐞𝐧𝐭 𝐜𝐨𝐬𝐭𝐬 - 𝐒𝐢𝐦𝐢𝐥𝐚𝐫 𝐪𝐮𝐚𝐥𝐢𝐭𝐲-𝐚𝐝𝐣𝐮𝐬𝐭𝐞𝐝 𝐥𝐢𝐟𝐞 𝐲𝐞𝐚𝐫𝐬 (𝐐𝐀𝐋𝐘𝐬) as ICA - 𝐂𝐨𝐬𝐭-𝐞𝐟𝐟𝐞𝐜𝐭𝐢𝐯𝐞𝐧𝐞𝐬𝐬 𝐦𝐚𝐢𝐧𝐭𝐚𝐢𝐧𝐞𝐝 𝐨𝐯𝐞𝐫 𝐥𝐨𝐧𝐠-𝐭𝐞𝐫𝐦 𝐟𝐨𝐥𝐥𝐨𝐰-𝐮𝐩 The full article is available here: https://bit.ly/48bTFvg #yesCCT #ValueBasedHealthcare #CardiacCT

Early detection is everything when it comes to #sepsis and can mean the difference between life and death. Yet, in many cases, the warning signs are recognised too late. Running exclusively on the abioSCOPE® platform, Pancreatic Stone Protein (PSP) is the first rapid biomarker that helps clinicians identify sepsis risk earlier, delivering lab-quality results from just a drop of blood in minutes. #PSP empowers clinicians with fast, accurate, and actionable insights for earlier activation of sepsis bundles, better-informed decisions, and improved patient outcomes. #SepsisDetection #CriticalCare #EmergencyMedicine #SepsisSummit #ICU #PSP Abionic Sepsis Alliance

https://zurl.co/LjbiV Pulmonary artery pulse pressure combined with an end-tidal CO₂ waveform of 17 mmHg indicates that atrial contraction can maintain transpulmonary flow and pulmonary venous return during ventricular fibrillation. As EtCO₂ reflects pulmonary blood flow and indirectly native cardiac output, values above 10 mmHg in VA-ECMO patients without ventricular ejection highlight significant pulmonary perfusion sustained by atrial systole.

Single-access high-risk PCI with #Impella support in a complex patient 🫀with Marco Covani, MD and Davide Donelli. 58-year-old male with new-onset heart failure (LVEF 20%). 🩻 Coronary angiography: #CTO of LCx and RCA, functionally occluded LAD with critical ostial lesion of D1 — the last remaining vessel. ▶️ PET showed extensive fibrosis but residual viability in the anterior, anterolateral, and inferolateral walls. 👥 The case was discussed with our referral #transplant center to define the best strategy for the patient. ⭕️ A heart transplant program was started. In the meantime, we performed #Impella-protected PCI with a provisional bifurcation strategy (DES on LAD–D1 and DCB on the side branch), followed by revascularization and stenting of the mid-to-distal LAD and revascularization of the proximal LCx. This case showed the quality of our regional network for advance #heartfailure, which I sincerly thanks. Giorgio Benatti; Iacopo Tadonio; Emilia Solinas; Andrea Denegri; Luciano Potena; Sofia Martin-Suarez; Marco Silenzi

This study indicates that photon-counting detector computed tomography (PCD-CT) provides high diagnostic accuracy for detecting in-stent restenosis in patients with prior coronary stents. This suggests that PCD-CT may be reliably used to evaluate suspected obstructive coronary artery disease in both stented and unstented coronary segments. https://lnkd.in/dZ2yEzqg Doosup Shin; Rick Volleberg; Roosha Parikh; @Christopher Chieh Yang Koo; Sarah Malik; Matthew Cannata; Jeffrey Moses; niels van royen; Carlos Collet MD, PhD; Richard Shlofmitz; Evan Shlofmitz; Allen Jeremias, MD, MSc;  #InterventionalCardiology #CT #ISR

Sci-fi to triage: artificial blood is edging into care. Hemopure is available via expanded access, and PEG-carboxyhemoglobin (PP-007) just earned FDA Fast Track for acute stroke. Off-the-shelf oxygen, anyone? 🩸⚡ In 2025, U.S. centers continue using HBOC-201 when transfusion isn’t possible, while PP-007 advanced after clean safety readouts—signals that oxygen carriers may fill critical gaps in trauma and “bloodless” care. 🚑 [1][2] Caveat: older HBOCs raised vasoconstriction/MI concerns; newer nano/PEG designs aim to deliver O₂ without nitric-oxide scavenging and oxidative stress. Momentum is building across AOCs. [3] Watch: PP-007’s next trials and synthetic RBCs like ErythroMer moving from bench to bedside. Clinicians should update protocols and consent language now. [4] 🤔 If safety holds, which indications should get priority—pre-hospital trauma, stroke, or surgical blood refusal? Sources [1] https://lnkd.in/dJ-D-vQJ [2] https://lnkd.in/d9DxNJkD [3] https://lnkd.in/dYqtT9Nv [4] https://lnkd.in/dV2nZ7xy #ArtificialBlood #MedTech #TransfusionMedicine Sciqst: AI-powered literature reviews in minutes.  Generate comprehensive, up-to-date scientific reviews from the latest papers with one click.  https://www.sciqst.com

A Phase III, pivotal trial of staged, bilateral magnetic resonance-guided focused ultrasound pallidothalamic tractotomy for motor complications in Parkinson's disease. Late-Breaking Abstract 21 Michelle matarazzo presents insightec study. Pallidothalamic tract (PTT) - open label 9 centres with MDS UPDRS off, off meds, UE LE primary outcomes- 40/54 did second side >6 month second side. reduction seen in scores - missing details as what parts of MDS UPDRS for each graph. Need more details about complications. FDA approved now.

🎓 Our latest Letter has just been published in Circulation Research (Dr. Marcel Benkhoff, Philipp Mourikis) https://lnkd.in/exb-AuVH We show that HDL from patients with coronary artery disease loses its cardioprotective properties due to reduced sphingosine-1-phosphate (S1P) content — a key mediator of lipoprotection. Importantly, S1P reloading restores HDL’s protective function, revealing a potential translational approach to improve cardiovascular outcomes. #CirculationResearch #CardiovascularResearch #HDL #S1P #TranslationalMedicine #TeamScience #CirculationResearch #CardiovascularScience #TranslationalResearch #AcademicMedicine #TeamScience #UKD #AGPolzin #KardiologieUKD