The Insiders Extract Volume 193

The Insiders Extract is an expertly curated cannabis newsletter that delivers the most impactful articles, insights, and ideas to over 12,000 subscribers.

This Month's Top Insights

1) Beyond THC – an interview with the famous Dr. Ethan Russo

2) Coining a New Term: Canndiculation by Dr Stephen Gipps

3) A Call for Caution in Cannabis Prescribing by Jessica Kindynis

Highlights

Beyond THC: Understanding the Full Therapeutic Potential of Cannabis – an interview with the famous Ethan Russo.

On cannabis pharmacology, Dr. Russo explains pure THC often produces disorienting effects while ignoring 149 other potentially therapeutic cannabinoids.

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The King Cries Cannabis - King Charles turns to medical cannabis for Cancer treatment – a growing trend among patients.

Royal family source reveals Charles "trying every cure in the book" including experimental cannabis options that may inhibit cancer cell growth.

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Insights

A Call for Caution in Cannabis Prescribing: Australian Clinical herbalist calls for greater pharmacovigilance & cross-disciplinary cooperation in cannabis medicine.

In cannabis purchasing patterns, women show preference for specific product forms (46% edibles vs 27% for men) while men spend more per transaction & buy more frequently across multiple dispensaries. #USEFULDATA

Cannabis plus pandiculation: a therapeutic modality for treating muscular tension imbalance via enhanced sensory awareness & central-peripheral sensitisation.

On beverage consumer demographics, 63% are ages 25-44 & 58% are men with slightly higher alcohol consumption rates than general cannabis users, suggesting comfort with drinking intoxicants. #USEFULDATA

Legal plant limits vs. harvest amounts: the contradiction in ACT's cannabis laws Study reveals mismatch between cultivation & possession limits.

On scientific misrepresentation, researchers & media frequently conflate correlation with causation when reporting cannabis studies, creating misleading narratives about heart disease & mental health risks.

Major News

While Canadians are increasing cannabis consumption, and reducing alcohol, pre-rolls close in on top cannabis sales spot in Canada – a trend that has been growing over the last three years.

Years in the making - France finally submits cannabis project to Europe, a key step towards authorising medical cannabis, both for its production and its dispensing.

Australian based GP’s develop resources to support doctors considering medicinal cannabis treatment for patients who choose to drive.

Whilst this is not cannabis specific – this highlights the issue of over regulating substances (especially ones of addiction). Deadly gang war erupts over illegal tobacco trade | 60 Minutes Australia.

For medicinal cannabis patients in Victoria, new drug driving reforms eliminate automatic license suspension when THC is detected, giving courts discretion based on valid prescriptions.

Whilst this is not cannabis specific – The Department of Veterans' Affairs (DVA) is preparing to fund the use of psychedelic-assisted therapies to treat veterans with PTSD and depression.

Studies & Research

For chronic pain treatment in the UK, survey of 250 doctors finds 84% open to prescribing cannabis if added to NHS toolkit despite current limitation to private prescribing.

For high-THC cannabis, systematic review identifies potential link to problematic use patterns while therapeutic outcomes show mixed results.

A call for concern: For young consumers, semisynthetic cannabinoids produce more intense effects than organic cannabis with symptoms lasting 4-12 hours when smoked & up to four days when ingested.

For cancer-related cannabinoid studies, bibliometric analysis reveals key research frontiers include anandamide, cannabidiol, cannabinoid receptors & cellular mechanisms like apoptosis & proliferation.

In public health data on prenatal cannabis use, not only was there no associations with negative developmental indicators, but the girls with prenatal cannabis exposure were found to have greater language development.

In people with alcohol use disorder, CBD lowered their brain activation to alcohol cues specifically in the precuneus region while showing no negative effects on cognitive function, mood or craving.

Quote of the Month

“The most meaningful way to succeed is to help others succeed.” — Adam Grant

About The Publisher

My name is Adam Isaac Miller; cannabis has been a part of my life since I was a child, with my father using cannabis to treat his military-induced PTSD. I’ve spent over a decade in the legal market, during that time I’ve worked for and advised multiple companies. I also have a licence to import and supply cannabis (amongst other scheduled substances).  This newsletter is a collection of what I think are the most important pieces of information to inform how I think about the global cannabis market, as well as understanding the therapeutic application of cannabis. This newsletter is a tool to keep me sharp and in the know. I hope you also find it valuable.

This is an industry newsletter for the purpose of providing scientific and regulatory updates in respect of medical cannabis industries globally. Nothing in this newsletter is intended to promote the use or supply of medical cannabis to members of the public.