1 A B C D 2 A B C D 3 A B C D 4 A B C D 5 A B C D 6 A B C D 7 A B

Alternative name for rational drug design is Mathematical drug design computer-aided drug design combinatorial drug design library screening Chime is a tool made for ____________ study 3D structure visualization Molecular Modelling Simulation Protein Primary sequence analysis _______is not a computational approaches to pattern matching and sequence alignment Bayesian methods Dot matrix Genetic algorithms ProtoMap the first protein to be sequenced, which consisted of just 51 residues Amylase Heamoglobin Insulin Myoglobin The first nucleic acid sequence determined was Bacterial mRNA Yeast tRNA Bacterial tRNA Yeast mRNA A ________database contains information of the sequence or structure alone Primary Secondary Tertiary Composite SCOP is an example of which type of database? Primary Secondary

C D 8 A B C D 9 A B C D 10 A B C D 11 A B C D 12 A B C D 13 A B C D 14

Tertiary Composite eMOTIF database has been developed by __________ Stanford University University College of London Swiss Bioinformatics Institute Cambridge University An example of composite database is? OMIM Prosite PDBsum NCBI The joint database of Genbank, EMBL and DDBJ is known as International Nucleotide Sequence Database Collaboration International Collaboration for DNA Sequence International Nucleotide Sequence Database Consortium International Nucleotide Sequence and Database Collaboration IntAct which is hosted by EMBL, holds what kind of data? Protein data Transcription factors data Protein-protein interactions Metabolic data HGS is a specialized database developed by? NCBI EMBL DDBJ EBI Protein Information Resource is maintained by _____________ National Biomedical Research Foundation PIR-International Munich Information Center for Protein Sequences Japan International Protein Information Database In swiss-prot entry,RX stands for

A B C D 15 A B C D 16 A B C D 17 A B C D 18 A B C D 19 A B C D 20 A B

Cross-reference Reference Comment Reference Number Reference Location In swiss-prot, _________contains the entries, which should be eventually incorporated into SWISS-PROT REM-TrEMBL SP-TrEMBL TrEMBL REF- TrEMBL If an entry is written PRELIMINARY in the TrEMBL, then the file has been checked by Scientists Computer Both A and B None of the above UniRef provides what type of information non-redundant views of the data contained in UniParc and the knowledgebase an expertly curated database new and updated sequences are loaded on a daily basis None of the above ____________provides a catalogue and structure- based classification of peptidases GCRDb YPD PIR-PSD MEROPS _________multiple aligned un-gapped segments corresponding to the most highly conserved regions of proteins BLOCKS PRINTS PROSITE PROCHECK In Genbank entry LOCUS specifies name for the entry short mnemonic name for the entry

C D 21 A B C D 22 A B C D 23 A B C D 24 A B C D 25 A B C D 26 A B C D

Entry origin Unique Identifier MSD stands for macro molecular structure database molecular structure database modeling and structure database None of the above The only protein fold named after the person who was the first to discover it is? Rossman fold Micheal fold Clark fold TIM barrel fold PDB-ISL is? Library containing potential intermediate sequences for proteins of known structure International standards for PDB sequences Databases contain large sets of sequences whose evolutionary relationships are known unambiguously Manually curated classification of protein domain structures Name the autonomous living organism whose complete DNA sequence was made available on 1995 Haemophilus influenza bacteriophage 0X174 C. elegans A. thaliana Name a specialized database for Synechocystis sp Micado Subtilist CyanoBase MIPS WormBase is a database for C. elegans E. coli Tubifex B. subtilis

27 A B C D 28 A B C D 29 A B C D 30 A B C D 31 A B C D 32 A B C D 33 A

Gene identification is very difficult in humans, because Presence of high frequency of introns Difficulty in finding protein coding genes Sequencing method is very difficult None of the above _________occurs only once in a genome or chromosome cDNA mRNA EST STS BRITE is a ______ database Pathway Human and Mouse genome EST database Motif database tblastx is a program meant for? Search protein database with translated nucleotide query Search translated nucleotide database with translated nucleotide query Search translated nucleotide database with protein query Search protein database with protein query The PAM 1 is the matrix calculated from comparisons of sequences with no more than 1% divergence with no more than 1% similarity with more than 1% divergence with more than 1% similarity Smith-Waterman algorithm is meant for Global alignment Local alignment Dot Plot Mulitple Alignment Global sequence alignment methods are most applicable to Highly similar sequences

B C D 34 A B C D 35 A B C D 36 A B C D 37

Highly similar sequences of approximately same length Homologous sequences Analogous sequences of varying lengths BLOSUM has been developed from local multiple alignments of more distantly related sequences Global alignments of more highly similar sequences Local one to one alignments of similar sequences Global alignment of homologous sequences For closely related sequences comparison one should use PAM with lower number PAM with higher number BLOSUM with lower numbers None of the above The Maxam-Gilbert sequencing method required the use of radioactive labeling at one 5' end of the DNA radioactive labeling at one 3' end of the DNA dideoxynucleotide triphosphates Chemical purification of deoxynucleotide triphosphates The later development by ______ of fluorescently labeled ddNTPs and primers set the stage for automated, high-throughput DNA sequencing

A B C D 38

Ben Maxam and coworker Gilbert and coworker Allan and Coworker Leroy Hood and coworker The process of cloning human DNA fragments by inserting them between two ecori digested sites of a plasmid cloning vector

A B C D 39

Constructing genomic libraries using plasmids Constructing DNA fragmentation libraries Creating cDNA libraries None of the above The human genome is partially digested with a restriction enzyme named______

A B C D 40

Sau3A SauA Sau2A Sau4A Name the enzymes recognize short DNA sequences and cleave at, or close to, their recognition sites

A B C D 41

Type I restriction enzymes Type II restriction enzymes Type III restriction enzymes Type IV restriction enzymes Name the tool that is freely available on the web and which analyzes DNA sequences for the presence of restriction enzyme sites

A B C D 42 A B C D 43 A B C D 44 A B C D

WebCutter REbASE RFLP NEBCutter MEME is used for motif discovery Multiple sequence analysis Expressed Sequence tag Sequence tagged sites Following is not a secondary prediction method Chou Fasman method
Garnier Osguthorpe Robson

Neural network method Singer Oswald method _______ is not used for 3D structure prediction Threading Homology Modelling Ab-initio prediction Neural network method

45 A B C D 46

1 femtosecond is equivalent to _______ seconds 10-9 10-11 10-13 10-15 Molecular dynamics involves solving the ________that predicts the motion of the atoms in the molecule over time.

A B C D 47 A B C D 48 A B C D 49 A B C D

Schrodingers equation Newtons equation Hisenberg uncertainty principle Hunds rule ChemSketch has been developed by Accelyrys ASD labs ACD labs Cambridge University A point on the potential energy surface where the forces are zero is called a stationery point Local Minima Global Minimum Local Minimum Which of these is not a docking program? DOCK GOLD NAMD AUTODOCK