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HIV-1 Reverse Transcriptase

The document lists 15 protein sequences from human immunodeficiency virus 1 (HIV-1) and simian-human immunodeficiency virus (SHIV). The sequences are for reverse transcriptase, polymerase protein, and DNA polymerase beta and range in length from around 50 to 300 amino acids. The sequences are identified by gene index numbers and include reference sequences from the NCBI protein database.

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Joshua Arrojo
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103 views3 pages

HIV-1 Reverse Transcriptase

The document lists 15 protein sequences from human immunodeficiency virus 1 (HIV-1) and simian-human immunodeficiency virus (SHIV). The sequences are for reverse transcriptase, polymerase protein, and DNA polymerase beta and range in length from around 50 to 300 amino acids. The sequences are identified by gene index numbers and include reference sequences from the NCBI protein database.

Uploaded by

Joshua Arrojo
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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1-2 UK, 3-Spain 4 germany 5- france 6- spain

1. >gi|58176811|pdb|1TKT|B Chain B, Crystal Structure Of Hiv-1 Reverse


Transcriptase In Complex With Gw426318
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTK
WRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETP
GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLL
RWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLC
KLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK
TGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETF

2. >gi|58176810|pdb|1TKT|A Chain A, Crystal Structure Of Hiv-1 Reverse


Transcriptase In Complex With Gw426318
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTK
WRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETP
GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLL
RWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLX
KLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK
TGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSG
LEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVL
3. >gi|306485743|gb|ADM92523.1| pol protein [Human immunodeficiency virus 1]
PQITLWQRPLVTIKIGGQVKEALLDTGADDTVLXEMNLPGRWKPKMIGGIGGFIKVRQYDQVSIEICGHK
AIGTVLIGPTPVNIIGRNLLTQLGCTLNFPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEM
EKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDV
GDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRIKIEELRDHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKES
WTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVILLTEEAELELAENREILKAPVHGVYYDP
SKDLIAEVQKQGLG
4. >gi|28872822|ref|NP_789739.1| reverse transcriptase p51 subunit [Human
immunodeficiency virus 1]
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTK
WRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETP
GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLL
RWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLC
KLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK
TGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETF

5. >gi|50513429|pdb|1S1U|B Chain B, Crystal Structure Of L100i Mutant Hiv-1


Reverse Transcriptase In Complex With Nevirapine
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTK
WRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETP
GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLL
RWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLC
KLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK
TGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETF

6. >gi|33357399|pdb|1N4L|A Chain A, A Dna Analogue Of The Polypurine Tract Of Hiv1


TWLSDFPQAWAETGGMGLAVRQAPLIIPLKATSTPVSIKQYPMSQEARLGIKPHIQRLLDQGILVPCQSP

1-2 UK, 3-Spain 4 germany 5- france 6- spain


WNTPLLPVKKPGTNDYRPVQDLREVNKRVEDIHPTVPNPYNLLSGLPPSHQWYTVLDLKDAFFCLRLHPT
SQPLFAFEWRDPEMGISGQLTWTRLPQGFKNSPTLFDEALHRDLADFRIQHPDLILLQYVDDLLLAATSE
LDCQQGTRALLQTLGNLGYRASAKKAQICQKQVKYLGYLLKEGQR

7. >gi|354803129|gb|AER40258.1| pol protein [Simian-Human immunodeficiency virus]


EGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGD
AYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQY
MDDLYVGSDLEIGQHRTK
8. >gi|354803135|gb|AER40261.1| pol protein [Simian-Human immunodeficiency virus]
EGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGD
AYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQY
MDDLYVGSDLEIGQHRTK
9. >gi|354802364|gb|AER39877.1| pol protein [Simian-Human immunodeficiency virus]
EGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGD
AYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQY
MDDLYVGSDLEIGQHRTK
10. >gi|62737000|gb|AAX97801.1| pol protein [Human immunodeficiency virus 1]
PQITLWQRPLVTXKIGGQLKEALLDTGADDTVLEEXNLPGRWKPKMIGGIGGFIKVXQYDQVTXEICGKK
XIGTVLVGPTPVNIIGRNLLTQMGCTLNFPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEM
EKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDV
GDAYFSVPLDKDFRKYTAFTIPSINNETPGXRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIGQHRTKIEELRQHLLXWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDS
WTVNDIQKLVGKLNWASQIYPGIKVRQLCXLLRGAKALTEVIPLTKEAELELAENREILKEPVHGVYYDP
SKD
11. >gi|162330188|pdb|2VG7|B Chain B, Crystal Structures Of Hiv-1 Reverse
Transcriptase Complexes With Thiocarbamate Non-Nucleoside Inhibitors
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTK
WRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETP
GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLL
RWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLC
KLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK
TGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQ
12. >gi|157832157|pdb|1NOM|A Chain A, Dna Polymerase Beta (pol B) (e.c.2.7.7.7),
31-kd Domain; Soaked In The Presence Of Mncl2 (5 Millimolar)
IRQDDTSSSINFLTRVTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQ
MQDIVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQLQKVRFITDT
LSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYT
IRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRSE
13. >gi|157420606|gb|ABS53043.2| pol protein [Human immunodeficiency virus 1]
FPQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEDIELPGRWKPKMIGGIGGFIKVRQYDQITIEICGK
KAIGSVXVGPTPVNIIGRNMLTQLGCTLNFPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEE
MEKEGKITKIGPENPYNTPIFAIKKKDSTXWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILD
VGDAYFSVPLYEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTQNPEIVI
YQYVDDLYVGSDLEIGQHRAKIDELRNHLXKWGFFTPDKKYQKEPPFLWLGYELHPDXWTVQPIQLPEKD
SWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGTKALTDIVPLTAEAE

1-2 UK, 3-Spain 4 germany 5- france 6- spain

14. >gi|153869578|gb|ABS53044.1| reverse transcriptase [Human immunodeficiency


virus 1]
NFPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICDEMEKEGKISKIGPENPYXTPIFAIKKKNS
TRWRNLVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSIPLYEDFRKYTAFTIPSTNNE
TPGIRYQYNVLPQGWKGSPAIFQASMTRILEPFRAQNPEIVICQYVDDLYVASDLEIGQHRAKIEELREH
LLKWGFFTPEEKHQKEPPFHWMGYELHPDKWTVQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQ
LCKLLRGTKALTEIVPLTEEAELELAENR
15. >gi|19571451|emb|CAD19729.1| reverse transcriptase [Human immunodeficiency
virus 1]
GPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKKTQDF
WEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGZHRXKIEELRQHLLRWGFTTPDKKHQKEPPF
LWM

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