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Phagocytosis

The document discusses the process of phagocytosis, which involves the engulfment and destruction of pathogens by phagocytes. It defines phagocytosis and describes the key steps of recognition and attachment, engulfment, and killing and degradation of pathogens. It also discusses the role of reactive oxygen species and diseases associated with defective phagocytosis, such as Chediak-Higashi syndrome and chronic granulomatous disease.

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3K views60 pages

Phagocytosis

The document discusses the process of phagocytosis, which involves the engulfment and destruction of pathogens by phagocytes. It defines phagocytosis and describes the key steps of recognition and attachment, engulfment, and killing and degradation of pathogens. It also discusses the role of reactive oxygen species and diseases associated with defective phagocytosis, such as Chediak-Higashi syndrome and chronic granulomatous disease.

Uploaded by

api-273068056
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Phagocytosis

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Phagocytosis
Dr. Rabiul Haque
Lecturer,
Department of Pathology,
Holy Family Red Crescent Medical College , Dhaka

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Phagocytosis
Topics Overview:
-Definition
-Steps

of Phagocytosis
-Recognition & Attachment
-Engulfment
-Killing & Degradation
-Role of ROS
-Disease Associated With Defective
Phagocytosis

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Phagocytosis

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Phagocytosis
(phagein) , meaning "to devour"

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Phagocytosis
(phagein) , meaning "to devour"
, (kytos) , meaning "cell"

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Phagocytosis
(phagein) , meaning "to devour"
, (kytos) , meaning "cell"

osis, meaning "process"

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Phagocytosis
Cell-eating
Definition

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Phagocytosis
Cell-eating
Definition
The process of engulfment of solid
particulate material by the cells.

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Phagocytosis
Cell-eating
Definition
The process of engulfment of solid
particulate material by the cells.
Ref. Harsh Mohan - Textbook of Pathology, 6th Edition

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Phagocytosis
Phagocytes

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Phagocytosis
Phagocytes
Cells that performs Phagocytosis.

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Phagocytosis
Phagocytes
Cells that performs Phagocytosis.
-Polymorphonuclear

Neutrophils

-Macrophages

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Phagocytosis
Cell-eating

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Phagocytosis
Cell-eating

Pinocytosis
Cell-drinking

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Phagocytosis
Steps of Phagocytosis:

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Phagocytosis
Steps of Phagocytosis:
-Recognition

& Attachment

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Phagocytosis
Steps of Phagocytosis:
-Recognition

& Attachment

-Engulfment

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Phagocytosis
Steps of Phagocytosis:
-Recognition

& Attachment

-Engulfment

-Killing

& Degradation

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Recognition & Attachment

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Recognition & Attachment


-Mannose Receptors

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Recognition & Attachment


-Mannose Receptors
-Scavenger Receptors

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Recognition & Attachment


-Mannose Receptors
-Scavenger Receptors
-Receptors For Opsonins

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Recognition & Attachment


-Mannose Receptors
-Scavenger Receptors
-Receptors For Opsonins

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Engulfment

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Engulfment
-Receptor Initiated Signal Integration

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Engulfment
-Receptor Initiated Signal Integration
-Membrane Remodeling

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Engulfment
-Receptor Initiated Signal Integration
-Membrane Remodeling
-Cytoskeletal Changes

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Engulfment
-Receptor Initiated Signal Integration
-Membrane Remodeling
-Cytoskeletal Changes
-Ploymerization of Actin Filaments

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Engulfment
-Receptor Initiated Signal
Integration
-Membrane Remodeling
-Cytoskeletal Changes
-Ploymerization of Actin
Filaments

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Engulfment
-Receptor Initiated Signal
Integration
-Membrane Remodeling
-Cytoskeletal Changes
-Ploymerization of Actin
Filaments

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Killing & Degradation

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Killing & Degradation

Intracellular Mechanism

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Killing & Degradation

Intracellular Mechanism
Extracellular Mechanism

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Killing & Degradation

Intracellular Mechanism
-Oxidative Bactericidal Mechanism By Free Radicals
-Oxidative Bactericidal Mechanism By Lysosomal Granules
-Non-oxidative Bactericidal Mechanism
Extracellular Mechanism

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Killing & Degradation

Oxidative Bactericidal Mechanism By Free


Radicals

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Killing & Degradation

Oxidative Bactericidal Mechanism By Free


Radicals

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Killing & Degradation

Oxidative Bactericidal Mechanism By Free


Radicals
- MPO Dependant

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Killing & Degradation

Oxidative Bactericidal Mechanism By Free


Radicals
- MPO Dependant
- MPO Independent

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Killing & Degradation

Oxidative Bactericidal Mechanism By Free


Radicals
- MPO Dependant
- MPO Independent

NADPH Oxidase

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Killing & Degradation

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Killing & Degradation


Oxidative Bactericidal Mechanism By Free Radicals

MPO Independent Mechanism

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Killing & Degradation


Oxidative Bactericidal Mechanism By Free Radicals

MPO Independent Mechanism

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Killing & Degradation


Oxidative Bactericidal Mechanism By Lysosomal
Granules

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Killing & Degradation


Oxidative Bactericidal Mechanism By Lysosomal
Granules
-Protease

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Killing & Degradation


Oxidative Bactericidal Mechanism By Lysosomal
Granules
-Protease

-Phospholipase

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Killing & Degradation


Oxidative Bactericidal Mechanism By Lysosomal
Granules
-Protease

-Phospholipase
-Trypsinase

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Killing & Degradation


Oxidative Bactericidal Mechanism By Lysosomal
Granules
-Protease

-Phospholipase
-Trypsinase

-Alkaline Phosphatase

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Killing & Degradation


Non-oxidative Bactericidal Mechanism

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Killing & Degradation


Non-oxidative Bactericidal Mechanism

Granules
-Lysosomal Hydrolase

-Defensins
-Lipase

-Protease
-DNAase, Permeability Increasing Factors
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Killing & Degradation


Non-oxidative Bactericidal Mechanism
Nitric Oxide
Peroxynitrite ( ONOO' )

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Killing & Degradation


Extracellular Mechanism

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Killing & Degradation


Extracellular Mechanism

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Frustrated Phagocytosis

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Diseases Due to Defective


Phagocytosis

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Diseases Due to Defective


Phagocytosis
-Chediak-Higashi Syndrome

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Diseases Due to Defective


Phagocytosis
-Chediak-Higashi Syndrome
-Chronic Granulomatous Disease

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Diseases Due to Defective


Phagocytosis
-Chediak-Higashi Syndrome
-Chronic Granulomatous Disease

-MPO Deficiency

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Phagocytosis

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