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Scientific Background of Some Ayurvedic Drugs

Gymnema sylvestre stimulates insulin release in vitro and appears to correct metabolic derangements in diabetic tissues through increased serum insulin levels and possible regeneration of pancreatic beta cells. Studies on Eugenia jambolana and Ficus bengalensis suggest they lower blood glucose levels by interfering with intestinal glucose absorption. Research on Momordica charantia fruit extract in diabetic rats found it exhibited hypolipidemic and hypoglycemic effects through a significant increase in pancreatic beta cells compared to untreated diabetics.

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24 views2 pages

Scientific Background of Some Ayurvedic Drugs

Gymnema sylvestre stimulates insulin release in vitro and appears to correct metabolic derangements in diabetic tissues through increased serum insulin levels and possible regeneration of pancreatic beta cells. Studies on Eugenia jambolana and Ficus bengalensis suggest they lower blood glucose levels by interfering with intestinal glucose absorption. Research on Momordica charantia fruit extract in diabetic rats found it exhibited hypolipidemic and hypoglycemic effects through a significant increase in pancreatic beta cells compared to untreated diabetics.

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© © All Rights Reserved
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Scientific back-up of some extensively researched herbs

GUDMAR (Gymnema sylvestre)


J Endocrinol 1999 Nov;163(2):207-12
Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability.
Persaud SJ, Al-Majed H, Raman A, Jones PM.
It appears to correct the metabolic derangements in diabetic rabbit liver, kidney and muscle.
This herbal therapy appears to bring about blood glucose homeostasis through increased serum insulin
levels provided by repair/regeneration of the endocrine pancreas.
Gymnema therapy appears to enhance endogenous insulin, possibly by regeneration/revitalisation of the
residual beta cells in insulin-dependent diabetes mellitus.. This is supported by the appearance of raised
insulin levels in the serum of patients after Gymnema supplementation.
Studies suggest that the component of Gymnema sylvestre inhibits the increase in the blood glucose level
by interfering with the intestinal glucose absorption process
Jamun & Nyagrodha
Hypoglycemic activity of Eugenia jambolana and Ficus bengalensis: mechanism of action.
Achrekar S, Kaklij GS, Pote MS, Kelkar SM.
Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
Karella (Momordica charantia)
Ahmed I, Lakhani MS, Gillett M, John A, Raza H
Diabetes Res Clin Pract 2001 Mar;51(3):155-61
Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit
extract in streptozotocin-induced diabetic rats. . These results suggest that M. charantia fruit extract exhibits
hypolipidemic as well as hypoglycemic effects in the STZ-induced diabetic rat.
Bangladesh Med Res Counc Bull 1999 Apr;25(1):11-3
Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM
patients.
Ahmad N, Hassan MR, Halder H, Bennoor KS.
Department of Pathology, Sher-e-Bangla Medical College, Barisal.

wThis hypoglycaemic action was observed in 86 (86%) cases. The results indicated that there was a
significant (Student's t-test, P < 0.004) increase in the number of beta cells in M. charantia-treated animals
when compared with untreated diabetics, however, their number was still significantly less than that obtained
for normal rats.

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