Preeclampsia
Inggrid Feby Silaban
11000017
FK UHN
Classifications of Hypertensive
Disorders of Pregnancy
1. Chronic Hypertension
2. Preeclampsia- Eclampsia
3. Chronic Hypertension with Preeclampsia
superimposed
4. Gestational Hypertension
Definition of Preeclampsia
Definition = Hypertension and proteinuria after
20 weeks gestation.
Categories
.
Mild Preeclampsia
Severe Preeclampsia
Epidemiology
Pre-eclampsia is a multiorgan disorder that
complicates 3%-8% of pregnancies in Western
countries and constitutes a major source of
morbidity and mortality worldwide.
Overall, 10-15% of maternal deaths are directly
associated with preeclampsia and eclampsia
Risk Factor
Anatomy of Uterine Artery
Anatomy of Artery
Physiology of Spiral Arteries
Pathophysiology Preeclampsia
Sign & Symptom
Preventing Preeclampsia at Women with
Risk Factor
Low Dose Aspirin
Aspirin should be taken in a low dose (75-162
mg/dl),
Who should receive aspirin, in what dose.
Aspirin is more effective in decreasing
preeclampsia:
(i) among high risk women
(ii) when initiated before 16 weeks
(iii) at doses >80 mg/day (75-162 mg/dl)
Mechanism of Aspirin
Oral calcium supplementation (of at least
1g/dl) decreases the incidence of preeclampsia
and gestational hypertension. Maternal death
or serious morbidity was reduced.
ECLAMPSIA
It is extremely difficult to predict which women
with pre-eclampsia will develop eclamptic
seizures. So that the required seizure
prophylaxis in preeclamptic women.
How Does it Work?
Magnesium sulfate mechanism of action in
eclampsia is not well understood. Eclampsia is
thought to occur secondary to ischemic caused
by cerebral vasospasm.[Magnesium sulfate is a
potent vasodilator, particularly in the cerebral
vasculature.In women with pre-eclampsia,
magnesium sulfate has been shown to improve
cerebral arterial circulation.
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