Detailed Syllabus

4th Year-7th Semester

THEORY PAPERS
Therapeutic Equipments
BME 701, Contacts: 3L, Credit: 3
Course objectives:
This course will provide to students brief review of physiology and common pathology from an engineering
point of view for understanding of therapeutic medical devices. The lectures will focus on function of
therapeutic medical devices so that the students will gain the ability to contribute in their design, development
and effective usage in their future careers.

Medical Image Processing

BME 702, Contacts: 3L, Credit: 3
Medical Image Processing
Course Objectives:
To learn the fundamental concepts of medical image acquisition and understand how to apply the image
processing techniques for various medical images. To learn the image fundamentals and mathematical
transforms necessary for image processing, study the various image enhancement techniques, apply various
image restoration procedures in Medical images. To gain knowledge about the basic concepts of image
compression procedures and study about the various segmentation techniques applied to Medical Images.

Artificial Organ & Rehabilitation Engineering

BME 703, Contacts: 3L, Credit: 3

Electives (PE)
Biological Control Systems
BME 704A, Contacts: 3L, Credit: 3
Biotelemetry & Telemedicine
BME 704B, Contacts: 3L, Credit: 3
Module
Module1

Module2

Module3

Module4

Module5

Topic

BASICS OF TELEMETRY
Introduction, fundamental of RF telemetry, basic telemetry, system components of
coding resolution, pulse code modulation, PCM multiplexing and conversion, PCM
data transmission, PCM PSD system. Theoretical comparison of telemetry systems,
sub modulation methods, power efficiency of combined systems, practical constraint
of telemetry methods optimized power efficiency.
BIOTELEMETRY
Measurement of Blood pressure Direct Methods and Indirect Methods
-Temperature - Respiration rate - Heart rate measurement - Apnea detectors
-Oximetry -Pulse oximeter, Ear oximeter - Computerized patient monitoring system
Bedside, Central Monitoring system Biotelemetry: Basics components, and its
different types.
TELEMEDICINE AND HEALTH
History and Evolution of telemedicine, Functional diagram of telemedicine system,
Telemedicine, Telehealth, Tele care, Organs of telemedicine, Global and Indian
scenario, Ethical and legal aspects
of Telemedicine - Confidentiality, Social and legal issues, Safety and regulatory
issues, Advances in Telemedicine.
TELEMEDICAL TECHNOLOGY
Principles of Multimedia - Text, Audio, Video, data, Data communications and
networks, PSTN,POTS, ANT, ISDN, Internet, Air/ wireless communications: GSM
satellite, and Micro wave, Modulation techniques, Types of Antenna, Integration and
operational issues, Communication infrastructure for telemedicine LAN and WAN
technology. Satellite communication. Mobile hand held devices and mobile
communication. Internet technology and telemedicine using world wide web (www).
Video and audio conferencing. Clinical data local and centralized.
TELEMEDICAL APPLICATIONS 9
Telemedicine access to health care services health education and self care.
Introduction to robotics surgery, telesurgery. Telecardiology, Teleoncology,
Telemedicine in neurosciences, Electronic Documentation, e-health services security
and interoperability., Telemedicine access to health care services health education
and self care, Business aspects - Project planning and costing, Usage of telemedicine.
TOTAL

No. of
Lectures
6

38

Text Books & References

1. Fundamentals of Remote Sensing by George Joseph, second Edition, Universities press, 2005
2. Khandpur R.S, Hand-book of Biomedical Instrumentation, Tata McGraw Hill, 2nd Edition, 2003.
3. Rajarao C and Guha S.K. Principles of Medical Electronics and Bio-medicalInstrumentation,
Universities press (India) Ltd, First Edition, Orient LongmanLtd, 2001.
4. Wootton, R., Craig, J., Patterson, V. (Eds.), Introduction to Telemedicine. Royal Society of Medicine
Press Ltd, Taylor & Francis 2006
5. O'Carroll, P.W., Yasnoff, W.A., Ward, E., Ripp, L.H., Martin, E.L. (Eds), Public Health Informatics
and Information Systems, Springer, 2003.
6. Ferrer-Roca, O., Sosa - Iudicissa, M. (Eds.), Handbook of Telemedicine. IOS Press (Studies in Health
Technology and Informatics, Volume 54, 2002.
7. Simpson, W. Video over IP. A practical guide to technology and applications. Focal Press Elsevier,
2006.
8. Bemmel, J.H. van, Musen, M.A. (Eds.) Handbook of Medical Informatics. Heidelberg, Germany:
Springer, 1997.
9. Mohan Bansal, Medical Informatics, Tata McGraw-Hill, 2004.
BioMEMs

BME 704C, Contacts: 3L, Credit: 3

Module

Topic

Module1

Introduction to BioMEMS and microfluidics Introduction to Bio nano technology,

Biosensors, fluidics. Introduction to device fabrication (Silicon and Polymers)
Introduction to device fabrication (Silicon and Polymers) continued. Sensors,
Transduction and Performance factors. Sensors, Transduction and Performance
factors continued
Important materials for fabrication of BioMEMS platforms Introduction to silicon
device fabrication Some Fabrication Methods for soft materials Transduction
Methods. About cell potential and SHEs Cell reaction, Nernst equation, Construction
of Ion selective electrodes Measurement and calibration of electrodes, ion-solvent
interaction
Design of ISE. Finding selectivity coefficient for a mixed ion system. ISE continued..
Gas sensing electrodes Applications for biosensors in Diagnostics, Zeta potential and
the model for electrode. Flow between two fixed plates. Comparison between plug
like flow of electro-osmosis Vs parabolic flow. Electro-kinetic flow in silicon
channels. Design of electro-kinetic network. Design of electro-kinetic network. Flow
rate calculations. Selection of good materials, Streaming potential.
Introduction to Cell biology, Basic structure of DNA DNA hybridization, , DNA
polymerization, PCR Thermal cycle , Real Time PCR.PCR design Electrophoresis,
Gel and Capillary electrophoresis, Agarose DNA microarrays (concepts, and utility).
Affymetrix and Nanogen approaches in realization of micro-arrays. DNA sequencing
(Sangers reaction). DNA nano-pores. DNA detection using Mechanical Cantilevers.
Basics of Protein structure.
Protein charging at different pH range, Amino acids, protein polymerization,
Transcription , Translation Antibody, Microencapsulation, Cyclic voltametry
Microfluidics, Similarity of Streamlines, Pathlines, Sreaklines and Timelines for a
steady flowStress tensor. Viscosity. Newtonian, non- Newtonian fluids,
Pseudoplastic, Dilatant, Bingham Plastic materials, Thixotropic fluids. Flow over
infinite plates, laminar and turbulent flow, Compressible and Incompressible flows
Flow over an infinite plate. Types of flows. Types of Fluids. Kinematics of fluids
Micromixers: Design and mixing principles Microvalves : Designing of pneumatic
and thermo pneumatic valves. Hydrogel based valves. Electrochemical valves.
Micropumps Microelectronic-fabrication processes: Review of basic fabrication
processes for silicon Introduction to microelectronic fabrication, Optical lithography,
photo-resists
Etching techniques, evaporation and sputtering. Vacuum science and plasmas, Theory
of plasma Review of basic fabrication processes for polymers Polymer materials for
microsystems, Polymeric
micromachining technology. Bulk and surface micro machining, Replication
technologies, laser machining, micro-stereo lithography, micro-molding, Assembly
and packaging.
Photolithography techniques Functionality of Polymer PDMS used in micro
technology Additive techniques, Thermal oxidation Single crystalline silicon,
Subtractive technique. Overview of Lab-on-chip technology/ biomedical and
chemical sensors, specific cases: Integrated gene analysis systems Chip technology
(Integrated analysis of pathogenic bacteria), Electrochemical and optical (labeled and
unlabeled).
TOTAL

Module2

Module3

Module4

Module5

Module6

Module7

Module8

No. of
Lectures
5

40

Text Books & References

1.
2.

3.

Fundamentals of BioMEMS and Medical Microdevices by Steven S. Saliterman

Mauro Ferrari (editor), BioMEMS and Biomedical Nanotechnology: I:Prospectus, Biological and
Biomedical Nanotechnology (A. Lee, L. Lee);II: Micro and Nano-Technologies for Genomics and
Proteomics (M.Ozkan and M. Heller); III: Therapeutic Micro/Nanotechnology (T. Desaiand S. Bhatia);
IV: Biomolecular Sensing, Processing and Analysis (R.Bashid and S. Wereley), Springer, 1st edition,
Nov. 30, 2006, ISBN:0387255613
Gerald Urban, BioMEMS (Microsystems), Springer, 1st edition, May 5,2006, ISBN: 0387287310.

4.
5.
6.
7.

Wanjun Wang, Steven A. Soper, Bio-MEMS: Technologies andApplications, CRC Press, 1st edition,
Dec. 15, 2006, ISBN: 0849335329.
Ville Kaajakari, Practical MEMS: Design of microsystems, accelerometers,gyroscopes, RF MEMS,
optical MEMS, and microfluidic systems, Small Gear Publishing, Mar. 17, 2009, ISBN: 0982299109.
Marc J. Madou, From MEMS to Bio-MEMS and Bio-NEMS:Manufacturing Techniques and
Applications, CRC Press, 1st edition, Jun.16, 2010, ISBN: 142005516X.
Ellis Meng, Biomedical Microsystems, CRC Press, 1st edition, ISBN:1420051229, Sept. 17, 2010.

Electives (OE)
Engineering System Modeling & Simulation
BME(ME) 705A, Contacts: 3L, Credit: 3
Module

Topic

Module1

Introduction to system dynamics; Solution methods for dynamic models; Spring and
damper elements in mechanical systems; State-variable models and simulation
method
Electric and electromechanical systems; System analysis in the frequency domain;
Transient response and block diagram models
Principles of Modeling and Simulation Modeling and Simulation of Mixed Systems
Block Diagram Modeling
MIMO: State-Space System Models
Constructing and Analyzing First Order Math Models Practical Applications of First
Order Math Models
Constructing and Analyzing Second Order Math Models Practical Applications of
Second Order Math Models
TOTAL

Module2
Module3
Module4
Module5
Module6

No. of
Lectures
5
6
6
5
7
7
36

Textbook
1. William J. Palm. System Dynamics. McGraw-Hill, 2ndEdition,2010
2. Mechatronic Systems: Modeling and Simulation with HDL by George Pelz. 2003
3. Mechatronic Systems Design by Shetty 2011
4. Feedback Systems: An Introduction to Scientists and Engineers by Astrom and Muray 2009
5. Automatic Control Systems by Golnaraghi and Kao 2010
6. Modeling of Engineering Systems: PC-based Techniques and Design Tools by Jack Lewis. 2000
7. Mechatronics Handbook Edited by Robert Bishop. 2002
8. Digital Control Systems: Design, Identification and Implementation by Landau and Zito 2006
Recommended References
Katsuhiko Ogata. System Dynamics. Prentice Hall, 2003.
Medical Robotics & Automation
BME(ME) 705B, Contacts: 3L, Credit: 3
Module

Topic

Module1

Introductory topics
Introduction to medical robotics (applications and paradigms), Basic kinematics
concepts (forward, inverse, remote center of motion), Basic control concepts
(impedance, admittance), Surgery for engineers, Interventional radiology for engineers
Minimally Invasive Surgery (MIS)
Human-machine interfaces, Teleoperation, Cooperative manipulation, Port placement

Module2

No. of
Lectures
8

10

Module3

Module4

for MIS, Robot design concepts, Video images in MIS, Augmented reality, Minimally
invasive surgery training
Image-Guided Interventions
Medical imaging modalities (e.g., MRI, US, X-ray, CT), Robot compatibility with
medical imagers,
Image segmentation and modeling, Tracking devices, Frames and transformations,
Surgical navigation, Calibration, Rigid and non-rigid registration, Radiosurgery
Applications of medical robotics
Cardiac, abdominal, and urologic procedures with teleoperated robots, Orthopaedic
surgery with cooperative robots, Prostate interventions with manual robots, Robotic
catheters for heart electrophysiology
TOTAL

10

10

38

Lasers & Optics in Medicine

BME(EC) 705C, Contacts: 3L, Credit: 3
Course Objective:
To study about the principles and applications of laser and fiber optics in medical field especially in diagnosis
and therapy.
Course Outcome
i)
Types of laser systems.
ii)
Operation of laser systems.
iii)
Role of laser systems in biomedical applications.

PRACTICAL/SESSIONAL
Medical Instruments & Systems Laboratory
BME 791, Contacts: 3P, Credit: 2
List of experiments:
1. Study on ECG heart rate monitor with alarm system
2. Study on peripheral pulse rate monitor with alarm system

3. Study on digital body/skin temperature monitoring system

4. Study on muscle stimulator
5. Study on spectrophotometer
6. Study on colorimeter
7. Study on flame photometer
8. Study on US Doppler / Foetal monitor
9. Study on hearing aid and audiometer: air and bone conduction
10. Study on EMG biofeedback system
11. Study on ECG simulator and servicing of ECG machine
12. Study on Baby incubator / Infusion pump

Medical Image Processing Laboratory

BME 792, Contacts: 3P, Credit: 2
Course Objectives:
To gain the practical knowledge about the processing of medical images, understand the fundamentals of digital
image and it s properties. To enhance the medical images by applying various filters and segment the region of
interest using various image processing Algorithms.

Project Part-I
BME 793, Contacts: 3P, Credit: 2