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Rifaximin Oral

This document provides instructions for compounding an extemporaneous rifaximin oral suspension with a concentration of 20mg/mL and a quantity of 60mL. It lists the necessary equipment, ingredients, and directions for crushing tablets and suspending them in a vehicle to achieve the final volume. A note is included about the bitter aftertaste and recommending chocolate syrup to improve palatability. References for stability information are also provided.

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Jayaraj T
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455 views1 page

Rifaximin Oral

This document provides instructions for compounding an extemporaneous rifaximin oral suspension with a concentration of 20mg/mL and a quantity of 60mL. It lists the necessary equipment, ingredients, and directions for crushing tablets and suspending them in a vehicle to achieve the final volume. A note is included about the bitter aftertaste and recommending chocolate syrup to improve palatability. References for stability information are also provided.

Uploaded by

Jayaraj T
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Pharmacy

Drug Name Route Dosage Form Concentration


Rifaximin Oral Suspension 20mg/mL
Formula Qty: 60mL Shelf Life: 60 days

Equipment needed:
GLASS mortar, GLASS pestle, graduated cylinder, stirring rod

Auxiliary Labels/Storage: Shake Well; Room Temperature


No refrigerated stability information.
Directions:
1. Crush tablets in a GLASS mortar and triturate to a fine powder.
2. Wet powder with a minimal amount of vehicle and levigate to form a viscous, but
smooth and uniform paste.
3. Continue adding vehicle, geometrically, mixing well after each addition.
4. Transfer to a graduate.
5. Rinse mortar with vehicle, adding rinse to graduate.
6. QS to final volume with vehicle. Stir well.

Note: The compound has a very bitter aftertaste. Pharmacists may recommend giving a
teaspoonful of chocolate syrup immediately prior to the dose to mask the aftertaste and improve
palatability. Can substitute Ora-Blend SF for Ora-Blend.

Ingredients QS Quantity Units


Rifaximin 200mg Tablets 6 Tablets
Ora-Blend (or 1:1 Ora-Plus/Ora-Sweet) X 60 mL

Citations/References
Cober MP, Johnson CE, Lee J, Currie K. Stability of Extemporaneously Prepared Rifaximin
Oral Suspension. Am J Health-Syst Pharm. 2010; 67(Feb): 287-289.
Reviewed: 4/7/2010 JEB

Nationwide Childrens Hospital Disclaimer


The information provided on this site is for educational and informational purposes and may not be relied upon to direct or provide care to a
patient. This material is not intended as a substitute for consulting health care professionals. The health care professionals remain solely
responsible to provide and direct patient care. The information contained on this site may not be up to date due to more recent medical
developments. The preparation, dispensing, and administration of pharmaceuticals is and remains the responsibility of licensed medical
professional or pharmacist. Nationwide Children's Hospital assumes no liability for any injury and/or damage to persons from use of any
information contained on this site.

700 Childrens Drive |Columbus, OH 43205

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