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Human Genetic Disease - Practice Final Exam

The document discusses a rare genetic disease shown in a pedigree. The pedigree is consistent with autosomal dominant inheritance but not autosomal recessive, X-linked recessive, or X-linked dominant inheritance. Scientists could use microarrays to compare SNP profiles of family members to determine the location of the disease gene.

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Raghav Goel
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60 views3 pages

Human Genetic Disease - Practice Final Exam

The document discusses a rare genetic disease shown in a pedigree. The pedigree is consistent with autosomal dominant inheritance but not autosomal recessive, X-linked recessive, or X-linked dominant inheritance. Scientists could use microarrays to compare SNP profiles of family members to determine the location of the disease gene.

Uploaded by

Raghav Goel
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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5/30/2020 Human Genetic Disease | Practice Final Exam | 7.

00x Courseware | edX

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Course  Pract…  Pract…  Hum…

Human Genetic Disease


Human Genetic Disease
Consider the pedigree below. This pedigree represents a family with a
rare genetic disease. Note two very important assumptions:

Individuals who marry into the family may carry a disease allele.

The disease is completely penetrant. That is, any individual with a


genotype corresponding to a disease phenotype will show the
disease.

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5/30/2020 Human Genetic Disease | Practice Final Exam | 7.00x Courseware | edX

Human Genetic Disease, Part A


1.0/1.0 point (graded)
i) Is this pedigree consistent with autosomal recessive inheritance?

No 

ii) Is this pedigree consistent with autosomal dominant inheritance?

Yes 

iii) Is this pedigree consistent with X-linked recessive inheritance?

No 

iv) Is this pedigree consistent with X-linked dominant inheritance?

No 

Submit

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5/30/2020 Human Genetic Disease | Practice Final Exam | 7.00x Courseware | edX

Human Genetic Disease, Part B


1.0/1.0 point (graded)
What technique could scientists use to determine the location of the
disease gene in the human genome?

RNAi

use microarray to compare mRNA levels in normal and diseased


individuals

use microarray to compare SNP pro les of family members from


the pedigree

cloning by complementation

cloning by protein expression

Submit

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