DRUG STUDY

Name of Drug Name of Indication Contraindication Side Effects Adverse Nursing

Mechanism Effects Responsibilit
ies
Generic Classification: ENGERIX-B Contraindicated -A Fibrous The most Baseline
Name: A 30.2 is a vaccine in patients Thickening of common Assessment:
Antigens indicated for hypersensitive to the Skin called solicited
Hepatitis B immunization yeast because Induration. adverse Questions for
Vaccine Clinical: against recombinant reactions history
infection vaccines are -Dizziness were allergies,
Brand Name: Engerix-B is caused by all derived from injection-site past health
safe, clinically known yeast cultures. -Erythema or soreness history and
Engerix-B well tolerated, subtypes of Use cautiously in skin redness (22%) and present
gives an anti- hepatitis B patients with fatigue illness.
Route HBs response virus. active infections -Fever (14%).
&Dosage: which is or compromised Patient
qualitatively cardiac and -Headache CNS:  Teaching:
0.5mL and pulmonary status headache,
Intramuscular quantitatively and in those for dizziness, Explain that
-Pain
similar to that whom a febrile or insomnia, hepatitis B
obtained with systemic reaction paresthesia, vaccine
  plasma- could pose a risk. -Sensation of neuropathy, provides
derived Spinning or transient protection
vaccines and Whirling malaise, against
confers slight fever. hepatitis B
protection only, not
against EENT:  against
infection and pharyngitis. hepatitis A or
disease. hepatitis C.
Engerix-B can GI: 
be considered nausea, Tell patient
as a valid anorexia, to expect
alternative to diarrhea, some
existing vomiting. discomfort at
hepatitis B injection site
vaccines. Musculoskel and possible
etal: fever,
arthralgia, headache, or
Peak effect: myalgia. upset
stomach.
6 months Skin:  Recommend
local acetaminoph
inflammation en to relieve
, soreness (at such effects.
injection Encourage
site). patient to
report
Other:  distressing
flulike adverse
symptoms, reactions.
 anaphylaxis.

References:
GlaxoSmithKline. (June 19, 2015) Engerix B. Retrieved from:
https://gskpro.com/content/dam/global/hcpportal/en_NA/PI/Engerix-B-GDS14.pdf

Andre Fe’. (n.d) Summary of clinical findings on Engerix-B, a genetically engineered yeast derived
hepatitis B vaccine. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/3317357/

GlaxoSmithKline. (June 2020). HIGHLIGHTS OF PRESCRIBING INFORMATION. ENGERIX-B.

Retrieved from:
https://www.gsksource.com/pharma/content/dam/GlaxoSmithKline/US/en/Prescribing_Information/Enge
rix-B/pdf/ENGERIX-B.PDF
Glowm. (n.d) Hepatitis B vaccine, recombinant. Retrieved from:
https://glowm.com/resources/glowm/cd/pages/drugs/h005.html