Chapter 6 Bones and Skeletal Tissue
Matching Questions
Using Figure 6.1, match the following bone types with the numbered structure:
A. Long B. Short C. Flat D. Irregular E. Sesamoid
1) Bone 1.Answer: C
2) Bone 2.Answer: A
3) Bone 3.Answer: C
4) Bone 4.Answer: D
5) Bone 5.Answer: A
6) Bone 6.Answer: E
7) Bone 7.Answer: B
8) Compact bone.Answer: C
9) Location of the epiphyseal line.Answer: B
10) Area where yellow marrow is found.Answer: D
11) Area with articular cartilage.Answer: A
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Match the following:
A) Osteomalacia B) Paget's disease C) Osteoporosis
12) Bones are porous and thin but bone composition is normal.
13) Bone formed is poorly mineralized and soft. Deforms on weight bearing.
14) Abnormal bone formation and reabsorption.
Answers: 12) C 13) A 14) B
A) Comminuted B) Spiral C) Greenstick
15) An incomplete fracture or cracking of the bone without actual separation of the parts.Common in
children.
16) Bone fragments into many pieces.
17) Common sports fracture resulting from a twisting force.
Answers: 15) C 16) A 17) B
Match the following:
A) Endosteum B) Canaliculi C) Osteoblasts D) Osteoclasts E) Lamellae
18) The lining of the marrow cavity.
19) Cells that can dissolve the bony matrix.
20) Layers of bone matrix.
21) Small channels that radiate through the matrix of bone.
22) Cells that can build bony matrix.
Answers: 18) A 19) D 20) E 21) B 22) C
A) Chondrocytes B) Appositional growth C) Epiphyseal line D) Diaphysis E) Epiphyseal plate
23) The cells responsible for the early stages of endochondral ossification.
24) The growth pattern of bone in which matrix is laid down on the surface.
25) The area of long bones where cartilage cells are replaced by bone cells.
26) The appearance of this structure signals the end of bone growth.
27) Area where bone longitudinal growth takes place.
Answers: 23) A 24) B 25) D 26) C 27) E
A) Short bone B) Long bone C) Irregular bone D) Flat bone E) Sesamoid bone
28) Radius.
29) Carpals.
30) Patella.
31) Scapula.
32) Hip bones.
Answers: 28) B 29) A 30) E 31) D 32) C
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True/False Questions
1) Hematopoiesis refers to the formation of blood cells within the red marrow cavities of certain bones.
Answer: TRUE
2) Compact bone is replaced more often than spongy bone. Answer: FALSE
3) Bones are classified by whether they are weight bearing or protective in function. Answer: FALSE
4) The periosteum is a tissue that serves only to protect the bone because it is not supplied with nerves or
blood vessels. Answer: FALSE
5) Short, irregular, and flat bones have large marrow cavities in order to keep the weight of the bones light.
Answer: FALSE
6) In newborn infants, the medullary cavity and all areas of spongy bone contain yellow bone marrow.
Answer: FALSE
7) The structural unit of compact bone (osteon) resembles the growth rings of a tree trunk. Answer: TRUE
8) The term osteoid refers to the organic part of the matrix of compact bones. Answer: TRUE
9) Sixty-five percent of the mass of bone is a compound called hydroxyapatite. Answer: TRUE
Diff: 1 Page Ref: 180 10) All bones formed by intramembranous ossification are irregular bones. Answer:
FALSE
11) An osteon contains osteocytes, lamellae, and a central canal, and is found in compact boneonly. Answer:
TRUE
12) The trabeculae of spongy bone are oriented toward lines of stress. Answer: TRUE
13) Bone tissue in the skeleton of a human fetus is completely formed at six months' gestation. Answer:
FALSE
14) Each consecutive bone lamella has collagen fibers that wrap in alternating directions. Answer: TRUE
15) Cartilage has a flexible matrix that can accommodate mitosis of chondrocytes. Answer: TRUE
16) Closure of the epiphyseal plate stops all bone growth. Answer: FALSE
Multiple-Choice Questions
1) The structure of bone tissue suits the function. Which of the following bone tissues is adapted to support
weight and withstand tension stress?
A) spongy bone B) irregular bone C) compact bone D) trabecular bone
Answer: C
2) Yellow bone marrow contains a large percentage of ________.
A) fat B) blood-forming cells C) elastic tissue D) Sharpey's fibers
Answer: A
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3) The cell responsible for secreting the matrix of bone is the ________.
A) osteocyte B) osteoblast C) osteoclast D) chondrocyte
Answer: B
4) What kind of tissue is the forerunner of long bones in the embryo?
A) elastic connective tissue B) dense fibrous connective tissue C) fibrocartilage D) hyaline cartilage
Answer: D
5) What can a deficiency of growth hormone during bone formation cause?
A) inadequate calcification of bone B) decreased osteoclast activity C) decreased proliferation of the
epiphyseal plate cartilage D) increased osteoclast activity
Answer: C
6) A fracture in the shaft of a bone would be a break in the ________.
A) epiphysis B) metaphysis C) diaphysis D) articular cartilage
Answer: C
7) The term diploe refers to the ________.
A) double-layered nature of the connective tissue covering the bone B) fact that most bones are formed of
two types of bone tissue C) internal layer of spongy bone in flat bones D) two types of marrow found within
most bones
Answer: C
8) Which of the following is a bone marking name that indicates a projection that helps to form joints?
A) meatus B) ramus C) foramen D) fossa E) epicondyle
Answer: B
9) Factors in preventing (or delaying) osteoporosis include ________.
A) drinking fluoridated water B) decreasing weight-bearing exercise C) increasing dietary vitamin C
D)decreasing exposure to the sun
Answer: A
10) Ossification of the ends of long bones ________.
A) is a characteristic of intramembranous bone formation B) involves medullary cavity formation C) is
produced by secondary ossification centers D) takes twice as long as diaphysis
Answer: C
11) Which structure allows the diaphysis of the bone to increase in length until early childhood, as well as
shaping the articular surfaces?
A) lacunae B) Haversian system C) epiphyseal plate D) epiphyseal line
Answer: C
12) The most abundant skeletal cartilage type is ________.
A) hyaline B) elastic C) fibrocartilage D) epiphyseal
Answer: A
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13) Which of the following is not a function of the skeletal system?
A) support B) storage of minerals C) production of blood cells (hematopoiesis) D) communication
Answer: D
14) What is the structural unit of compact bone?
A) osseous matrix B) spongy bone C) lamellar bone D) the osteon
Answer: D
15) Bones are covered and lined by a protective tissue called periosteum. The inner (osteogenic)layer
consists primarily of ________.
A) cartilage and compact bone B) marrow and osteons C) osteoblasts and osteoclasts D) chondrocytes and
osteocytes
Answer: C
16) The periosteum is secured to the underlying bone by dense connective tissue called________.
A) Volkmann's canals B) a bony matrix with hyaline cartilage C) perforating (Sharpey's) fibers D) the struts of
bone known as spicules
Answer: C
17) The canal that runs through the core of each osteon (the Haversian canal) is the site of ________.
A) cartilage and interstitial lamellae B) osteoclasts and osteoblasts C) yellow marrow and spicules D) blood
vessels and nerve fibers
Answer: D
18) What are the small spaces in bone tissue that are holes in which osteocytes live called?
A) lacunae B) Volkmann's canals C) Haversian canals D) trabeculae
Answer: A
19) For intramembranous ossification to take place, which of the following is necessary?
A) A bone collar forms around the cartilage model. B) An ossification center forms in the fibrous connective
tissue. C) The cartilage matrix begins to deteriorate. D) A medullary cavity forms.
Answer: B
20) The process of bones increasing in width is known as ________.
A) closing of the epiphyseal plate B) long bones reaching adult length and width C) appositional growth D)
concentric growth
Answer: C
21) Bones are constantly undergoing resorption for various reasons. Which of the following
cellsaccomplishes this process?
A) osteoclast B) osteocyte C) osteoblast D) stem cell
Answer: A
22) Which hormone increases osteoclast activity to release more calcium ions into thebloodstream?
A) calcitonin B) thyroxine C) parathyroid hormone D) estrogen
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Answer: C
23) The universal loss of mass seen in the skeleton, which begins about the age of 40, ________.
A) is slower in females than in males B) is absolutely uniform throughout the skeleton C) reflects incomplete
osteon formation and mineralization D) is greater in African Americans than in Northern Europeans
Answer: C
24) Wolff's law is concerned with ________.
A) vertical growth of bones being dependent on age B) the thickness and shape of a bone being dependent
on stresses placed upon it C) the function of bone being dependent on shape D) the diameter of the bone
being dependent on the ratio of osteoblasts to osteoclasts
Answer: B
25) Cranial bones develop ________.
A) from cartilage models B) within fibrous membranes C) from a tendon D) within osseous membranes
Answer: B
26) Which of the following glands or organs produces hormones that tend to decrease
Blood calcium levels?
A) pineal gland B) thyroid C) parathyroid D) spleen
Answer: B
27) Osteomyelitis is ________.
A) partially due to insufficient dietary calcium B) literally known as "soft bones" C) due to pus-forming
bacteria D) caused by altered vitamin D metabolism
Answer: C
28) Cartilage grows in two ways, appositional and interstitial. What is appositional growth?
A) growth at the epiphyseal plate B) the secretion of new matrix against the external face of existing
cartilage C) along the edges only D) the lengthening of hyaline cartilage
Answer: B
29) Which of the following statements best describes interstitial growth?
A) Growth occurs in the lining of the long bones. B) Fibroblasts give rise to chondrocytes that differentiate
and form cartilage. C) Unspecialized cells from mesenchyme develop into chondrocytes, which divide and
formcartilage. D) Chondrocytes in the lacunae divide and secrete matrix, allowing the cartilage to grow from
within.
Answer: D
30) In the epiphyseal plate, cartilage grows ________.
A) by pulling the diaphysis toward the epiphysis B) by pushing the epiphysis away from the diaphysis C) from
the edges inward D) in a circular fashion
Answer: B
31) Spongy bones are made up of a framework called ________.
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A) osteons B) lamellar bone C) trabeculaeD) osseous lamellae
Answer: C
32) Osteogenesis is the process of ________.
A) making a cartilage model of the fetal bone B) bone destruction to liberate calcium C) bone formation
D) making collagen fibers for calcified cartilage
Answer: C
33) Lengthwise, long bone growth during infancy and youth is exclusively through ________.
A) interstitial growth of the epiphyseal plates B) the secretion of bone matrix into the medullary cavity
C) differentiation of osteoclasts D) calcification of the matrix
Answer: A
34) Growth of bones is controlled by a symphony of hormones. Which hormone is important for bone
growth during infancy and childhood?
A) thyroid hormone B) somatomedins C) growth hormone D) prolactin
Answer: C
35) In some cases the epiphyseal plate of the long bones of children closes too early. What might be the
cause?
A) over production of thyroid hormone B) elevated levels of sex hormones C) too much vitamin D in the diet
D) osteoblast activity exceeds osteoclast activity
Answer: B
36) Normal bone formation and growth are dependent on the adequate intake of ________.
A) calcium, phosphate, and vitamin D
B) potassium, phosphate, and vitamin D
C) sodium, calcium, and vitamin E
D) vitamin D, phosphate, and chloride
Answer: A
37) Ostealgia is ________
A) a defect called clubfoot B) a disease of the bone C) pain in a bone D) fractured bone
Answer: C
Fill-in-the-Blank/Short Answer Questions
1) Blood cell formation is called ________.Answer: hematopoiesis
2) A bone embedded in a tendon is called a(n) ________ bone. Answer: sesamoid
3) A central (Haversian) canal may contain arteries, veins, capillaries, lymph vessels, and________ fibers.
Answer: nerve
4) A long bone forms by a process known as ________ ossification. Answer: endochondral
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5) ________ growth is growth in the diameter of long bones. Answer: Appositional
6) ________ are multinucleated cells that destroy bone. Answer: Osteoclasts
7) ________ is a disease of the bone in which bone reabsorption outpaces bone deposit, leaving the person
with thin and often very fragile bones. Answer: Osteoporosis
8) A round or oval hole through a bone that contains blood vessels and/or nerves is called a(n)________.
Answer: foramen
9) List the steps in the repair process of a simple fracture. Answer: Hematoma formation, fibrocartilaginous
callus formation, bony callus formation, and remodeling.
10) What is found in a Haversian canal? Answer: Blood vessels and nerve fibers.
11) Several hormones control the remodeling of bones. Which two respond to changing blood calcium
levels? Answer: To keep bones in proper dimensions, PTH and calcitonin are the major determinants
of whether and when remodeling will occur in response to changing blood calcium.
12) Why are the bones of young children much more flexible than those of the elderly?
Answer: Bones of children are not completely calcified, with a higher ratio of more flexible organic fibers.
Bones in the elderly are more completely calcified, which gives the characteristic of rigidity.
13) Inflammation of bony tissue is called ________.Answer: osteitis
14) Bones appear to be lifeless structures. Does bone material renew itself?
Answer: Bone only appears lifeless in gross anatomy. Microscopically, bone is full of cells and blood vessels
that maintain and renew bone tissue. Approximately 5% to 7% of our bone mass is recycled each week. Up
to 0.5 g of calcium may enter or leave the bones each day, depending on the negative feedback hormonal
mechanism and gravitational forces.
15) Compare the function of the organic materials in the bone matrix with the function of the inorganic
materials in the matrix. Answer: The organic matrix contributes to the bone structure and its tensile
strength, while the inorganic matrix contributes to hardness and resistance to compression.
16) What are the differences between the diaphysis and the epiphyses of long bones?
Answer: The diaphysis bone is composed almost entirely of compact bone (except in irregular and short
bones), while the epiphyses are composed almost entirely of spongy bone. The epiphyses are on the ends of
the bone; the diaphysis is the "shank" of the bone. The diaphysis in long bones has a large medullary cavity,
whereas the epiphyses do not.
17) Describe how oxygen is carried from outside a bone to an individual osteocyte.
Answer: Blood vessels enter through the periosteum into a perforating canal. The vessel may follow along
the axis of the bone through a central canal. Osteocytes have long, almost dendritic-like extensions or arms
that reach out through tiny holes called canaliculi. The canaliculi connect one cell to another and to
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the central canal. Oxygen would leave the blood vessel in the central canal and travel through the canaliculi
from cell to cell until it reaches the cell in question.
18) How is the beginning of intramembraneous ossification different from endochondralossification?
Answer: Intramembraneous ossification starts in connective tissue from mesenchymal cells that
become osteoblasts. These osteoblasts cluster together into an ossification center. Endochondralossification
starts with a hyaline cartilage "template." Mesenchymal cells become osteoblasts and begin forming bone
around the cartilage.
19) If your doctor notices a marked decrease in calcium ion levels in your blood, what gland might he suspect
is not functioning properly and why?
Answer: The parathyroid gland normally responds to low calcium ion levels in the blood and releases PTH,
which mobilizes osteoclasts to step up bone destruction, releasing more calcium into the bloodstream. If the
parathyroid is not functioning properly it may release too much PTH or not respond at all, which seems to be
the case here.
Clinical Questions
1) While on vacation last spring, June fell on the pavement and broke her wrist. At the emergency room, a
resident placed a cast on her wrist after manipulating the bones. It seemed to heal within a few months.
However, recently she has noticed lumps in the area where the break happened and she has been
complaining of pain. What could be causing the lumps and the pain?
Answer: June probably has "bony spurs," which are abnormal projections from a bone due to bone
overgrowth.
2) Alice and James adopted a 3-year-old child from a developing country. They noticed that her legs were
bowed and there were some deformities in her cranial and pelvic bones. They brought her to a physician for
a diagnosis. What was the diagnosis, and what was the treatment for the disorder?
Answer: The child most likely has rickets, a condition caused by poor diet, especially one deficient in vitamin
D. The parents were told to increase her intake of calcium and vitamin D andt o make sure that she gets
some sunshine every day.
3) Emily, a 64-year-old obese woman, was brought to the hospital suffering pain in her legs, and an X ray
revealed that she had a simple fracture in her right femur and a crack in her left tibia. Other tests revealed
that her bones were brittle and porous. What might have happened to Emily,and what advice would she
have been given by the physician?
Answer: Emily has osteoporosis, a debilitating bone disease that strikes more women than men after age 45-
50. The bones become weak and brittle due to leaching of calcium from the bone. Emily has been told that
she needs to lose weight because her bones may not have the strength to support her body mass.
4) A 75-year-old woman and her 9-year-old granddaughter were victims of a train crash. In both cases,
trauma to the chest was sustained. X rays of the grandmother revealed several fractured ribs, but her
granddaughter had none. Explain these different findings.
Answer: The child had more organic material in her bones, which allows them to bend, while her
grandmother's bones are extensively calcified, with little organic material, and are probablythin due to
osteoporosis.
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5) Johnny fractured the lower third of his right tibia in a skiing accident. The soft tissues in the area were
severely damaged and their surgical removal was necessary. After prolonged immobilization, it was found
that Johnny was healing very poorly. The explanation offered by the orthopedic surgeon was that
vascularization of the fracture site was still inadequate and good healing was absolutely dependent upon an
adequate blood supply. Describe how a long bone receives its blood supply and trace the path of nutrient
delivery to the osteocytes.
Answer: Long bones are nourished by nutrient arteries that frequently enter the shaft. Removal of the soft
tissues probably reduced the flow of blood to the affected area. The pathway would include diffusion of
nutrients from blood vessels to periosteum to Volkmann's canals to Haversian canals to canaliculi to lacunae.
6) People who live in the north should take supplemental calcium with vitamin D. Explain why.
Answer: Vitamin D is manufactured by sunlight and is needed for absorption of dietary calcium. People who
live in the north where the winter months are severe may need supplemental vitamin D because of the
decreased amount of sunlight exposure.
7) When does prevention of osteoporosis start?
Answer: The prevention of osteoporosis should begin with children. Parents need to provide children with
the opportunity to develop as much bone as they have inherited the ability to develop. If people increase
their peak bone mass as young adults, they will have additional protection from osteoporotic fractures in the
future.
8) If your elderly patient's blood calcium level is normal, does that mean the patient does not
have osteoporosis? Explain.
Answer: No. The level of calcium in the blood is expected to be normal, even in advanced cases of
osteoporosis. The calcium in the bones will be low, but that is not indicated by the bloodnourishment.
9) Mrs. Brown was outside on her patio cleaning windows when she fell off her step ladder and fractured her
right hip. She had emergency surgery for an open reduction and internal fixation of the right hip. Three days
postoperative, she asks you if she will have trouble going through airport security. What has prompted
her concern?
Answer: Open reduction is the correction of the bone alignment through a surgical incision. Itmay include
internal fixation of the fracture with the use of rods, wire, screws, pins, or nails,metal items that may trigger
security alarms.
10) How can a tooth be moved in a bony socket during orthodontic treatment?
Answer: Because bone deposition and reabsorption can occur, and because bone responds to mechanical
stress (Wolff's law), a tooth can be moved. By applying slight pressure to a tooth, the bone on the forward
side will reabsorb, while the bone on the reverse side will be reformed.
11) Explain why swimming is not generally recommended as an exercise to prevent osteoporosis.
Answer: Mechanical stress and gravity help to promote skeletal remodeling. Swimming is notc onsidered a
weight-bearing exercise. The water, not bones, supports the body's weight while swimming
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