SHEILA MAE C.

SACLOT DRUG STUDY

Indications/Contraindications/
Drug/ Dosage/
Action Administration Adverse Reaction Cautions Nursing Considerations
Classification

Midazolam The actions of > Midazolam Physical and Indications: > Before administering,
benzodiazepines administration can be psychological > For short-term treatment of have oxygen and
such as midazolam through oral, intranasal, dependence with increased or frequent seizures resuscitation equipment
are mediated buccal, intravenous, and withdrawal called seizure clusters or acute available in case of
through the intramuscular routes. symptoms; repetitive seizures. In children over severe respiratory
inhibitory decreased tidal 12 years old and in adults. depression.
neurotransmitter > For the perioperative volume and
gamma-aminobutyric use of midazolam, the respiratory rate, > Used before surgery or a > Monitor and record
acid (GABA), which is induction dose is 0.15 to apnea headache, procedure. It helps to cause patient response to
one of the major 0.40 mg/kg via the hiccup, nausea and drowsiness, decrease anxiety, and medication.
inhibitory intravenous route. vomiting, cough and to decrease your memory of the
Pharmacological neurotransmitters in increase of appetite. surgery or procedure. Midazolam > Observe site closely for
the central nervous > For the works by calming the brain and extravasation.
class: system. premedication, the dose nerves.
Benzodiazepines is 0.07 to 0.10 mg/kg > Monitor for adverse
Benzodiazepines increase the activity with the intramuscular Contraindications & Cautions: reactions.
Contraindications for the use of
of GABA, thereby route.
midazolam include acute angle-
producing a sedating > Continuous
closure glaucoma, hypotension, and
effect, relaxing > For intravenous shock. Careful dose adjustment is cardiorespiratory
skeletal muscles, and sedation, the dose is necessary in cases of kidney and liver monitoring.
inducing sleep, titrated at 0.05 to 0.15 diseases, alcohol, and drug-dependent
anesthesia, and mg/kg. For children 1 to individuals. Caution is necessary for > Monitor BP and oxygen
amnesia. 5 months old, the pregnant individuals, children, and saturation.
recommended individuals with comorbid psychiatric
intranasal dose is conditions. Administration in elderly > Assess sedated infant
0.2mg/kg. individuals and acutely ill patients for signs of pain
requires caution to prevent the (midazolam does not
accumulation of active metabolites.
> For children six possess analgesic
Extra precautions should be taken in
months and older, 0.2 properties).
critically ill individuals as dose
to 0.3 mg/kg intranasal accumulation can occur.
dose is the > And known hypersensitivity to
recommendation. midazolam