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SPVC Online Test Series Pharmaceutics-Ii Module 5 Question & Answers

This document provides 50 multiple choice questions related to pharmaceutical topics such as parenterals, ophthalmic preparations, and sterilization. The questions cover areas like common pharmaceutical dosage forms, components, manufacturing processes, quality tests, and regulations. Key areas assessed include isotonicity, preservatives, sterilization methods, packaging, and stability testing parameters. The questions are multiple choice with a single correct answer for each.

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Akhil Sharma
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421 views

SPVC Online Test Series Pharmaceutics-Ii Module 5 Question & Answers

This document provides 50 multiple choice questions related to pharmaceutical topics such as parenterals, ophthalmic preparations, and sterilization. The questions cover areas like common pharmaceutical dosage forms, components, manufacturing processes, quality tests, and regulations. Key areas assessed include isotonicity, preservatives, sterilization methods, packaging, and stability testing parameters. The questions are multiple choice with a single correct answer for each.

Uploaded by

Akhil Sharma
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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SPVC Online Test Series

PHARMACEUTICS- II Module 5
Question & Answers
1. Sealed glass containers with an elongated neck:
a. Gauge
b. Ampoules
c. CSP
d. Vial

2. A solvent that dissolves a lyophilized powder or dilutes a solution:


a. Diluent
b. Solvent
c. Additive
d. Admixture

3. Movement of particles in a solution through permeable membranes:


a. Filter
b. Dialysis
c. Flow rate
d. Anhydrous

4. Methods that maintain sterility products:


a. Aseptic technique
b. Bleaching
c. A clean person
d. Admixture

5. The rate (in ml/hour or ml/minute) at which the solution is administered to the
patient:
a. Gauge
b. Coring
c. Diluent
d. Flow rate

6. The A drugs molecular weight divided by its valence, a common measure of


electrolyteconcentration:
a. Coring
b. Valence
c. Flow rate
d. Equivalent weight

7. When a solution has an osmolarity equivalent to that of blood:


a. Hypotonic
b. Isotonic
c. Hypertonic
d. Therapeutic
8. When a solution has a lesser osmolarity than that of blood:
a. Hypotonic
b. Hypertonic
c. Isotonic
d. Tonic

9. What percentage of NaCl is isotonic with eyes:


a. 0.5%
b. 0.9
c. 1.9
d. 5

10. What percentage of boric acid seems to be isotonic with eyes:


a. 0.9
b. 1.9
c. 0.5
d. 2.9

11. Which layer of eye is also called as white of eye:


a. cornea
b. Sclera
c. Iris
d. Retina

12. WFI contains bacteriostatic agents when in containers of:


a. 100ml of less
b. 30ml of less
c. 50ml of less
d. 10ml of less
13. Parenteral in the form suspension are usually given by:
a. IV
b. SC or IM
c. ID
d. IA

14. Which of the following used as enteric resin in microencapsulation:


a. stearic acid
b. PVA
c. Cellulose acetate phthalate
d. Ethyl cellulose
15. Which of the following is not a water soluble coating material:
a. Ethyl cellulose
b. CMC
c. PVP
d. Gelatin

16. Most commonly used preservative in ophthalmic preparation is:


a. Chlorobutanol
b. Phenyl mercuric acetate
c. Phenyl mercuric nitrite
d. Benzalkonium choride

17. Which of the following surfactant prefer in ophthalmic due to less irritation?
a. ionic
b. cationic
c. amphoteric
d. Nonionic

18. Which of the following is TRUE:

a. Rabbit pyrogen test is quantitative biologic test


b. Pyrogenic effect is high with IM compared to IV injection
c. Greater danger of pyrogens exists in LVP's than SVP's
d. LAL test is in vivo test

19. Powdered glass test challenges the leaching potential of:


a. Exterior structure of glass
b. Plastic containers
c. Interior structure of glass
d. Intact surface of glass

20. Which of the following in NOT true about LAL test:


a. It is a in vivo biological test
b. It is performed using lysates of amebocytes of the horseshoe crab
(LimulusPolyphemus)
c. It is a biochemical test perfomed in a test tube
d. It is simple, rapid and more sensitive (5 -10 times) than rabbit pyrogen test
21. As per USP which of the following is correct:
a. WFI should contains NMT 1000 ppm of solids
b. WFI should contains NMT 100 ppm of solids
c. WFI should contains NMT 10 ppm of solids
d. WFI should contains NMT 1 ppm of solids

22. Cryoprotectants or Lyoprotectants used in freeze dried parenteral products:


a. Mannitol
b. Starch
c. Magnesium stearate
d. PVP

23. Freeze dried injectable products have to be reconstituted with _ to form solution or
suspension for administration:

a. Sterile Water for Injection


b. Water for Injection
c. Purified water
d. Boiling water

24. Sterility testing of Parenteral products uses Soyabean Casein digest medium for:
a. Aspergillus niger
b. Pseudomonas aeruginosa
c. E.coli
d. S. aureus
25. Which amongst following is the easy to prepare ophthalmic dosage form:
a. suspension
b. ointment
c. solution
d. gel

26. Non-swellable water insoluble polymer:


a. Ethyl cellulose
b. HPMC
c. Carbopol
d. Polycarbophil
27. Particle size of microcapsules is:
a. 10-5000 micron
b. 5000- 10000 micron
c. 10000-12000 micron
d. 15000-30000 micron

28. State the method of microencapsulation for cinnamon oil:


a. Air suspension coating
b. pan coating
c. coacervation phase separation by salt addition
d. coacervation phase separation by temperature change

29. Topical drug delivery systems are used for treating:

a. local infections

b. diabetes

c. hypertension

d. hypotension

30. Ocular inserts have following feature:

a. blurred vision

b. low bioavailability

c. sticking of eyelids

d. Increased retention

31. In the equation log C = log Co – KEt/2.303, what does Co stand for _______

a. Plasma drug concentration after 60 min of i.v. injection

b. Plasma drug concentration after 15 min of i.v. injection

c. Plasma drug concentration after 30 min of i.v. injection

d. Plasma drug concentration immediately after i.v. injection


32. The acceptable limits of osmolarity with respect to tonicity for parenteral solutions are:

a. 250- 269 mosm/L


b. 278 – 328 mosm/L
c. 329-350 mosm/L
d. 240 -260 mosm/L

33. Trehalose, mannitol, dextrans are examples of --------------- used in parenterals:


a. Preservatives
b. Buffers
c. Cryoprotectants
d. Vehicles
34. The recommended particle size of dispersed active pharmaceutical ingredient in
ophthalmicsuspension is:
a. More than 10 microns
b. Not more than 10 microns
c. Not more than 5 microns
d. Not more than 20 microns

35. Grade A aseptic area used for manufacturing of ophthalmic solutions prepared by:
membranefiltration comprises of :
a. Not more than 100 particles per cubic meter of size 0.5 microns
b. Not more than 100 particles per cubic foot of size 0.5 microns
c. Not more than 1000 particles per cubic foot of size 0.5 microns
d. Not more than 1000 particles per cubic meter of size 0.5 microns

36.---------------------are materials used for primary packaging of ophthalmic products:


a. Polypropylene, low density polyethylene, high impact polystyrene
b. Polyvinyl chloride, Polyvinylidene chloride, high impact polystyrene
c. Polyvinyl chloride, Polypropylene, low density polyethylene
d. Polyvinyl chloride, high impact polystyrene, polypropylene

37. The drug of elimination half life upto ----------- is an ideal candidate for sustained
release dosage forms:
a. 2 – 8 hours
b. 6- 10 hours
c. Less than 2 hours
d. More than 8 hours

38. The process variables that affects quality of microencapsulated product prepared by
Wurstertechnique are:
a. Density
b. Particle size
c. Velocity of atomization air
d. Density, particle size, velocity of atomization air, inlet and outlet temperature
39. Absolute bioavailability of drug is measured by comparing AUC of drug:
a. Given by oral route to that by topical route
b. Given by oral route to that by rectal route
c. Given by oral route to that by subcutaneous route
d. Given by oral route to that by intravenous route

40. The Sterility test of Liquid involves:


a. Colorimetric Assay
b. Guinea Pigs Assay
c. Culturing in the fluid thioglycollate medium
d. HPLC assay

41. Bacterial endotoxin test is used to determine:


a. The amount of Pyrogens
b. The level of Pyrogens from Gram negative bacteria
c. The level of bacterial endotoxin from Gram negative bacteria
d. The level of bacterial endotoxin from Gram positive bacteria.

42. Suspension & oily injection can be administered through:


a. intravenous
b. intraarterial
c. intramuscular
d. intraspinal

43. For preparations intended for parenteral administration USP 24 requires the use of
pharmaceutical aid except:
a. Water for injection
b. Sterile water for injection
c. Bacteriostatic water for injection
d. Purified water

44. The DOP test is used for checking the efficiency of:
a. HEPA filter
b. Membrane Filter
c. Asbestos filter
d. Water filter

45. One of the organism given below is used as biological indicator in IP for ethylene
oxidesterilization. Choose the correct one:
a. Bacillus stearothermophillus
b. Spores of Bacillus subtilis
c. Spores of Bacillus cereus
d. spores of Bacillus stearothermophillus
46. All the following viscosity builders have been used in ophthalmic solutions except:
a. Veegum
b. Methyl Cellulose
c. Polyethylene Glycol
d. polyvinyl alcohol

47. Which of the following statement is false:


a. Sesame oil is preferred oil for most of the official injections in oil
b. Water miscible solvents used in parenteral formulations include glycerine, ethyl alcohol,
propylene glycol
c. Water for injection must be stored at Room Temp if it is to be held for 24 hrs.
d. Inert gases purging improves product integrity of Oxygen sensitive materials
48. Sterility testing can be done by using?
a. Direct inoculation method
b. Membrane filtration method
c. Pyrogen test
d. All of the above

49. Parenteral preparations can be sterilized through?


a. Chemical sterilization
b. Membrane filtration
c. Desiccation
d. Dry heat method

50. Size of pore size of membrane which is used for membrane filtration sterility testing?
a. 1 microns
b. 45 microns
c. 4 microns
d. 100 microns

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