HOW

TO MAKE

GOOD THINGS

HAPPEN

Know Your Brain, Enhance Your Life

MARIAN ROJAS ESTAPÉ, MD

Translated from the Spanish by Sofia Smith-Laing

To my six men
 CONTENTS

The Start of a Journey

1. DESTINATION: HAPPINESS
Self-Esteem and Happiness
Happiness and Suffering
Trauma
Bedside Manner Is the Best Painkiller
Suffering Has Meaning

2. THE ANTIDOTE TO SUFFERING: LOVE

Love for Another Person
Love for Others
Love of Ideals and Beliefs
Love of Memories

3. CORTISOL
Get to Know Your Traveling Companion
What Happens If You Return to the Site of a Traumatic Event?
 What Happens If You Live with Constant Anxiety?
Understanding the Nervous System
Symptoms Caused by “Toxic Cortisol”
My Mind and My Body Can’t Tell Truth from Fiction
Nutrition, Inflammation, and Cortisol
What Role Does the Digestive System Play in Inflammation?
Is Depression an Inflammatory Illness of the Brain?

4. NEITHER WHAT HAS BEEN NOR WHAT IS TO COME

Healing the Wounds of the Past and Getting Excited for the
Future
Guilt
How to Pacify Feelings of Guilt
Depression
Forgiveness
What Is Compassion?
Living with Anxiety for the Future
Highly Charged Emotional Memories
How to Deal with an Amygdala Hijack

5. LIVING IN THE PRESENT MOMENT

A Fundamental Discovery
Belief System
State of Mind
Attentive Capacity: The Ascending Reticular Activating
 System (ARAS)
Learning to Look at Reality Again
Neuroplasticity and Attention

6. EMOTIONS AND THEIR IMPACT ON HEALTH

What Are Emotions?
Positive Psychology
A Study with Surprising Participants
The Principal Emotions
The Molecules of Emotion
Drowning in Swallowed Emotions
Learning to Express Your Emotions
What Happens to Repressed Emotions?
What Does Crying Do?
Principal Psychosomatic Symptoms of Blocking the Emotions
Attitude as a Key Factor in Health
And . . . What About Cancer?
What Happens in Metastasis?
Simple Steps for Managing Emotions Well
Telomeres

7. TRIGGERS AND ATTITUDES THAT INCREASE CORTISOL

Fear of Losing Control
Perfectionism
Chronopathy: Obsession with the Efficient Use of Time
 The Digital Era

8. HOW TO LOWER CORTISOL LEVELS

Exercise
Handling Toxic People
Six Keys for Managing a Toxic Person
Positive Thoughts
A Simple Guide to Worrying Less
Meditation/Mindfulness
Omega-3

9. BEST POSSIBLE SELF

Who Am I?
BPS: Best Possible Self
Knowledge
Willpower
Setting Goals and Objectives
Passion

It’s Never Too Late to Start Again: The Case of Judith, the
Porn Star

Author’s Note to the 10th Spanish Edition
Acknowledgments
Bibliography
Index
 THE START OF A JOURNEY

A journey of a thousand miles begins with a single step.

—Laozi

Planes, trains, and other modes of transportation are generally excellent places
for surprising things to happen. You just have to let yourself be carried along,
observing and intervening if a good opportunity arises. My best stories have
come out of such situations.
A few years ago, on a flight from New York to London, I was traveling in
the window seat. I always choose this seat because I like watching the sky, the
clouds, and the sea; above all, I like to remind myself of the insignificance of
human beings in the face of nature’s immensity, so as to gain some perspective
about what happens to us on Earth.
I always pay attention to the traveler seated next to me. Over the long hours
in flight, one develops a certain connection to one’s neighbor. Analyzing what
they’re reading and what they watch on their screen, observing whether they eat
or sleep—speculating about their circumstances and the reasons for their trip is
unavoidable. Do they have a family? Are they traveling for work? At one
moment or another, one of you gets up, and good manners require that you
exchange a few simple words. Generally, at the end of the flight, you wish each
other a friendly goodbye.
I’ve always believed that if you pay close enough attention to anyone, they
become interesting. One usually has a conversation at some point during the
flight. Thanks to these interactions, I’ve met truly fascinating people, and things
have happened to me that have made an impact on many aspects of my life.
On this particular flight, taking off from New York, I sat next to an older
gentleman. He was reading the newspaper, and I got some course notes out of
my bag. They were on anatomy; the drawings I’d done in class weren’t very
good—I’ve always been bad at drawing—and while I was trying to memorize
the hundreds of names, I noticed the man’s gaze directed at my papers. I smiled
at him.
“I study medicine.”
He answered, “My father is a doctor.”
I did a quick analysis of the man—I’ve loved doing this since I was young—
but he maintained, despite our cordiality, a cold, unapproachable look. I grew
curious, and asked, “Have you followed in your father’s footsteps,
professionally?”
“No. I’ve always preferred investigation.”
“What kind?”
“I investigate terrorism.”
I closed my notes. A conversation had fallen in my lap that promised to be
very interesting. My collection of muscles and strange little bones would still be
there when I got to Madrid. My interlocutor revealed to me that he had just
retired after more than thirty years with the CIA. For a while now, he had been
allowed to speak more freely of his work, and during the rest of the flight he
explained the war in Iraq and geopolitical tensions in the area, conflicts over oil
and pipelines, the interests of different Western countries . . . all of it on an
improvised map of the Middle East with arrows pointing in every direction.
I’m a politics and history buff, and I have to confess that I didn’t stop taking
notes the whole time. At one point in the conversation, I told him I was studying
to be a psychiatrist. He scrutinized me and was silent for a few moments before
beginning to ask me the strangest questions about my tastes and personality. I’m
not used to being asked about myself with so much intensity, as it’s usually me
who’s posing the questions, but I tried to respond as sincerely as possible.
After a pause, he proposed that I do a stint at the CIA when I had finished
my specialized studies and undertake some kind of work as a forensic or
my specialized studies and undertake some kind of work as a forensic or
investigative psychiatrist. In that moment my eyes lit up. The world suddenly
seemed so exciting. I smiled and said, “As long as I don’t have to do field work
—I tend to be a little nervous.”
He left me his contact details and we said goodbye. I wrote to him several
times and we maintained an email correspondence for a few years.
Unfortunately, reader, I never did go and work at the CIA. My life took
another course, but I keep that card from my “analyst friend” in my wallet, to
remind myself that opportunities are close by—you just have to go look for
them.
In my opinion, few notions have done more damage than the idea that “it
will arrive when you least expect it.” No one is going to come looking for us at
home to offer us our life’s work. We have to go out and find it.
One of the things in life that causes us the most anguish is the inability to
know what we should devote ourselves to or what path we should choose.
Making a decision becomes an impossible challenge. We live in a world full of
opportunities—we have never had so much available for so little effort. We find
ourselves living at the most overstimulated point in history; today, any seven-
year-old has absorbed more information and stimuli—music, sound, food,
flavors, images, videos—than any human being who previously walked the
Earth.
This overstimulation makes decisions hard. Today’s younger generations—
the so-called “millennial” generation, where I have one foot planted, and “Gen
Z”—find themselves bewildered, unsure what to choose or where to go.
Professionally, they have to decide between innumerable fields of study, and,
once their studies are complete, between innumerable job opportunities; both of
these choices seem impossible. Multiple possibilities crowd in, and they don’t
know where to direct their lives. Ours is a society of confusion and commitment
phobia. I see more and more young people who are “blocked” without knowing
it, because to decide, one needs to know what one feels.
Millennials and members of Gen Z are saturated with emotions and feelings
that make them reliant on constant gratification to move forward. We’ll speak
more about this later, and we will try to understand better what is happening in
the minds of many young people. There is a clear breach between two
the minds of many young people. There is a clear breach between two
generations who are living in the same world: those born before 1980 and those
born after 1990. Those of us born between 1980 and 1990 have lived through an
important period of transition.
Those born before 1980 have generally struggled quite a bit: many were born
to the children of twentieth-century wars and have given their families a good
start; most important of all, the digital world of the internet and social networks
has caught up to them after adolescence. This is key. Their personal
relationships, their ways of working and confronting life, as well as their beliefs,
are all based on other concepts—I don’t mean specific ideologies, I mean the
way that they’re formed.
After 1990, something decisive happens: the birth of the internet. In this
book, we’ll examine the impact of the constant assault of stimuli that the
youngest members of our society are subjected to as soon as they’re born, as
well as the effect of social networks on the gratification system of the brain,
which is the reason that we find ourselves dealing with a profoundly unsatisfied
generation. To motivate them—in educational, emotional, affective,
professional, and economic terms—more and more frequent and intense stimuli
are often required.
How to Make Good Things Happen draws on many different tools. Life
contains very difficult moments, when the most important thing is to survive and
find some support to sustain oneself. The rest of the time, we need to fight to
bring out our BPS—Best Possible Selves.* We’ll talk about attitude and
optimism; the way that we confront life has a big impact on what happens to us.
Predisposition—the attitude we already have in place—determines how we
respond to any situation.
Years of experiments have shown that the way you decide to respond to
problems and questions encountered on a daily basis can influence the outcome.
The brain, physiological markers, genes, cells, feelings, emotions, and thoughts
function as a whole. Physical ailments, in many cases, have a direct relationship
to the emotions, and we can always try to channel the effect that a physical
ailment has on our state of mind. To help you understand the brain, I will
attempt to simplify what is fundamentally complex. By understanding our brains
and managing our emotions, we can enhance our lives. Nowadays, neuroscience,
specifically neurobiology, taken together with what we call the unconscious—
specifically neurobiology, taken together with what we call the unconscious—
from surface emotions to the depths of the psyche—can explain a large part of
our behavior.
This book talks about happiness, because we all long to find it, and about
success. But success can be a great liar. In my therapeutic practice, I often find
myself admiring people who, faced with suffering, pain, and failure, have been
capable of overcoming them. Failure reveals what success conceals, says the
great teacher of my life, my father.
In this book I want to try to explain not only the troubles of the mind, heart,
and body, but, much more than that, the good and healthy aspects of life. I want
to show what can help the reader to enjoy better health in soul and body, and in
this way, perhaps, to get closer to that longed-for happiness.
This is the start of an exciting path toward understanding and reinventing
ourselves. Everyone has a second chance to find their passion and to choose a
better way through life.

* We’ll look at this formula, BPS, in Chapter 9.

 1

DESTINATION: HAPPINESS

Happiness can’t be defined; it can only be experienced. You have to feel it to

recognize it, and once you do, words seem to fall short of expressing it. All the
same, we’re going to try to explain it, approaching it from different angles.
The first idea I want to get across is this: there are no cheat sheets or
shortcuts that guarantee happiness. There’s already a lot of criticism out there of
self-help books that promise a simple recipe to happiness, but what’s true is that
we now have a multitude of studies and scientific data that give us a fairly
specific sense of the level of physical and psychological well-being
indispensable to happiness.
Psychiatrists study mental illness—or rather, we study people who suffer
from mental or emotional disturbances. Frequent professional conferences are
held on the most varied issues in the field: the brain or some specific region of it,
neuronal markers and the physiology behind them, internal or external factors
that make psychiatric illness more likely; or how to improve the reliability of
diagnostics, and the latest experimental treatments. In general, we look at mental
afflictions through every possible scientific lens.
Since I was young, my vocation has been to treat and help people suffering
from sadness and anguish. This has led me to investigate happiness, pleasure,
love, compassion, and joy and to pose myself a series of difficult questions. Why
are there people with a tendency to suffer and complain, no matter their
situation? Does good luck exist or is it not as random as it seems? What
importance do genes carry in forming people’s minds and their characters?
Which factors predispose me to be—or prevent me from being—happier?
Investigating these issues has pushed me down lots of different paths, in search
of the most thought-provoking reading.
Our society is, at present, richer than ever in comparative terms. We have
never had as much as we do now. Generally, our primary needs are taken care of
and we have almost any item at our disposal, in most cases only a click away. As
a consequence, though it isn’t desirable and should be avoided, overabundance is
becoming normal.
Sometimes we believe that we deserve everything, an attitude encouraged by
our reigning materialism, which makes us think that it’s good to have access to
everything that we desire. However, no accumulation of things on its own can
grant access to happiness, to an interior state of plenitude.
Happiness consists in having a fully realized life, in which we try to get the
best out of our values and aptitudes. Happiness is making a little work of art out
of life, striving every day to bring out our best selves.

Happiness is intimately related to the meaning we give our

lives and our existence.

As we will see, the first step toward trying to be happy is recognizing what
we are asking for from life. In a world that has lost its meaning and its sense of
direction, we tend to substitute “sensations” for that “sense.” Society is suffering
from a huge spiritual vacuum that it tries to fill with a frantic search for
sensations: bodily satisfaction, sex, food, alcohol, etc. There is a widespread and
insatiable need to experience new and ever more intense emotions and
sensations. There is nothing bad per se about sex, gourmet cooking, or the
pleasure of a glass of good wine—I’m talking about when the search for these
sensations is substituted for true meaning in life. In these cases, where the sense
of direction has been lost, the accumulation of sensations produces a momentary
gratification; meanwhile, our interior void grows like a black hole, slowly
engulfing our lives, inevitably leading to psychological ruptures or destructive
behaviors.
Only then, when the damage is done, does the affected person, or someone
close to them, realize that recovery is beyond their own strength and seek
close to them, realize that recovery is beyond their own strength and seek
external help. This is when someone in the role of a psychiatrist or psychologist
becomes necessary to help rebuild a person’s life.
Human beings seek to possess, and we connect happiness with possession.
We spend our lives seeking economic, social, professional, and affective
stability. We seek security, prestige, material things, friends. But true happiness
is not in having, it is in being. Our way of being is the foundation of true
happiness.

Careful! Take care not to confuse happiness with happiness

lite, which is sold to us as though it were only a click away.
You know there’s something wrong with this materialist
concept when 20 percent of the population is seeking
treatment for emotional problems.

If amassing material things isn’t the solution to happiness, what is? In my

opinion, in this constantly changing and rapidly evolving world, happiness must
necessarily involve a return to values. And what are values? Values help us to be
better people, to perfect ourselves. It’s a very basic definition, but it serves as a
guide in moments of chaos and uncertainty.
When someone loses themself and doesn’t know where to go, having values
and a few guiding principles helps stop the boat from running aground. Aristotle
said it long ago, in his Nicomachean Ethics: “Shall we not, like archers who
have a mark to aim at, be more likely to hit upon what is right?” Today there are
no marks to aim at, the archers have died out, and arrows are flying randomly in
all directions.
To understand the world we’re facing, I find this acronym from the US Army
War College helpful: VUCA. It’s a phrase that really nails our sociological
context: volatility, uncertainty, complexity, and ambiguity. This notion was
formed to describe the state of the world in the aftermath of the Cold War. Now
it’s used in leadership strategy, sociological analysis, and education to describe
sociocultural, psychological, and political conditions.
Volatility refers to rapidity of change. Nothing seems stable: online news
portals update every few seconds to suck in readers, trends in what to wear and
where to be seen can change in a matter of days, and the economy and stock
where to be seen can change in a matter of days, and the economy and stock
exchanges fluctuate hour by hour.
Uncertainty: few things are predictable. Events follow one after the other,
and we feel flattened by a whirlwind of fresh occurrences. There are algorithms
that try to foresee the future, but reality ends up surpassing fiction.
Complexity refers to the interconnectedness of our world, where all areas of
human knowledge have reached an infinitesimal level of precision. Even the
smallest details influence outcomes in our lives—the famous “Butterfly Theory”
of chaos.
Ambiguity—which, for me, has a connection to relativism—leaves no room
for clarity in our ideas. Everything might or might not be. There are no clear
ideas left about almost any aspect of existence.
I’ve always thought that psychiatry is a marvelous profession. It is the
science of the soul. We help people who come to us asking for help in
understanding how their minds, their information-processing systems, their
emotions, and their behaviors work. We try to heal past wounds or teach them to
manage situations that are difficult or impossible to control. There are plenty of
books out there now to teach you to find your focus in life or deal with different
aspects of it. Like everything, you need to know how to filter through these, and
above all, how to find the way of dealing with things that suits you best. We
psychiatrists and psychologists must adapt ourselves to our patients,
understanding their silences, their difficult moments, their fears, and their
worries, all while providing order and calm without judgment and knowing how
to communicate serenity and optimism.
I find it fascinating to look into how we think, why we react the way we do,
what emotions are, and how they’re reflected in the mind. Ultimately, happiness
has a lot to do with the way in which I observe, analyze, and judge myself, and
with my expectations for myself and my life. Put simply, happiness is to be
found in balancing my personal, relational, and professional aspirations with
what I have actually achieved, piece by piece. Finding this balance has results:
adequate self-esteem and a fair evaluation of my worth.

CASE STUDY: MAMEN

 Mamen is a 33-year-old patient. She works as an administrator in a large
company. She lives with her parents, with whom she has a good relationship.
She has a boyfriend, a shy and withdrawn guy who cares for her very
attentively. There’s a good atmosphere at her work and sometimes she meets
up with people from the office.
One day she comes to my practice. She says her self-esteem is through the
floor. She can’t explain why, and adds: “My parents love me, I like my job, I
have friends, but I feel like a waste of space.”
After giving me a summary of her life, she stops short and tells me, “I’m
ashamed to be here, telling my problems to a stranger when I have nothing to
complain about.” She gets up, heads for the door, and leaves. I go after her
and tell her to come back, that we had better finish the session because, if she
is sad or upset, it’s because something isn’t working internally. In the end she
calms down and agrees to come back.
She’s been in therapy for eight months. She is much better, but I know that
every day in the middle of consultation she’ll have what I call “one of her
moments.” She gets overwhelmed and confesses, “I’m ashamed to be here,
I’m telling my life to a stranger.”
And she tries to leave. It’s a struggle for her to accept that she is sharing her
life with another person. Little by little she’s understanding and articulating
the reasons she needs to resolve those internal conflicts that are preventing her
from growing.
I could always say to a person acting like this, “No need to come back,
when you feel comfortable call and make an appointment.”
But I accept her experience in the moment and continue the counseling
session without judgment, as though she hasn’t said anything.

SELF-ESTEEM AND HAPPINESS

Self-esteem and happiness are intimately related. A person at peace with
themselves, who maintains a certain internal equilibrium and takes pleasure in
the little things in life, will normally have an adequate level of self-esteem.
 NO SELF-ESTEEM PROBLEMS HERE
Miguel de Unamuno was one of the best authors of the great Spanish
“generation of 98.” He was well known for his earthy, familiar personality.
On one occasion he was honored with the Grand Cross of Alfonso X the
Wise, given to him by King Alfonso XIII himself.
Unamuno, known for being a militant republican and a member of the
Socialist Party, at the moment the award was being conferred, remarked, “I
am honored, majesty, to receive this cross that I so richly deserve.”
The king, surprised but familiar with the writer’s reputation, replied, “How
curious! In general, most of those honored insist that they don’t deserve the
cross.”
Unamuno, with his habitual familiarity, responded with a smile, “Sir, in
those cases it was true—they did not deserve it.”

HAPPINESS AND SUFFERING

They say you don’t know what happiness is until you’ve lost it. When
confronted with pain, suffering, grief, or financial problems, an inner voice says,
“I’m not happy! This is hell! Why do I have such bad luck?” At those times we
find it difficult to look back at happy moments we have had or to appreciate the
glimmers of joy that filled us at other times.
Life is a constant beginning again, a path where we walk through joyful
occurrences or moments of happiness, but also hard times. To be happy we must
be capable of rebuilding ourselves as much as possible in the face of trauma and
hardship. The reason is simple: there is no life story without its wounds.
Failures, and how one frames them, are the most decisive aspect of anyone’s
trajectory in life. We as human beings, over the whole course of our lives, pass
through very demanding and difficult moments, which mean that we will not be
able to be happy if we do not learn to get over them, or at least try.
As a psychiatrist, in consultation, I’ve treated every kind of trauma, and I am
conscious in writing these lines that very difficult life stories exist, some much
more than others. There are things beyond our control that we cannot change.
We cannot choose a lot of what will happen to us in life, but we are absolutely
We cannot choose a lot of what will happen to us in life, but we are absolutely
free, each and every one of us, to choose the attitude with which we confront it.
We are dealt some cards, good or bad, but they’re the ones we have and we must
play them as well as we can.
Man needs tools to overcome the wounds and traumas of the past. The
periods that demolish us physically and psychologically leave important traces
on our life stories. The ways in which we as individuals overcome and start
again mark many aspects of our personalities. This talent is born from an inner
strength that we all have, though it may be developed to a greater or lesser
degree: resilience.
The concept of resilience was made fashionable by the French doctor Boris
Cyrulnik. This psychiatrist, the son of Jewish immigrants from the Ukraine, was
born in Bordeaux in 1937. Under the Nazi occupation, when he was only five
years old, his parents were arrested and deported to concentration camps, but he
fled, hid in a series of locations, and finally was taken in at a farm, living under
the false identity of a non-Jewish boy called Jean Laborde. The war over, his
foster family encouraged him to study medicine and become a psychiatrist.
Young Boris soon realized that, through his own life story, he could
understand the causes of trauma and try to help others—for the most part,
children—to rebuild themselves after a trauma or an emotional rupture.

The Oxford English Dictionary defines resilience as “the ability

of a substance to return to its original shape after it has been
bent, stretched or pressed.” Cyrulnik expanded the meaning
of the concept to include “the capacity of a human being to
recover from a trauma and, without being marked for life, to
be happy.”

Resilience sends us a message of hope. It used to be thought that traumas

suffered in infancy were impossible to erase, and endured, leaving a decisive
mark on the trajectory of the affected child’s life. How can we overcome such
deep and painful wounds? The key lies in solidarity, love, and contact with
others; in essence, the key is warmth.
Cyrulnik, over the course of his long experience, shows many examples of
 Cyrulnik, over the course of his long experience, shows many examples of
this. At the University of Toulon, where he is a professor, he works with
Alzheimer’s sufferers. Many of them have forgotten words, but not attachments,
music, gestures, or demonstrations of affection. Cyrulnik insists on the flexibility
of the psyche. Before, it was thought that a person was permanently marked by
pain and suffering. If a person overcomes their trauma, their wound, they
become someone resilient.
In helping them to overcome, it is key not to blame someone for their past
errors, and to give them support and affection. There are multiple therapies for
this. A few years ago I worked in Cambodia freeing girls from child prostitution.
It was unequivocally one of the periods of my life that has most marked me.
I devoted myself to visiting the brothels of Cambodia and rescuing girls in
deplorable conditions. I remember with crystal clarity one girl, aged 13 and
recently rescued from a prostitution network, who asked me with a hopeless
look, “Will I ever be able to have a normal life—to enjoy anything?”
The message of hope is there, science explains it, and my experience has
taught it to me. There are methods for curing the deepest wounds. Over the
course of these pages, I’ll tell you how I ended up collaborating on this passion
project in Cambodia and some of the other stories that have marked my life.
Every step on the path I’ve traveled has helped me to understand the human
brain better. Along with it, I have understood suffering better too, and,
ultimately, the road to happiness.

TRAUMA
A traumatic event destroys one’s identity and one’s convictions, about others
and about the world. This rupture is the beginning of what we know as trauma.
Cyrulnik has established that in order for us to suffer a trauma, we must undergo
what is known as a double blow. The first blow is the perturbing event itself, the
traumatic occurrence proper; but for this to take root in a person’s life, a second
blow must occur, dependent on the behavior of those around them. In broad
strokes, the second blow is an implication of rejection or abandonment,
stigmatization, disgust, contempt, or humiliation, with incomprehension being a
quality common to all of these.
According to Boris Cyrulnik, these are the three pillars of resilience:
 According to Boris Cyrulnik, these are the three pillars of resilience:

• Personal. Having internal tools to rely on from birth; secure attachment.

This is one of the strongest means there is overcome a trauma.
• Social and familial context. The kind of support delivered by carers,
parents, and other close figures. These are key for pulling through after a
painful trauma (this is where the second blow really comes into play).
• Societal context. That is to say, being able to rely on social and legal
support at such times—the support of the community—mitigates the
trauma and strengthens the victim.

Cyrulnik: “Imagine a child has had a problem, that he has

received a blow, and when he tells his parents about the
problem, they let slip a movement of disgust, a reproach. In
that moment, they have transformed his suffering into
trauma.”

CASE STUDY: LUCÍA

Lucía is a six-year-old girl. She lives with her parents and her two brothers,
who are seven and two. She goes to the school in her neighborhood and is a
very happy, creative girl with a huge imaginative capacity.
One day, at a birthday party at the house of one of her school friends, she
goes into the bathroom. When she goes in, she sees that the father of a boy in
her class is already in there. She steps back out and politely apologizes. The
man in question—he doesn’t deserve a name—tells her in a friendly way to
come in. He drops his trousers and asks Lucía to touch him.
The little girl, frightened, obeys. The next thing he does is take off her
underwear and put his hand under her dress.* Paralyzed, Lucía can’t speak or
cry out.
The man threatens the little girl, telling her she mustn’t tell anyone
anything, or he’ll hurt her and her brothers. Lucía leaves the bathroom and
hides in a corner to cry. Her parents aren’t at the party, but she hopes they get
there as soon as possible.
 there as soon as possible.
Half an hour later, she sees them come into the house. She observes the
man from the bathroom approach them and greet them amicably, saying that
their daughter has behaved very well and is very polite. Lucía starts to sweat
and wants to cry. The man approaches her, takes her by the hand, and says:
“Your parents are here, and I’ve already told them that you behaved very well.
Give your brothers a kiss when you see them.”
Lucía is sure of herself, and, once they get in the car, the first thing she does
is tell her parents what happened. They don’t believe it, but they listen to her
with absolute attention. After a couple of days, they come to my practice to
ask advice and see how to deal with it. They’re not sure that it’s true, but
whatever the case, they don’t want to hurt their daughter any further.
I treated Lucía for half a year. She had nightmares, she was afraid of
dealing with older men, she felt sad, and she didn’t want to go to school.
From the first moment, her parents showed her their support. The matter
was brought to court; Lucía learned to develop her inner strength; today she is
a healthy and happy girl of 13. A few months ago, she came to see me at my
practice to tell me that she’s going to Ireland for a term to learn English. Her
words of farewell were: “I’m not afraid anymore, I’ve overcome it. I want to
thank you for supporting me, for believing me, and for strengthening my
relationship with my parents. I know they doubted me for a little while; the
fact that they supported me to the end and that you treated me from the start
has freed me from a huge trauma for good.”

Being happy means being capable of overcoming setbacks

and getting up again after.

The present moment can at times become a nightmare. Sometimes one longs
to flee into the future. At other times one gets blocked and remains paralyzed
inside a particular memory or a past traumatic event. Getting stuck in the past
turns us into bitter, rancorous people, incapable of forgetting the damage done or
emotional suffering.
We have all passed through stages when we realize we need a pause or a
break in order to regather our strength after a physically or psychologically
demanding period, or simply in order to get ready to try again for a goal that we
have yet to achieve. During such a lull, above all at the start of a holiday,
exhaustion and tension tend to crop up. We feel more vulnerable than ever. This
vulnerability is more than just psychic; relaxing the body after a period of
exertion produces a general lowering of our defenses, which makes it likelier we
will contract colds, flu, or other sicknesses.
It is precisely those post-tension moments that are the most important to our
psychological trajectory, given that the way we confront them dictates whether
we can overcome major mental upsets. We must be vigilant in these seasons
because frequently it is only when we slow our activity and have more time,
when we stop to think, that we can tell whether our psychological health is at
risk from anything that has happened. In any case, battles are won by tired
soldiers, wars by the masters of inner strength. This inner strength will help us to
overcome our problems. We cultivate it by learning to dominate the inner “I,”
those thoughts of the past or worries for the future that torment us and stop us
from living in a balanced way in the present.
Time does not heal all wounds, but it does shift what is most painful away
from the direct gaze. Suffering is therefore the school where we learn strength.
When the torrent that rushes out of suffering is accepted in a “healthy” way, one
gains an important form of self-control fundamental to life.

Balance means learning to maintain a certain inner peace,

equanimity, and harmony despite the thousands of challenges
life throws at us.

After the blow, one must take back the reins of one’s own life in order to
achieve the life purpose that one has decided on. We must be masters of our own
destinies. The simplest thing is to think short-term, to live according to our
reactions to the anarchic external impulses that affect us, letting ourselves be
carried along; what is better, although more difficult to achieve, is to design
one’s life with long-term objectives, so that, even if something turns us out of
our path, we can reorient ourselves toward our goals. A person without a project,
who doesn’t know what they want to become, and who doesn’t find meaning in
their life, cannot be happy.
The solution does not lie in pills. Medication is key for moments of blockage
when the organism itself is incapable of recuperating on its own, or when
circumstances are so adverse that we require an extra support in order not to
collapse. Medication regulates elevated or depleted chemicals in the brain. It
does not replace cerebral or mental functions, but it allows you to feel or
accomplish these functions when they aren’t working.
Medication can offer solutions, but there is another effective and helpful
therapy: the doctor’s bedside manner. A few encouraging words and true,
engaged listening can have a significant healing effect.

BEDSIDE MANNER IS THE BEST PAINKILLER

An article published in The Journal of Pain in May 2017 discussed the
importance of the doctor’s attitude in consultation. It has been demonstrated that,
if a patient has confidence in their doctor, their sensation of pain diminishes. The
doctor herself acts as a placebo. For example, what happens if the doctor
vacations in the same place as a patient, or has similar tastes? Elizabeth Losin, a
researcher working on the University of Miami study, observed that a feeling of
social, educational, cultural, or religious connection helped lower patients’ pain
levels. If someone visiting a doctor feels sure that their pain is going to be
lessened, this feeling of confidence has a positive effect. The brain, presented
with the mere hope of relief, releases chemical substances from the endorphin
family that assuage pain.
It very often happens that when someone visits a trusted doctor, a long-
standing therapist, or a specialist in their particular ailment, after explaining
what’s bothering them, they notice an automatic improvement in their
symptoms.
A doctor should be a “human vitamin” for their patients. In a world like
today’s, with its overextended health service, this is not easy. There isn’t the
time. It is often simpler, more practical, and more efficient to cure symptoms
with pills. But sometimes a smile, a positive remark, or a hopeful phrase is
enough to halt the development of a disease.
SUFFERING HAS MEANING
Contemporary society flees from suffering, and when we come across it certain
questions arise: Do I deserve it? Is this happening because of my past mistakes?
Why has God allowed this to happen? Let’s consider some potentially helpful
aspects of suffering.

Pain Possesses a Human and Spiritual Value

It can lift us to a higher plane and make us better people. How many people have
you met who have been capable, after a blow, of getting back up and finding
new ways forward in their lives, even expressing gratitude after the fact? It isn’t
rare to meet people who, after carrying on a superficial and conformist existence,
have been transformed by suffering a difficult setback.

Suffering Helps Us to Reflect

It takes us to the heart of many questions that we might otherwise never have
asked ourselves. Pain, when it arises, pushes us to clarify the meanings of our
lives and of our deepest convictions. Masks and appearances fall away, and our
real selves emerge.

Pain Helps Us to Accept Our Own Limitations

We become more vulnerable beings and come down from the pedestal that we or
others have set ourselves on. At such times we must lower our gazes and
recognize that we need help and the affection and support of others. On our own,
we are not enough. Sharing our limitations with others can be the first step
toward simplicity and overcoming the calamities we’ve suffered. The
consciousness of our limitations reinforces our solidarity with others, our
empathy with their pain, and, ultimately, our love for them.

Suffering Transforms the Heart

After a difficult period in which pain plays a leading role, one gets closer to
other people’s souls. We become capable of empathizing and of better
understanding those around us. When someone feels loved, their life changes—
they become illuminated and transmit that light in their turn. Authentic love is
strengthened by pain when it is accepted in a healthy way that frees us from
egotism. Anyone who expands their capacity for empathy is more lovable—they
let themselves be loved—and turns their environment into a more welcoming
place to live.

Suffering Can Be the Pathway to Happiness

We all have the will to achieve happiness and possess the tools to do so. Pain
leads to a true maturing of the personality, more care for others, and a better
knowledge of oneself.

There is only one antidote to suffering, pain, and sickness:

love.

Let’s turn now to look underneath the surfaces of ourselves as human beings
to understand the thoughts and emotions that hinder us and how our brains
respond to stress or conflict. Simplicity takes a long time to achieve. Let us
begin.

* I will refrain from giving further details that might trigger the reader’s
sensitivities.
 2

THE ANTIDOTE TO SUFFERING: LOVE

In this chapter I divide love into five chief types:

• Healthy love for oneself: self-esteem*
• Love for another person
• Love for others
• Love of ideals and beliefs
• Love of memories

LOVE FOR ANOTHER PERSON

There is no man so cowardly that love cannot transform him into a
valiant hero.

—Plato

Falling in love is the greatest thing there is. Everything changes when you give
your heart away to someone else! Everyone holds marvels and treasures in the
depths of their being, which are revealed by real love. There is no human being
that love cannot turn into someone more passionate and full of life. Human
beings need to love. Love is the great matter of life.

Falling in love marks a person forever, and life’s most intense

 Falling in love marks a person forever, and life’s most intense
feelings come from love.

The aim of this book is not to discuss love between couples, but how healthy
romantic love affects all aspects of life positively.

LOVE FOR OTHERS

Acting in solidarity and doing charitable work—in order to give oneself to others
—have a protective effect on the mind and body. Feeling loved and not feeling
alone are among the keys to happiness. In this life, the majority of our
relationships, agreements, exchanges, and moments of enjoyment and pleasure
are related to our interactions with others. For a romantic relationship to work
well, or a negotiation, a business, a family—whether blood relations or ones by
marriage—it is fundamental that relations between the people involved are easy,
or at least relatively healthy.
On occasion, certain people around you will rub you the wrong way, and
their mere presence will unsettle you. If you don’t change something, they risk
becoming toxic elements in your life. If living or working with certain people
constantly gives you the sense of being in a hostile, tense atmosphere that keeps
you on the alert, you may eventually get sick or mired in deep suffering. These
people are “emotional vampires,” at least for you, because they drag you down
emotionally. We instinctively tend to cultivate connections and friendships with
people who are positive and healthy to relate to, as much in our social lives as in
a familial or professional context. We push away hostile, negative people, whose
contributions always feel poisonous.
Robert Waldinger is an American psychiatrist in charge of the best study yet
made of happiness. It consists of a long-term experiment that is still relevant
today. The study began by examining the lives of two groups of men: a first
group who were, in 1938, second-year students at Harvard, and a second group
of boys from the poorest, most marginalized neighborhoods in Boston. The
objective was to study these people’s lives from adolescence through to
adulthood, with the goal of determining what made them happy. Over the course
of 75 years, the subjects of the experiment were asked questions about their
work, their family life, and their health. Today, 60 of the 724 men who began the
experiment are still participating in it—most of them by now are 90 or older—
and they are currently beginning to study the more than 2,000 children the
subjects fathered.
At the beginning of the study, these young people were interviewed just as
their fathers had been. They underwent medical examinations, family reunions
were held, their clinical histories were followed, their blood analyzed, their
brains scanned. . . . What conclusions were drawn from the experiment?
Researchers were surprised by the results. They held no lessons about wealth,
fame, or the importance of working particularly hard, or even about the
physiological and medical aspects of life. The message was clear and simple:
good relationships make us happier and healthier.
Thanks to this study, we have learned three things about human relations:

• Social connections benefit us, and loneliness kills. Baldly stated, it looks
extreme, but it’s true: loneliness kills. People who have more bonds with
family, friends, or a wider community are happier, healthier, and live
longer than people with fewer relationships. Loneliness has been shown to
be profoundly toxic. People who live in isolation are statistically more
likely to be unhappy and more susceptible to a decline in health during
middle age; their cerebral function is more prone to swift decay in old age;
and they die sooner. It’s a serious and urgent issue, which we ought to deal
with, given that in our society, a solitary existence is becoming more and
more common. In 2017, studies were carried out that linked loneliness to
Alzheimer’s disease and other forms of dementia.
• The important thing is not the number of social bonds, but their quality,
and the more intimate they are, the more important their quality becomes.
Living in a constant state of conflict is harmful to the health. Marriages
with high levels of conflict, or lacking in affection, are very detrimental.
On the other hand, living with warm and healthy relationships affords us
protections. In the study, cholesterol levels weren’t found to predict how
the subjects would age—their relationship satisfaction levels were. Those
who felt the most satisfied at the age of 50 were also the healthiest at the
age of 80.
 • Good relationships don’t just protect the body—they also protect the brain.
We might have guessed this, but the study proved it. Having a secure
attachment to someone else during old age affords protection, and these
people’s memories remained clearer for longer. Conversely, those people
caught in relationships where they didn’t feel they could rely on the other
person lost their memories earlier.

What Are the Foundations of Good Relationships?

I would say that the foundation of any affective, social, or emotional bond—
professional, friendly, or romantic—depends on the ability to have a proper
relationship with others; that is to say, to connect in a way sufficient to generate
a friendly atmosphere.
They say you don’t get a second chance to make a first impression. Unless
they really have to, nobody buys anything from a person they don’t like or find
off-putting. I’ve treated a few bankers in my practice, and I always think that it’s
impossible for anyone to let someone manage their money or their inheritance if
there isn’t a cordial relationship or even an affinity between them; similarly, all
things being equal, we will buy a car or other goods from the person who has
treated us best—unless the price is unbeatable.
Friendship is the highest form of interaction with others, after love. For a
true friendship to arise, there must be harmony, an exchange of experiences and
emotions. Friendship is formed of confidences and it breaks up over
indiscretions. It must be carefully nurtured. Friendship consists of an equal
relationship that contains intimacy and learning, which is why we need to work
at it with persistence and attention to detail.

How Do We Build Proper Relationships with Others?

Here I bring together a few little ideas to guide us. You don’t have to follow the
suggestions below to the letter, but they can be very helpful. You can also use
them as a way to test yourself and understand why there have been times in your
life when negotiations, friendships, or family relationships broke down.

1. Take an interest in people

I know a lot of people who tell me: “I just don’t like people.”
 I know a lot of people who tell me: “I just don’t like people.”
This statement shocks me, because our best memories, in general, are
of times spent with others, and one of the greatest satisfactions life holds
is rooted in relating to others and feeling loved. I particularly remember a
stand-offish friend of mine, taciturn but warm-hearted, telling me: “I
can’t stand most people.”
His job was one where success and remuneration depended on
forming adequate connections with people. When I asked him how he got
through the day—we were close enough that I could be frank with him—
he answered: “My clients interest me.”
If you show up to a family reunion with cousins, aunts and uncles, or
in-laws, the best way to connect is to take an interest in them, their lives,
their work, and their health. But it has to be real, not for show. Don’t
give the impression of quizzing or investigating them—just approach
them in a sincere and amiable way. Always make an effort to interest
yourself in other people’s lives.

2. Try to remember important information

Not everyone is lucky enough to be able to rely on a good memory for
names and dates. Those people who successfully remember information
about others, however, create much stronger bonds in a shorter time. If
you bump into someone after not seeing them for a while, and you
remember their wife’s name or that their father was undergoing treatment
for an illness, you automatically generate an agreeable sense of
closeness. We all like for people to remember things about us without
prying, but it takes an effort to achieve this.
David Rockefeller—of Chase Manhattan Bank—had a private index
filled with more than 100,000 names, where he kept information about
the encounters he had had with those individuals. This information
helped him to create a sense of familiarity and make everyone he came
across feel important and special.
My father has the habit of noting down everything about the people
he knows. A while ago, while I was looking for the number of a
restaurant in his phone, I came across this information:
 restaurant in his phone, I came across this information:

Pepe, the proprietor; married to Ana. They have three

children; the youngest son worries them because he didn’t
finish his studies. His father passed away a few months ago
of Alzheimer’s. Paco, the head waiter, has always worked
there and has arthritis.

I was impressed, and I know that if he went into the restaurant, calling
everyone by their names and asking them about their concerns, he would
be able to quickly connect with everyone. I must emphasize that this
quality requires effort, either by strengthening your hippocampus—the
brain’s memory center—or getting into the habit of keeping track of
information such as birthdays, anniversaries, or the concerns of those
around you in a notebook or diary.

3. Deepen your knowledge of people’s lives, interests, and

professions
This is especially important in the world of work. You must remember
that the majority of agreements are made between people who have
formed bonds of cordiality and friendliness. If you have a meeting with
the director of your company, try to find something out about him or her.
If you want to surprise your friends, do your research. If you want to
bring joy into the life of a family member, involve yourself in what
interests them. This requires time and willpower. Call your family and
friends so as not to lose touch. A small effort produces huge results.
Personalize things. Look for what each individual enjoys. Don’t use the
same speeches or messages with everyone around you. This obliges you
to pay more attention to the details. If you need to get a present, look for
something special—not necessarily expensive or costly, but simply
something that shows you made the rounds to find the most intimate or
personalized gift.
4. Avoid judgment
Everyone is different. We tend to judge, analyze, and pigeonhole people
as soon as we meet them. This can be a defense mechanism or simply an
automatic mental process designed to avoid internal change. Very critical
people may experience a constant need to feel superior, or, on the other
hand, may have a problem with insecurity and a lack of self-esteem.
To judge fairly, we must be very empathetic and have at our disposal
a lot of information that we don’t usually hold. Whatever the case, it is
always wiser to remain silent. Silence is the gatekeeper of intimacy.
One must accept others as they are, even if they’re different and what
we see of them doesn’t fit with our ideas. This doesn’t mean that we
should ignore reality—there are people who do wrong, or that we should
distance ourselves from because they’re toxic—but regarding most
people, the healthiest thing is to keep a pluralistic, generous frame of
mind and be open to admitting that there are people who don’t conform
to our criteria at all. Closing oneself off harshly to everything different
should be avoided. If you only accept people who have a certain level of
education or come from a certain class within society, if you’re obsessed
with fans of a certain football team or members of a certain trade or
profession, if you systematically reject everyone who comes from a
certain region, country, or continent—without a doubt your capacity to
understand the world and those around you will be reduced and you’ll
lose out on many of the subtle nuances that make our world so rich and
diverse. It’s no good generalizing and rejecting social groups or
particular categories of people. Everyone has something to offer us.
In my practice, I’m often surprised by what leaves me shaken or
perturbed. In spite of my more than ten years of experience listening to
stories of broken lives, from people who have suffered deep wounds, I
still feel twinges of disquiet when certain experiences are related to me.
Doctors must be wary of countertransference; that is to say, what we
feel towards patients, the ensemble of emotions, thoughts, and attitudes
that come up for us in reaction to their stories. It’s inevitable that certain
individuals, whether because of their life stories, their ways of being, or
their actions, provoke an initial sensation of recoil in me. It might be due
 their actions, provoke an initial sensation of recoil in me. It might be due
to how they tell me about their trauma or suffering, or because their story
triggers my own vulnerability, or simply because their way of behaving
runs counter to my ethical principles.

SOMETIMES YOU CAN’T HELP JUDGING . . .

I remember a patient I was seeing a few years ago, an anxious and very
sensitive man who was very much in love with his wife. He worked in a
company’s IT department, and his wife was a journalist. He was always
worrying that she was unfaithful to him, largely because she traveled a lot
internationally and had a life rich in friendships and social networks. She
denied any kind of infidelity, but even so, he suffered greatly from this fear.
After three or four sessions, I asked the wife to come to my office. She
came in, greeted me coldly, and almost before she sat down, said to me:
“You’re obliged to keep client confidentiality, so you can’t say anything to
my husband. Of course I’m unfaithful to him, I have been ever since we
started dating, but he’ll never find out. Is there anything else?”
I have to confess that a chill ran down my spine. All the same, I tried to
create a cordial atmosphere in the consulting room. It wasn’t possible—in the
face of this revelation, made with such determination and sense of impunity, I
was blocked. She insisted that she enjoyed the adrenaline rush of cheating and
having a double life, that she had always been that way and didn’t want to
change.
After listening to her life story for a while, I explained to her gently but
firmly the reason why she was playing with her husband’s feelings. She didn’t
care. Displaying the same coldness with which she had entered my consulting
room, she left without saying goodbye. I continued to see the husband for a
time, but they moved to another city and I didn’t follow up with them. I don’t
think their future was rosy.

5. Don’t impose your views, beliefs, or values

Work on being a role model for your children, employees, or friends. If
 you try to impose your views, you’ll be met with rejection. Nowadays we
know that demanding parents who impose their will without moderation
on their offspring end up with erratic, rebellious children who are always
looking to contradict them. Limits are necessary, and it’s essential that
people respect our ideas and beliefs, but we mustn’t stray into severity or
aggression. Society doesn’t need masters, but instead, leaders. A leader
sets an example for living, blending integrity, solid values, and
modernity with the knowledge that they’re an authentic and rational
person.

If you want to influence someone or communicate your ideals,

learn to be a good example.

It’s one thing to impose your ideas, and another to ask that they be
respected. There is no good leader who is not a good person. Today, the
politics of many nations are full of talk of supposed leaders who really
aren’t; they’re given that label in the media, but often when their private
lives are revealed, it becomes clear that it was all a façade, just an
appearance, and their conduct is directed by consultants and designed to
create a good image—one that doesn’t match up with reality. A good
person is authentic. And authenticity is a matter of balance, where theory
and practice must have a healthy relationship. We are what we do, not
what we say. Actions speak louder than words. In this matter, the facts
speak for themselves.

6. Surprise yourself by making the most of shared interests

Friendship and good relationships arise where there are interests, values,
and tastes in common. Look for these; it’s rare that you have nothing in
common with someone, even the most random person in your life, from
your child’s pediatrician to your financial adviser or the handyman who
helps you out with odd jobs. You’ll find, even if you aren’t expecting it,
that when you spend time on inner things—not just external, practical
needs—you’re taking an important step forward in your life. You see
further, and your heart isn’t just focused on the superficial aspects of
 relationships—getting advantages or instant gratification out of people—
but on what’s inside them. Your relationships will be more honest and
your inner growth will be exponential.

THE PIMPS AND BROTHELS OF CAMBODIA

When I arrived in Cambodia, I realized that accessing brothels in order to give
therapy, or any other kind of help, as I hoped to do, would be complicated.
The “hustlers” put all kinds of obstacles in our way. They demanded certain
conditions and, for there to be any benefit in going into the brothels and
speaking to the prostitutes, the procurers had to be cooperative.
I needed to find something in common with them, but it wasn’t easy. Over
the course of my life, however, I’ve come to realize through trial and error
that there’s one thing very few people will turn down: a Starburst. You might
be laughing, but I go through a bowlful a day at my practice. Patients tell me
that they’re taking them for their children or grandchildren, but deep down I
know that’s not true. The candy is for them. Pineapple flavored Starbursts are
particularly sought after. I’ve asked the company to send me bags of
pineapple ones, but so far I haven’t been successful.
I arrived in Cambodia with ten kilos of Starburst. After two weeks I had
none left, but I found a perfect local copy. At the door of a brothel,
accompanied by two nurses, with complete seriousness, I would say to the
pimp in Khmer:
“Nek chom ñam skor krob te?”—that’s how I pronounced it, anyway, and I
was told that it meant, Do you want a candy?
Nobody ever said no. The guy in front of me, who gave off the worst
impression, with a dirty, unscrupulous look, would sketch out a smile and nod
his head yes. This infinitesimal little detail opened up the possibility of my
entering their space in a warmer, less hostile way.
During the final weeks of my time there, the girls called me Madame
Bonbon, which gave me a feeling of enormous tenderness.
7. Smile and laugh with people
If there isn’t an easy way to connect, use a touch of humor. Very few
people turn down a smile if it comes their way. Laughter is the shortest
distance between two people, and, at the same time, it’s one of the most
efficient methods for increasing endorphin levels in the blood. Alice Isen,
of Stanford University, conducted an important study on how expansive
emotions—smiling, laughter, the pleasure of humor—markedly improve
cognitive abilities and social conduct. She observed that these things all
improve our creativity, organization, and planning and problem-solving
abilities. This is due to the fact that laughter activates the flow of blood
to the prefrontal cortex, the area in charge of these functions.
In another interesting study carried out in Bonn, Germany, it was
observed that happy, joyful people show greater productivity and better
performance at work.

Laughter and smiling have the capacity to alter the chemistry

of our bloodstream, protecting us from certain illnesses and
infections.

8. Sing, especially in a group

Singing in a group is beneficial to mental health. Recently a study was
published in the journal Medical Humanities on how the act of singing in
public can have a beneficial effect on mental health.
The authors—from the University of East Anglia—participated in a
project called Sing Your Heart Out, in which they organized singing
workshops every week and focused on at-risk members of the population
as well as the general public. Some 120 people participated in the
activity, of whom 80 had visited a mental health service. The groups
were evaluated at various points over a six-month period.
Observation showed that singing and socializing have a striking
effect on well-being, the improvement of social skills, and a sense of
belonging. This is a clear demonstration of what Robert Waldinger
describes in his research.
The strange thing is that while singing on your own—like we all do
 The strange thing is that while singing on your own—like we all do
in the shower!—has always been a strong motivational tool, the act of
singing in public has different and very positive effects for a sector of the
population. Participants called the project a “lifesaver.”
This brings to mind the case of the orchestra conductor Íñigo Pirfano.
Now approaching 50, he is the founder of A Kiss for All the World. With
his organization, he visits very tough places—prisons, hospitals, refugee
camps, extremely poor areas—and conducts performances of
Beethoven’s Symphony No. 9, inspired by Schiller’s Ode to Joy.
People assembled together to listen often weep, become emotional,
and are generally moved—joy is contagious, and higher feelings spread
from each person to those around them. In one hospital in South
America, the patients insisted that it had been one of the most
unforgettable experiences of their lives. While they listened to the
mellifluous music, some moved to the beat; others held each other’s
hands. Something important was happening inside all of them.

9. Help if you can

If you have the opportunity, don’t miss out on doing something for
others. This doesn’t mean collecting favors and keeping track of who’s
given you what or which services you’ve handed out to others. Few
things create a greater sense of satisfaction than finding it in our power to
help others. Give without asking for anything in exchange—without, of
course, becoming a do-gooder. It can also be a bridge to other people.
Life has many reversals and may end up surprising you.

10. Don’t be afraid of feeling vulnerable in front of someone, or of

asking for help
We don’t always need to try to create strong ties in relationships;
sometimes we just want a friendly hand to help us get out of a
predicament. Be humble in those moments. Don’t be afraid of being seen
as weak or caught in a delicate situation; look for the right people, who
don’t judge and can give you a boost.
ASKING FOR MONEY
A few months ago, a patient told me that he had just separated from his wife.
He has three children. The couple’s situation was unsustainable—they were
fighting every day and finally they chose to live separately. His current mental
state is low, he feels somewhat depressed, and he lacks energy. At work they
are restructuring, and they’ve lowered his salary. He doesn’t have enough to
give to his wife for the children, their school fees, and food.
He’s moved twice and now, so as not to worry his ex-wife by failing to give
her money, he is living in shared accommodation with some students. This is
making him sink even further, because on the days he has his children, he
avoids going home with them, not wanting them to see where he’s living. He
feels like a bad father; he has no money even to take them out for a treat
somewhere nice. His gifts to his children are very simple, sometimes things he
gets second-hand from the internet.
His father comes to my practice one day to talk to me; he’s worried,
because he sees that his son is sad. While he’s speaking, I realize that he isn’t
aware, or hasn’t been informed of his son’s financial situation. At one point he
tells me:
“He’s my only child, and anything I could do for him would make me
happy. My wife and I have some money saved that we don’t need and maybe
it would be useful to him.”
Days later, I see my patient again. I tell him about my conversation with his
father and he responds, “It’s hard for me to ask for favors; it’s hard for me to
ask for money.”
I explain that, in the face of the dramatic and difficult situation he finds
himself in, there is no one better than his father to help him. I add that there
are moments when we need to know how to lean on our support systems,
without taking advantage. It was part of his therapy to be able to ask for help,
but it turned out to be a determining factor in his state of mind and his
relationship with his children.

11. Speak well of others; don’t criticize

 I’ll say it again: Speak well of what is good, and maintain a neutral
position about the bad. One must seriously commit to avoiding criticisms
or negative judgments in conversation.
It’s so nice when, during a dinner or a gathering of friends, someone
holds back a criticism or halts a negative conversation about others.
Speaking ill of others creates a toxic emotional state in our bodies—full
of cortisol!†—and we know the risks that that brings.
Criticism is practically an international sport, and we have grown too
used to it as a part of our lives. If you want people to trust you, if you
want them to value you as someone with integrity, seeking out your
friendship, believing in you or in your business, be discreet. Everyone in
the world, despite their wrongdoing or bad attitude, has something good
inside them to be redeemed. If you don’t know what it is or can’t see
anything good in them, just leave it. Don’t make the atmosphere worse
by harping on a subject that doesn’t seem to have a solution. In those
cases, focus more on figuring out and solving the problem than on the
problem itself. It’s better to learn how to manage the person in question
—at times it might be most convenient to distance yourself from them—
than to pick them apart with your words. Not speaking ill of anyone,
even when people make it easy for us, produces an enormous sense of
peace—it’s like a sedative built into our behavioral design.

12. Tell stories

People like stories. Sometimes bringing a bit of imagination, excitement,
and magic to our way of expressing ourselves can create a good
ambience. For example, we know that stories are emotionally satisfying
for audiences, at business meetings, and even during official councils.
Humans have always sought stories—we still seek them now and will
continue to seek them in the future. Think of magicians: their way of
creating rapport with the public is rooted in storytelling, and without
stories their tricks have a watered-down feel to them. A great friend of
mine, a magician, always wins us over with the magic, but also with his
patter about the alchemical display.
Scientifically, we know that stories cause the brain to release
 Scientifically, we know that stories cause the brain to release
oxytocin, a chemical substance associated with empathy and sociability.
Empathy brings into play our mirror neurons. These deal with
understanding the conduct and emotions of others. Discovered by
Giacomo Rizzolatti, they represent a significant advance in the world of
neuroscience.

A CEMENT WALL
A few years ago, two patients found themselves sharing a room in the
palliative care unit of a hospital. Luis, in the bed next to the window, would
talk to Daniel. Every day he would tell him, in luxuriant detail, what happened
in the street. Mostly he narrated the adventures—seen from the window—of a
family who lived near the hospital. The mother would often play with her
children in the garden.
He spoke naturally and with grace, although his voice was slurred from the
chemotherapy. For Daniel, the last months of his life were rendered
entertaining by his roommate. On those days when they were alone, without
family or friends, Luis would say, “Shall I tell you what I see?”
Daniel’s eyes would light up. And a recital would begin that might last
hours. Months later, Luis passed away, and within a few days his bed was
occupied by another patient.
Daniel, excited by the thought that he would once again be able to hear the
stories his friend had told him, asked his new companion to inform him about
the children in their garden. The response stunned him:
“There’s no garden here, just a cement wall.”
Luis had used his imagination—his one remaining resource—to make up
stories that would entertain Daniel.
Using empathy, Luis had been capable of putting himself in his comrade’s
shoes and successfully got him excited about something, helping him to
overcome the suffering caused by his illness.
13. In love and war (and friendship!), strategy is what counts
Napoleon said it. Don’t be afraid to grab a pencil and a piece of paper. A
four-colored ballpoint, a felt-tip pen, a blackboard . . . Write, cross out,
draw arrows. Whatever you do, make a plan. You’ll be surprised at how
many mutual acquaintances you find, you’ll discover past experiences
that might be useful now, and, if you need to work on some skill because
you notice it doesn’t come easy, read, inform yourself, and ask for help.
There are multiple methods for improving your assertiveness and
social skills. There are books and tutorials available on all of these topics.
With practice, humor, and willingness, you can improve if you just
decide to.

14. Mind your manners

There are a few words that go straight to people’s hearts: thank you,
sorry, and please. We’ve gotten used to taking everything for granted. In
this book, I’m going to insist on the importance that words have in our
minds. Our body is not indifferent to the words we use, both in our
internal monologues and in the language we employ with those around
us.

15. Don’t forget that in order to receive you must first give
Don’t expect everything to happen without you doing your bit. Instant
results are often deceptive, and you need to accept that it’s difficult to
build stable and durable relationships—in any area of life—in a matter of
minutes. It requires patience, perseverance, and knowing how to give of
yourself.
If you manage to be valued and counted on by everyone, and be
someone important in their lives, you’ll be pleasantly surprised to find
that you’re sought after, and your presence is needed in both good times
and bad. People will have you on their mental radar. This goes for
relationships with friends, as well as family members or business
acquaintances. Try to make sure people are left with something after they
see you, whether from your conversation, your way of being, or your
abilities. Whatever your goal, always try to get better, to give value and
 abilities. Whatever your goal, always try to get better, to give value and
to help bring the best out of others. Try to be a human vitamin, someone
who adds, who helps, who brings joy and optimism even to periods of
uncertainty.
Aim for a good end result, whatever your goal; when your objectives
have a positive value, you attract positivity. If your ways of going deeper
with people have a toxic taint, you’ll attract negativity.
Don’t forget, misery loves company and embittered people are
surrounded by bitterness. The European Psychiatric Association
describes such people as neurotic, sour, resentful, hurt, and spoiled. I’ve
said it already in previous pages: Optimism is a powerful tool and a
unique way of observing reality. Knowing how to look is also knowing
how to love and understand.

16. Try to be friendly and amiable—it’s more important than you think
I buy fruit at a shop right by my house. It’s not especially cheap, but the
grocer, Javi, helps everyone attentively. He knows our names, he treats
us with a special cordiality, and every time I go, he gives a free slice of
fruit to one of my children. He was away for a few months, and we all
noticed his absence. When he come back, he acknowledged that he had
been laid low by a serious back problem and told me what medication he
was taking. It’s strong medication that doesn’t get rid of the pain, but
does allow him to work. Impressively, he continues, despite this chronic
pain, to treat everyone with the same pampering attention; he advises us
on our choice of fruit and vegetables as though it were the most
important choice of our lives.
People like Javi make coexisting easier and more agreeable. In a
society ruled by haste, digital interaction, and time poverty, many people
believe that friendliness is obsolete. We can’t be bothered to stop and
make an effort to greet someone or take the time to ask about their lives.
The Oxford English Dictionary definition of someone who is amiable
describes them as “friendly, lovable, likable.” You almost gasp reading it
—it’s too perfect!
There are people whose amiability seems to be hardwired into their
genes. They almost don’t need to try—it flows out of them so naturally.
 genes. They almost don’t need to try—it flows out of them so naturally.
Being amiable means being capable of communicating cordiality and
sympathy, of treating others with dignity. Let us not forget that people
possess a “friendliness gene” from their earliest days. This tool
influences us in an important way. For example, when faced with stress,
adversity, or dangerous situations, having worked on this ability leads us
to care for and help others, instead of only looking after our own survival
or well-being. Another fact: Among people who have suffered a stroke,
those who perceive affection and amiability around them feel less pain
than those who find themselves alone.
We know of more benefits from friendliness, besides just those that
improve our relationships. This touches once more on a biochemical
element that we will discuss in depth in this book. Amiability generates
endorphins, which in turn lower levels of cortisol—the stress and anxiety
hormone—and increase oxytocin—the love and trust hormone. As a
consequence, hypertension and cardiovascular problems are ameliorated
and painful sensations diminish. All these effects create in us a feeling of
balance and internal well-being. Simply observing friendly people—even
in films—improves our mood and has significant physiological effects.
Of course, to everything there is a season! If someone struggles to be
friendly, affectionate, or intimate, they should practice little by little. You
should avoid seeming phony; very few things provoke more repulsion
than a sense that someone is faking or being hypocritical. Nor should one
confuse friendliness with naïveté or being a do-gooder or a martyr. Faced
with an attack, a rejection, or an aggression, one must know how to
detach, take some space, and note any damage sustained.

CASE STUDY: SUSANA

Susana studied as an optician and works in her cousin’s pharmacy in
Valencia. She’s married to Jorge, a hard-working man who owns car
dealerships with his siblings. They have two children, one and five years old.
When Susana comes to my office, she tells me that her husband has left.
 She’s devastated “because my marriage was working very well, we hardly
argued at all, and I don’t understand what could have happened.” According
to what she tells me, nothing out of the ordinary occurred; Jorge simply told
her one day that he couldn’t take it anymore and left. She insists the
relationship between them was good and that their marriage was envied by
many. When asked if there was someone else, she responds that she’s sure
there must be, but that he denies it. We start to unpack Susana’s character and
life story, and we uncover a woman with a big heart—lovable, warm, a friend
to everyone. She’s always caring for those around her.
Her father is a man of strong character; he’s impulsive, but she knows how
to get along with him and, when everything looks like it’s going to fall apart,
she knows how to salvage the situation. When she tells me about the last few
years of her marriage to Jorge, I detect a certain lack of respect on his part: he
humiliated her, made absurd demands, and had various manias. On the
weekend, he wanted the house to be clean and would yell at Susana to wash
the glasses or the floor over and over. She, with her habitual desire to
accommodate, would obey in order to make him happy, without realizing that
the relationship had become a dictatorship, where she had undertaken to make
his life agreeable without reflecting. Susana described it to me like this: “I’ve
always been friendly, intimate, and affectionate with my loved ones, without
thinking too much—that’s the key to good relationships.”
Evidently, Susana is right, but if you don’t know how to measure the degree
of amiability that you show, you can end up becoming the victim of someone
who uses or manipulates you. There are people who will take advantage of
this personality type in the most scandalous way!

What the World Needs Now Is . . . Oxytocin

This hormone plays a fundamental role in birth, labor, and lactation. It’s the
hormone that triggers the body to push out the baby when undergoing labor, as
well as acting as a signal to let down milk during the postpartum period. We
know that this hormone is foundational in two primordial phenomena of
emotional life: trust and empathy. For this reason, it’s an essential tool in social
relations, and in our way of interacting with others.
 Both being friendly and presenting yourself in a positive way can activate
oxytocin, which has marvelous effects on our body: It diminishes sensations of
anxiety, it protects the heart, and it even lowers cholesterol levels.

Company Agrees with Us: Oxytocin and Dopamine

Two hormones are secreted when we’re in good company and enjoying life
along with people we love: oxytocin, mentioned above, and dopamine—the
pleasure hormone. Research is currently underway into the applications of
oxytocin sprays or vaporizers for people with autism, but the results of the first
experiments are as yet inconclusive.
Oxytocin may also be a key factor in the world of business and economics.
In an article published in the journals Nature and Neuron, the director of the
Institute for Empirical Research in Economics at the University of Zurich, Ernst
Fehr, demonstrated that oxytocin boosted people’s ability to trust their money,
inheritance, or savings to others. They observed that participants in the
experiment who had been stimulated with oxytocin trusted their money to others
more easily than those who had received a placebo; 45% of the first group
agreed to invest a large sum of money, while of the second group only 21% did.
When a person’s oxytocin levels rise above normal, emotions like love,
empathy and compassion grow more intense. It has even been observed that in
those cases where the hormone is really through the roof, it becomes more
difficult for people to stay resentful or annoyed. When oxytocin is elevated, the
amygdala—the area of the brain in charge of fear—is deactivated, and therefore
anxiety, anguish, and obsessive and negative thoughts diminish in intensity.
With this in mind, have a go at being nice. During the next few weeks,
choose a person you find difficult and try to create a more agreeable connection
with them. Search out those people with whom you spend a lot of time, and try
to make the relationship closer; smile, try not to judge so much, and—knowing
what’s at stake, and that if you make a good faith effort you might change your
brain, your emotions, and your biochemistry—try to love more, love better, and
be more compassionate toward those around you!
Your life is measured not by what you receive but by what you give. I often
ask my patients, “What do you do for others?”
 Pay more attention to your relationships, from your family to your friends,
your colleagues, and even your neighbors. Invest in people, for real. If you do it
authentically with affection, it won’t wear you out as much as you think. Show
up and offer your help sincerely, and not with a generic “whatever you need”
that doesn’t really mean anything. In a society where loneliness and isolation are
on the rise, look for ways to step out of yourself.

LOVE OF IDEALS AND BELIEFS

We have ideas, but we are situated in our beliefs.

—José Ortega y Gasset

We all know of people who have survived terrible trials, sustained by their love
for their ideals. From Nelson Mandela on Robben Island—love for his people—
to Thomas More in the Tower of London—his beliefs—or even Maximilian
Kolbe, giving his life for another man’s—the father of a family—in the
concentration camp at Auschwitz. Or think of Russian soldiers in World War II,
who endured adverse conditions and battlefields where the temperature was 20
degrees below zero, for love of their country. Everyone has their own ideals, and
if they’re strong, they can become allies in times of suffering.
Viktor Frankl is a great teacher in many ways. He suffered in Nazi
concentration camps and analyzed the “psychopathology of the masses” in
World War II. He emphasizes one idea above all: you can take absolutely
everything away from a man, except the last of his human freedoms, which is the
choice of his attitude toward life. This is where memories, values, and ideals
come into play. With the right attitude, one can choose one’s own destiny,
despite circumstances. This inner freedom, which cannot be taken from us,
allows us to find meaning in our lives, whatever our circumstances. Even in the
concentration camps during World War II, there were people who, holding fast
to that inner freedom, knew how to rise above the atrocities that surrounded
them.
Viktor Frankl didn’t know about the biochemical aspects of passion and
hope, but he observed that when somebody had memories or ideals to cling to,
that person was capable of surviving any type of trauma, both physically and
psychologically. Having ideals, and keeping hold of pleasant memories to return
to when oppressed by circumstance, can constitute a significant support for
confronting problems that arise in the future.
Of course, be careful with extremist ideals! Extremism justifies any idea or
action as a means to a certain end. Extremist reasoning confers legitimacy on
anything, including true barbarities lacking any moral value, as long as it helps
reach an ultimate goal. It is right that our system of values should serve as our
compass for navigating life, a guide for our behavior. But extremism has become
a problem if, on the path to our legitimate goal, we ride roughshod over others.
A person with radical ideas is not only incapable of understanding and
respecting other people’s convictions but eventually justifies any infringement
on others’ rights if it brings them closer to their desired end.

As Einstein aptly said, “Worry more about your conscience

than your reputation. Your conscience is what you are, your
reputation is only what others think of you.”

LOVE OF MEMORIES
There are moments in life whose memory is enough to erase years of
suffering.

—Voltaire

Are you surprised to learn that a cherished memory can mitigate suffering?
To continue with Viktor Frankl, he observed that there were people in
Auschwitz who died a few days after arriving, regardless of their physical state,
and others who endured for long periods, though they seemed no stronger than
those who had succumbed first. His own experience in the extermination camp
confirmed his new theory of logotherapy, which he had been studying since
before the war. Those people whose lives had meaning were better able to
tolerate the suffering of Auschwitz.
How can we interpret this, adapting it to the conditions of modern life?
 How can we interpret this, adapting it to the conditions of modern life?

People who find an aim, a goal, and a meaning in their lives

have more reasons to be happy.

There are so many people who can’t find a reason to get up in the morning!
If your thoughts and memories are constantly connected back to the people
you love, special moments, or things you’re looking forward to, you’ll be
happier and more joyful. Careful—this doesn’t always come naturally, and
sometimes you have to fight for it! We must be capable of reflection, of thinking
about our lives and finding in them those people, moments, or hopes that we can
turn into our motivations. There are a lot of people who let themselves go, who
don’t search within themselves, who simply let themselves be carried along day
after day.
We’re touching on an important subject here. Remembering agreeable scenes
has a strong impact on the brain: the act of recalling special moments from the
past can produce the same substances and activate the same areas of the brain
that were activated when these things happened in reality. This constitutes, in my
opinion, the beginning of a genuine revolution in the world of neuroscience.
Dr. Herbert Benson, a physician, cardiologist, and professor at Harvard, was
one of the first Western scientists to thoroughly explore relaxation and
meditation, inspired by Eastern philosophy. He is a pioneer in the study of mind
and body, or what he calls “behavioral medicine.” His objective is to
demonstrate the value of meditation and certain mental attitudes in facing the
pernicious effects of anxiety and stress. His ideas form a bridge between religion
and medicine, faith and science, uniting East and West, mind and body. Dr.
Benson has a name for this concept: remembered wellness. Recalling gratifying,
moving, or joyful past events allows our bodies to release biochemical
substances with antidepressant effects.
When I perceive tension within a couple, I usually ask, “How did you meet?
How did you fall in love with your husband?”
Even with a build-up of annoyance and tension, the act of remembering
joyful past events manages to change, at least for a brief time, the emotional tone
of the person speaking. For this reason, many relaxation techniques or cures for
stress or trauma create what we call a “safe space” in the mind. This is a
stress or trauma create what we call a “safe space” in the mind. This is a
sensation, memory, or image that gives us a feeling of peace, simply by calling it
to mind.
Dr. Benson maintains that a person with a headache or back pain can get
better just with a placebo. The cause? Remembering the sensation of well-being
they felt after ingesting medication. This is why the placebo effect is so
magically potent, as we all know.

SUSUMU TONEGAWA:
THE SCIENTIFIC POWER OF A HAPPY MEMORY
The Japanese molecular biologist, Susumu Tonegawa, was awarded the Nobel
Prize in Medicine in 1987 for discovering the genetic mechanism that
produces the body’s entire range of antibodies—this constituted a huge
advance in immune research. In 1990, he abruptly changed his field of study
and began deepening his knowledge of the molecular basis for memory
formation and recall. Two years later, he discovered an enzyme that he named
CaMKII—calmodulin-dependent protein kinase II—involved in the
transduction of signals between cells and an essential mediator in learning and
memory processes. Poor regulation of this enzyme is associated with
Alzheimer’s.
An investigation led by Tonegawa at MIT, published in the journal Nature
in 2017, postulated that recalling past events has a beneficial effect on an
individual’s state of mind because it activates both their reward and
motivation systems.
Bringing positive experiences from the past to mind serves as a powerful
antidote to depression and other disordered mental states. That might not
come as much of a surprise, but it’s comforting to know that this common-
sense advice has a verified neuroscientific basis.
Various areas of the brain are involved in this process: on the one hand, the
hippocampus (the memory zone par excellence); the amygdala (which
manages fear and recalls experiences with elevated emotional content); and
the nucleus accumbens (our reward system).
 Memories have a healing power even greater than that of
positive experiences themselves.

* See Chapter 1.
†† In the next chapter, we’ll talk about this hormone.
 3

CORTISOL

Thinking alters our internal world. Imagine that you’re in a cinema or a theater
and you hear someone shout, “Fire!”
You’d immediately be on the alert and start running for the nearest exit in a
panic.
What’s happening in your body in that moment? The startled body sends a
signal to the hypothalamus, which, in turn, activates other areas of the brain. An
involuntary response is triggered through hormonal and nerve signals—the mind
may not even have become aware of the danger yet—giving rise to tachycardia,
sweating, and an increase in temperature, as we have all experienced at one time
or another. This information passes through the thalamus and the cerebral cortex,
where it’s processed cognitively, and the brain makes a decision, as rationally as
the feeling of fear will allow it, about how to respond to the threat.
Next, the suprarenal glands, located above the kidneys, having received the
signal from the hypothalamus, release a series of hormones—among these, we
want to pay particular attention to adrenaline and cortisol.

GET TO KNOW YOUR TRAVELING COMPANION

I’m now going to introduce you to one of life’s most important traveling
companions. Once you’ve read the next few pages, you’ll understand why
certain things happen to you, you’re going to understand certain experiences
you’ve had, and you’re going to comprehend much of the behavior of those
around you. Pay special attention to this chapter.

Cortisol isn’t harmful in itself—what’s bad for us is an excess

of cortisol.

Let’s continue our story. We’re still in the cinema. If cortisol wasn’t involved,
we’d probably stay in our seats enjoying the spectacle of smoke and flames.
Cortisol is therefore fundamental to survival.
Imagine, on the other hand, the real situation. You get up from your seat,
experiencing tachycardia, hyperventilation, and a feeling of distress, and you
look for the nearest exit. You see the frightened faces of those around you;
you’re finding it difficult to think clearly. Finally, you succeed in getting out to
the street, sweating and trembling. Once you’re outside, someone tells you that
there’s no need to worry, they’re adjusting the alarm system and it went off for
no reason—there’s no fire. In that moment, the doors are opened again and ten
minutes later the whole audience has taken their places again. In one sense,
everyone has returned to their original positions, but in reality nobody is in the
same physiological or mental condition as before the alarm went off.
Why? That shot of cortisol that we received will take several hours to
disappear completely and return to its normal levels. It must have happened to
you at some point, perhaps while driving: Someone passes you with a clumsy
maneuver, and although nothing happens and you don’t collide, your body
nonetheless perceives a threat and your heart starts racing. But nothing
happened! This is your body’s warning signal.
What, then, is cortisol’s function?

• Cortisol has a profound effect on multiple systems within the body. When
our cortisol levels are elevated, we are ready to start running; our blood
travels from our intestines to our muscles to help strengthen our evasive or
defensive actions, which is why we lose our appetites at moments of
distress. The senses are activated (“My nerves are on a knife’s edge”),
trying to detect any stimulus that would help us to identify an intuited
threat. Our musculature receives the necessary signals (nerve signals as
 well as biochemical ones) to prepare for either evading the danger or
fighting the danger. Cortisol helps oxygen, glucose and fatty acids to fulfill
their respective functions in the muscles. An elevated heart rate means the
heart beats faster, facilitating the circulation of the blood and the nutrients
it carries to the muscles, so that these can respond in the face of the
eventual threat.
• Cortisol also inhibits the secretion of insulin, provoking the release of
glucose and proteins into the blood. Because of this, if cortisol isn’t
properly regulated, it doesn’t take long before the dreaded diabetes can
appear.
• This hormone helps to regulate the body’s osmotic system, its fluids. This
is key for controlling blood pressure and has an impact on the bones
(cortisol can heighten the chances of developing osteoporosis) and muscles
as well (spasms, stitches, cramps, and so on).
• Cortisol has an essential function: It profoundly affects the immune
system, inhibiting inflammation (to begin with). We’ll look at this in more
detail, because it’s indispensable for understanding the appearance of
certain serious illnesses. When dealing with stress, the body saves its
energy resources. The immune system requires a huge quantity of energy;
that’s why you feel worn out when you’re ill—most of your energy is
being channelled into your defense system.
• Finally, cortisol alters various systems on an endocrinological level:
º The reproductive system: stress and suffering can change a woman’s
normal cycle or affect her ability to get pregnant.
º The body’s growth system can be inhibited.
º The thyroid system can become irregular (hyper or hypothyroidism),
or other illnesses related to this gland can arise.

To all of this can be added a factor that relates to the body’s growth. Faced with
an imminent threat, your body requires all of its stored energy. To capture it, it
paralyzes and blocks anything judged dispensable, including the functions that
have to do with growth. Millions of cells die every day, and human beings
require daily cellular regeneration, but if we interfere—due to stress—with the
growth of these cells, the body will fall ill, having failed to replace the cells it
growth of these cells, the body will fall ill, having failed to replace the cells it
loses.

WHAT HAPPENS IF YOU RETURN TO THE SITE OF A

TRAUMATIC EVENT?
Some time later you return to the same theater. You sit down in the same seat
and suddenly, you don’t know why, you’re on high alert. You get up and do a
visual scan for the emergency exit. Then you have second thoughts about the
seat you’ve chosen and change places so that you’re closer to the door. What’s
happening is that you’re reliving the distress of the previous occasion. At that
moment, your body is generating the same amount of cortisol that was produced
when the alarm really went off.

Your mind and body can’t distinguish reality from imagination.

The brain, therefore, has a profound effect on our inner equilibrium. When we
think of things that worry us, those thoughts have a similar impact to the real
situations. Every time we imagine something we find overwhelming, our
organism’s warning system is activated, and cortisol is released, because our
body thinks it’s necessary to face up to the threat.

WHAT HAPPENS IF YOU LIVE WITH CONSTANT

ANXIETY?
Prolonged worries or feelings of danger—whether real or imagined—can push
cortisol levels up to 50 percent higher than what they should be. This fact is
fundamental to understanding stress: real dangers and threats aren’t the only
ones that trigger the body. It’s also activated, and in exactly the same way, by
anxiety about losing a job, a friendship, or a possession; or by the possibility that
our status, our position in the community, or our role in a group is in question.
Cortisol is a cyclical hormone: during the night, levels decrease, then ascend
to a peak at about eight in the morning, then steadily decrease again. The release
of cortisol follows a pattern, which is usually tied to the rhythm of daylight:
of cortisol follows a pattern, which is usually tied to the rhythm of daylight:
more is released on waking, which has a beneficial effect on our ability to be
active in the morning; then it decreases over the course of the day and rises again
slightly as night falls.

When cortisol levels are chronically elevated, it begins to act

as a toxin.

Stress is one of the dominant factors that dictates the body’s inflammatory
response. Through the three main circuits of the body—endocrine, immune, and
neuronal—stress provokes substantial modifications in the correct functioning of
the systems involved in the inflammatory process.

• In the endocrine system, the body responds by activating the release of

cortisol and norepinephrine. If someone gets “toxified” by the levels of
cortisol in their blood, an alteration occurs in their inflammatory response.
• The immune system also has an important relationship to inflammatory
response. The defense cells, which have specific cortisol receptors in their
membrane, become more sensitive and stop being able to control
inflammation as precisely.
• The nervous system is responsible for preparing and coordinating the
body’s response to a threat or a danger. The brain, by means of the
peripheral nervous system (the sympathetic nervous system holds an
important function), aided by the hormonal system (cortisol), puts the rest
of the body on alert. These signals will allow for the changes in our
organism referred to above, in order to adapt to the danger. If stress
becomes chronic, the adaptation and reaction mechanisms become
saturated, and a neurological block can arise, resulting in various illnesses.

A person under constant stress struggles with two main

problems: on the one hand, the healthy growth and
regeneration functions of the body are halted, and on the
other hand, the immune system is inhibited.
UNDERSTANDING THE NERVOUS SYSTEM
The vegetative nervous system is formed by the ensemble of neurons that
regulate our involuntary functions. This system is in turn subdivided into the
sympathetic and parasympathetic nervous systems, two completely antagonistic
systems—the first is involved in action, and the second in repose.

The Sympathetic Nervous System

This system has to do with our survival instincts, and the behaviors that are
activated at moments of high alert. It triggers mechanisms for accelerating and
strengthening cardiac rhythm, and stimulates capillary erection and perspiration.
It facilitates voluntary muscular contraction, provokes bronchial dilation in order
to promote rapid oxygenation, and encourages the constriction of the blood
vessels, redirecting blood away from the internal organs toward the muscles and
the heart. It provokes the dilation of our pupils, so we can scan our surroundings
more easily, and triggers the release of adrenaline and cortisol from the adrenal
glands. All of this is very handy for staying alert in unfamiliar situations, where
we feel uncertain or our personal safety is under threat. If it becomes necessary
to flee, it’s convenient for the blood not to be tied up in our digestive system, but
available to the muscles in our extremities—we’ll have time enough to digest
when we’ve reached a place of safety, away from the threat bearing down on us.
The sympathetic system is, therefore, key to the stress reaction that occurs
when faced with the unknown, the unfamiliar, or something out of our control.
But the constant activation of this system can have very harmful effects on our
health because it impedes the regeneration of tissues that aid the function of the
parasympathetic system, among other reasons.

The Parasympathetic Nervous System

This prioritizes activating the peristaltic functions and secretions of the digestive
and urinary apparatuses. It enables the relaxation of sphincters, allowing for the
evacuation of excrement and urine, and provokes bronchial constriction and
respiratory secretion. It foments vascular dilation, in order to redistribute the
flow of blood toward the internal organs; it encourages sexual excitement; and is
responsible for a diminution in the force and frequency of the heart’s muscular
contractions. In general, the parasympathetic nervous system is involved in the
maintenance of cells and tissues, preventing or reducing their deterioration, so
that we can live longer and in better condition.

SYMPTOMS CAUSED BY “TOXIC CORTISOL”

Life as it is currently lived is more “inflammatory” than ever before.
Chronic stress reduces the sensitivity of immune cells to cortisol. That is to
say, the body’s defense system is deactivated and incapable of combating a real
threat. The capacity to regulate inflammation has been reined in, and therefore
the body is incapable of defending us from danger. In fact, threatening situations
or situations that provoke tension or fear can activate substances—
prostaglandins, leukotrienes, cytokines—that can be very damaging to our
tissues. This is the reason that we’re more prone to contract infections at certain
times. Who hasn’t experienced an illness coming on a few days after the start of
a holiday? Our body grows weak and gives way to a cold, a urinary tract
infection, or gastroenteritis.
This cortisol-immune system alteration occurs even on a genetic level. We
know that “toxic cortisol” can modify us even at the deepest levels. “New” cells,
arriving from the bone marrow, will be insensitive to cortisol from their birth.
This can become the cause of many illnesses and disorders that are currently
widespread. In today’s world, we’re effectively living through an experiment.
The mere idea of being threatened increases the production of inflammatory
cytokines, proteins that can be very damaging to certain cells in the body. This is
usually associated with a reduction in the cells of the immune system, which
makes us more liable to contract infections.
The opposite is also true! When, instead of feeling threatened by others, we
feel understood, and we cooperate with those around us, the vagus nerve, which
forms part of the parasympathetic system, is activated.
What happens when cortisol levels remain elevated for a prolonged period
because of stress or any kind of problem, fear, or tension? People who live in a
constant state of stress, high alert, or apprehension suffer more cellular
deterioration and premature aging. We now know that many illnesses are
initiated following periods of chronic stress, during which people live constantly
initiated following periods of chronic stress, during which people live constantly
with such feelings.
Cortisol levels, as I’ve explained, rise in circumstances that provoke fear, a
sense of danger, sadness, or frustration. If we’re “toxified” by cortisol, the
hormone will inundate our blood in the place of serotonin or dopamine,
hormones that have a positive impact on mental and physical wellbeing.
The symptomatology of this condition manifests on three levels: physical,
psychological, and behavioral.

Physical Symptoms
I’ll list a few symptoms: alopecia (hair loss), uncontrollable blinking, excessive
perspiration of the hands and feet, dry skin, feeling a lump in the throat,
tightness in the chest, a feeling of suffocation, tachycardia (fast heart rate),
paraesthesia (getting a dead arm or leg), gastrointestinal problems or alterations,
irritable bowel syndrome, muscular pain, thyroid problems, migraines, tics,
arthritis, fibromyalgia . . .
It’s very common among women to see irregularities in the menstrual cycle;
as the hormones responsible are particularly sensitive to stress.

Why Does Everything Hurt?

Bumping into things, cutting yourself, falling over—these accidents are part of
all our lives. The body responds to such mishaps by triggering self-healing
mechanisms, one of which is inflammation. This is a good, healthy response—it
prevents infections and further harm, helping to repair any damage done to cells
and tissues. Muscular stiffness (which makes fiber ruptures more likely), a
constant sensation of pain, heaviness, tightness, or contraction is something
we’ve all experienced: All of these have an explanation whose final cause isn’t
always to be found in the locomotive apparatus. Chronic stress, a lack of healthy
exercise, or poor nutrition are some of the causes of this constant pain. This is
one of the reasons for the current rise in overuse of NSAIDs, or anti-
inflammatory medications such as ibuprofen.
Muscular pains are not due solely to inflammation triggered by the adrenal-
cortisol-immune mechanism; they are also caused by the activation of the
sympathetic nervous system, which forces the body to adopt a defensive posture.
sympathetic nervous system, which forces the body to adopt a defensive posture.
Sometimes muscular discomfort is very intense around the jaw area—a
disruption of the temporomandibular joint (TMJ). This pain arises due to a
constant grinding movement of the teeth—bruxism—that finishes by wearing
them down and damaging the joint. Bruxism is especially intense at night. It’s
now very common to sleep with a dental apparatus adapted to deal with the
problem.

Psychological Symptoms
Changes can occur in sleep patterns—we’ll devote a section to this—along with
an increase in irritability, sadness, inability to enjoy things, aimlessness, and
apathy. In a permanent state of alert, lapses in concentration, memory, or other
mental functions occur. Permanent anxiety opens the door to depression. Many
instances of depression come from living in a state of high alert for long periods
of time.
Our memories are very sensitive to cortisol levels. The hippocampus is the
area of the brain responsible for learning and memory, and it’s directly affected
by changes in cortisol levels. I’m sure this has happened to you: you arrive at an
exam, more or less prepared but very nervous, and your mind goes blank. But
you studied for it! This is easily explained: what’s happened is that your
hippocampus is blocked by a sudden rise in cortisol. Anticipatory nerves,
stemming from worries like “I might fail, I don’t know what’s going to happen, I
can’t remember, they’re sure to ask about the things I didn’t review” block the
hippocampus and the memory, meaning that our fears, unfounded to begin with,
end up becoming reality.

Behavioral Symptoms
High levels of cortisol encourage us to isolate ourselves; it’s no longer tempting
to see friends or relatives, initiating a conversation is difficult, and we begin to
avoid our habitual activities. We also might not engage at social events or feel
the desire to open ourselves up to others.

Physiological stress—eustress—is neither harmful nor toxic.

 On the contrary, it’s our body’s natural response to a real or
imagined threat, indispensable for our survival at moments of
danger, which helps us to respond in the best possible way to
challenges. It becomes harmful when the threat disappears or
is revealed to be unfounded, but the mind and body continue
to experience a sensation of danger or fear.

MY MIND AND MY BODY CAN’T TELL TRUTH FROM

FICTION
This is another of the main ideas I want to get across with this book. The brain
doesn’t know how to differentiate what is real from what is imaginary. Every
time we modify our mental state—consciously or unconsciously—a change
occurs in the body that is as much molecular as cellular and genetic. In the same
way, when we modify our physical state, the mind and the emotions take note.
I’ve highlighted over and over in this chapter the importance of being conscious
of one’s thoughts. Thinking alters our body. The mind adapts and reconfigures
according to the changing factors, circumstances, and experiences of each day.

A stressed-out brain is the consequence of being inundated

with toxic thoughts.

The mind has an extraordinary degree of control and influence over the
body. Thoughts directly influence both mind and body. If you close your eyes
and picture someone you love, in a nice setting, your body secretes oxytocin and
dopamine. You might even feel a shiver run through your body, or get goose
bumps or a number of other physical signs. People in love (I could write an
entire separate book about people in love!) experience a very strong sensation of
emotional, psychological, and (especially) physical wellbeing. If I imagine
something that frightens me—an exam, a meeting, the possibility of getting fired
or not having money—I automatically generate stress hormones.
I’ll give you a basic example. Close your eyes and visualize a lemon. It’s
yellow, ovoid, etc. Feel it in your hand, really touch it. Bring it to your nose.
Take a knife and cut it open. What do you observe? Have you started salivating
yet? Cut a slice and bring it to your lips, taste it, take a risk and bite into it. Open
your eyes, and of course the lemon isn’t there—but your body reacted as though
it were. The imagination has significant power over the mind.
Your thoughts exercise great power over your brain and your body. If you
run over a past event or a negative future possibility in your mind again and
again, your brain understands it as present in your current situation, getting in
the way of what you want to focus on. What happens? Your attention is always
hooked, and you’re imprisoned by toxic thoughts of the past or the future; that is
to say, the mind can’t successfully manage and focus its attention as it wants to.
To express this more visually, every time we think of something negative,
worrying, or harmful, the brain receives a signal to develop specialized neural
circuits that will keep us locked into these ideas. The mind cannot tell truth from
fiction. Later we’ll look at practical tips for permanently redirecting our thoughts
and controlling the current of negative ideas that can block up our minds.

NUTRITION, INFLAMMATION, AND CORTISOL

Some say that we are what we eat. I’m more inclined to believe that we are what
we feel, what we think, and what we love—but I’m aware that nutrition plays a
fundamental role in our health. We know that some foods have a significant
correlation to certain serious illnesses, such as cancer, and it’s therefore
something we shouldn’t ignore. In recent years, our dietary habits have visibly
shifted. Currently, according to data used by nutritional specialists, the average
person ingests 30 percent more pro-inflammatory food than a few years ago.
People with chronic inflammation have lower than recommended levels of
certain vitamins—C, D, and E—and omega-3. In addition, persistent
inflammation alters the intestinal barrier, leading to a greater degree of
permeability to certain substances. This finishes by harming the immune system
and can lead to discomfort and adverse reactions after ingesting certain foods.
Foods that activate inflammation have a strong correlation to the release of
insulin by the pancreas; among the “usual suspects” are alcohol—especially in
large doses—saturated fats, sugary drinks, and refined flours, above all those
used in industrial baking.
Be careful with inflammatory fast food. According to a recently published
Harvard study, women with a diet rich in inflammatory ingredients—white flour,
saturated and trans fats, sugary drinks, and red meat—have a 41 percent greater
chance of suffering from depression. We must reintroduce those foods that have
an anti-inflammatory effect into our diets, such as:

• Omega-3 (which we’ll discuss in more detail in Chapter 8)

• Some spices such as turmeric, which has powerful anti-inflammatory
properties
• Citrus
• Vitamin D. More and more studies connect depression to low vitamin D
levels. We psychiatrists are beginning to evaluate vitamin D levels in our
patients, and we’ve observed an improvement in depressive symptoms
after treatment with vitamin D.
• Onions, leeks, parsley, bay leaves, and rosemary. In fact, in some cases of
injury to the foot or ankle, soaking the foot in water infused with bay leaf
and rosemary has a beneficial effect on diminishing inflammation.

WHAT ROLE DOES THE DIGESTIVE SYSTEM PLAY IN

INFLAMMATION?
A couple of years ago I was asked to be involved in a study on probiotics and
intestinal flora and their direct relationship to emotional and mental states. I got
hold of a lot of information on the topic, reading articles and publications on the
theme. It’s an exciting field, with many discoveries still ahead, and in the last
few years studies in this area have multiplied.
A significant connection prevails between the brain and the intestines. The
digestive tract, comprising the whole stretch from the esophagus to the anus, is
carpeted in over a hundred million nerve cells—that’s an equivalent amount to
the entirety of the brain’s central nervous system, from the cerebellum to the
spine! In addition, more than a hundred billion microorganisms are contained
inside the digestive tract. They fulfill an important function in the processing of
food and nutrients, releasing a huge quantity of molecules into the intestines.
These can eventually influence the body in a fundamental way.
Investigation in this area is recent, and in research terms, the field is still a
baby in diapers, but the first studies published on the topic, based on
experiments with mice, show that a lack of bacterial flora has important
repercussions on the body, including the brain. Special attention is being paid to
the relationship of cause and effect between certain sudden changes to bacterial
flora and simultaneous alterations in a patient’s conduct or state of mind.
There are many theories. A review published in 2015 (Kelly et al.) suggests
that deficits in the permeability of the intestine might be the cause of the
inflammation that appears in conjunction with emotional disturbances.
Elsewhere, it’s been postulated that some microorganisms secrete substances
that perform the same tasks as neurotransmitters in the brain. Finally, there are
speculations that some of the substances produced by these microorganisms in
the digestive tract directly affect the immune system or the nervous system.

Microbiota have a fundamental role in the regulation of

intestinal permeability and in the inflammatory aspect of
depression.

Serotonin, the happiness and well-being hormone implicated in appetite,

libido, and many other mental and physical functions, is responsible for a state
of anxiety or depression. But it would be a mistake to reduce depression simply
to cerebral serotonin levels. Approximately 90 percent of the body’s serotonin is
produced in the intestines, and the rest in the brain.
More research into probiotics and mental states is constantly emerging. In
December 2017, a study was published in the journal Brain, Behavior, and
Immunity about how probiotics counteract depressive tendencies. At the
University of Aarhus, researchers highlighted the benefits of probiotics not only
to intestinal health but to subjects’ state of mind.
Recently a study led by Dr. Nicola Lopizzo was published, which drew a
connection between Alzheimer’s disease and inflammation and microbiota. She
observed that the sick individuals had different microbiota from the healthy
subjects who participated in the study. It’s now being postulated that
subjects who participated in the study. It’s now being postulated that
inflammation plays a key role in the development and evolution of Alzheimer’s.
It is believed that inflammation can be influenced by a body’s microbiota. This
is an exciting field, and there’s a push to further research in this direction.

IS DEPRESSION AN INFLAMMATORY ILLNESS OF THE

BRAIN?
Based on everything we’ve read and understood up to this point, we know that
there’s an important relationship between inflammation, especially chronic
inflammation, and illness. But what happens with depression? What role does
inflammation play in depressive processes?
In recent years, various voices have been heard within the scientific
community attempting to explain this relationship, something I find very
exciting. In the February 2018 edition of the prestigious journal Lancet, Dr. Jeff
Meyer’s team published the first scientific evidence of inflammation’s role in
depression. After an exhaustive image analysis—using positron emission
tomography, or PET scans—it was observed that people who had suffered from
depression for years showed alterations to their brains, with an increase in
inflammatory cells, which is to say an excessive immune response.
In addition, it has been observed that after administering certain
immunomodulatory pharmaceuticals, such as interferon alpha (IFN-α), for the
treatment of multiple sclerosis, melanoma, hepatitis C, and other illnesses, many
subjects presented comorbidity in the form of depressive symptoms.
What happens when children suffer violence, trauma, serious wounds, and
bullying?
Recent studies (Cattaneo, 2015), suggest that childhood stress—bullying,
separation from parents, physical or psychological abuse—provokes
inflammatory processes that can make children more likely to suffer from
emotional disturbances and greater vulnerability, and can even provoke
depression in adulthood. This can now be “measured” in the blood. We mustn’t
forget that one of the main problems in the diagnosis and treatment of depression
is a lack of markers that allow us to confront it in a personalized, specific way.
One of the most trustworthy parameters in this regard is the presence of C-
reactive protein in the blood.
reactive protein in the blood.

Elevated levels of C-reactive protein (CRP) in the blood are

connected to a lack of energy and alterations in sleep patterns
and appetite.

It’s reasonable to offer alternatives to patients who don’t respond to known

antidepressants. One solution may reside in the measuring levels of
inflammatory markers like IL-6, TNF-alpha and CRP. We know that these can
be trustworthy markers in the diagnosis and monitoring of depression; people
suffering from depression have almost 50 percent more C-reactive protein than
others.

Chronic, sustained, low-grade inflammation is a key player

when it comes to the likelihood of developing depression or
psychosis.

In October 2016, an article was published in the journal Molecular

Psychiatry, by Dr. Golam Khandaker of the Cambridge University Psychiatry
Department. The article studied the effects of applying anti-inflammatories to
depression. Researchers employed anti-cytokine pharmaceuticals—anti-
inflammatory molecules—to treat autoimmune inflammatory illnesses. When
they collected their results and analyzed the secondary effects, they noticed with
surprise that there was an improvement in depressive symptoms.
Pharmacological treatments are far from infallible: a third of patients don’t
respond to the antidepressants currently on the market. Faced with this treatment
gap, inflammation seems to be an essential factor for many people suffering
from depression. Perhaps in the not-too-distant future, it will be possible to
prescribe anti-inflammatory pharmaceuticals* to patients resistant to
conventional treatments for depression. We would be talking about biological
anti-inflammatories, similar to those used on autoimmune diseases—anti-
cytokine monoclonal antibodies.

Around a third of patients who do not respond to conventional

 antidepressants show clear evidence of inflammation.

To sum up:

• Depression goes hand in hand with chronic low-grade inflammation linked

to immune system activation (caused by cytokines and other substances).
• Depression frequently presents along with inflammatory illnesses,
cardiovascular ailments, and cancer.
• The application of some immunomodulatory pharmaceuticals produces
depressive symptoms.
• Diabetes sufferers are twice as likely to suffer from depression.
• We now know that stress, tobacco, digestive modifications, and low
vitamin D levels are accompanied by an inflammatory response.
Inflammation doesn’t just trigger the beginnings of depression—it’s also a
key factor in its remission.
• Inflammation is a key process of depression. It needs to be taken into
account at several different points: as a marker of the illness but also as a
response to treatment. It can be useful to monitor the levels of
inflammation over the course of treatment, to take note of its possible
resistance or response.
• Studying inflammation has opened up a new world of possibilities in the
care of depression resistant to conventional treatments.
• Inflammation is key to understanding and finding the links between
coexisting symptoms and organic disorders (such as cardiovascular
illnesses and depression, chronic anxiety, and endocrine disorders.).
• When we get ill, we generate substances that alert the body that something
isn’t working: cytokines. With depression, cytokine levels increase
notably. With other mental illnesses, such as bipolar disorder, we know
that cytokine levels stabilize during periods of remission.

* This doesn’t mean commonly used anti-inflammatory medications such as

ibuprofen, but they are similar, although they deal specifically with the
biochemical aspects of the inflammatory processes of depression.
 4

NEITHER WHAT HAS BEEN NOR WHAT IS TO

COME

HEALING THE WOUNDS OF THE PAST AND GETTING

EXCITED FOR THE FUTURE
As a psychiatrist, I usually define happiness as the capacity to live healthily,
anchored in the present, having overcome the wounds of the past and looking
hopefully toward the future. People who spend their lives stuck in the past are
depressive, neurotic, and embittered; people who spend their lives terrified for
the future are anxious. Depression and anxiety are the major illnesses of the
twenty-first century.

At least 90 percent of what we worry about never happens,

but the body and the mind live through these anxieties as
though they were real.

We live in a constant state of bombardment, worried by things that aren’t

particularly likely to happen. What if I don’t pass this test? What if I get made
redundant? What if I don’t get a place at university? What if I don’t finish this
project? What if they don’t renew my scholarship? What if my partner leaves
me? What if something happens to my children? What if I get sick? What if my
parents get sick? This recurrent “what if” has a strong effect on the body and
mind. Don’t forget that you can only act, feel, and respond in the present
moment. You must take responsibility for your actions in each moment, for your
capacity to proceed in the here and now.

If you ask someone what’s worrying them, their response will

be about the past or the future—we’ve forgotten how to live in
the present!

Living Stuck in the Past

The past is a valuable source of information, but it doesn’t determine your
future. The act of living with your mind anchored in the past, turning over and
over things that have already happened, can have adverse effects, bringing up
emotions and sensations from melancholy, frustration, guilt, sadness, or
resentment all the way to full-blown depression.
All of these have an element in common—they prevent us from enjoying the
present. Getting stuck in the past prevents us from moving forward in life.

GUILT
Few emotions can be as toxic and destructive as guilt. Guilt consists in the
feeling that we haven’t acted correctly or haven’t fulfilled what was expected of
us, thereby disappointing other people—or ourselves.
Guilt can have a range of origins or causes: the level of demands placed on
us by others or by ourselves, what we’re taught by our parents, taboos, school,
our relationships to our classmates or colleagues, sexual feelings that have been
malformed or misdirected in childhood and adolescence, or incorrect or extreme
interpretations of religious teachings. Guilt, therefore, has various focal points:

• It can come from inside you. In this case you are always turning your mind
towards failures and disappointments. Your gaze is directed inward to your
limitations and mistakes. You treat yourself with disdain, with a harshness
that prevents you from moving forward and seeing the positive.
• It can arise externally, when the people around you make you self-
conscious or point an accusatory finger at you: in childhood, “You should
 be ashamed,” “It makes Daddy sad when you do that”; or in adulthood,
“You should have studied Economics,” “You shouldn’t have married X,”
“You shouldn’t have gotten involved in this business,” “You should have
seen it coming.”

Careful! Inner voices can be just as damaging to your mind

and body as those coming from outside.

Guilt demoralizes us; it allows no forward progress. Some feelings of guilt

can lead to very severe mental states. It’s relatively common to encounter very
neurotic personalities in treatment—depressed people who have locked
themselves into a cycle of guilt that they cannot manage to heal. When guilt has
a basis in reality—we sometimes do do the wrong thing—try to use this past
mistake as a motivation to improve, to learn, and to overcome.

CASE STUDY: CATALINA

Catalina got married when she was 31. She has worked all her adult life for a
multinational company, traveling through Spain and Europe. She enjoys her
work, and had never felt any maternal urges.
At 33, she became a mother for the first time. After the birth, during her
period of maternity leave, she began to feel enormous attachment to her son,
Eduardo. She surprised herself, reading insatiably about babies, breastfeeding,
and motherhood. She signed up to various websites to learn and become more
informed. She attended postpartum group sessions with other mothers, took
her son to baby massage, and devoted herself to talking with other women
about the daily development of little Eduardo.
Four months passed, and the day arrived when she was meant to return to
work. She had always been someone with a lot of professional drive, but she
began to experience feelings of anxiety a few days before her return. When
she went back, she was incapable of disconnecting from home—she installed
a system on her phone for monitoring how her baby was all day long.
When she left the house, a “horrible feeling of guilt” over abandoning her
son would well up in her. This thought led to a state of high alert and distress
son would well up in her. This thought led to a state of high alert and distress
that prevented her from performing at work. Guilty thoughts flooded through
her mind, and her one desire was to get back home, embrace her son, and be
with him. She realized that she was forging an unhealthy mother-son
relationship. A couple of months later, she asked for leave due to anxiety.
When I see her in consultation for the first time, I realize that her guilt has
developed into an anxious-depressive state. She never imagined that she could
feel a maternal instinct—a very natural one, but unacknowledged by her for
many years—and now still, every time the thought of work occurs, thousands
of toxic voices crowd together in her head, judging and criticizing her for
abandoning her son.
We begin therapy to determine the exact level of distress she’s presenting.
At the same time, we begin a minute examination of her inner state, her
blockage and anxiety derived from guilt. We realize that she comes from a
family in which the mother always worked—her parents were separated and
her father lived far away—and she has never had a particularly close
relationship to her. She explains: “My mother spent the day working. She left
us in a neighbor’s house, where we did our homework and played with the
other kids. She’s only kissed me or told me that she loves me a few times.
She’s very cold, extremely pragmatic, and she judges me very harshly when I
do something wrong.”
The therapy lasted a few months, until she began to accept her feelings of
attachment, which had been inhibited. She learned to understand her mother,
the circumstances that surrounded her childhood, and to love her as she was.
Now she works reduced hours and is looking forward to having her second
child.

HOW TO PACIFY FEELINGS OF GUILT

• Pay attention and take note of the main triggers of guilt that come up for
you throughout the day. Observe which life events affect you most. Accept
that you might be judging yourself too harshly in some situations.
• Make a list of failures, faults, and actions you feel guilty about that you
 have performed over the course of your life and have marked you in some
way. Do this without exaggerating, being neither excessively harsh nor
excessively indulgent, trying to find a middle ground. Rate them from zero
to five. These scores will help you realize that you can measure your
perception of guilt quite accurately.
• Observe a past event that you’re tormented by as though you were sitting
in a train, watching this scene from your life pass by. Acknowledge that
there is no way to change the outcome now. Guilt doesn’t help the
situation or make you grow. It isn’t constructive. It’s just a toxic emotion
that prevents you from moving forward and that must be processed and
eliminated.
• Return to your present moment by asking this bold question: What am I
losing in the present because I’m living mired in guilt? You’ll be surprised
—I guarantee that good things are happening all around you—you just
aren’t capable of seeing them.
• Learn to love yourself, and to move through life with a sense of well-
being. The most important thing is knowing how to be good to yourself.
People who remain stuck in a state of guilt can’t manage to see their
strengths or their talents. They see everything as crashing down on them
because of their limitations or defects—because their perception is
distorted!
• Be careful of developing a victim mentality. Guilt is a slippery slope that
finishes, in many cases, in a constant state of victimhood, a neurotic and
toxic behavior that obstructs your clear vision of life and your way of
relating to others.
• Look for things that you like about yourself. They exist, but sometimes
your state of mind or your links to the past stop you from seeing them. I’m
sure that inside you there are abilities that can motivate positive growth,
even if others don’t like them! Your main challenge: Let go of the opinions
and judgments of others.
• Focus on your values. Guilt carries the seeds of destruction of entire value
systems. You don’t know what to believe or why to believe it. What
governs your life? Think about whether you’re being hard on yourself
 because of something imposed from outside or because of demands that
you have chosen to take on over the course of your life.

DEPRESSION
Depression is the malady of our times. It would really be more accurate to speak
of depressions in the plural, because there are multiple types that can crop up in
the clinical context. Depression currently constitutes one of the major epidemics
of modern society. In my country, Spain, there are approximately 2.5 million
people suffering from it.
It’s a disease, and as such there are causes, symptoms, prognostics,
treatments, and, in some cases, preventative measures that go with it. There are
two types: endogenous depressions and exogenous depressions. Between them
falls an intermediate spectrum of mixed forms of depression. In addition, there
are reactive depressions, arising in response to life itself.
It is now thought that all of these types are much more intertwined than was
previously believed. There are various neurological circuits and substances
implicated in depression, among which the most studied are the monoaminergics
—serotonin, dopamine, and norepinephrine—but it hasn’t yet been demonstrated
that any of these circuits present a degeneration or dysfunction that is clearly
responsible for the symptomatology, as happens with Alzheimer’s, Parkinson’s,
or other neurological diseases.
Some now postulate that the neurobiological hypothesis of depression has a
relationship to neuroplasticity in the circuits charged with cognitive and
emotional functions. This means we might really be talking about a disorder
with the circuits rather than with the transmitters themselves.

Depression is a disease of sadness. An infinite number of

negative symptoms can converge in depression: pain,
dejection, apathy, loss of appetite, disillusionment, a lack of
desire to live, indifference and lethargy (lacking the energy to
perform any activity), suicidal ideation, disrupted sleep, and
problems with attention and concentration.
 Depression leaves you without the energy or the desire to do anything. Its
symptoms are extremely varied and can range from the physical (headaches,
chest pain, or generalized pain distributed throughout the body); to the
psychological (most important, a psychological downturn, although a lack of
vision for the future is also common, with everything becoming colored by
negativity and feelings of guilt); the behavioral (behavioral paralysis and
blockage, isolation); the cognitive (struggles with concentration and memory,
dark thoughts, and ideas that deform our perception of reality and turn it against
us); or the social, also known as assertive (social abilities become blurred and
lost, and communication and interpersonal exchanges grow clumsy and distant).
The symptomatology of depression can, in many cases, be vague and manifest as
bodily symptoms; according to some studies, around 60 percent of cases initially
seek medical advice for a physical symptom.
A person who hasn’t experienced clinical depression doesn’t know the true
nature of sadness. The suffering caused by depression can become so profound
that suicide seems like the only way out.
Nobody is immune from depression. It’s true that there are factors that
increase one’s risk—family, genes, socioeconomic status—but consulting rooms
are full of people from all walks of life making their way through the dark tunnel
of depression: writers, athletes, musicians, actresses, singers, politicians, wealthy
entrepreneurs, and extremely successful people of all stripes . . . Many among
them have confessed to suffering from depression or undergoing treatment.

FAMOUS SUFFERERS FROM DEPRESSION

Vincent Van Gogh.

The genius artist was a patient at a psychiatric hospital; unfortunately for him
and the history of art, his condition worsened to the point where he committed
suicide. The red-headed Dutch painter, with his mutilated ear, felt that his
stormy life lacked meaning; professionally, he considered himself a failure,
and in fact he only sold one picture in his lifetime. In the end he let himself be
overcome—his last words were, “The sadness will last forever.”
 Michelangelo Buonarroti.
In the case of the man many believe to be the greatest sculptor in history, his
depression originated in what we would now call body dysmorphic disorder,
that is to say an obsession with a body part one finds displeasing.
Michelangelo is said to have had an unprepossessing face, with a nose
disfigured by an act of violence by one of his many jealous enemies, Pietro
Torrigiano, a legendarily bad-tempered sculptor. Torrigiano worked in the
court of Lorenzo de Medici, who had a great admiration for Michelangelo.
One day, in a fit of envy or jealousy, he broke his nose. Michelangelo,
traumatized, isolated himself and avoided the company of others for many
years. His good friend, the poet Poliziano, gave him excellent therapeutic
support during this period of his life.

Ernest Hemingway.
He suffered a serious depression at the end of his life. He felt a profound
sadness and disillusionment. In an attempt to cure himself, he underwent
various rounds of electroshock therapy. At the time, this treatment was
relatively new and quite rudimentary, and it gave rise to serious adverse
effects in patients. Ernest lost his memory, and his cognition was severely
affected. When he received the Nobel Prize in 1954, in recognition of his
writing career, he said, “Writing, at its best, is a lonely life. Organizations for
writers palliate the writer’s loneliness but I doubt if they improve his writing.”
His father had committed suicide in 1928. On learning of it, he wrote, “I’ll
probably go the same way.”
And indeed, some years later, in 1961, his prophecy was fulfilled.

Depression in children translates into a different set of behaviors and

symptoms. The depression is externalized, demonstrated through the child’s
conduct. A child of 10 or 12 still doesn’t have enough emotional vocabulary or
mastery of verbal self-expression to explain what he is feeling. This is why, to
uncover possible depression in a child, we must be alert and correctly interpret
his changes in behavior: he may stop playing, speak very little, turn inward, get
bored, cry frequently, struggle to concentrate, and fall behind in school. Parents
bored, cry frequently, struggle to concentrate, and fall behind in school. Parents
should be capable of looking below the surface and seeing when their children
are adrift, lose motivation, or have changed their demeanour.
Fortunately, today we have the benefit of real improvements in the treatment
of depression at every level, although it’s true that advances in the field aren’t
occurring as rapidly as we might like, and we all know or have heard of someone
who spends their whole life on medication. Attacking the symptoms from the
get-go and finding the right treatment increase the chances of a cure. Many
depressions stem from a state of permanent anxiety—I’ll talk more about this
later—and therefore treatment should be oriented toward reinforcing the
foundations of a positive mental state: good management of stress and the
emotions as well as the background personality.

A Therapeutic Example
In my consultation practice, I tend to work schematically. I try, in the simplest
way, to build a model—an actual chart—of the patient’s personality, reflecting
their way of being, their style of stress management, and their psychological
symptoms, so that the person understands what’s happening to them and can
work on it. Let’s look at an example.
CASE STUDY: ALEJANDRA
Alejandra comes in seeking counseling for her depression, panic attacks, and
recurrent migraines. She’s been undergoing pharmaceutical treatment for five
years, during which she’s experienced periods of improvement that last a few
weeks. On analyzing her personality more deeply, we find a woman with
avoidant traits—exaggerated shyness—who tends to get trapped in circular
 avoidant traits—exaggerated shyness—who tends to get trapped in circular
thinking and displays hypersensitivity. We look at what she sees as her stress
triggers—interacting with others, working in a public-facing role, and seeing
her ex (with whom she has a complicated relationship), as well as reaching the
end of the month, when she always experiences financial difficulties.
In this case, it isn’t simply a question of administering medication for her
sadness or panic attacks but of working on the cause (her avoidant
personality); on her stress management (for her, working with the public and
attending social events are important factors in creating tension); on the
symptoms of anxiety (I manage this with awareness and relaxation
techniques); and then on the depression, which may or may not require
medication.

In my experience of counseling, working with a scheme allows the patient to

better understand what is happening to them and exactly how we’re working on
their inner state, as well as the therapeutic aim of any medication administered.

FORGIVENESS
Forgiveness is an act of love and an elevated mindset with which to approach
other human beings and life in general. To forgive is to respond positively when
you have been treated negatively. It’s a special form of surrender, and it lifts
human beings to a higher plane.
I’m not naïve—I know how difficult it is to forgive certain behaviors. It’s not
the same to pardon someone after being lightly wounded as it is to forgive them
after suffering in a significant and really damaging way. Disdain, unjustified
aggression, humiliation, betrayal, marital infidelity, or harsh criticism can
generate levels of suffering that can be difficult, or nearly impossible, to
overcome.
In Cambodia, I listened to the most chilling, terrifying stories of my life. I
kept notebooks of what I heard, and sometimes, reading back over them, I still
end up crying all over again. I wanted to help girls who had lived or were living
in prostitution, and who had suffered cruelly, but I didn’t know how to help them
find a way out of their pain. I’ve always thought that psychiatrists and
psychologists help people who are suffering, wounded, or blocked to find a way
out; in Cambodia, however, I didn’t know how to provide that “therapy.”
One day I met Mey, and she gave me a solution.
I met Mey on a hot, gray day in August. Somaly* had told me about a house
in the Cambodian hills that sheltered a center for very young girls. When we
arrived at the center, what I saw remained stuck in my mind’s eye. The girls
were all dressed the same, so as not to call out their differences: They wore a
shirt and pants in a Hawaiian-type floral pattern. Somaly went toward them,
sitting down in the middle of the room. Their maman had arrived, and the girls
came running to hug her. In a few faces you could see deep sadness, their gazes
lost in a cruel and painful past. The smallest girls, five or six years old, flitted
about and danced around Somaly. Others, seated in the corners, stayed
completely still. Somaly, with her sweet voice, began to tell them a story in her
language, Khmer. Little by little, the stragglers came to sit closer to her; a
change came over their countenances, and their faces grew less cold and tense.
While I was observing this scene, a girl with a mischievous smile came up to
me. I introduced myself in my rudimentary Khmer, which was very basic but
sufficient to start a simple conversation. She was called Mey; she was 13 and
had been at the center for a few months. When she noticed my difficulty with the
language, she smiled in amusement and let slip a few words in English—it was
obviously going to be easier to communicate in that language than with my
Khmer. After a short conversation, I asked if she was happy. She answered
intently, “Now I am. I want to be a journalist to write stories for children so that
their mothers will read to them. The stories will have to be about how parents
love and take care of their children, and don’t sell them into prostitution.”
Mey had brought up prostitution fearlessly, without batting an eyelid. A
shiver went down my back. After a few seconds of silence, I gathered my
strength and asked, “Did they sell you?”
“Yes, my grandmother sold me, and I’ll never understand it.”
Silence . . . then she looked up and continued. “I don’t have parents. My
memories begin with my grandmother, who I lived with. A year ago they took
me to the house of an older foreign businessman. There were a lot of us girls in
the house, some cooked, others cleaned . . . One day he called me to his room,
took off my clothes, and did horrible things to me that I didn’t know existed. I
screamed and screamed but nobody could hear me . . .”
I embraced her, to try and console her in the face of such a memory, but she
didn’t show any pain, seeming to remember it at a distance. She carried on.
“This happened again on different days, until I realized I couldn’t endure it
anymore. I decided to escape, and one night I jumped the gate and ran away. I
didn’t know where to go, and I didn’t have anywhere to go back to. I
remembered that a while before, I had met an Indian man who brought rice to
our neighborhood when we didn’t have any food. He was a good man. I ran to
the house where he lived. He was a missionary. I had never heard about
Christians. He told me about his God and how he died on a cross. I wasn’t
brought up in any religion, but I was interested in his story and I asked, ‘How
did he overcome it?’ His response was, ‘He forgave them.’ I started to attend the
little chapel nearby in the mornings, and I talked to the man on the wooden
cross. I asked him to help me to forgive, so I could be free of the anguish and the
rage. One day, while I was sitting on the ground, I realized that I didn’t feel hate
or anger anymore. I’d forgiven the foreigner. From that day my life changed.”
With excitement, I realized I was getting a glimpse of a viable solution to so
much pain. She continued: “The missionary was looking into the best place to
take me. We finally decided to go to the police, who brought me here. A few
days later I met Somaly. Now I’m happy. I have a mother and many sisters. It’s
essential to overcome such immense pain through forgiveness. There’s no other
way to achieve peace. I try to do it with my sisters [as they call each other at the
center]. I love them, I listen to them . . . I’m very lucky. I’m very happy.”
I spoke to Mey at length, and all in a rush. I was impressed at how the power
of forgiveness had healed her deepest wounds. Over the course of the following
weeks, I tried to follow the “forgiveness model” that she had shown me.
I was profoundly marked by it; I studied, I read everything I could find on
the capacity to forgive, and I based the process on the idea that understanding is
healing. This means that when you understand or comprehend the reasons that
motivate someone to hurt you—their life history, their way of being, their envy,
their internal conflicts, etc.—you manage to relieve your own suffering.
In Mey’s case, where she had so much anger against her grandmother for
 In Mey’s case, where she had so much anger against her grandmother for
selling her, she told me, “Faced with the desperation of having nothing, without
ill will, she was looking for an easy solution, so my sisters could eat.”
There are of course bad people in the world, but the majority of those who
hurt you have their reasons. Sometimes even they don’t know them, but if you
look, if you really hunt for them, you might be surprised by the consolation you
can find.
Our suffering in life can be truly painful and torturous; this is the reason we
must struggle to overcome the harm that falls to our lot. When someone holds on
to their hatred, when they aren’t capable of recovering from the offenses and
humiliations they receive, they can turn into a bitter, resentful, neurotic person.
To avoid these negative consequences, even in cases where the person who
provoked the trauma has no possible justification, the victim is better off
“selfishly” forgiving.

The drama and traumas that flatten and destroy one person
can strengthen and regenerate another, giving them the gift of
a greater capacity for love.

One toxic ingredient derived from a lack of forgiveness is resentment—re-

sentiment: the repetition of a feeling, and of the thoughts that go with it, in a
recurrent and harmful manner. Every religion and ethical system includes
forgiveness as one of its foundational principles. Buddhism considers it in depth;
there are teachings from the Buddha on the human need to forgive. In Judaism,
the concept of forgiveness is fundamental, and very similar to that held by
Christians. To illustrate the theme, I’m going to tell a remarkable story.
What if you can’t understand . . . at all?
Simon Wiesenthal was an Austrian Jew, a professional architect. After being
imprisoned in five different concentration camps during World War II, he was
liberated from Mauthausen by the Americans in 1944. Once he had recuperated,
he began his famous work as an implacable Nazi-hunter, traveling all around the
world. He managed to bring more than a thousand Nazis to justice.
In his book, The Sunflower: On the Possibilities and Limits of Forgiveness,†
he relates his personal story and his ideas about the great dilemma of
forgiveness.
The anecdote that stands out on the page—and in his life—is as follows. One
day, in a concentration camp, a nurse asked him to follow her. He was brought to
a room where a young member of the SS, Karl Seidl, 21 and dying, had a
peculiar request to make of him. Karl had received a bullet wound, and was
experiencing his death throes. Barely capable of speech and almost completely
covered in bandages, he had begged the nurse to bring a Jew to him before he
died, so he could speak to him. During the hours that followed, Simon stayed by
the young man, who told him his life story. He needed to express who he was,
recounting his childhood, and how he had ended up with the SS youth arm,
committing atrocities. He revealed to Simon, all the while tightly holding his
hand, one of the worst brutalities he had carried out: beating and attacking a
group of Jewish families and finally burning them in a house in Dnipropetrovsk,
now in Ukraine. He continued his recital, stressing the aspects that caused him
the greatest pain, among them the gaze of a small boy, who tried to jump from
the window but whom Karl shot. During the hours he stayed by his side, Simon
didn’t utter a word.
Karl’s last words were: “Here I am with my guilt. In the last hours of my life,
you’re here with me. I don’t know who you are, I only know that you’re Jewish,
and that’s enough. I know that what I’ve told you is terrible; time and again I’ve
yearned to speak of it with a Jew and to ask his forgiveness. I know I’m asking
too much of you, but without your response, I can’t die in peace.”
Simon couldn’t stand it; he walked out of the room. His book deepens his
exploration of this question: “Should I have forgiven him? . . . Was my silence at
the bedside of the dying Nazi right or wrong? This is a profound moral question
that challenges the conscience . . . The heart of the matter is the question of
forgiveness. Forgetting is something that time alone takes care of, but
forgiveness is an act of volition and only the sufferer is qualified to make the
decision.”‡
The situation I’ve described provoked, in Simon, a huge moral dilemma over
guilt, the capacity to forgive, and repentance. In the second part of his book, he
interviewed 53 thinkers, intellectuals, politicians, and religious leaders—Jewish,
Christian, and Buddhist; witnesses of the genocides in Bosnia, Cambodia, Tibet,
and China—about what they would have done in his place. Twenty-eight of
them responded that they wouldn’t have been capable of forgiving, sixteen asked
whether it was possible, and nine didn’t have a clear position. Of those who did
opt for forgiveness, the majority were Christian and Buddhist. The position
taken by the Dalai Lama, founded on his memories of the conflict in Tibet, was
in support of forgiveness, but without forgetting, so that never again could
similar atrocities occur.
This book, which doesn’t come to any conclusion, deciding that in the end
forgiveness is a matter of individual conscience, constitutes a classic work on
forgiveness and reconciliation from different points of view, both religious and
personal.
Forgiving doesn’t mean deciding that what the other person has done is
acceptable or comprehensible. At times the crime is so atrocious and inhuman
that there is no way to analyze the conduct of the perpetrator and thereby get
relief. In spite of everything, even in those cases, forgiveness is necessary,
because the pain that the guilty party has created doesn’t deserve to find a
permanent home in your mind. That wound, that poison, that resentment—each
could turn you into an embittered person, if you’re not capable of letting it go.
Forgiving relieves the pain caused, dodges resentment, and therefore opens the
way to the future up to the victim, a way which, without forgiveness, would
remain permanently closed. The capacity to forgive belongs solely to the victim,
and doesn’t depend on the repentance of whoever caused the offense. Forgiving
is a way of shedding burdens, which helps us to move forward even if the
damage done is terrible and the person who caused it doesn’t repent. In my
clinical experience, it’s always worth it.

Forgiving is traveling to the past and returning safe and

sound.

If we don’t forgive, if we aren’t capable of purifying ourselves, we can stay

stuck with our rancor, hatred, and desire for revenge. Revenge means deciding
that I want to hurt the other person in return, that I want them to suffer and for
bad things to happen to them. Rancor means I stay wounded and bleeding,
incapable of forgetting and overcoming the harm. If this happens to us, we’ll
find ourselves unable to recover peace and equilibrium.
How does one forgive?

• Accept what happened. Don’t deny reality.

• Try to get a little perspective on what has happened. Sometimes we’re
minor players in a drama unfolding elsewhere, and there’s nothing we
could have done to intervene. Life is full of injustices and complications
that we cannot control.
• Try to distance yourself from the scene in your head by using techniques
such as EMDR. EMDR—Eye Movement Desensitization and
Reprocessing—was discovered by Francine Shapiro in 1987. It’s a
psychotherapeutic technique employed to work with post-traumatic stress
disorder. It integrates elements of different psychological approaches.
Using bilateral stimulation by means of eye movements, sounds, or
tapping, it stimulates one cerebral hemisphere at a time. EMDR has been
validated by multiple scientific studies. It’s useful to patients dealing with
severe trauma (due to deaths, assaults, or physical or psychological abuse)
or other difficult events that have created a blockage for one reason or
another. I employed it in Cambodia with very satisfactory results.
• Work on your levels of self-esteem. The capacity to forgive—to overcome
rage, the thirst for vengeance, or self-pity—is greater in people who have
inner strength. If the person who suffers from a terrible act is capable of
overcoming it and forgiving, they’re demonstrating a sense of security in
themselves that accompanies healthy self-esteem.
• Be optimistic. It sometimes takes time, but the simple fact of knowing that,
faced with pain, you can choose to grow, that there is hope of overcoming,
can act as a soothing balm on your wounds.
• Avoid practicing denial through feelings of guilt. Be wary of turning
yourself into a victim! There are people who, faced with misfortune, close
themselves off and avoid making progress. The consequence of returning
time and again to past incidents in order to justify ourselves only further
shuts ourselves down, cutting off our vital impulse.
• Look to the future.
• We learn to forgive by being forgiven ourselves. It’s a healthy exercise to
 look at our recent past, and our lives, to find times when others have
offered us forgiveness.
• See the other person as worthy of compassion. John Paul II said, “There is
no justice without forgiveness, and no forgiveness without mercy.” We
must try to replace the negative with powerfully positive feelings like
compassion and mercy.

WHAT IS COMPASSION?
Empathy is feeling what another person feels, putting oneself in another’s place.
Compassion—literally “suffering together”—is a capacity that elevates whoever
exercises it. You don’t just understand the pain that someone else is going
through—you connect to their suffering, trying to use all your personal tools to
help them move forward.
Exercising compassion from the heart has amazing effects on the mind, the
body, and our relationships with others. It’s a way of freeing yourself from rage
and hate, making space for peace and equilibrium. Obviously the capacity to
empathize is different in each individual, but it can be cultivated and helps
everyone in their personal and professional relationships.
Today there is a great fear of feeling other people’s pain, of getting close to
someone else’s suffering, in case it ruins our day in one of these ways:

• By making us feel vulnerable. Encountering other people’s emotions might

reopen wounds from our own lives.
• If we aren’t able to help, it may give rise to the frustration of feeling
useless.
• By causing us the anguish of feeling too much, and obliging us to “take the
problem home.” This happens occasionally with therapy, or in the case of
very sensitive people: the pain being witnessed is such that one becomes
excessively moved. Because of this, it’s very important to know oneself
and to know how far one can go when giving of oneself to others.
LIVING WITH ANXIETY FOR THE FUTURE

CASE STUDY: JOHN

John, a 35-year-old man, was working in the Twin Towers on September 11,
2001. Finding himself in the second tower when it was hit, he raced down the
stairs at the speed of light, managed to get out of the building, and remained
among the ruins for several hours. When he realized that he had survived a
terrible attack, he looked for other survivors in the rubble. He felt death close
by him while he shouted, desperately searching for traces of life among the
cadavers that surrounded him.
Several of his colleagues died that day. Months later, he couldn’t endure
being in the dark; he had recurring nightmares from which he awoke sweating
and trembling. He wasn’t able to get on a plane until many years later. His
mind was easily blocked, and his body tensed up at small sounds, or images
and memories of that day. John required therapy for years to overcome his
anxiety, his trauma, and his horrible fear.

Let’s begin at the beginning: Fear is with us from the moment we’re born. It’s a
reality that has always existed. Without fear, we would be foolish, careless
creatures. The way in which we manage this emotion defines us in our
development as people. Fear is, in principle, a primary defense mechanism, but it
can become our number one enemy and upset our perception of life. Titus Livius
put it well when he considered the matter: “Fear always disposes us to see things
as worse than they are.”
A fearful person sees their environment as hostile and upsetting, making
them vulnerable to everything. We shouldn’t forget that the best challenges
possess an element of uncertainty; nothing great can begin without a little fear.

Dealing with fear isn’t a question of eliminating it but of

acknowledging its existence and learning to manage it well.

Fear is a key emotion, fundamental to our inner equilibrium and our survival.
 Fear is a key emotion, fundamental to our inner equilibrium and our survival.
We must be afraid of certain things in order not to launch ourselves imprudently
into all kinds of schemes and ventures. Every human being has their fears in life,
including the brave and triumphant ones. The difference is that the triumphant
know how to manage their fear.
Anxiety, when we give in to it, has a terrible effect on the body. Anyone who
has suffered an anxiety or panic attack has experienced a terrifying reality. Even
though you’re conscious that you won’t die of a heart attack, in the moment,
your mind doesn’t allow you to keep hold of that thought with any clarity.
Anxiety is characterized by fear, a vague and diffuse fear, often without a clear
origin, that develops into anguish and emotional blockage.

Courage doesn’t exist in the absence of fear, but in the ability

to thrive and carry on in spite of it.

The management of emotions is fundamental to personal equilibrium.

Sometimes fear is so intense that it carries out a “palace coup,” taking control of
our minds and monopolizing our behavior. In these cases, the vulnerability of the
sufferer is huge, and any external stimulus, no matter how small, can provoke a
disproportionate reaction that disturbs the body both chemically and
physiologically. In an ecosystem like this, anxiety emerges, a pathological fear
that blocks us and prevents us from living a normal life.
How does the brain work when faced with fear? What exactly happens with
anxiety?
The fear center is found in the cerebral amygdala, which has small physical
dimensions but a very large effect on our lives and behavior. The amygdala,
according to recent studies, is active during gestation, from the end of
pregnancy. It has a great capacity to store emotional memories and reacts
depending on the emotions that arise. It processes information relative to the
emotions and warns the brain and body of danger, signaling that something isn’t
right, activating the reaction or response of anxiety or fear. The hippocampus—
fundamental to learning and memory—codifies threatening or traumatic events
in the form of memories.
A REAL EXAMPLE FROM MY LIFE
I was studying for my degree in medicine. During the exam period, many of
us went to the library at the Universidad Autónoma in Madrid, because it
didn’t close at night and there was a good ambience for studying. I had a
Medical Physics exam the next day, June 13. I remember the date because it’s
my saint’s day, and I was going to celebrate in the afternoon.
I had stayed in the library so that two friends studying engineering could
help me understand some concepts I was struggling with. I left at about a
quarter to one in the morning, got in my car, and headed toward the city
center.
I was driving on a well-lit dual carriageway. I wasn’t going especially fast
but, suddenly, on a curve, I caught sight of a car heading straight toward me,
driving in the opposite direction in the same lane. The approaching headlights
of the car are fixed in my memory; I swerved sharply and avoided it. My heart
was beating a mile a minute, and my whole body was trembling. I stopped on
the hard shoulder a few miles further on and started to cry. Suddenly I heard
an awful crash behind me; I looked but I couldn’t see anything.
I arrived home terrified and woke up my parents. I couldn’t stop crying. I
prayed, thanking God I was still alive, but I couldn’t manage to relax. I put the
radio on to see if the sensation of panic that was still in control of my mind
would fade. After a few minutes, I heard a voice saying, “There has been an
accident on the Colmenar highway, a kamikaze collision between two cars.
Four people have been killed.” That night marked me deeply.
I didn’t sleep a wink. My exam the next morning was a real disaster. I spent
the afternoon visiting friends and relatives. I was really distressed. Even
weeks later, if I heard braking in the street or a louder motor noise than usual,
my whole body was thrown back to that moment, experiencing tachycardia,
trembling, and anguish. It took me several months to get over it. Every week I
took exactly the same route: I didn’t want to become blocked and be incapable
of using the car or taking certain roads. I’m completely over the event now,
but the experience has helped me greatly in understanding blockages caused
by fear or anxiety.
 Here’s another example to illustrate this mental circuit.

CASE STUDY: BLANCA

Blanca went one night to collect her car in an underground parking garage.
She usually traveled by bus, but on this particular day she’d had various
errands to run before work, and had left the car in a nearby parking garage.
When she arrived, she noticed that it was poorly lit and empty, with no
security guard or checkpoint. She was very tired—she’d had a difficult day
containing a certain amount of conflict, and she felt weak and exhausted.
She went hurriedly to the automatic ticket machine to pay, and then she
heard a noise. A man with “a nasty look about him” came up to her. At that
moment she remembered something that had happened years before, when she
was working in Brazil and was robbed one night. Her heart began thumping,
she started to sweat, and she couldn’t think clearly. She wished she were
already in her car. There was no one else nearby, and fear gripped her by the
throat and choked her.

What had happened in Blanca’s mind? Her amygdala had put her on guard,
because the parking garage at night is—at least in her memory—a risky place,
and so is the person approaching her. Her memory has retained—in the
hippocampus—data about her bad experience in Brazil. To these “memorized”
ideas she adds more: “I won’t park here again,” “I won’t collect the car at night-
time,” and “If I have to collect my car, I’ll make sure I’m not alone.”
Recollections, anxiety, memory, physical activation—it all comes together; the
hippocampus and amygdala are a key pairing in the processing of memories and
in episodes of anxiety.
The majority of circumstances that activate our mind’s fear response are
learned: they develop according to our experience, whether direct or reported by
others. That is to say, the brain codifies certain things as “fearful,” and, adapting
itself, when it perceives something similar to a past event, it activates the alarm
system. These fearful situations can arise from past traumatic events or events
that we haven’t overcome or confronted appropriately.
that we haven’t overcome or confronted appropriately.
When the brain perceives all of reality as threatening, this is because the alert
system has become hyperactive. At that point we’re dealing with generalized
anxiety disorder, which requires a comprehensive approach, but which usually
has a good prognostic; or with post-traumatic stress disorder, which arises when
a terrible event has marked us, and our mind, faced with simple stimuli,
discharges a disproportionate physical reaction, recalling and reliving the day of
the trauma.

HIGHLY CHARGED EMOTIONAL MEMORIES

Certain events or recollections hold a potent emotional charge. This means that,
when we relive them, our neuronal connections activate in such a way that the
whole body is affected—trembling, tachycardia, sweating, hyperventilation—
with a consequent rise in cortisol and adrenaline.

A person with an affected or damaged amygdala has serious

problems detecting warning, danger, and risk.

An amygdala hijack, to use the term coined by Daniel Goleman in his book,
Emotional Intelligence, refers to those emotional responses that arise in an
abrupt and exaggerated way.
When a stimulus is received, the body’s reaction is excessive and explosive.
This doesn’t refer to a mental problem, necessarily, but rather a past event with a
huge emotional charge that blocks the sufferer, so that, faced with a current
event that indirectly recalls it, the subject isn’t capable of making choices or
reasoning with clarity. The individual who responds in this way finds themselves
overtaken by their emotions.
We all know people who have been through this. These are people with short
tempers: faced with minor stimuli, the repercussion for others is a head-on
collision. You might talk about someone “blowing his top,” or say “He doesn’t
have a filter,” or “He’s got a short fuse.” Is there a solution? There is, in learning
to manage the emotions and working on understanding the origins of these
abrupt reactions.
 CASE STUDY: GUILLERMO
Guillermo has been married to Laura for three years. He works in a
laboratory, and she’s a cardiologist. They met at a medical conference in
Atlanta. She almost always came to conventions with her partner at the time,
another doctor at the same hospital, but on this occasion he hadn’t been able
to accompany her.
Guillermo had already interacted with Laura a few times through work. She
struck him as an attractive woman and he liked spending time with her. He
was aware that she had a partner, a doctor that he’d seen on professional
matters at times, and because of this he kept his distance. During the
conference, he perceived a change in Laura—she was friendlier and more
intimate and he noted that she tried to make more time for him. Guillermo,
nervous, didn’t know how to act, but one night, after having a few drinks
together after dinner, they ended up in her room.
Guillermo, feeling awkward, wanted to know what Laura was feeling, what
would happen with her boyfriend—too many questions. Guillermo was
passionate and impatient—he needed to resolve his sentimental dilemma. She
explained that her relationship to the other man was over, and she was going
to break up with him when she got back. And she did. A few months later,
Guillermo and Laura got together officially, but he was very jealous and
couldn’t stand for her to attend conferences alone. If anyone so much as came
near her or invited her to a meal to discuss work, he would have an explosive,
disproportionate reaction that was difficult to control. His excuse was always:
“It happened with me, it could happen with someone else.”
Guillermo was suffering an amygdala hijack around this issue.

Stimulus → immediate and disproportionate explosive reaction → inability

to deal with reality → paralysis, blockage, or aggression/being blinded by
emotions → repentance or forgiveness (in the best-case scenario).

HOW TO DEAL WITH AN AMYGDALA HIJACK

We’ve seen how this circuit works. Now let’s look for a solution. Imagine that
we’re “mental electricians”: The easiest thing would be to short-circuit the
problem. Let’s see how.

1. Analyze it
What stimulus triggers you? Understanding yourself is key in these
cases. Aim fearlessly for the heart of what’s causing it. Is it a person, a
look, a situation, perceiving something threatening? It could be the sight
of blood, a conversation about a divisive issue, a thought that crosses
your mind, the actions of someone around you, someone saying “no” to
something you were excited about . . . The point of origin might be
anything, but you need to understand what it is.

2. What’s happening in your body?

You’ll notice that the hijack is accompanied by physical symptoms. Try
to focus on how your body feels just before—how you feel physically in
the instants before the emotional explosion—and on the physical signs
that arise in your body during the process—tachycardia, hypertension,
temperature increase, etc.

3. Think about someone you know and admire

How do they react in similar situations? What is the worst version of
them, when frustrated or angry? Having a model to look to for reference
in difficult moments is a great help.

4. Short-circuit that explosive connection!

This can be complicated; sometimes we have very elaborate and deeply
embedded reaction systems that prevent us from exercising control.
Being aware of it is already a sign of progress. If you manage to realize
what’s happening and put a brake on the cascade that you’re about to
initiate, even if only for a moment or a few seconds, you’ve gained
something. In that little space of time, try to breathe deeply, sending a
positive message to your mind: “You can do it!” or “Keep going!” The
mind needs approximately one to two minutes to remove the blockage
 mind needs approximately one to two minutes to remove the blockage
from a toxic emotional state, so any victory, no matter how small, brings
you closer to triumph.

5. Ask for forgiveness

In those moments of lost control, we have bad reactions and say things
we don’t mean. The vast majority of people repent their reactions and
comments after the fact. Have the humility necessary to say you’re sorry,
and try to repair any damage you’ve caused. Forgive yourself as well—
you may be thinking of your reaction as another failure, and it doesn’t do
any good to shroud yourself in feelings of guilt. Get over it. Tell yourself
you’ll do better next time, and find the tools that will let you.

CASE STUDY: GUSTAVO

Gustavo comes to see me because, two days previously, on his way back from
a meeting in London, just after getting on the flight home to Spain, he began
to notice tightness in his chest and experience shortness of breath, along with
a feeling that he was losing control of himself. He tried to implement
relaxation techniques on the plane, while a stewardess offered him herbal tea
and attempted to calm him down.
Staying on the plane was unbearable, and he felt an urgent need to get off at
any price. In spite of this, he endured the two painful hours of the flight, and
after landing, nauseated and distressed, he showed up at emergency services,
where they explained that he had suffered a panic attack and that he should
see a psychiatrist and get medication.
Once in my consulting room, he tells me that he doesn’t understand what
could have happened. He recognizes that he’s stressed, but what happened on
the plane had never occurred before, and he describes it as the worst time of
his life. He also tells me that for the past year he’s traveled almost every day
of the week for work. He barely has time to see his partner between journeys
and meetings. He sleeps very little because of jet lag, and all of this is making
him more nervous and irritable by the day. Gustavo puts the spotlight on what
happened on the plane; he doesn’t want it to happen to him again. I explain
that he’s under too much stress, that being constantly on alert has resulted in
an alteration of his survival system, which has raised the cortisol levels in his
body to help him overcome the demanding situations that he confronts every
day.
Gustavo describes being constantly nervous and says he’s beginning to
have lapses of memory. Occasionally he notices his fingers and hands falling
asleep, along with tachycardia and shortness of breath. I explain that he’s
reached a crisis point, that he suffered a panic attack on the plane and that his
brain is currently in a vulnerable state; because of this he may experience
another attack if he carries on in the same fashion. I emphasize that he has to
learn to lower his frantic level of activity, and that the first step is to recover
the restorative capacity to sleep. He has to find a way to disconnect his brain
from his hectic level of activity, because he’s locked in a toxic cycle that
could break down again at any moment.
In addition, I give him guidelines for avoiding a crisis on the plane. Before
boarding, he must try to relax, through a series of positive cognitive cues and
breathing techniques. He should also carry a supply of a certain medication
with him in case of emergency. The effect of this pill is almost immediate—it
will act in a very short time, should he start to suffer another attack.
Many people feel secure enough, by merely keeping the medication I’ve
described with them, to overcome a panic attack without needing to take it;
they postpone taking the pill, strengthened by the conviction that as a last
resort it will help them over the attack, which eventually allows them to
control their attacks without pharmaceutical aid. I prescribe another
medication to unblock, little by little, Gustavo’s accumulated cerebral tension.
In psychotherapy, I work in depth on the origins of his level of anxiety: he’s
constantly on high alert, with no time to relax. He doesn’t allow himself any
mistakes, he doesn’t rest, he eats badly—all of which has provoked his brain
into a collapse, reining him in through a panic attack. A panic attack is what I
sometimes call a “mental fever.” That is to say, in the same way that a fever is
an indication that something isn’t working well in the body, a crisis of anxiety
or panic tells you that something isn’t right in your mind, leading finally to a
collapse. In therapy I teach Gustavo to relax, to take things in a calmer way, to
know how to let things go, how to make his boss see that he needs support
 with his tasks, and how to delegate some of his responsibilities. All of this has
the aim of alleviating his excessively heavy workload.
Little by little, Gustavo begins to feel better. At the beginning, his fear of
flying persists, but I don’t force it because it’s a secondary issue—we can
postpone the goal of overcoming it until he’s doing better. With time, he
begins to take short flights, of about an hour or ninety minutes, which he
prepares himself for with positive cognitive messages, remembering that he’s
carrying emergency medication, and using relaxation and breathing control
techniques. Using these methods, and with the security that carrying the
emergency medication gives him (he’s only needed to go so far as taking it
twice, in a year of treatment), Gustavo is doing much better; he can now take
a plane without too many complications, and his body is slowly recovering its
equilibrium.

If a person lives in a constant state of high alert, it produces

an interpretation of reality that makes it seem worse than it is.
Your internal responses to events treat them like real threats.
The brain’s responses become confused.

Controlling the breathing,§ with eyes closed, while paying attention to every
sensation in the body, is one of the most effective methods for stimulating the
function of the parasympathetic nervous system. This, as we’ve already seen,
regulates our internal equilibrium, or homeostasis, activates the organs that
maintain the body in periods of calm—like the salivary glands, stomach,
pancreas, or bladder—and inhibits those that prepare the body for emergencies
or periods of tension—like the pupils, heart, or lungs.
When we manage to keep our attention fixed on our breathing, in the present,
in the here and now, putting aside any thoughts that direct us toward the past or
the future, each breath brings us closer and closer to relaxation, and we are able
to recover our lost serenity and confidence.
Here are a few simple keys to confronting your fears and anxiety:
• Learn to recognize what these are. Be conscious. Don’t hide or suppress
them; every repressed emotion finds its way in again through the back door
and can become the starting point for deep wounds and physical and
psychological suffering.
• You overcome fear by feeling it and taking a step forward. It is vanquished
by change.
• I can’t say it enough: don’t hesitate to go back to the beginning to untangle
the starting point and cause of your insecurities—but be wary of
“impossible therapies” that end up harming you more than they help.
• Try to understand your fears—you’ll be able to confront and overcome
them better. If we understand something, we know how to face it, and our
fear diminishes.
• Fear will always exist; learn to be an optimist and find a way out of the
painful cycle of thoughts that is blocking you. Don’t forget that fear is a
terrible liar—it always paints reality as worse than it is.
• Trust yourself. The way in which you project yourself has the power to set
the best version of your brain free. Having confidence in yourself and
getting excited about achieving your goals activates your creativity, your
problem-solving abilities, and a more enthusiastic view of life.
• Improve your attention span. We’ll talk about this more deeply in Chapter
5, along with the Ascending Reticular Activating System. Fear and anxiety
become chronic when one lacks the ability to focus one’s attention
correctly.
• Teach your inner voice to be polite. It should be there to get you excited,
not to bring you down or be a negative influence! Avoid toxic thoughts
that seek to carry you once more into a crisis of anxiety or magnify your
fears.
• Take care of your nutrition. For example, hypoglycemic episodes can
profoundly upset you and activate your fear. Try to avoid caffeine and
alcohol.
• Rest. A lack of sleep makes us more vulnerable to our fears and makes us
interpret reality as more threatening than it actually is.
 We become our thoughts.¶ Fear is inevitable, but the suffering it produces is
optional. Our fears can be cured by learning to enjoy life, looking to the future
with excitement, and living in the present in a balanced, compassionate way.

* Somaly Mam is a Cambodian activist I collaborated with in Cambodia. In

Chapter 5, I describe how I ended up getting to know her.
† I recommend reading this book to deepen your knowledge of suffering and of
forgiveness in difficult situations.
‡ The Sunflower, S. Wiesenthal.
§ This consists of interested observation of the slow, harmonic movements of
inhalation and exhalation—the lifting and sinking of the abdomen and thorax,
and the coming and going of air through the nostrils. I explain the technique in
more detail in Chapter 6.
¶ And we become what we love! But this chapter is focused on thoughts.
 5

LIVING IN THE PRESENT MOMENT

Happiness doesn’t lie in what happens to us, but in how we interpret what
happens to us. It depends on the way we assimilate reality; our capacity to orient
or focus that assimilation is key to our ability to be happy. What we’re going to
talk about here, then, is your capacity to choose happiness instead of
unhappiness. From the beginning of this book, we’ve discussed pain, suffering,
trauma, and deep wounds. We aren’t here to deny reality—we’ll talk about
tolerating frustration further on—but to learn to enjoy as much as possible, in
spite of . . . life’s spitefulness.
Your reality depends on the way you decide to perceive it.
I understand that you might find this message surprising, and a thousand
sentences—barriers, resistance!—are bubbling up inside you, of the following
variety: “I’ve already tried everything,” “My life is very hard,” “Everything
depends on circumstance,” “My childhood was terrible,” “Easier said than
done” . . . If you reject the possibility of choosing to cling to the good in your
life—however little of it there is—you’re declaring yourself vanquished in the
most decisive battle of your existence.
Happiness isn’t an accumulation of joys, pleasures, and positive emotions.
It’s much more; it also depends on having successfully overcome wounds and
hardships and continuing to grow. It means living with a certain gusto despite
pain and suffering, which are, to a greater or lesser degree, inevitable.
If we negate or constantly block suffering, our mind loses the knowledge of
how to confront and overcome it. This doesn’t mean visiting the mental
equivalent of a “bad neighborhood” and trying to wage each and every battle
equivalent of a “bad neighborhood” and trying to wage each and every battle
that’s offered to us, but learning to manage difficult moments. I know a lot of
people who don’t know how to face conflict or negative emotion, and who deny
them automatically and unconsciously as a means of escape. This approach is
risky; constantly avoiding the negative means cutting off part of your life and
often leads to a disconnection from the suffering of those around you. We
discussed the importance of compassion in the last chapter, as well as connecting
in a healthy way with the suffering of others in order to help them move forward.
Let’s not forget that a big mistake people often make is aspiring to an
excessive degree of happiness, a constant, utopian state of joy and pleasure. This
turns people into frustrated beings, permanently dissatisfied. Is happiness a
person’s greatest aspiration? It seems so; and happiness can be instantly
gratifying—eating good food, seeing friends, taking a trip—but it also has a
more structural component, resting on the fundamental pillars of life: family,
relationship, work, culture, friends. The happiness of gratification is like a
fleeting spark, while structural happiness is a symptom of a balanced life.
I’m going to communicate various practical ideas to you here. You’ve
probably read many of them or even experienced them at some point in your life.
I’ve brought together everything my father taught me—I’ve been learning by his
side for more than 30 years—along with the numerous books, articles, and
studies I’ve read,* and, above all, what I’ve observed of the inner life of the
many people I’ve accompanied through their worst moments and their recovery.
My intention is that what you read on this theme will be useful to you in your
life, as you try to help those around you.
The reality of your life depends on how you decide to respond or react to
certain circumstances, that is to say the behavior that arises in the face of
external stimuli. Here I want to communicate another important idea.

Every emotion is preceded by a thought.

The mind is responsible for generating emotions. A feeling is the physical

reaction to an emotion. Without the brain, there are no emotions. In cases of
brain injury, stroke, or malformation, areas of the brain can be affected in such a
way that a person no longer “feels.” Someone can lose the feeling in their
extremities—and get burned when they don’t react!—if this area of their brain is
deactivated or injured.
Beginning a few years ago, through looking at people who have lost their
speech after a cerebral infarction (or stroke), much has been discovered about
the areas of the brain in charge of this function. This was the starting point of
cerebral mapping. We now have tools that allow us to examine the functioning
of the brain in real time, which in turn allows us to carry out direct observations
of how certain areas react and are altered when someone carries out an activity
or experiences a stimulus. One of these techniques is functional magnetic
resonance. This is used for clinical treatment as well as for research. The
technique allows us to detect changes in the distribution of blood flow from
moment to moment, thereby permitting us to understand the mind and the
nervous system in a much deeper, more comprehensive way, without the need
for more aggressive approaches, such as opening up the brain or waiting for an
autopsy. This advanced neuroimaging technique gives us the opportunity to
observe how our brains are activated by certain thoughts, motivations, or states
of anxiety or depression.

A FUNDAMENTAL DISCOVERY
Every thought generates a mental and physiological change. I emphasize this
idea at various points in the book. Don’t forget this, because if you are one of
those who suffer, who lose control of themselves, or who want to understand
themselves better, understanding this process is going to help you a lot.
From a very young age, we must reckon with ideas about ourselves that may
be self-imposed or assimilated from outside, such as: “I’m impulsive,” “I’ve
always been this way,” “My father was the same,” “I’m nervous,” “I hate
crowds,” or “I’m afraid of flying.” These sentences about yourself function in
practice as mental barriers that prevent you from progressing freely in these
areas. I say “sentences” because they have a blocking effect on you, as if they
were condemnations passed down from on high.
Harmful emotions are caused by thoughts, whether conscious or not. And
thoughts can be learned or reeducated. To successfully become a happy person,
fulfilled and at peace, you must work on the way you think. If you do, you’ll be
fulfilled and at peace, you must work on the way you think. If you do, you’ll be
surprised by the results.

You change your reality when you change the way you think!

Make a thorough examination of the ideas you have about yourself or the
ones that come up in dark moments of sadness or anguish. That toxic emotion
arises because something crosses your mind and then enters you in a harmful
way.
This isn’t easy. You’ll be dealing with what I call “automatisms”: reactions
that arise involuntarily because you’ve spent your life performing them when
triggered by certain stimuli or thoughts. It’s complicated to untangle yourself
from the “should haves” that have attached themselves to your behavior over
time. To modify toxic thoughts, or one’s belief system—one’s way of processing
information—one must pay attention to which thoughts are acting as limits or
barriers.
A belief system isn’t necessarily bad, and indeed in many cases it may be
good. For example, if every time you see the sun come out, you feel joy and you
think that today you’ll give a little bit extra because the sun grants energy to
your body, your belief system is helping you; if, on the other hand, you see gray
skies or it starts to rain and you say, “Today is going to be horrible,” your belief
system is limiting you. This can happen with external events or internal ideas
and sensations. If you arrive at a dinner with friends and something hits you the
wrong way or makes you feel uncomfortable, there’s probably something there
that has unconsciously recalled a negative past experience—the food, a person,
everyone’s positions around the table, a smell, or something similar.
We can train the mind and regulate our emotions. Think, for example, about
riding a bike. When you get on a bike for the first time, in general you use
training wheels to avoid falling. As you shed your fear, you dare to go faster, to
go downhill, or even to take a hand off the handlebars. One day, you take off the
extra wheels and you struggle to balance. You think you won’t be able to do it,
that you’ll fall—and maybe you do!—but, suddenly, you’ve got it. Months or
years might pass, but next time you get on a bicycle, you’ll still have the knack;
there’s no need to put the training wheels back on, because your “mind” already
knows how to balance.
knows how to balance.
Something similar happens when training your thoughts. As you’d expect,
it’s not quite such a simple process, but mental practice has an extraordinary
effect on the way in which we perceive reality. If, every time you ride a bike or
drive a car or ski, you only think about the times you fell, had an accident, or
injured yourself, you’ll end up avoiding those activities, because of the mental
strain they put you through. This is how a thought becomes a limiting certainty,
when you double down on it and it becomes an excuse to avoid something. Your
mind has been fabricating automatisms all your life that lead to useless
blockages around certain challenges or goals that arise before you.
This is why I’m talking about making a decision! Take control of yourself,
and avoid throwing blame elsewhere, on the toxic people around you or on your
social or financial circumstances.

Let go of the role of victim; start being the hero of your own
life story.

Here I want to present a chart that may help you to understand your way of
being and feeling in the present moment.

After receiving an external signal, we react and interpret reality according to

 After receiving an external signal, we react and interpret reality according to
three factors:

• Our belief system

• Our state of mind
• Our capacity for paying attention to and perceiving reality

After this interpretation is made, the body will respond by going into one of
two modes: alert or protective, calling on the sympathetic and parasympathetic
nervous systems, respectively, and thereby affecting both mind and physiology.
Let’s analyze each of these factors in detail, beginning with the belief
system.

BELIEF SYSTEM
What makes a belief system? Your belief system is based on your
preconceptions about how to look at life and the world around you, as well as
what you believe about yourself—whether because you’ve arrived at a
what you believe about yourself—whether because you’ve arrived at a
conclusion all on your own or because as a child or adult it’s been repeated to
you over and over: “I’m like this,” “I’ve always struggled to wake up,” “I don’t
get along well with people,” “I’m afraid of flying,” “I’m not good at sports,” and
so on.
These beliefs are opinions we have about the different aspects of life.
They’re intimately linked to the way in which we interpret the world and can be
both conscious—“I realize I think this”—or unconscious, having been there all
our lives.
A belief system includes values, which color our way of feeling, acting, and
reacting. Beliefs continue to form throughout our lives, translating the
personalized, specific vision that each of us has of life. Sometimes adolescents
smoke and drink at an early age because they feel more “adult.” There are other
factors that can influence people to begin drinking, but one very common cause
is insecurity, and the fact that drinking makes them feel more socially accepted.
Even knowing that it’s bad for their health and that it can be profoundly
damaging, their unconscious beliefs about themselves eclipse the rational risks
that they know alcohol and tobacco use entail.

Why Is This So Important to Think About?

Our belief system predisposes us to expect certain things in life and holds a
potent influence over us. It supplies us with ready-made arguments for acting
one way or another. These judgments are deeply rooted in our minds and never
questioned; they can be decisive, in the sense that we build our interpretation of
reality and our reactions to it on this foundation. These beliefs are universal: we
have them about the world in general, about others, about ourselves, about
concepts, about ideologies . . .
When things never turn out as we hope or we’re always suffering because of
our surroundings, or if we feel radically maladapted, perhaps we should first
analyze our vision of the world, or how our belief system is constructed. We
may find that our beliefs are limiting our inner growth. Don’t be afraid to
question what’s limiting you, because it may lead to an improved capacity to
perceive reality and focus on your Best Possible Self (BPS).†
Some of these beliefs form serious obstacles to our ability to achieve our
goals or confront challenges in a healthy way, because they block our minds
goals or confront challenges in a healthy way, because they block our minds
with feelings of insecurity and fear.
Let’s continue.

STATE OF MIND
Happiness—as I’ve been saying throughout these pages—doesn’t depend on
reality itself but on how I interpret that reality. Here, my state of mind has a
significant impact. I’ll give you a common example: you’re happy because your
team won the Champions League; if you see your boss, with whom you have a
bad relationship, the next day and he supports the same team, you’ll probably
look at him with a less critical gaze and be capable of carrying on an amicable,
enjoyable conversation with him. If, on the other hand your team loses, and your
brother, a fan of the rival team that won, calls you to talk about the defeat, you
might not even answer the phone, instead just switching it off and going to bed
with no supper.

So what does our state of mind depend on?

There are different factors that modulate and change our state of mind. There
isn’t room here to go into excessive detail, and you could write a whole book
just on this specific topic. But let’s explore the basics.

1. Drug and alcohol consumption

Consuming these substances is seriously harmful to mental health. One
 Consuming these substances is seriously harmful to mental health. One
of their principal effects is a grave alteration in the perception of
sensations and stimuli. We all know people who, after ingesting alcohol,
become more sensitive and vulnerable, around whom we need to take
care with our reactions and comments. Frequent consumption of or
addiction to these substances profoundly alters the state of mind and
interpretation of reality of those who consume them.

2. Biochemistry or genetics
There are people who are more prone to depression or breakdown, due to
genetic factors or having previously suffered severe illnesses like bipolar
disorder, recurring depression, or generalized anxiety. Hormonal states
also have an influence, creating special vulnerability in women—
premenstrual tension, postpartum depression, and so on. It’s likely that
people who come from families where various members have depression
possess a more fragile mental state and are more sensitive to external
events.

3. Physical health and external circumstances

If we’re going through a difficult period professionally or experiencing a
significant physical ailment, this will influence the way in which we
perceive reality, because our state of mind will be rendered more
sensitive and vulnerable. When we fall ill, or a difficult time or extreme
situation arises in our lives, being conscious that we aren’t perfectly
objective can help us not to be so hard on those around us.

4. Personality type
This section touches on everything from severe personality disorders
(borderline, avoidant, schizoid) to marked personality traits that have a
profound influence on mental states. For example, young people with
borderline personality disorder—defined by impulsivity, emotional
instability, intense fear of abandonment, self-harm, and low tolerance of
frustration—suffer intense emotional highs and lows, put radical
interpretations on reality, and perceive their environment as continually
 interpretations on reality, and perceive their environment as continually
threatening. All of this means that, far from acting rationally, their
reactions are often guided by aggression and rage. Getting them to a
point where they can enjoy life and maintain internal equilibrium
requires them to do significant work on their personalities, using methods
from pharmacotherapy to individual or group psychotherapy. Another
personality type that is prone to suffering is known as the HSP: highly
sensitive person. This type can’t currently be found in DSM-5—the
manual of mental disorders—but it exists and has important
consequences for those who fall in this category.

CASE STUDY: ERNESTO

Ernesto is a patient who comes to see me about his anxiety. He began having
episodes at university, around his exams, but now he suffers them in a
multitude of places and situations. To this he adds his acknowledgment that he
is a “depressive” person. He elaborates: “For no apparent reason, I’ll be
somewhere and need to get out of there, I get nervous and can’t enjoy
myself.”
He runs a few men’s clothing shops, a family business where he works with
his wife. He has two small children. He describes himself as someone who
tends to get sad easily. He admits to having lots of mood swings he can’t
explain. I ask him, after our first session, to take note of his worst moments in
order to analyze the causes of his daily emotional crashes. When he next
comes to my office, he comments, “You’re going to think I’m worse than I
am.”
I smile. It’s a phrase I hear very often in the consulting room, when
someone is ashamed to tell me about some mania or strange thought. He
explains that after many years he’s realized that the décor of the places he
visits and the way people are dressed have a profound effect on his mood. He
describes in meticulous detail how one day at the house of his parents-in-law
he saw that the wall paint was flaking, and in that moment he felt he “had to
get out of there; I just couldn’t stand it.” He indicates that if the places he
spends time aren’t well cared for, they give off “something bad, and I get
blocked.” He adds that this also happens to him with clothing, noises and
blocked.” He adds that this also happens to him with clothing, noises and
smells. “I need people to take care of the details and be well-mannered; if they
aren’t, I don’t want to go there or see them again. I don’t enjoy it.”
He adds that, if he’s eating dinner out with his wife and he doesn’t like her
shoes or her dress, “I’m incapable of being affectionate, I become surly and
want to go home as soon as possible.”
He remarks that he startles easily at loud noises or dissonant stimuli. In
Ernesto, I see a person who’s so sensitive that he’s actually raw. What Ernesto
is suffering from is known as the HSP personality—Highly Sensitive Person.

WHAT DEFINES AN HSP: HIGHLY SENSITIVE PERSON

Do you notice that you worry about other people more than normal? Are you
constantly looking for tranquillity and calm? Are you upset by chaotic
environments? Do you have a more intuitive understanding of reality than the
people around you?
These are some of the traits of people described as HSPs, individuals whose
nervous systems are more sensitive, and who perceive changes and details in
their environment more intensely. Excessive stimulation is profoundly
upsetting for them. This personality type has probably existed throughout
history but has only recently become known or been studied at all. It may also
be that it’s becoming more common, given that we now live in the most
overstimulated society in history and, therefore, it’s easier for certain people’s
senses to become saturated.
These people are particularly intuitive, but poor control of their emotions or
a lack of awareness of their issues can lead them to become overwhelmed and
emotionally blocked.
To list a few of their characteristics:
• They feel things with greater intensity.
• They intuitively pick up on the smallest details of their surroundings.
They have great observational capacity: they notice everything about a
room, clothing, art, the weather, or others’ moods.
 • They feel tired and overwhelmed by excessive stimuli more easily.
• They have enormous empathy and are capable of putting themselves in
others’ shoes, worrying a lot about those around them. They’re easily
moved.
• Many of these individuals have a certain degree of shyness.
• They tend to be more reflective and cautious than other people when
confronting a situation or a challenge. They need a lot of security before
making a decision or launching themselves into a project; because of
this, they tend to gather a lot of data beforehand and only decide after
meticulous analysis.
• They process information with a lot of subtlety and depth; they’re often
perfectionists, given the great value they place on details.
• They value etiquette highly and are very conscientious about their
behavior.
• They’re more sensitive to criticism; it costs them a lot to accept the
negative things that others say.
• They’re intensely affected by minor details, sounds, smells, or changes
in temperature.
• It’s as common for men as for women to be highly sensitive, although it
may seem more frequent in women. The truth is, this set of symptoms
has increased among men in recent years, and they often don’t know
how to deal with the feelings it brings up.
• Some individuals develop more frequent bouts of anxiety or depression,
due to their increased vulnerability to both internal and external worlds.
These individuals must learn to adapt, and be aware of places that trigger
them more, or the types of people or environments that tend to block them. In
the case of children with this personality type, one must learn how to treat
them without tipping into overprotectiveness, by understanding their
disproportionate reactions to certain situations.
5. Sleep
This section has special importance. We spend—or at least we should—a
third of our lives in the arms of Morpheus. Sleep is important, and we
should care for it accordingly.
Let’s take a look at the night-time world of sleep. We all know what
it’s like to toss and turn all night without getting any sleep, or falling
asleep but waking up multiple times. In both cases one gets up in the
morning with a feeling of exhaustion. Without enough sleep, the mind
doesn’t function normally. Problems with learning and memory arise,
along with difficulty paying attention and various cognitive mistakes. A
lack of rest or insufficient rest turn us into sensitive, irritable creatures
who can’t respond adequately to external stimuli.
A lack of sleep also affects the immune system: the parasympathetic
nervous system, in charge of rest, recuperation, and manufacturing
lymphocytes, becomes weakened and profoundly imbalanced.
Nightmares, waking up in the night, sleeping lightly, or a feeling of
not having rested are some of the chief reasons that people seek medical,
neurological, or psychiatric help. At some points in life medication may
be necessary, but chronic use of pharmaceuticals has harmful effects on
the brain. The first long-term studies of the consequences of abusing
pharmaceuticals in order to sleep are now becoming available.
Benzodiazepines—alprazolam, lorazepam, diazepam, and other
derivatives—introduced into the body will induce sleep, each according
to its particular mechanism, but sustained use over time will lead to
tolerance, abuse, and dependence. Withdrawal is, in the majority of
cases, a problem.
Sleep is fundamental because it’s the basis for repairing certain areas
of the brain, among them the hippocampus—the key to memory and
learning, which regulates fear at various levels. During the night our
memory reconstructs itself, and what has been learned in the day is
relived. This is why students who sleep badly get worse exam results. Be
careful of burning the midnight oil, staying up all night, and fueling a
marathon study session with caffeine! Perhaps the next day you’ll get
through the test, but your brain will not have consolidated what it learned
 through the test, but your brain will not have consolidated what it learned
at night; it will simply have drawn on short-term memory to get through
the immediate challenge.
During sleep, emotions are also stored, whether they are appreciative
ones or feelings of resentment and rage. This is why it’s so important to
practice bringing joyful or positive thoughts to mind before going to bed.

JUST CURIOUS, WHY DOES COFFEE KEEP YOU AWAKE?

Strange, but very interesting. Let’s see. Any activity we carry out—working,
studying, practicing a sport, moving around—requires the use of energy. What
is our physical energy called? Its name is ATP—adenosine triphosphate. Each
cell nourishes itself on molecules of this substance, principally furnished by
what we eat. When we engage in exercise, work, study, or thought, we make
use of ATP, which the body consumes little by little.
Every time we use an ATP molecule, it’s broken up and divided: it can shed
up to three molecules of phosphate, leaving one of adenosine. This adenosine
molecule is important for rest, because it brings on sleep. The brain contains
sensitive receptors, specialized for adenosine. If levels of the molecule are
elevated, our body perceives a feeling of sleepiness, and our sleep will be
deeper. The body—which is very wise—uses this system to generate a
sensation of tiredness and induce sleep after exertion, exercise, and study.
There are other molecules responsible for the process of repose, but elevated
levels of adenosine have huge repercussions on sleep and help us experience
better rest.
What role does coffee play? This is where caffeine enters the picture: the
anti-sleep molecule par excellence. It was discovered by the German chemist
Friedlieb Ferdinand Runge in 1819.
It has a strong resemblance to adenosine and is what we call a non-selective
antagonist to adenosine receptors; this means that consuming caffeine blocks
the brain receptors sensitive to adenosine. At that point the brain is no longer
receiving the signal that it’s tired, and so it can stay awake longer, working or
carrying out other activities.
 Getting too little sleep has damaging effects on both body and mind. A
human being generally needs four or five sleep cycles a night, each of which last
about 90 minutes.
Here’s an example, which I’m sure has happened to you at some point. You
wake up in the middle of the night, feeling wide awake. You manage to go back
to sleep, and then when your alarm goes off and you get up in the morning, you
feel befuddled and tired. Why? It’s related to sleep cycles.
There are five phases: phases 1 and 2 are light sleep, phases 3 and 4 are deep
sleep, and phase 5, the REM (rapid eye movement) phase, is where we have
dreams. Every cycle lasts, as we’ve said, about 90 minutes: 60 to 65 minutes in
phases 1 to 4, plus 20 minutes in phase 5. Sleep scientists currently maintain that
good sleep depends less on the number of hours spent in bed than on the number
of sleep cycles achieved.
Here’s something to try, especially if your sleep phases are regular. Choose a
time to get up; measure in 90-minute intervals to coincide with the approximate
length of a sleep cycle, so first 90 minutes, then three hours, four and a half
hours, six hours, seven and a half hours, and so on. The time you choose
depends on whether you need to get up early for a flight or to get something
done in the morning, or if you’re learning to manage your sleep. Let’s look at an
example: If you go to bed at 12 a.m. and set the alarm for 7:30 a.m., it will be
less effort to wake up, and you might even notice that your brain activates more
easily and is more refreshed. If you set it for 8 a.m., even though you’re sleeping
more, oddly enough you’ll need to make a greater effort to get out of bed. Your
alarm clock will have gone off in the middle of a phase of deep sleep.
Each person is different, and sleep cycles may be affected by factors like
exercise, stress, medication, or alcohol. We all know someone who sleeps less
than five hours a night and yet can function and seems perfectly able to work.
Every individual’s sleep cycles, therefore, deserve particular study, in order to
adapt our schedules to our personal needs.

Sleep Hygiene: Five Tips for Sleeping Well

Avoid using electronic devices before sleeping: Be careful with screens,

video games, social media, and the like before putting yourself to bed. There
have been various studies indicating that light from a screen—whether it’s your
phone, a tablet, or a television—has a harmful effect when you absorb it before
going to bed. A study published in 2014 in the British Medical Journal carried
out on 9,846 adolescents aged between 16 and 19 demonstrated that the use of a
screen disrupted their normal patterns of sleep. The more you use a device
before sleeping, the greater the risk of inadequate rest. The problem is rooted in
sleep onset latency (SOL): the time needed to actually fall asleep. The blue light
of a screen blocks the secretion of the sleep hormone, melatonin. Studies
confirm that this light diminishes production of this substance by up to 22
percent. Some devices have a nighttime mode, in which the light emitted by the
screen is filtered and has a much weaker effect on melatonin.

Be careful with emotional stimulation: A worrying conversation, a dinner that

ends in an argument, a heated discussion with your partner—these are the
ingredients of a bad night’s rest. If you see a terrifying film or hear upsetting
news, your mind will go over and over the last thing you saw when you go to
bed.
Each person is different when it comes to sleep. There are people who can
fall asleep in the middle of an action movie, and others who can’t get any sleep,
tortured by stimuli so small as to be imperceptible to the rest of us. The
important thing is to know yourself and accept that there are points in your life
when you’re more vulnerable. In order not to decrease the quality of your rest,
you may have to pay more attention to the emotions that are impacting your
sleep.

Choose the last thought of the day carefully: Be wary of mentally going over
everything that’s worrying you once you’re in bed, and try not to dwell on all the
bad things that happened during the day, or might happen tomorrow. Focus on
something joyful and positive that happened to you or brought a smile to your
face. However bad the day has been, there’s always something positive to hold
onto.
Adopt a healthy routine: Sleep hygiene relies on the brain’s ability to prepare
itself to enter the phases of sleep in a healthy way. It’s recommended to the
parents of newborns that they develop a “ritual” for putting their babies to bed,
so that the babies’ brains become conditioned to sleep. Something similar
happens in adults. A shower, reading something calming, drinking an herbal tea,
mediating or praying, listening to music, or watching a series that helps you to
disconnect—all of these can be “rituals” for preparing your mind to dive into the
depths of sleep.

TWO FRIENDS—OR ENEMIES

Be careful about doing too much exercise at night. Just as it can help some
people to release cortisol and achieve a more profound rest, it can be
activating for others, and prevent them from sleeping.
Large dinners and alcohol are disruptive agents for sleep. Be careful with
caffeine, tea, and other stimulants before sleeping.

Sleep in the dark: This might surprise you. Many people take advantage of
summer weather to sleep with the window open and wake up when the first rays
of sunshine enter the room. This isn’t a problem, as long as you don’t mind
getting up early. What I’m referring to here is keeping a light on in your room,
from the television’s standby light to notifications that illuminate your phone’s
screen, or a light in the hall. However small and imperceptible these lights seem,
they have a harmful effect on melatonin production.

Mood depends on attitude: The attitude you bring to any situation determines
how you will respond to it. A job interview, a date, a test—the outcomes of all of
these are influenced by the way I approach them. There are people who prefer
always to “expect the worst” in order not to be disappointed. It’s true that,
thinking like this, you might be pleasantly surprised by the unexpected; but we
know that the brain is ignited by placing a positive attitude at the center of your
behavior.
My attitude is the decision I make about how to confront life. Because it’s a
 My attitude is the decision I make about how to confront life. Because it’s a
decision, I can always work on and improve it.
Attitude is a powerful activator of mood. There are times when one finds
oneself in a depressive state that doesn’t respond to any attitude, but we know
that if a person who is suffering, ill, and experiencing pain deploys their best
mindset—even if it’s a huge effort—things shift and improve little by little.

ATTENTIVE CAPACITY: THE ASCENDING RETICULAR

ACTIVATING SYSTEM (ARAS)
The true act of discovery does not consist of going out to seek new
countries, but in learning to see the old country with new eyes.

—Marcel Proust

The ascending reticular activating system has an ugly name, but it is honestly an
interesting and inspiring part of the brain.

THE DAY MY LIFE CHANGED: MEETING SOMALY MAM

I had finished my degree in medicine. I was undergoing the official
I had finished my degree in medicine. I was undergoing the official
examination in order to be able to choose my specialism. Days before I was to
visit the health ministry with the purpose of entering my name for a place as a
psychiatrist in Madrid, I spoke to a good friend from my course. She had a
crazy but exciting proposition for me: let my place go—I could come back
and do the exam a year later—and go to Cambodia to work for an NGO that
she and her family had collaborated with for a while. I was thrilled by the
idea. Minutes before my number was called at the ministry, I got up and
walked out. I called my parents who, gobsmacked, couldn’t believe what I’d
done. I spent the next few days planning my trip.
I didn’t know much about the history or way of life of the Cambodians, so I
went to a bookstore on Calle Serrano, in Madrid, that sells travel books, and I
bought a few on Buddhist culture, the history of Cambodia, and the traditions
of Southeast Asia. Suddenly my attention was caught by one book in
particular: The Road of Lost Innocence, by Somaly Mam. Written on the back
was a brief summary of her life: she had been sold to a Cambodian
prostitution ring and had spent more than ten years working in brothels until
she fell in love with a client and managed to leave.
She founded one of the main NGOs fighting against people-trafficking,
sexual abuse, and prostitution. The book was dedicated to Queen Sofía of
Spain: “To Queen Sofía, for your constant attention to others. You gave me
the strength to carry on my struggle.”
I bought the book, which uncovers a world without morality, full of
violations and aggressions. Those pages are the hardest I’ve ever read. They
gave rise in me to a strong desire to meet this survivor, this fighter. I saw, over
the course of the book, that in some ways Somaly hadn’t managed to
overcome all of the traumas and wounds of her past. Whenever she rescued
another girl, her way of expressing herself revealed a pain that had yet to heal.
I tried to locate her, searching on the web, looking at her foundation and so
on. I wrote a few emails but I never got a response. I knew that she had been
traveling through Europe and the United States, denouncing this blot on
humanity. I decided to help her, for which I would need to meet her. I would
use every means necessary to cross paths with her at some point. The first step
was obvious: I had to fly to Cambodia.
The planned flight itinerary was Madrid-London-Bangkok-Phnom Penh.
 The planned flight itinerary was Madrid-London-Bangkok-Phnom Penh.
Arriving in London, a storm delayed our landing by two hours, meaning I
missed my connection to Thailand. I spent the night in a hotel by the airport
and, the next morning, booked myself on another flight with another airline.
At the gate, they told me that my luggage had been lost in the airport. They
asked whether I wanted to wait until it appeared, or put in a claim for it at my
destination. I got on the plane—I had decided to go to Cambodia and losing
some suitcases wasn’t going to stop me.
I landed in Bangkok. After a six-hour wait, I was able to take a flight to
Phnom Penh. Once I was there, I hurried to the baggage office to put in my
lost luggage claim. Next to me, a Cambodian lady was putting in her own
claim. I stared at her; she looked like Somaly—from the book!—but I wasn’t
familiar with Cambodian facial types, so I wasn’t sure. Just in case, I got the
book out and put it on the counter.
“You have my book,” she said to me in English.
I couldn’t believe it, but it was her! A shiver ran down my spine. What
luck! I told her, in a hurried, nervous way—I hadn’t slept and I was flooded
with emotion—that I had come to Cambodia to look for her, and that I had an
idea for how to help her in her work with young girls. She didn’t believe me.‡
She looked around her for her bodyguard. It was one of the most exciting
moments of my life and it was slipping between my fingers.
“There’s someone you love very much,” I added.
“Who?” she asked
“Queen Sofía,” I answered, and she looked at me carefully.
“Do you know her?”
“We all know her!”
Finally she gave me a warm smile and said, “Here’s my number, give me a
call tomorrow!”
After this providential encounter I got to know a true fighter, pouring
herself into helping other women in her situation. Through her I gained entry
into the world of prostitution and brothels, carrying out HIV and STI
prevention, and therapy on girls and young women who had been raped and
abused—I even met Queen Sofía and worked with her on a few occasions, as
she was interested in collaborating with Somaly.
 she was interested in collaborating with Somaly.
I entered into contact with a terrible world, full of pain and physical
suffering, but above all psychological anguish. I attended to women with
authentic trauma, and in exchange I received the satisfaction of being able to
help, to be of use in the midst of this underworld, to lend a helping
professional and personal hand to people who had nothing. An experience like
that enriches the giver more than the receiver, because it creates gratitude and
helps you to value what you have more, and not to ignore those who are
suffering. And all of this from a casual encounter at the airport, putting in a
claim for lost luggage . . . Was it fate? Thanks to that moment, my life
changed. I’m so lucky I missed that flight—and lost my suitcase!

Ascending Reticular Activating System (ARAS)

Every second, our mind captures a few million bits of information, but it only
pays attention to what interests us, or feeds into our hopes or dreams.
Since we are exposed to a bewildering multitude of stimuli, the ARAS is
charged with filtering and prioritizing among all this information those things
that are relevant to our goals, worries, or survival. If our brains assimilated and
paid attention to every stimulus, we would be completely overwhelmed.
When a woman is pregnant and walks down the street, she may think, “Look
how many babies there are in the neighborhood!” In reality, there isn’t a fertility
boom. What’s happening is that her brain is more “sensitive” to this particular
type of information. If something interests us, the brain does what it can to find
it among all the inputs we receive. When we’re looking for a flat to rent,
suddenly our brains notice signs in every window. If we’re interested in a certain
model of car, soon we’ll be bumping into it at every traffic light. A lot of those
notices and cars have probably already been there for a while, but we didn’t have
the intention or capacity to see them. Our minds were on other necessities.

If you really long for something, you’ll be able to manifest it.

This doesn’t mean that simply by wanting something you can make it happen
the next day. The key is to give the brain objectives and aims, so that it’s open to
them if they pass by. The problem is that many people don’t know what they
them if they pass by. The problem is that many people don’t know what they
“long for”; they just let themselves be carried along. For the majority of people,
the fact that nothing interesting happens to them in life has a very simple cause:
they don’t know what they want to happen.

Think, imagine, and dream on a big scale. Act on a small one.

Use your imagination in a healthy way. If you really want something—

within reason—and you imagine it in detail, you can achieve it. Let your heart
fly, make a plan of action, and execute it. The plan is fundamental: Without a
plan and short-term goals, good things remain out of reach. In the words of
Bernard Shaw, if you have built castles in the air, that is where they should be—
now put the foundations under them. Use your imagination. Dream. In terms of
neurobiology, very significant things happen in the brain when you imagine
something in detail, with excitement. Your brain undergoes a change; you’ve
induced an emotional state that is capable of modifying the normal proceedings
of your neurons.

In this life, we attract what we think about.

Focus on what you really want, use your passion to get excited about a big
project—or a small one! It should be whatever awakens the deepest aspects of
your being; you’ll begin to feel something happening inside you.You’ll gain
security, confidence, and joy, and, even more surprisingly, your brain will
change. States of excitement maintained over the duration of several days
activate a process of neurogenesis: stem cells gravitate to the hippocampus—the
memory and learning zone—and transform into neurons. We know very few
ways of producing new neuronal cells, but passion and enthusiasm are two of
them!

Every human being, if he chooses to, can be the architect of

his own brain. —Santiago Ramón y Cajal

Your mind and your body are transformed when they see that good things
can happen. It’s not a question of being obsessed with achieving a specific goal
—life doesn’t always take you where you want to go—but of attaining a mental
state that will guide you toward your BPS, or your “best possible self.”§
Remember that dwelling on a goal can also have the opposite effect; that is to
say, it can prevent you from seeing interesting alternatives that arise in your life
because you’re only focused on achieving something very specific. Sometimes
you need to take distance, get a wider perspective, and maybe direct yourself
toward a different goal. We’re always getting “signals” from life—you can call
them what you like—that direct us toward the right path, the one where we can
develop into the best versions of ourselves.

HOW TO GET THE MOST OUT OF YOUR ARAS

• Every morning, when you get up, whether in bed or when you’re
drinking your coffee, choose a goal for the day. It could be something
insignificant (speaking to someone, having a particular conversation or
making a call) or a more important challenge that you’re excited about
(something that puts your brain in its optimal emotional state).
• Imagine yourself achieving this goal, with excitement, calm, and
confidence. Feel it, relish it, enjoy it to the full. Just for a few moments
—be careful not to let your imagination run away with you and lose
time idly daydreaming.
• Think of the first step toward your goal and make a simple plan.
Have courage! You’re close to achieving your goal: you’ve activated your
ARAS, so it will now be easier to accomplish.

It’s fundamental to open your mind. If we don’t activate our attention—and

our ARAS—we won’t see the possibilities that unfold before us. If, on the other
hand, we maintain a receptive, optimistic, hopeful attitude, we’ll be capable of
understanding what happens to us and give meaning to our experiences.
We have a problem: In this world we don’t pay attention to what happens to
us anymore, nor are we surprised by anything. Today society needs to recover a
us anymore, nor are we surprised by anything. Today society needs to recover a
more attentive, curious way of looking at reality; if you observe anything with
attention, it soon becomes interesting. This requires stopping and being able to
listen to the silence. Silence is not the absence of sound! It’s the capacity to look
inside calmly, cutting off the racket outside.
Walk down the street with a child, and you’ll realize how much captures
their attention. From my house to the nursery my younger son attends is a
distance of a third of a mile. It takes almost half an hour to walk there with him,
and less than five minutes to come back. The reason? There are multiple
“distractions” to attract his attention along the way: police cars, garbage trucks,
people on motorbikes, planes, colored lights, shop windows, loud music coming
from cars, strangers going by whom he has to greet . . .

LEARNING TO LOOK AT REALITY AGAIN

Knowing how to look is knowing how to love.

—Enrique Rojas

Observe the reality that surrounds you, take delight in it—you’ll find that there’s
always something to be drawn to. Looking attentively reinvests life with interest
and fascination. We should learn to look at reality with new eyes, without
harshness. What’s missing that would allow us to do so? Care and amazement.
I sincerely recommend looking again at your job, your family, your children,
your house—but this time with amazement! Maybe you’ll be caught by some
detail that you’ve gotten used to without realizing, or maybe you’ll rediscover
positive things that you’ve been ignoring. This is particularly important in
relationships; look at your husband or wife as though it were the first time, take
note of their face, their body language; deepen your awareness of their gaze, the
way they relate to others and you. Don’t ever get used to the person you fell in
love with—it requires attention not to be ground down by routine.
If you look at reality with indifference or ennui, taking everything for
granted, without stopping to take notice of subtleties, you’ll likely get bogged
down by the same things over and over, stuck in negativity, difficulty, and
problems lacking simple solutions.
problems lacking simple solutions.

CASE STUDY: EMILIA

Emilia has been divorced for eight years. She had been with her husband Juan
for twenty, and was very much in love with him. They had three adolescent
children, aged 19, 17, and 16. Their relationship worked well and they
respected and loved each other, experiencing ups and downs like all couples,
but stable on the whole.
Juan began traveling to the United States frequently for his work. He spent
long periods in New York, Miami, and Los Angeles. Emilia resented this—
she was used to being part of a solid couple, and she noticed that relations
between them were getting colder. And indeed, one day when Juan had
returned from a trip, he sat Emilia down and told her that he had fallen in love
with someone else. Emilia tried to dissuade him, to convince him otherwise,
and took him to see various therapists, but he had made his decision. The
other woman was young, only 27, and they were expecting a child together.
Emilia realized that, even though she loved him, it would be impossible to
forgive him.
The first four years were hell for her—she suffered, she cried all the time,
and she fell into a severe depression. After receiving pharmaceutical
treatment, she got better, and her medication was gradually withdrawn.
When she comes to see me, as I said, it has been eight years since the
separation. She is accompanied by her eldest daughter, now 27 years old, a
medical resident in a Madrid hospital. She tells me that her mother has never
returned to her former self, and despite the passage of time, she has never
recovered any passion for living. She explains that she has something negative
to say about everything, she judges everyone harshly, and she looks at the
world with scorn. She denies feeling sad or depressed and only speaks in order
to criticize or judge others. She fixates on the tiniest details and finds
something to be desired in everything around her. She’s going to be a
grandmother in a few months and her children are worried by her attitude.
When I speak to Emilia, I discover a woman who is “angry at life.” From
 the first moment, she complains about the weather, the Madrid traffic, and
how demanding her children are. During our hour-long interview, I can’t get
her to speak well of anything or anyone. I ask about her house at the beach—
her daughter tells me that it’s a very pleasant and charming place—and she
remarks that it gets very dusty when it’s shut up, and she doesn’t enjoy going
there in summer anymore.
When asked about her daughter, who’s soon to be a mother, she tells me,
“She’d better not be counting on me to help her when it’s born, I already told
her she was too young to be having children yet.”
The daughter who has accompanied her confirms that she was truly
depressed—she cried all the time and spent days in bed—but that now the
dominant note in her personality is her constant complaining.
I explain to Emilia how important it is to look at her world again with fresh
eyes. She looks at me, surprised. She asserts, with no hesitation, “I’m
completely objective.”
I emphasize that happiness depends on one’s interpretation of reality. I map
out her personality chart, taking into account happiness and beliefs, and
explain that she has trapped herself in a role in which criticism and judgment
reign over every impulse. She’s incapable of visualizing good things, or
looking at her surroundings with amazement, compassion, or tact.
We began a course of therapy that lasted ten months. I helped her to
overcome the wounds of her past, not to hate the present so much, and to be
capable of getting excited for the future. It wasn’t easy, but today she’s aware
that her problem was rooted in how she was interpreting reality. Her attentive
capacity, as she has said, “was infected.”

An optimist looks you in the eyes and speaks from the heart; a pessimist looks at
the floor, shrugs, and forgets to communicate with the heart.
Fix your attention. Try to concentrate.
José Ortega y Gasset, the great Spanish philosopher, was one of the most
important thinkers of recent times. The author of “I Am Myself and My
Circumstances” had serious concentration problems, due to the number of ideas
crowded together in his head. To attain the mental state needed for him to be
able to write, he required “self-absorption,” which allowed him to abstract
himself from the world outside. He would walk back and forth in the enormous
empty hallway of his house, kept nearly dark. Once he was able to put his
thoughts in order, he would sit at his desk to map out his ideas in a black
spiderweb across the wall at eye height. This is how he maintained the
inspiration that he found in his hallway.
What techniques do you employ when you really need to concentrate?

Look up, let go of your phone, see with new eyes and with
your heart, and have hope that something will manage to
astonish you!

In today’s world, the Ascending Reticular Activating System (ARAS) is

blocked. One of the main causes is the rise of the screen. It’s very difficult to pay
attention to the good things that arise in front of us. Having control over your
attention is key. We must all learn to divert the stimuli that assault our sense
without stopping, and to pay attention to what really matters.

NEUROPLASTICITY AND ATTENTION

Neuroplasticity is responsible for “rewiring” neuronal connections, from the
establishment of new connections between cells to the adaptive phenomena that
arise in the brain in response to changing circumstances and challenges.
Diverse factors, such as stress, illness, genes, infections, trauma, or
accidents, can negatively influence this capacity. Activating your ARAS makes
neurons connect, facilitating your ability, faced with a multitude of stimuli, to
pick out what’s important and necessary.

We sculpt the brain in real time, shaping it according to what

we attend to and give our full attention.

In our brains, neurons work according to how we focus our attention. When
you aren’t capable of controlling where you direct your attention, when you
can’t concentrate adequately, the efficiency of your decision-making process is
seriously affected. The good news is that we can “deconstruct” our disruptive
mental automatisms, redirecting our attention to where we really want. Attention
is an act of will, and therefore it can be trained.

To control our wills, we must be masters of our attention.

Now begin to:

• Train your attention: try to focus on the positive things that surround you.
• Savor the present moment. I say “savor” because sometimes we get used to
the information flowing in from our senses and stop paying attention to
them. If you eat an orange, a banana, or a slice of ham, enjoy it. Really
make yourself experience its scent, texture, and flavor. When you’re next
in a park, dare yourself to close your eyes and concentrate on your senses
of hearing and smell. Don’t let music just be a distraction—don’t just hear
it, listen to it.
• Decide. Take the reins of your life. Find something valuable, something
objectively good in your environment, and take a minute to make positive
remarks about it to yourself. You’ll be surprised. Try to do this with
people, events, circumstances, etc. There’s a lot of good you’re not
noticing because you’ve blocked off this area of your mind. Don’t forget
that the mind and the body are one at the deepest level.
• Medication can help, but it’s never the only solution to your problems. It
may push you to get better, but you must work on your mind if you want to
avoid falling back into the same position.

* I recommend many of these in the bibliography.

† In Chapter 9, I’ll expand on my ideas for bringing out your Best Possible Self.
‡ Somaly is a woman who has been profiled and persecuted by different mobs
and organizations. In the last few years, articles and interviews have been
published that are critical of her life and work. In these pages I describe
objectively what I experienced—working in her foundation, the therapies we
cooperated on, and my personal relationship to her.
§ In Chapter 9, we’ll look at the formula for BPS.
 6

EMOTIONS AND THEIR IMPACT ON HEALTH

WHAT ARE EMOTIONS?

Emotions are affective states of greater or lesser intensity, the body’s response to
life’s circumstances, everyday occurrences, and our subjectivity; they reveal our
way of being, and they express the way we feel.
The same facts can elicit different emotions, and emotions are what give
color and flavor to the events of our lives. But emotions are also related to
physical and mental health. For example, if I say “I feel good,” I experience
well-being and peace; if I affirm that “I feel healthy,” I improve my health; and
if, conversely, I assert that “I feel alone,” I experience loneliness.

POSITIVE PSYCHOLOGY
The term “positive psychology” was coined by American psychologist Martin
Seligman in 1998. There are two ways of responding to events: with positive
emotions or negative ones. According to which ones dominate and steer us, we’ll
feel one way or the other.
Let’s look at this in more detail. The most studied emotions have historically
always been the negative ones—pain, anguish, anxiety, rage, loneliness. Science
has of late been investigating the positive emotions more, especially since the
relatively recent appearance of positive psychology.
Another scientist of interest in this field is Richard J. Davidson, doctor of
neuropsychology and founder/president of the Center for Healthy Minds at the
University of Wisconsin–Madison. There, they investigate the positive emotions,
University of Wisconsin–Madison. There, they investigate the positive emotions,
behaviors, and qualities of human beings, such as friendliness, affection,
compassion, and love. It all started after Davidson met the Dalai Lama in 1992,
and he asked him this question:
“Has it never occurred to you in your work studying the mind to investigate
friendliness, tenderness or compassion?”
Since then he has been researching positive emotions in human beings,
guided by the motto that “kindness is the foundation of a healthy brain.”

A STUDY WITH SURPRISING PARTICIPANTS

Doctors David Snowdon and Deborah D. Danner carried out a study on 180
Catholic nuns in the United States who had written short accounts of their lives
at the average age of 22. These nuns were then analyzed 60 years later, on a
number of dimensions. Researchers discovered a correlation between positive
emotions displayed in their autobiographies and longevity: Ninety percent of
those who had a quantifiably greater number of positive emotions were still alive
at the age of 85, whereas this was only true of 34 percent of those who had
demonstrated fewer positive emotions. In a later evaluation, 54 percent of those
who displayed more positive emotions were still alive at the age of 94, while of
the group with fewer positive emotions, only 11 percent survived. They also
discovered that the nuns who expressed more thoughts or had richer
vocabularies had a smaller chance of developing any type of senile dementia
after 85, an age at which the risk of Alzheimer’s is about 50 percent.
The study continued even after the death of its participants; the vast majority
donated their brains for later analysis. At this stage, the chief discovery was that
there was no clear relationship between pathology and symptoms; that is to say,
nuns whose brains presented serious damage had demonstrated good physical
and mental health, and the reverse was true too. Tissues were discovered to be
intact in nuns who had shown clear symptoms of some type of senile dementia.
They also discovered that the healthiest brains corresponded to the nuns who had
lived for more than 100 years.
Oddly enough, Professor Snowdon began the study completely by chance.
He visited the convent to investigate the dietary habits of the religious
He visited the convent to investigate the dietary habits of the religious
community, and their effect on aging. Once there, he realized that they formed
an unexpectedly interesting study group, with ideal characteristics for research,
such as low stress levels, and no alcohol or tobacco consumption. Seven of the
nuns in that convent lived past 100: They were known as “the magnificent
seven.” The study received an official grant of several million dollars due to the
interest it provoked.

This brings us to a very interesting conclusion: senility and

mental aging do not appear to be inevitable, however ancient
we are. The key seems to reside in positive emotions.

THE PRINCIPAL EMOTIONS

Many authors have gone into this question thoroughly, detailing the emotions
and studying them in different countries and societies in order to come to a
consensus. The American psychologist Paul Ekman—a consultant on the Pixar
film Inside Out—has studied the emotions in depth, along with the ways we
demonstrate what we’re feeling through facial expressions or body language.
Why do we shrug when we feel sad? Why do we gesticulate differently when
experiencing disgust or fear?
Ekman created what is known as the Facial Action Codification System
(FACS), a taxonomy that measures the movements of the 42 facial muscles, as
well as those of the head and eyes. Through this system, he established in 1972
that there are six universal facial expressions, related to what he considered the
six basic or primary emotions: anger, disgust, fear, happiness, sadness, and
surprise.

THE MOLECULES OF EMOTION

Now we’re getting into exciting territory. The American neuroscientist Dr.
Candace B. Pert, who died in 2013, was director of NIMH, the National Institute
of Mental Health, and author of the bestseller Molecules of Emotion, about the
effects of emotion on health. She provoked a true revolution with her studies on
the mind-body connection and was also the discoverer of the opioid receptor.
I’ll try to give a simple explanation of her discovery. Opioid receptors can be
found on the surfaces of our cellular membranes, and they bond selectively with
specific molecules of the key-lock type. The molecules that reach the receptors
are called neuropeptides. These form the basic substratum of emotion.
What’s interesting is that each and every emotion activates the production of
these neuropeptides. When a receptor in the membrane receives a molecule of
emotion—a neuropeptide—it transmits a message to the interior of the cell. This
message can modify cellular biochemistry and frequency, affecting its behavior.
What are we referring to when we talk about cellular behavior? Anything
from the generation of new proteins or cellular division to the opening or closing
of ionic channels or even the modification of epigenetic expression—genes!
That is to say, these neuropeptides act as mechanisms that alter our physiology,
behavior, and even our genes. Part of a cell’s “history” derives from signals that
the neuropeptides of emotion send through the membrane.
According to the words of Dr. Pert, “neurotransmitters called peptides carry
emotional messages. As our feelings change, this mixture of peptides travels
throughout your body and your brain. And they’re literally changing the
chemistry of every cell in your body.”
Due to this and other discoveries, she is considered the founder of what is
now called psychoneuroimmunology.
Illness is therefore unavoidably associated with the emotions. When an
emotion is expressed, the body responds. When an emotion is negated or
repressed, it remains trapped, seriously damaging the individual. As Dr. Pert
says, every emotion has a biochemical reflection inside the body.

DROWNING IN SWALLOWED EMOTIONS

There’s a saying in Spanish: if you keep swallowing, you’ll drown. In the last
few pages, we’ve discovered the importance of thoughts and emotions for our
health and conduct. Let’s look at a concrete example.
If someone says to me, “Your outfit is horrible,” I can react in a variety of
ways:
 • Replying “You’re horrible.”
• Bottling up my emotions, becoming resentful and sad, and going over and
over the incident: “Why did they say that to me? It’s not that bad, is it?
What do they have against me? Should I have dressed differently?”
• Blocking and denying what happened, not thinking about it, ignoring it.
• Replying along these lines: “Well, I like it, I’ve always had unique and
original taste.”

Each response has a different impact on the body, on each cell, and, of
course, on the mind. In the first case—where I respond in an impulsive, direct,
and even slightly aggressive way—perhaps my body isn’t altered, but I’ll end up
losing friends and breaking or complicating many personal relationships. The
second and third cases will make me ill. I’m silencing and blocking negative
emotions, and this has repercussions on my physical and psychological health.
Freud explained it in this way: “Repressed emotions never die. They’re buried
alive and will come to light in the worst way.” The final response is the
healthiest. But it’s not always possible to act and respond in the best possible
way. Sometimes our personalities or circumstances make us take unexpected or
inadequate actions, and we only become aware of it sometime later.
We live in a society that incites us to block and deny our emotions. This is
due to the fact that appearing to feel things or get emotional is a sign of
weakness or a lack of strength. At times it even seems inadequate or
inappropriate to express what one is feeling, especially if it has an emotional
component.
Those of us dedicated to the world of the mind and emotions know that
repressing an emotion is equivalent to refusing to accept it. These emotions
remain sealed off and stored in the subconscious. It’s only logical that they
should crop up in one way or another at some point in our lives, profoundly
disturbing our equilibrium. A clear example can be found in the instances of
depression that occur during pregnancy or in the postpartum period, both
moments of great vulnerability for women.
If one keeps one’s feelings in check for fear of what others will think, afraid
of looking ridiculous or incapable of expressing oneself, that will end up causing
damage. Emotions build up and can harm us—like menacing shadows falling
damage. Emotions build up and can harm us—like menacing shadows falling
over our bodies and minds.

LEARNING TO EXPRESS YOUR EMOTIONS

When one isn’t capable of emotional self-expression, sometimes one hopes that
other people will realize when harm has been done. The reality is that, in the
majority of cases, those who judge, criticize or wound us don’t do so with ill
intent. They may even be ignorant of the damage they’re causing to others.
There are people who enjoy offending and aggravating others, but they’re a
minority. In such cases we may even be dealing with people with severe
personality disorders. Someone affected by an antisocial disorder, commonly
called a psychopath, enjoys wounding others and does so with the intent to
inflict harm.
On the other hand, there are people with heightened sensitivity and
vulnerability to the comments and actions of others. They have excessively thin
skin, psychologically speaking, and have to be treated with great care, because
they feel offended at the slightest thing.

CASE STUDY: BEATRIZ AND LUIS

Beatriz and Luis have been married for six years. They have three small
children—the oldest is three, and they have one-year-old twins. Luis is an
architect who for many years worked and traveled a lot, but in the wake of the
economic crisis he has suffered considerably; he’s changed jobs and now he
accepts freelance projects to supplement his finances. Luis is direct,
impulsive, quick and efficient, and a perfectionist. He fixates on details and
likes everything to be just so. He sees things with clarity and expresses what
he’s feeling at any given moment.
Beatriz is an interior decorator—they met on a project, remodeling a
building of cultural significance in the north of Spain, and they quickly got
together and married. She comes from a family where she is the oldest of four
sisters. She has a very close relationship with her sisters and her mother. She’s
always been very sensitive. Her father was sick for many years with kidney
problems, and she has always helped her mother with everything. She tends to
swallow or bottle up everything bad that happens to her, so as not to worry
anyone else.
Beatriz comes to see me because for a few months now she’s been sad,
apathetic, and lacking strength. She connects this to the birth of the twins, but
it’s already been a year and she isn’t getting any better. She can’t enjoy
anything; sometimes during the day, when Luis is working, she locks herself
in her room to cry, something she tries to hide from her children.
When her husband comes home, tired and irritable—it takes more effort to
earn the same money now—he sees toys on the floor, a messy house, and the
children crying, and he starts shouting, giving orders to tidy everything up
quickly, for the children to eat dinner at once, and for them to be quiet so he
can sit in the living room watching the news without anyone bothering him.
Beatriz, silenced, doesn’t say anything, but tidies, cleans, prepares food,
and when the children are in bed, she just wants to cry again. Luis doesn’t
realize—he’s caught up in himself and his worries, and Beatriz doesn’t say
anything. Not a thing, because she doesn’t know how to say it; she doesn’t
know how to express herself.
When Beatriz first comes to see me, she tells me that a few days earlier, she
was diagnosed with irritable bowel syndrome.* I carry out a complete
interview during which she tells me her family history. She recognizes that
she has never known how to confront her husband, or anyone she’s close to,
and that she seeks to avoid conflict. She prefers maintaining surface harmony
to answering back or saying that something doesn’t seem right to her. Lately,
apart from her digestive symptoms, she’s been experiencing vertigo and
nausea. Psychologically, she admits that she doesn’t take pleasure in anything,
and she has memory lapses and difficulty concentrating.
When we have a session with her husband, Luis doesn’t understand how
she can have gotten into this predicament. He explains that his wife has a big
heart and never gets angry. He recognizes that he has an explosive personality,
but says his wife “deals with it very well.” I explain to each of them
separately, using a chart, how their minds, emotions, and behaviors function
in response to external stimuli; Beatriz, in response to the shouting and
 impatience she experiences from him, and Luis, in response to financial and
professional frustration. I put their two personality charts together so they can
understand each other, and I give them some very concrete guidelines for
improving their relationship.
After a few months of therapy, Beatriz is better. I prescribe an
antidepressant medication to improve her mood, which helps her to regulate
her physical symptoms. Luis is prescribed a mood stabilizer to short-circuit
his impulsive moments. After undergoing psychotherapy, the relationship
improves significantly. Each has a better understanding of how the other
functions, but above all, they are learning to manage their emotions in a
healthier way.
So, if we don’t express how we feel, there’s a strong chance that the person
in front of us won’t be conscious of the harm they’re doing. Women, in
general, are more sensitive than men, and because they dwell on things more,
they suffer more. This is aggravated by the fact that in many cases male
partners—due to a lack of time, attention, aptitude, or all of the above—don’t
know how to read the subtle external signs that women sometimes use to try
and communicate. Men tend to be less emotive and more pragmatic. In
today’s culture, women have a greater capacity for teaching how to love, feel,
and self-express than men do. Of course, as in all things, there are exceptions
to the rule, but this is the most common dynamic I encounter in my practice.
I’m not saying that it’s necessarily good to blurt out the first thing we feel
or that comes into our heads, but neither is it healthy to omit any conversation
with our companions about something that is hurting us. The important thing
is to achieve equilibrium between situations in which it is necessary to express
oneself emotionally, and others in which it is better to keep silent in order to
safeguard our inner peace and external harmony.

WHAT HAPPENS TO REPRESSED EMOTIONS?

We’ve noted that repressed emotions will return through the back door at some
point, in the form of physical or psychological illness. I would consider
“neurotic” those people who, incapable of handling their emotions in a healthy
way, get stuck in the past. They’re ground down by events, thoughts, or feelings
that haven’t been overcome or have been badly processed, and this transforms
their characters, turning them into unwell people, exhausting to relate to.
We’ve already seen how positive emotions facilitate longevity, prevent the
appearance of illnesses, or contribute to their cure. Negative emotions, on the
other hand, can favor the appearance of illness.

CASE STUDY: EMILIO

Emilio comes to see me one day to find out the diagnosis and recommended
treatment for his 14-year-old daughter, who has been in therapy for a few
months because of bullying, which had given rise to problems with her mood
and changes in her behavior.
He avoids coming to sessions with his wife, because he doesn’t consider his
daughter’s therapy necessary, and everything relating to psychology seems to
him to be useless and absurd. He greets me coldly and sits down. In cases like
this I try to discuss trivial matters until I see that the atmosphere has warmed
up. A few minutes in, I start talking to him about his daughter and how much
she admires and loves him. Suddenly, I notice that his voice is slightly broken,
and he changes the subject.
“Is this making you emotional?” I ask him.
“I don’t like to get emotional or to feel anything intensely. It’s a sign of
weakness, and sentimentalists don’t get very far in life.”
“Ah! Big mistake. Sentimentality and emotivity aren’t the same thing.”
After that day I begin a very interesting course of therapy with Emilio. We
dive into his life story: he comes from a wealthy family, with an American
father and a Spanish mother. His mother is cold, emotionless, and has never
allowed expressions of affection in their family setting. He never saw a
gesture of affection between his parents at home, not a hug, a caress, or even
an “I love you.”
When he was little he had a neighbor he talked to a lot, but he moved away,
and Emilio never again confided in anyone completely. Interestingly, the day
he speaks about this neighbor, whom he hasn’t seen in thirty years, he gets
very emotional and cries. I’ve already explained to him that my consulting
 very emotional and cries. I’ve already explained to him that my consulting
room is an appropriate place to cry. Nobody is judging or criticizing him.
Tears are a powerful source of liberation from anguish.

WHAT DOES CRYING DO?

Never forget that the only species that cries for emotional reasons are humans.
When someone observes another person crying, prosocial emotions or behaviors
are frequently triggered in the observer, moving them to empathize. It therefore
makes sense to assume that at some point in the evolution of Homo sapiens,
tears became a way of expressing the emotional state of an individual’s mind.
The body produces more than 25 gallons of tears a year on average. If we
think of all the people who can’t remember the last time they cried, we must also
remember others who compensate by crying gallons and gallons of tears!
There are three types of tears: basal tears (which serve to keep the eye
hydrated), reflex tears (provoked by physical shocks, dust motes, fumes, etc.),
and emotional tears.
Emotional crying is prompted when the body perceives a state of alert—
sadness, anguish, danger—and sends tears to the eyes as a reaction. At the same
time, an increase in heart rate and blushing may occur.

THE BENEFITS OF A GOOD CRY

In 2013, a therapy arose in Japan known as rui-katsu, which can be translated
as “the search for tears.” Japan, for various cultural and historical reasons, is
one of the nations of the world most lacking in emotional education. It is not
socially permissible to express emotions. This technique helps people to
liberate tension and repressed emotion, and recover inner peace.
The technique is a group therapy based on crying. People are encouraged to
avoid doing it alone because of its resemblance to a depressive state in which
someone might seek to be alone in order to cry and let everything out. The
first rui-katsu was organized by an old Japanese fisherman, Hiroki Terai, in
 2013.
The process is as follows: in a room with 20 or 30 people, videos,
announcements, or short films with an elevated emotional charge are
projected, until the attendees begin to cry. A session lasts approximately 40
minutes. The result is that people go away flushed out, relieved, and with a
genuine improvement in their mood.

The researcher William Fey carried out a study a few years ago of the
biochemical makeup of tears gathered from intense weeping caused by anguish
or extreme sadness. He found elevated levels of cortisol. This is why one feels
liberated after a bout of crying: it discharges tension and uneasiness by shedding
significant quantities of cortisol.

PRINCIPAL PSYCHOSOMATIC SYMPTOMS OF BLOCKING

THE EMOTIONS
When emotions turn into physical illnesses, we are dealing with what is known
as psychosomatic illness (psyche, “mind,” and soma, “body”). A psychosomatic
illness is an affliction that originates in the mind but whose effects are felt in the
body.
When a person feels embarrassment or shame, their cheeks blush. It’s an
involuntary reaction and it can’t be consciously modified. When two people
argue, their blood pressure may rise. Faced with a presentation, an exam, or a
speech, one might experience tachycardia and hyperhidrosis (excessive
sweating).
A high percentage of people who suffer from chronic stress, anxiety, or
depression suffer physical symptoms such as migraines, back pain, muscular
stiffness, gastrointestinal disruption, or other manifestations such as vertigo,
nausea, or tingling in the extremities. The problem arises when the illness that
has installed itself in the body is more serious, from gastritis with associated
ulcers that require surgical intervention, to incapacitating neurological or
oncological illnesses.
The principal psychosomatic disorders are:
 The principal psychosomatic disorders are:

• Related to the nervous system: migraines, headaches, vertigo, nausea,

tingling (paraesthesia), and muscular paralysis
• Related to the senses: double vision, transitory blindness, and aphonia
• Related to the cardiovascular system: tachycardia and palpitations
• Related to the respiratory system: tightness in the chest and shortness of
breath
• Related to the gastrointestinal system: diarrhea, constipation, acid reflux,
pharyngeal pouches, and difficulty swallowing.

Don’t forget: Long before it fell ill, the body was sending us warning signals
in the form of discomfort, weakness, or pain. The illness, in these cases, is a
message sent by the body, which never stops communicating with us, hoping to
achieve equilibrium and peace.
Living in an era of hurry and rush, where everything is developing at such an
intense pace, we don’t connect to ourselves internally, or we’re unable to give
voice to those symptoms that are warning us something isn’t working.
Those indicators are fundamental if we are to avoid ulterior sickness, or at
least to slow down the progress of our symptoms. The body has a double
function: on the one hand, it listens to everything our mind says and, on the
other, it speaks to us through pain, unwellness, psychological unease, or
disorders.
It is often said that anxiety is a fever of the mind and soul, warning us that
our environment is hostile or that we’re submitting our body to an excess of
activity, emotion, or a situation it can’t withstand. These processes of discomfort
or pain—everyone has their own!—are therefore asking us, shouting at us to
take notice of what’s harming us, what’s presenting a threat, or something that is
becoming too much for the body and the mind.

Ignoring the body’s signals is the first step towards weakening

our health and creating an imbalance.

Some discomforts may be due to bad habits having to do with nutrition, poor
 Some discomforts may be due to bad habits having to do with nutrition, poor
sleep hygiene, a sedentary lifestyle, or bad physical posture. If we’re capable of
taking a good look at our lives, with honesty, and without searching for a
perfection that creates more anguish than peace, we’ll be on the right track. We
have to allow ourselves a bit of time to analyze our lives and consider what
we’re achieving, our goals and objectives, all while observing and physically
sensing our bodies, verifying if they’re sending us signals, and deciphering what
the causes might be. Sometimes the help of a professional—a doctor, or
someone who understands the body and its connection to the mind—can be of
material support.
Science shows us many clear examples of illnesses related to the emotions.
Dermatologists have documented that certain skin diseases are prevalent among
patients who experience resentment, frustration, anxiety, or guilt. Cardiologists
have demonstrated that heart attacks are more common in aggressive,
competitive people, or those who have developed chronopathy.†
Gastroenterologists have observed a correlation between emotions like anxiety—
over an exam or a job interview, for example—and intestinal or stomach
ailments such as peptic ulcers. But, without a doubt, it’s in the field of oncology
that the mind-body relationship is being investigated most thoroughly.
The American clinical psychologist Lawrence LeShan has analyzed the lives
of more than 500 cancer patients and unveiled a significant relationship between
depression and the appearance of cancer. Many of the people he studied had
been flattened by the rupture of close relationships and had tried to repress their
related emotions. These repressed emotions modified their neurohormonal
equilibrium and were counterproductive for their immune response. I’ll go into
the oncological implications in more detail later on.

CASE STUDY: TOMáS

Tomás, sixteen, comes to see me. He’s the eldest of three brothers, a good
student, and the child of an architect father and a housewife mother. For the
past year and a half, he’s been experiencing problems with his vision. It all
started one day in class, when he realized that the blackboard looked fuzzy.
He told the teacher, and that afternoon he went to urgent care with his mother.
He was diagnosed with an accommodative spasm. They prescribed some
 He was diagnosed with an accommodative spasm. They prescribed some
eyedrops and sent him home. For a couple of days, things improved, but one
day in the middle of class, he realized that he couldn’t see anything at all.
They visited another specialist to get a second opinion. He was assessed, and
they carried out various tests, but the problem kept getting worse. His degree
of myopia changed at every eye exam and the cause remained a mystery.
After visiting various specialists—among them some neurologists—he was
scanned and given an MRI, but the results were completely normal, at which
point he was sent to see a psychiatrist. When I see Tomás at my practice, I’m
surprised at how calm he is despite the fact that he “can’t see.” We
psychiatrists call this la belle indifférence. He says that he’s gotten used to not
being able to see and that it doesn’t worry him. I interview the parents and
discover in Tomás’ personality very marked traits of perfectionism and
rigidity. He demands a lot of himself, he doesn’t allow himself to make
mistakes, he’s always skipping ahead of his class in school to do more
advanced work and he always wants to know more—to “see” further than is
necessary at his age and maturity level. His body is pulling him up short: He
can’t see anything at all. He was in therapy for a few months, and we worked
on his way of perceiving himself and managing his emotions. Little by little
he recovered his sight and hasn’t had problems with it since.

There are many known cases of people who cease to speak, see, or even
walk, all for emotional reasons. The body is wise. I remember, one of the first
times I was on call, encountering a 38-year-old woman who had suddenly
stopped walking at work. The traumatologists and neurologists had ruled out an
organic pathology. The case was sent to the psychiatric ward and, after various
therapy sessions of different kinds, she recovered mobility in her lower
extremities. That was one of the triggers of my desire to deepen my
understanding of the mind-body relationship.

ATTITUDE AS A KEY FACTOR IN HEALTH

Over the course of these pages I’ve talked about the importance of our thoughts
to our state of mind, our interpretation of reality, and our health.
A healthy and constructive attitude may be the most powerful natural
medicine available to us, as well as, perhaps, the least often remembered. In the
six years of study required to earn a Spanish medical degree, barely more than
one lecture is typically dedicated to this topic. Despite this, we doctors are very
conscious of the importance of a patient’s attitude to their prognostic. Clinical
data show that positive feelings and the emotional support of family members,
friends, and even the health professionals involved in treatment possess an
unquestionable curative power. In addition, what a patient feels, perceives, or
believes can be as relevant as their diet and lifestyle when it comes to facing, for
example, coronary disease.
Americans Meyer Friedman and R. H. Rosenman carried out a study on
3,500 men over the course of ten years. First, they divided the subjects into two
groups: the type A group comprised those individuals with more rigid, impatient,
or chronopathic (time-conscious) characters; the type B group was more relaxed
and tranquil. After this preliminary classification, they investigated the health of
their subjects—asking whether they smoked, how much physical exercise they
performed, measuring their blood cholesterol levels, and analyzing their diets.
Subsequently, they waited to see how their subjects would get on. In ten years,
more than 250 of the physically healthy subjects suffered a heart attack. It
emerged that data about their diets and physical activity were unable to predict
these results. The only datum capable of predicting what would happen, the only
datum with diagnostic value, was the preliminary classification based on their
mental disposition. The subjects classified as type A had an incidence of heart
attacks three times higher than the type B subjects, independently of whether
they smoked, had a healthy diet, or exercised sufficiently.

AND . . . WHAT ABOUT CANCER?

Cancer would appear to have some relationship to stress and the emotions. The
process isn’t clear, but more and more scientists are voicing their instinct that
emotions or stress can be risk factors in the development of cancer. As you
would expect, oncological diseases possess varied and complex etiologies. There
are as yet no serious studies drawing a direct relationship between emotions and
are as yet no serious studies drawing a direct relationship between emotions and
cancer, but we all know someone who has suffered enormously in life and one
day tells us, distraught, that they’ve been diagnosed with a serious illness. In our
heart of hearts we aren’t surprised: “After all they’ve suffered!”
In a project directed by the epidemiologist David Batty and carried out
jointly by University College London, the University of Edinburgh, and the
University of Sydney, sixteen studies completed over the course of a decade
were analyzed. A total of 163,363 people began the study, and of these, 4,353
died of cancer. They were looking for the relationship between certain types of
cancer, hormonal components, and lifestyle. At this point in the book, you know
that depression generates a hormonal imbalance with elevated cortisol levels.
This halts necessary repairs to the DNA and inhibits the adequate functioning of
the immune system. The study results showed that people with depression and
anxiety had an 80 percent higher incidence of colon cancer and twice the
incidence of pancreatic and esophageal cancer. One has to read these results with
care and not be blinded by their force: don’t forget that anxious and depressive
people have higher levels of alcohol and tobacco consumption, and obesity—
three of the most common and most studied factors in cancer.
Cancer is related to multiple causes—environment, nutrition, toxic habits,
genes—but a theory being postulated more often and with ever greater
conviction is that the emotions also play a role. For a tumor to develop, various
factors must coexist.
Cortisol, which we’ve already discussed, is a hormone that, maintained over
time at abnormally high levels, provokes inflammatory processes that are
harmful to the cells of the body. In July 2017, Dr. Pere Gascón, who was until
recently head of the Barcelona Hospital Clinic Services, acknowledged in an
interview that “chronic emotional stress can initiate the development of cancer.”
This oncologist is one of the most renowned researchers into the relationship
between the mental-nervous system and cancer. I’ll try to explain this theory in
simple terms. To begin with, don’t forget that all oncological illnesses possess
extremely complex developmental processes. I want to avoid any kind of
reductionism around this very serious topic, but I think that a simple sketch can
help you to understand the issue and pick out the broad strokes of how the body
reacts to certain stimuli and the related importance of our mental equilibrium.
 As we know, cortisol generates inflammation by releasing substances like
prostaglandins and cytokines and is activated by situations creating chronic
stress. Then we have tumors, each of which is a conjunction of malignant cells
that take root and grow in some part of the body. With cancer, once the tumor is
installed somewhere, the immune system—the body’s defenses—stop attacking
the tumor and “join its team.”
For example, macrophages—a subtype of white blood cells—are charged
with eating up the body’s extraneous material. They form part of the innate
response of the body’s defense system. In the case of cancer, they stop
functioning and start “working for” the tumor. The body’s own immune system
shows an auto-aggression toward it.
In the body, there are between five billion and 200 trillion cells, depending
on an individual’s age, sex, and other characteristics. Around these cells is
blood, whose composition is determined by the purpose of the cells. What
controls the blood? We’ve looked at this in previous chapters: The
neurohormonal system is key. Researchers have uncovered a curious fact: if they
put a cell into a toxic environment, it gets sick. If I surround it with a healthy
environment, it heals. The cellular environment, as much as the information
received by its membrane, plays a fundamental role.

Just as occurs on a cellular level, if a person—a conjunction

of cells, and of course, a little something more!—it frequents a
toxic environment, whether the toxicity is due to people,
atmosphere, or adverse circumstances, they’ll get sick.

Careful! If, despite being in a healthy environment, the mind interprets it as

threatening, it will go on the alert and provoke the same changes in the body and
the composition of the blood as if it were in the most toxic possible atmosphere.
Don’t forget, the mind and the body don’t distinguish reality from imagination.
There are people who, despite being situated in a relatively normal environment
and average circumstances, live constantly on the alert. These people, through
insufficient focus on their actual situation, force their bodies, both physically and
psychologically, into a harmful state of tension.
 If I’m capable of changing the way in which I interpret reality, reality
changes. Happiness depends on the interpretation of reality that I make! It’s
fundamental to accept a change in my beliefs, myself, or what surrounds me—
without judging myself too harshly. From there, the benefits of fomenting
positive thoughts, or even of deliberately calling on the placebo effect, can have
an effect on my mind and body.

WHAT HAPPENS IN METASTASIS?

Now we’re getting into an area of research that is currently developing very
quickly. Metastasis, the process of dissemination of a tumor, which determines
the prognostic and survival of the patient, often arises in a spot where an
asymptomatic chronic inflammation already exists. That is to say, the cancer
disseminates itself, develops, and progresses in inflamed nuclei. These form its
microenvironment, the place where it feels most “at ease” and able to grow and
expand. Not all inflammations carry the same risk of forming a breeding ground
for cancer. Catarrh (inflammation of the amygdala) and strained ligaments (with
muscular inflammation) aren’t of this type. A smoker, every time he or she
smokes, damages his or her bronchial cells, producing a chronic inflammation of
the area. This inflammation arises in order to defend and safeguard the area; in
principle, this is a good and healthy thing. But if the vice of smoking and
consequent inflammation are maintained over time, and if, in addition, this
person has a precedent for lung cancer in his family, and if, finally, we add to
this explosive cocktail a serious emotional problem, this person is a likely
candidate for cancer. Of course, not all smokers get cancer, but we know tobacco
is a potent activator of oncological processes. This is why patients are asked how
long it’s been since they smoked at medical check-ups—it’s pertinent to know
how much time the body has been granted to recuperate from the constant
assault it was submitted to, accompanied by the whole inflammatory process
occurring during a patient’s years as a smoker.
Studies have proliferated in this area, with astonishing results. It’s been
discovered that there’s a direct relationship between cancerous cells and the
nervous system. That is to say, there are receptors on tumorous cells for
substances related to the brain, such as adrenaline or cortisol. The emotions and
the impact of severe stress alter the body, but they also affect cancer cells. Direct
communication occurs between a cancer and the mind—it touches the nervous
system, and therefore the emotional system as well.
The aim of this explanation is not to upset or disturb the reader. On the
contrary, it should serve to help you understand even better the profound
connection that exists between the most serious, difficult to control illnesses and
our minds.
Cancer has deep links to the immune system. Stressful situations, worries,
sadness, and chronic trauma alter our defenses and increase the likelihood of
developing a serious illness. These emotional states are reflected on the
physiological and biochemical levels, by latent inflammatory states.
To sum this up, harmful emotions in themselves do not produce cancer. That
said, chronic emotional stress can trigger, activate, or accelerate the spread of
cancer from its origin point. What provokes emotional stress? Situations like
loneliness, having an ill family member, bad relationships with those around
you, unresolved trauma, grief, or financial or work-related problems.
Being capable of positively redirecting our thoughts has a huge potential to
help us control the level of inflammation in our bodies.

SIMPLE STEPS FOR MANAGING EMOTIONS WELL

1. Know yourself
Learn to understand what upsets you. If you have always blocked your
emotions, it will be more difficult for you to explore the origins of certain
problems. But try anyway—do some reading and speak to people who
can help you. The first step is the most important.

2. Identify your emotions

Put a name to what you’re feeling. Rage isn’t the same as resentment, nor
is feeling joy the same as being moved. Be realistic when you do this,
and don’t blow harmful emotions out of proportion. This analysis has a
direct impact on your body.
 3. Try to be assertive
Say what you think, without being hurtful. Don’t silence your emotions,
speak to someone you trust. Learn to express yourself, but be careful
when you do—you might end up opening doors you can’t close
afterwards. Go little by little. Unburdening yourself should allow you to
recover inner peace and equilibrium.

4. Don’t be afraid to become your Best Possible Self

Learn to give the best of yourself. He who denies his emotions ends up
becoming a worse version of himself, a watered-down version without
the capacity to feel excitement about anything.

5. Place limits on the effect that others have on you

Learn to identify toxic people, who have the capacity to upset you deeply
when you encounter them. It isn’t possible for everyone in the world to
disrupt your internal equilibrium, and you should try to keep your
distance from those who do.
We all go through moments at which we experience displeasure or distress,
when we feel anxious, apathetic, frustrated, or resentful. Experiencing negative
emotions on occasion is a healthy thing: it alerts us to what isn’t working in our
environment and motivates us to roll up our sleeves and fix it, in order to restore
our equilibrium both psychically and physically.
The problem arises when negative emotions become chronic, permanently
modifying our state of mind.

Our way of thinking and feeling determines the quality and

duration of our lives.

TELOMERES
Telomeres, discovered by the American biologist and geneticist Hermann Joseph
Muller in the 1930s, are the extremities of our chromosomes. Their principal
function is to provide structural stability for the chromosomes, preventing them
from getting tangled and stuck to one another; they’re essential to cellular
division. Because of all of this they’re intimately related to cancer—don’t forget
that oncological illnesses presuppose an abnormal division of cells.

Telomeres are the timekeepers of our cells: They set the number of times that
a cell can divide before dying and serve as the chronometer of cellular aging.
After earning her doctorate in molecular biology at the University of
Cambridge in 1975, the Australian-born American biochemist Elizabeth
Blackburn began studying chromosomal telomeres, first at Yale University and
later at the University of California, Berkeley.
In 1984, while studying telomeres, Dr. Blackburn discovered a new enzyme,
telomerase. She began creating artificial telomeres, with the aim of studying
telomerase. She began creating artificial telomeres, with the aim of studying
cellular division. She discovered that the lower the telomerase levels were, the
smaller the telomeres were and, therefore, the fewer times a cell could divide,
creating a greater risk of illness and aging.
Bad habits impact the longevity of a telomere—we’re talking stress, diet,
obesity, sedentary lifestyles, loneliness, pollution, or even sleep problems.
Blackburn studied telomerase in a specific group: mothers of children with
severe neurological illnesses. She observed that those women who felt alone
presented with lower levels of telomerase, with a consequent diminution in the
telomere. Their life expectancy was much lower than normal for women of the
same age. She also observed something fascinating: Those women who shared
their feelings and supported and understood each other had higher telomerase
levels and a consequent enlargement of their telomeres. For her work on
telomerase, Blackburn received the 2009 Nobel Prize in Medicine, alongside her
collaborators Dr. Carol W. Greider and Dr. Jack W. Szostak.
As we saw with Robert Waldinger’s study,‡ loneliness is a risk factor for
depression, but also for aging with shorter telomeres, making depression less
healthy for us to endure.
How do we produce more telomerase and enlarge our telomeres? The first
studies are now being carried out on how to foment telomerase secretion with
the goal of achieving telomere enlargement. Positive effects have been observed
from exercising, eating a healthy diet, and practicing mindfulness. In 2017, in
conjunction with one of the most important labs in the world, I began a study on
the influence of mood and emotions on telomerase levels and telomere
measurements. The objective is to confirm that cortisol, when chronically
elevated, inhibits telomerase levels, and that anxiety shortens telomeres. I’m
confident that interesting results will emerge, which will be published when the
study concludes.

* Irritable bowel syndrome (IBS) is characterized by abdominal pain and

changes to one’s digestive rhythm. The exact cause isn’t known, although we do
know that it has a significant emotional-psychological component. The intestines
are connected to the brain in various ways through neurological and hormonal
processes. Faced with stress, worries, or sadness, these receptors become more
sensitive, worsening the symptoms. The condition is more frequent among
women. It’s diagnosed when an individual has symptoms at least three days a
month over three months or more. It consists of abdominal pain, feelings of
inflammation and strain, bloating, and a change in digestive rhythm, whether to
diarrhea or constipation.
† Explained more fully in Chapter 7.
‡ Chapter 2, on happiness and love for others.
 7

TRIGGERS AND ATTITUDES THAT INCREASE

CORTISOL

There are a multitude of situations that can upset and harm us, altering our
normal cortisol levels. We are immersed in a society that works, generates news
and trends, travels, entertains itself, and even rests at a frenetic rhythm—
sometimes we’re unable to keep up the pace and we break down. There are
certain emotional myths—being perfect, losing control—that have a more
damaging effect on the body than we can imagine.
We mustn’t forget that chronic stress is harmful and injurious to the body
and the mind. On the other hand, eustress—good stress—is activated by the
presence of a goal or a threat. This is what helps us to get going and look for the
best solutions. We’ve all had moments when, under pressure, we’ve gone above
and beyond. A classic example is the night before an exam. The brain suddenly
memorizes more facts than it did during all the preceding days combined. Why?
Small doses of cortisol improve concentration and the capacity to work
efficiently, helping to focus the attention better in order to respond to challenges.
But we can’t always be under eustress; it will end up turning toxic, wearing us
out, and making us ill.
Let’s analyze a few situations that can result in a chronic rise in cortisol
levels.

CASE STUDY: ALBERTO

Alberto works as a communications director for a multinational company, and
is transferring to their office in Mexico. Before going, he comes to see me
because he’s noticed that he’s feeling sad, but doesn’t understand why. Given
that he’s leaving in two days, I ask him to write to me from there, to see if it’s
a passing feeling or something more permanent.
Studying his case, I realize that he’s a person who exerts excessive control
over his life, over what he feels, what he expresses, or what he shows to
others. His relationship seems more like a job than a romance. Both members
of the couple are executives, in both the professional and the emotional
senses. They didn’t want to have children, because they couldn’t find the time
for it, due to the demanding jobs they both have. Neither ever appears to have
a low moment, and they always wear perfect smiles. Alberto maintains
complete control over himself. Nothing changes him or gets him worked up.
When I inquire about the cause of his sadness, he answers me, “There’s no
reason. Sadness is for the weak.”
I add, “And is there anything that moves you?”
He responds, “Perhaps speaking to my father and spending time with him.”
Alberto’s responses are always too vague for me to probe with my
questions. He tries to maintain absolute control over himself and over what he
communicates to me. If he isn’t very happy, he smiles. He’s always very
correct. Before saying goodbye to him in my office, I tell him, “If you carry
on like this, you’re going to break down. Any person who’s constantly
controlling themselves will end up crumbling at one point or another.”
A few months later, I receive an email in which he tells me he’s doing well
and on his upcoming holiday he’s thinking of returning to Spain. I indicate
that if he wants to see me when he’s in Spain he can, but he considers it
unnecessary—he’s currently stable.
One day in July, when I’m in my consulting room, the nurse alerts me that
Alberto is on the phone and it’s very urgent. I interrupt my session and go out
to speak to him. On the other end of the line, Alberto, panting, nervous, and
upset, tells me that something’s happening to him. “We’re in Málaga, in the
middle of our holiday. This morning when I got into a taxi I started feeling
bad, I couldn’t breathe normally.”
He needed to get out of the taxi at once, nauseated and experiencing
 He needed to get out of the taxi at once, nauseated and experiencing
vertigo, trembling, sweating, a sensation of losing control, and an intense
anguish that wouldn’t go away. He was having a panic attack.
His wife gets on the line because he can’t speak, and asks me for help
dealing with the situation. Despite her reluctance—she says it’s only
“something psychological”—I tell her to call an ambulance to take Alberto to
Urgent Care as soon as possible.
Once at the hospital, his wife calls again. The medics have told him he
needs to take a pill, and Alberto refuses. He, always so correct and balanced,
has a terrible fear that the pill will make him lose control of himself, as much
of his thoughts as of his behavior. I try to calm him down, explaining that he
must accept the medication in order to get control and recover his equilibrium,
but, beside himself, he roundly refuses.
His wife communicates a while later that the doctors at Urgent Care
finished by injecting him with an anxiolytic to calm him down. Once he’s
discharged, they want to come to Madrid so he can begin comprehensive
treatment.
A few days later, Alberto comes to see me in Madrid. He’s anxious, alert,
nervous, locked in an unending cycle of anguish, practically unable to walk
down the street. I begin a course of pharmacological therapy with an
intravenous medication—long-acting benzodiazepine—which blocks his fear
and anguish circuits. I explain exactly what happened to him and the
physiological and emotional mechanisms that brought him to this state. I
prescribe an “emergency pill” to take if he has another panic attack,
explaining that it acts within a few minutes. With this pill, he can travel and
attend meetings, carrying “peace of mind in his pocket.”
His greatest fear revolves around the idea that taking medication will make
him lose the ability to manage life without it. To address this, every time he
ingests a pill, I make him write in a notebook—and his wife also takes notes
—sentences for him to repeat that neutralize this negative expectation:
“Nothing’s going to happen to me,” “I’m not going to lose control or lose my
identity,” “I’m still going to be me,” “These are the effects of the pill,” “You
can do this,” “Don’t give importance to sensations, don’t overanalyze them,”
and so on.
 After two weeks he’s more stable, and we adjust the medication so he can
take it orally. We also begin psychotherapy. Using his personality chart,* we
explain his way of being and the apparent causes of his panic attack. I explain
how cortisol and fear function, and we begin to explore some very exciting
territory: the management of his emotions. If something seems funny to him,
he can laugh; if something makes him sad, he can cry; if he’s in an emotional
situation, a reunion of family or friends, he can feel happy—nothing bad will
happen.
One day during a session he confesses, “You’re helping me to forge a
vulnerable personality. Until now, I blocked my feelings in order to feel
strong, but now I’m becoming capable of being moved, of feeling.”
For him, so cold and cerebral, if someone lets themselves be carried away
by their emotions, they become a slave to them, and suffering, pain, or passion
can get in the way of correct decision making.
After a year of treatment, we begin withdrawing medication little by little;
he has learned to navigate moments of high anxiety—he always carries his
“emergency pill,” which he’s only used three times in a year—and, more
important, he’s turned into a warmer, more human, more affectionate person.

FEAR OF LOSING CONTROL

Human beings feel strong when they have control and are in the right. It is so
hard to accept that we’ve made a mistake! The mind directs. The mind orders.
The mind controls. We follow the directives of reason, responding to questions
exclusively from a cognitive perspective. In today’s society, reason has become
a tyrant, empowered by material and spiritual insecurity. The desire to control
everything generates a huge amount of anguish. We think that having security in
every aspect of life is a source of happiness. And indeed it’s completely logical
and prudent to procure the pillars of a secure, protected life: a stable job, a
healthy family life, a comfortable financial situation. What’s pathological,
what’s sick, is taking this to an extreme, distressing ourselves and embittering
our lives in pursuit of an absolute security that can never be attained. Constantly
looking for supports and material benefits that reinforce our lives and can’t ever
evaporate or fail us is utopian. That is where the error lies.
It’s typical of our rational materialist society to make us believe that we can
control everything: the point at which we get pregnant, the sex of our children or
their academic brilliance, the type of work we do, our household income and
spending, the perfect holiday, our health or the health of our loved ones, the
perfect party. However, life teaches us that it can be difficult to get pregnant, and
these difficulties are getting more and more common. Sometimes it’s not
possible to have one boy and one girl, or our offspring don’t have the intellectual
abilities we would have liked—although maybe they have other virtues that we,
obsessed with intelligence, can’t perceive in them. The business we’ve devoted
our lives to can force us into early retirement. Income and spending are more
and more uneven all the time. Maybe during a ski trip, a snowstorm shuts down
the roads or the airport, or it rains on Paradise Island even though it isn’t
monsoon season. Even though we exercise every day, eat well, and get frequent
medical check-ups, something can go wrong. Or when the day we scheduled our
perfect party arrives, we find we’re tired, sad, or overwhelmed and prefer to go
hiking alone in the mountains.
Life is rich because of its variety, because it can’t be controlled, and will
resist any attempt to get an iron grip on it, however calculating one is, creating
great anguish in whoever tries to control it. The Roman slave’s whisper at the
scene of a triumph is still relevant: memento mori, “remember that you must
die.” We mustn’t lose sight of our own insignificance, we must be flexible, and
practice the healthy art of letting go, enjoying the here and now.

The constant search for control prevents us from enjoying

good things that are happening to us now, and makes us
forget the present moment in our obsession with the future.

If this control is rooted in dominating my emotions, my moods, and what I

communicate to others, this has a malignant effect—as we saw in Chapter 6, you
can drown in swallowed emotion.

CASE STUDY: ANTONIO

CASE STUDY: ANTONIO
Antonio is the vice president of a company. The past weeks have been very
tense, professionally, because the company is in the middle of negotiations to
merge with a foreign multinational. One day, the president calls him to a
special board meeting to discuss an important issue. Antonio is a very hard-
working man, meticulous, extremely organized and consistent. He’s shy, and
for him, interacting with people requires an effort; he has to work hard to
come out of himself, and only feels socially at ease when he’s in situations
where he’s very confident.
When he arrives at the meeting, he finds thirty or so people around the
table. The president takes the floor and says, “A few days ago I found out I
have cancer; it’s serious, but I’m going to fight it. I need to consecrate all my
time and energy to getting better. Therefore, during my absence, I’d like our
vice president Antonio to direct and coordinate the merger.”
Antonio stands to say a few words, but he can’t speak; he’s suffering
“aphonia.” But a few minutes ago he spoke to his wife on the phone! He
explains in a whisper, giving the first excuse that occurs to him, that he’s
recovering from bronchitis. He adds that he wishes the president all the best
during his treatment, and that he’ll lead the company as best he can during his
absence.
He leaves the meeting and calls his wife; his voice is still faint, and he
decides to see a throat specialist he knows at once. A few minutes into
explaining to the doctor what happened, his normal voice returns. He doesn’t
understand at all. A few days pass and in his first meeting with high-ranking
executives, when he’s about to take the floor, the same thing happens! He
can’t speak. When he comes to see me he’s afraid of two things: first, of
speaking in public, a fear he already suffered from; but now he’s also afraid of
being “mute” in front of a group of people.
We begin the therapy with an explanation of exactly how to relax just
before he’s going to speak, using breathing techniques and repeating a series
of messages that neutralize his fear. In a notebook, I draw a map for him,
showing the nerves that touch the vocal chords, so that he can visualize the
physical process and feel reassured on that count. In addition, we use
sociotherapeutic techniques to overcome his fears and shyness in front of
people.
 people.
During the president’s cancer treatment, Antonio was able to direct the
merger with success, and with a much greater control of people and of voice
than he enjoyed before. All of this allows him to feel much more security in
himself.

Exposure Therapy to Deal With Fear

This type of therapy consists of forcing the patient to confront the problem that
causes his or her distress or irrational fear. It must be carried out little by little, to
allow the brain to adapt and to allow the patient to feel secure with each step he
or she takes.
In Antonio’s case, exposure therapy consisted of first having him speak to
the whole team at my office alongside his wife and another person he invited.
Here, he gave a presentation on the structure and business of the company he
worked for. Later on, we pushed him to say a few heartfelt words about different
events he’s attended—his son’s first communion, or his cousin’s wedding.
For people who suffer from agoraphobia, we usually recommend that a close
friend or family member—someone they trust—accompany the patient to an
open space. This is repeated at the next step, and the patient is left alone
somewhere nearby, with an agreement to meet in another location. To all of this
is added a series of useful breathing techniques, and internal affirmations of
support for what the patient is doing. Little by little, the brain changes and
adapts, and the body stops sending signals that it is anguished and overwhelmed.

How to Breathe
When someone says to a nervous person, intending to help, “Just breathe!”, they
usually think, “But I am breathing . . .” Obviously, when we ask someone to
breathe when they’re experiencing a moment of distress or anxiety, we’re asking
for deeper and more conscious breathing. Let’s analyze this.
For a while now there’s been a lot of talk about relaxation techniques, and
there are multiple studies and articles on the topic. The majority of people
believe that mindful breathing simply means inhaling deeply and exhaling
slowly. They’re not wrong, but here we’re going to try to apply the idea in a
slowly. They’re not wrong, but here we’re going to try to apply the idea in a
more efficacious and organized way.
The first step is to find a comfortable spot that isn’t too noisy. You could
also dim the lights—switch off lamps, lower blinds, draw curtains—and put on
some relaxing music.
Let’s begin:

• Sit down on a chair—it should have a straight back but still be

comfortable.
• Start by paying attention to your physical sensations. Focus on the feet.
For the first few seconds, concentrate on feeling the weight of your entire
body. Feel your lower extremities anchored to the floor. From there, move
upward through the legs, the shoulders, the arms. Allow peace to suffuse
your body as you enjoy the moment.
• Observe your breath. Before trying to “control” or “exercise” it, pay
attention to the smooth movement of your abdomen as you inhale and
exhale. Then turn your attention to the area around your nose as air enters
and exits your nasal passages.
• After these first moments of observation and calm, we’re going to begin
with what’s called diaphragmatic or belly breathing. This is more
efficacious because it fills the area underneath your lungs with air,
allowing for better oxygen absorption.
• Place a hand on your chest and another on your stomach, and observe
which hand is lifted during inhalation. If the stomach lifts, you’re doing it
correctly.
• Draw air in deeply through the nose, hold it for a few seconds, and release
it with control through the mouth.

One of the best-known breathing methods was designed by Dr. Andrew

Weil, director of integrative medicine at the University of Arizona. He’s been
featured in Time magazine twice, and was interviewed by Oprah Winfrey about
his theory of breathing. He recommends a 3-3-6 or 4-7-8 breath, depending on
the number of seconds that the breath takes at each stage. In the case of 4-7-8,
the breath follows this pattern:
 • Inhalation lasts 4 seconds
• A pause, holding the breath, lasts 7 seconds
• Exhalation lasts 8 seconds

Practicing this technique at night while lying in bed can be very useful when
trying to fall asleep. As with everything, it’s good to start small, trying it out a
couple of times per day, then increasing gradually. In this way, the body, the
breath, and the sympathetic and parasympathetic nervous systems will learn to
self-regulate.

When you’re blocked or afraid of losing control, when stress is

taking over, your mind is overwhelmed, or your body is failing
to respond—breathe, take heart, and send yourself messages
of peace and growth. This will get you out of the cycle.

PERFECTIONISM

CASE STUDY: LOLA

Lola is from Salamanca, married with two children, a five-year-old boy and a
seven-year-old girl. She works as a clerk for the council, but she studied
education and has always wanted to be a university professor. When she
comes in for counseling, she’s been working on her doctoral thesis for three
years. She confesses that it’s nearly finished, but every time she revises it, she
finds things to tweak.
She tells me that she can’t manage to relax at home—when she gets back
from work she always finds the house is dirty. The people she hires to clean
and help her with the children never last more than two or three weeks.
According to her, this is because they don’t do a good enough job. At work
she’s very demanding and never submits what’s been asked of her on time.
In counseling, she complains about high anxiety and stress, and repeats
several times that she “just can’t anymore.” Lately she’s been unable to sleep
and has been feeling irritable. At the next session, her husband accompanies
 and has been feeling irritable. At the next session, her husband accompanies
her and remarks that for him, the issue of hired help is exhausting and always
ends up monopolizing their conversations as a family.
“My wife is obsessed with cleanliness,” he says.
He explains how, when she arrives home, she starts going over everything,
running her finger along the furniture looking for dust, checking that the
ironing hasn’t been wrinkled, and that the clothes have been put away by color
in the specific way she prefers. Nothing ever satisfies her, which invariably
creates tension in the house, the marriage, and the family.
As a psychiatrist, I begin to wonder whether this person might have more
than simple anxiety, perhaps suffering from some type of obsessive disorder.
When I question her along these lines, she tells me that she washes her hands
up to twenty times a day—when she touches food, when she pays with cash,
etc.—either with water and soap when she’s at home, or with antiseptic wipes
when she’s out. She’s unable to go to bed with her husband if he doesn’t smell
the way she judges he should—she demands that he shower beforehand every
time and that he use a particular brand of deodorant. When she furnished her
house, she requested that the carpenter build cupboards according to the exact
dimensions of the things they were going to contain, and the chests of drawers
where she keeps her clothes were made to measure. She confirms that her
mother and grandmother were the same. I ask her, “How much time do you
take in the shower?”
She responds, “Oh, forty-five minutes or so.”
She—on her own—goes through two or three big bottles of shower gel per
week, because she needs to feel clean. I explain that she’s suffering from an
obsessive compulsive disorder that is provoking terrible perfectionism.

Perfectionists are eternally unsatisfied, in a state of permanent suffering because

nothing ever meets their expectations. This type of person is great at finding
flaws: They notice if something isn’t clean or orderly; if it isn’t harmonized; if
there are streaks on the wall, a glass, or a mirror. Lola is very meticulous in her
work, and when she’s asked to write a report on something, she’ll be double-
checking it and verifying all is correct up to the very last minute. The same thing
has happened with her thesis—whenever she rereads it, she finds errors to
has happened with her thesis—whenever she rereads it, she finds errors to
correct, and she never manages to finish it. She is a born sufferer, and the people
around her are always on the alert, because she’s always analyzing their defects.
One common trait of perfectionists is their rigidity when it comes to
changing from one thought to another: They think about one thing and aren’t
capable of putting it out of their minds, creating a closed thought loop from
which it’s difficult to escape. In Lola’s case, we prescribe a medication that
works very well for this kind of disorder. In addition, we begin
psychotherapeutic work with a notebook in which we mark down goals: these
have to do with anything from cleaning, organizing, and the way she treats her
husband and children to the recurrent thoughts that block her.
I emphasize learning to navigate moments of tension, with cognitive
messages she can repeat to herself at those times when she feels the need to
undertake her cleaning rituals: “Nothing’s going to happen, you’re fine, you’re
clean, remember that you have a disorder that prompts you to wash your hands a
lot, because if not you can’t calm down. Nothing bad is going to happen if you
don’t wash your hands this instant.” Behaviorally, I recommend that she play in
the park with her children without needing to clean herself before she gets home.
Little by little, working on thoughts and behavior, she has substantially
improved.

The Cingulate System

There is a specific brain area responsible for obsessions, compulsions, and
mental rigidity. This is the cingulate cortex. Dr. Daniel Amen compares this area
of the brain to the gearbox in an old car. The correct functioning of this area of
the brain involves being able to change gear—or idea, or focus—easily. When
we get stuck in one gear—or on one idea—the car doesn’t function well, and,
mentally, this produces what we call an obsession.
This is the area charged with visualizing different possibilities and options
for any given problem, giving us greater or lesser flexibility in navigating the
setbacks and changes of daily life. When it’s working badly, or is over-activated,
rigidity increases, and the probability of having toxic thoughts or getting stuck in
a loop goes up.
A typical example of cognitive rigidity is the constant need to have things
 A typical example of cognitive rigidity is the constant need to have things
done when and how we want them done. There are people who have very
marked obsessive traits, who are habituated to particular routines—almost rituals
—so that any breach provokes a disproportionate reaction in them. Excessively
rigid people need plans, schedules, and even the arrangement of rooms to be
according to their hopes or desires. Perfectionists add another dimension: it all
needs to be done in the best possible way.

Another Subtype of Rigid Person: The “Negaholic”

“No, no, no; I said no and that means no.” We’ve all spoken to a telephone
operator or a bureaucrat who ignores what you’re asking for and gives an
automatic, unjustified refusal. We have people in our lives who can’t agree with
us on anything. We deal with people who won’t accept any advice or
recommendations, and who never want to change.
For Dr. Chérie Carter-Scott, an expert on this type, “negaholics are those
people who present an addiction to the negative.” Whatever the situation, they
constantly manifest a visceral, automatic, irrational negativity and are incapable
of perceiving the positive or even the merely neutral. Their vision of reality is
tipped toward the negative. Complaints and laments are the most frequent
elements of their conversation.
This accumulation of negative attitude and commentary in the end does
serious harm to the affected person. So-called negaholics are incapable of
moving forward, and end up giving up on their own dreams, due to their
unfounded fears and the pessimism that pervades their minds. They live in a
state of constant anguish and suffering. Everything gives rise to toxic thoughts,
which devolve into destructive speech and behavior.
This attitude alters their relations to others; it costs them a huge effort to
celebrate others’ successes, and they’re always looking to “bring people down”
with negative comments, expressions, and behaviors. Interacting with these
people isn’t easy, and those around them tend to want to keep their distance.
They end up becoming obstacles for others, toxifying the environments they
frequent.
Negaholics have many origins. Sometimes they’re embittered by a personal
trial they haven’t overcome, other times after a traumatic period. After
experiencing this pain, these people grow bitter and twisted; they break down or
experiencing this pain, these people grow bitter and twisted; they break down or
get depressed. The key, if you think you might be a negaholic, is to go outside
yourself, ask for help as soon as possible, and recognize that this toxic internal
process is seriously harming your life. A curious fact, according to studies
carried out by Harvard University, is that 75 percent of people who have
suffered a personal catastrophe have recovered after two years. At the very least,
science urges us to be optimists in spite of catastrophe.

CHRONOPATHY: OBSESSION WITH THE EFFICIENT USE

OF TIME

THE ART OF RELAXING IS PART OF THE ART OF WORKING

John Steinbeck
We find ourselves living in a historical moment when the highest human
aspirations are productivity and efficiency. This is what we call the
commodification of time.
Today, everything related to velocity or the capacity to take better
advantage of time is given a positive value. What is the consequence of this?
The appearance of a particular stress, which, like a malignant disease, is
extending into all aspects of our society, becoming chronic and seriously
harmful.
Time is the most democratic resource there is. Every person in the world
has 24 hours in their day. Everyone is responsible, not just for how they fill
the day, but for how they perceive the sensation of time. Human beings define
themselves according to the way in which they organize their days and, by
extension, their lives. Organized people arrange it so that the hours multiply—
don’t forget that “order is reason’s pleasure.” At this point, we can
differentiate between two extremes: those people who lose or waste their time,
resulting in empty lives that lead to depressive states; and those people who
suffer from chronopathy, or excessive time consciousness. We all know
someone who’s incapable of giving up any plans, who needs to arrange
everything way in advance, and who fills every gap and opening in their diary
with multiple activities. Be careful of these people—their lives end up turning
 with multiple activities. Be careful of these people—their lives end up turning
into a desperate flight into the future. Don’t forget that life’s great experiences
can’t be savored amidst bustle, hurry, or while checking one’s watch. Life is
neither full nor gratifying without containing some moments of peace and
quiet.

Do You Know How to Rest for Real?

I truly believe that rest—real rest—is in danger of extinction. A new syndrome
has arisen: chronopathy—from cronos, “time,” and pathos, “sickness”—the
disease of time. As Gregorio Marañón said, “Speed, which is a virtue, engenders
a vice, haste.” We live with the conviction that hurry and acceleration produce
more and better results in life. We’re accustomed to hearing, if we try to set a
date to meet someone, the response, “I don’t have time, I’m too busy . . .”
We take this in stride, perceiving it as normal and correct.
Immediacy has become a key protagonist in our lives. We want everything,
here and now. We can’t wait a week to watch the next episode in a series, and
we expect prompt refunds when our new kitchen tongs aren’t delivered in 48
hours as promised.
Who hasn’t experienced the sadness of a Sunday afternoon? I call it “gloomy
Sunday.” It’s also known as “Sunday blues” or even “Sunday scaries.” It
particularly afflicts those whose lives during the week are especially intense. On
Friday and Saturday, they rush around between different planned activities, most
of which usually involve drinking alcohol. Sunday arrives, and they notice a dip
in body and mood, which makes them wish it were Monday. The reason?
They’re racehorses who, week after week, arrive at the finish line with depleted
resources. They don’t know how to be in a state of rest. Any hiatus causes
anxiety, feelings of guilt, emptiness, and sadness.
People today seem to need to use “a meeting” as an excuse to make
themselves a space for leisure or tranquility. It doesn’t look good to say that
you’re free or you aren’t busy. How does this constant business and lack of
downtime affect us? Suddenly, a friend calls, and very serious, with a worried
gaze, reports that after suffering muscular problems, migraines, tachycardia,
anxiety attacks, or even a heart attack, “My doctor has prescribed rest.”
 Then one begins to rebuild one’s life, and a new phase begins, in which the
meaningful things in life are given the importance they deserve.

CASE STUDY: FRANCISCO

Francisco is an executive in a multinational company who, when he was very
young, sat the exam to be a government lawyer and got excellent results.
Since then he’s been on a meteoric rise: He began in public administration,
and then he transferred into the business world. At certain periods in his life,
he’s been involved in politics, but without dedicating himself to it completely.
In general, he’s a man who loves to be taken up with as many matters as
possible: politics, history, philosophy, and, naturally, law. He also likes to
write. Because of this, his schedule is completely full from the moment he
gets up until he goes to bed.
When he has free time, he gets overwhelmed; he likes the feeling that he’s
making the most of the time he has. When he’s eating breakfast with his
family, he asks everyone what their plan is for the day. He always finds a gap
during which he thinks one or the other of them could take better advantage of
their time if they did something different. His children spend their afternoons
at school, attending extracurricular classes and activities—music, Chinese,
English, art, sport—except for Friday afternoons, which he likes them to
spend tidying their rooms and playing. On the weekend, he always has a
perfect plan organized—going to the beach or the mountains, visiting another
city. His wife lives “in his wake,” and often tells him that she can’t keep up
the pace, that he needs to slow down, at which point he answers that we have
to take advantage of life and seize opportunities as they pass.
He’s begun to worry because he’s starting to sleep badly and to suffer from
migraines and occasionally from vertigo. He decides to see the doctor—after
some difficulty rearranging his schedule, given that he has so little time—and
he’s prescribed some pills that have a slight effect. He’s always living with a
sense of being pressed for time and can’t enjoy anything.
His family comes to see me with a specific request: “He needs to stop and
learn how to do nothing.”
But he insists that he doesn’t want to stop, that this is his way of being, that
 But he insists that he doesn’t want to stop, that this is his way of being, that
if he slows down, it stresses him out, and he doesn’t know how to live with
calm.
I prescribe a medication for his anxiety in a very small dose—smaller than
a therapeutic dose; the next day he calls to tell me that he’s finding himself
falling asleep at work. As soon as he slowed down a little bit, his body reacted
as though he had ingested a brutal quantity of sedatives.
What we try to show him is that he doesn’t know how to live in a state of
relaxation. He himself recognizes that as soon as he detects a feeling of quiet
or stillness, his anxiety wells up, and then sinks away again when he starts
doing an activity. The most important thing for Francisco is not to teach him
to relax—he’s incapable of practicing relaxation techniques, yoga, or
mindfulness, because they give him tachycardia—but to make him aware that
he needs to learn to rest.
Becoming conscious of this—what we call insight—is his first step in
therapy. The second is that he learns to do something that isn’t wholly
dynamic, that is to say, that he learns to “waste” time and relax. He achieves
this with great difficulty, due to his strong internal resistance: he’s always
been this way, and his education and upbringing placed great emphasis on
making the most of his time. His prognostic is therefore uncertain.
He’s been in therapy for a few months, improving little by little. He’s
managed to grant his family spontaneous moments in which they’re able to
enjoy doing nothing or very little, or even improvising—something previously
unimaginable.

Let’s learn to stop. To slow down, in order to see, observe, and enjoy. Have
you noticed that in order to really observe and contemplate something, you have
to stop? When you’re running you don’t notice the beauty around you. Take
delight in a beautiful landscape, a sunset, a captivating read; stop to enjoy
wandering through a town hidden just off the beaten track, listen to a song that
moves you . . . and do all these things without feeling guilty or like you’re
wasting time. This has benefits for our health, our enjoyment, our happiness, and
our quality of life.
 Jacques Leclercq explained this in his speech on joining the Free Academy
of Belgium in 1936: the great philosopher René Descartes had visions and
dreams over the course of several months of rest; Newton discovered one of the
main principles of physics sitting under a tree; Plato constructed the pillars of
philosophy in the gardens of Akademos. None of them arrived at their insights at
a frenetic moment in their lives. It’s not by running around in a huge hurry that
we arrive at the deepest knowledge and experience of life’s beauty.
Solitude, rest, silence, going slowly—all of these are keys to creating and
beginning projects with excitement. The world is sick, effectively suffering from
chronic stress. How will society function if we only produce hyperstressed
beings, always running and operating at terminal velocity? A frenetic life
indicates that our environment is directing us, rather than the other way around.
Listening to your inner voice is one of the first steps to understanding and
overcoming yourself. This voice can’t be heard over the frenetic clamor of daily
life. Inner peace and ease are what all current therapies are asking for. In many
places, every day sees a new yoga, mindfulness, or meditation class pop up,
trying to disconnect from the external uproar.
We look at the clock so often that we don’t give any time to what’s
important! Take advantage of a Sunday afternoon to disconnect from your phone
and your watch; use airplane mode when you’re at home, without worrying
about missing a call, an email, a news alert, or a tweet. You don’t need to be
online 24 hours a day. Learn to “waste” a little of your time, thereby gaining in
peace and serenity.

Don’t take on too much. Learn to say no. Live in the present
moment. Try to relish nature, the beach, the ocean, and the
mountains, from time to time. You’ll open yourself up to great
experiences that will truly fill you up. Sure, do this without
losing sight of your personal projects. Make plans, have
checkpoints, but enjoy yourself whenever a special moment
arrives, something you were hoping for or something that
moves you.
THE DIGITAL ERA
I was coming back from Mexico, and imagine my surprise when I read this news
in the paper: “Facebook admits to playing with the minds of its millions of
users.” This took place at a medical event in Philadelphia where Facebook’s
cofounder, Sean Parker, recognized that the business had been created to exploit
“a vulnerability in human psychology . . . a social-validation feedback loop.”
The idea they proposed when they began the social network was to make users
spend as many hours as possible there. That’s how they had the idea of adding a
“like” button to the platform.

What Happens in the Brain Every Time We See a Like?

Let’s try to understand this mental and digital process. Those of us who are
immersed in the study of emotions and behavior know that the universe of
screens—internet, social networks, videos, and apps—is having a profound
effect on the way we relate to each other, the way we process information—
memory, concentration, multitasking, education, motivation—and therefore, in
the long run, our happiness.
Nowadays, there are many businesses and programmers focused on making
sure that individuals dedicate the greatest number of hours possible to their
devices. This focus is conscious. That is to say, the makers of these devices
know exactly how the mind functions in front of a screen or other technology,
and they make apps to generate an addictive effect.
Essentially, recently developed gadgets and apps are designed to be
addictive. This is something crucial and important to understand—as much for
oneself as for parents and educators. Allow me to explain how this works.
Every addiction has a molecular and physiological base, something we’ve
known for many years. Drugs like alcohol, cocaine, pills, or marijuana, or
activities like gambling and watching pornography are all regulated by the same
hormone: dopamine.
Dopamine is the pleasure hormone. It regulates the brain’s reward system. It
operates in the moment that an individual interacts with a pleasure object (sex,
alcohol, drugs, or a social network) and in the moments leading up to that one—
quite often merely anticipating pleasure activates the impulse. At times, it
generates a posterior void, provoking a need to consume the product again
within a short period of time. A person addicted to cocaine, sex, or social media
experiences a profound impairment of their attentive capacity, has a modified
will (regulated by self-control), and, in the end, comes to experience feelings of
sadness and profound emptiness.
What did the cofounder of Facebook reveal at the event in Philadelphia?
That every time someone gets a like, they receive “a little dopamine hit,”
motivating them to upload more content.
What’s happening? Companies today aren’t just carrying out traditional,
conservative marketing; they’re trying to bring together psychology,
neurophysiology, and neuroscience. Hooking your mind and capturing your
attention, they generate more content, more data, and a greater ability to control
what you buy, what you see, what you decide, and what you do.
This is the foundation that drugs work from: mechanisms are activated in the
brain, propelling us toward further, prolonged consumption of these substances.
The majority of these products are either prohibited or regulated. We don’t seem
fully aware that children, from an early age, are exposed to this digital world—
without any restriction—and with a huge possibility of profoundly altering their
minds, their information processing systems, and their capacity to manage
frustration and the emotions.
Every human being, beginning in childhood and adolescence, is looking for
escape routes to navigate their highs and lows, their frustrations and their voids.
Don’t forget that screens have relaxing and learning functions as well. When
children and young people find themselves in conflict, bored or stressed, they
look to a device for relaxation. Their minds are accustomed, when faced with
effort, to find a way out through the screen, social media, or the internet. A high
percentage of the population flocks to platforms like WhatsApp, Instagram,
Facebook, Twitter, and Tinder in search of that hit of dopamine that is triggered
on contact. We’re in the era of excess information and superabundant
stimulation. This hyperstimulation has deep links to the immoderate
consumption of information, as much as material or even fictitious goods.
Everything is easily achieved, with just one click. When we don’t get what we
want when we want it, frustration circuits are activated in our brains, which are
the starting point for the weakness of character of many young people, who are
often lacking the ability to make any kind of effort—it’s so difficult to wait for
gratification! From this point arise numerous problems in education as well as
some psychological disorders. I’m surprised—and very worried—by the number
of young people I see in counseling who are suffering from extreme apathy and
disillusionment; there doesn’t seem to be a way of activating their attention and
motivation. Don’t forget that the only two things that really fulfill a human being
completely are love (romantic or platonic) and professional satisfaction. These
two pillars of life are achieved through effort, constancy, and patience.
Technological advances are progressing at an impressive speed, and
preventing society from slowing down, stopping, and reflecting on the impact all
of this is having on minds, bodies, and lives. When we’re already completely
saturated and, to some degree, altered, we raise our heads and look around us,
trying to get perspective. In these moments—when voices are being raised on all
sides—we ask ourselves: Is it too late? Have we created a monster that we can’t
control? The programmers of Silicon Valley send their children to schools where
they barely even have computers. What are we losing?
Technology has brought us enormous benefits. Like anything, we have to
relearn how to use it; each one of us needs to decide how we wish to direct our
attention, beginning by looking at how we dedicate our time and later carrying
out a real examination of how connected or addicted we are. The internet and
associated technologies grant powerful advantages for making life simpler in
many ways, but their abuse results in behaviors harmful to one’s mind and way
of being in the world.
Growing up with technology doesn’t make us more intelligent. It’s true that
it’s facilitated an endless list of activities, but above all it’s made it easy to
develop a particular mental characteristic: multitasking. Neuroscience refers to
this as alternating or divided attention. This means that the brain devotes a few
minutes or seconds to carrying out one task, then another, and then another. The
brain can’t carry out two actions at the same time if they involve the same
cerebral area. If we find ourselves listening to song lyrics while reading a book,
we aren’t carrying out either task to its fullest. An alternation in the focus of our
attention arises, because both tasks call on the same area of the brain.
The reality is that, when we multitask, the brain is capable of picking out a
lot of information in a superficial way but isn’t capable of retaining it. Clifford
Nass, a sociologist at Stanford, was one of the pioneers in studying the
relationship between attention deficit and multitasking. In spite of what you
might think, people who do various things at once—talking on the phone while
answering emails, for instance—are less efficient. It’s true that they’re able to
change the focus of their attention with more agility, but studies confirm that this
carries with it a memory blockage of the work you’ve done. If this becomes the
norm, we’ll end up living in a superficially informed society that in fact lacks
real knowledge.
Researchers at the University of Saarland in Germany, Ben Eppinger, Jutta
Kray, Barbara Mock, and Axel Mecklinger have published some interesting
studies in this area. When the mind alternates between tasks, cerebral circuitry
pauses between switching from one to the other, consuming more time and
generating less efficiency in the processing of the tasks. We’re talking about a
reduction of up to 50%!
The twenty-first century is the century of hyperstimulation: thanks (or no
thanks) to “new” technologies, the brain is exposed to and obliged to process
tremendous quantities of data, which arrive through the senses—mostly sight—
erupting in waves or simultaneously. This hyperstimulation has serious
consequences; children and young adults, accustomed to this bombardment,
require ever stronger and more intense stimulation in order to feel motivated.
This undermines their curiosity, sense of wonder, and desire to learn anything
that goes beyond the digital world. They find themselves lacking in motivation,
and their creativity and imagination are completely undermined. It’s not just that
—from infancy, they become accustomed to a rhythm of life and an intensity
that make serenity and the enjoyment of silence difficult. One could say that
children jump constantly from one stimulus to another.
Don’t forget that success in life is achieved by people who are capable of
concentrating and focusing on what they really want and who are capable of
persevering in their goals. The brain’s attention is developed in the prefrontal
cortex. This area is in charge of volition, self-control, and the planning of tasks.
This area of the brain must be developed in children from the time they’re small.
It is one of the most important areas to be found in the mind.
Let’s take a look at how the prefrontal cortex develops, beginning at birth.
 A baby begins to pay attention when it sees light; a few months on, its
attention focuses on light, movement and sound. The main goal of education
consists in getting children to pay attention to things that are neither mobile nor
luminous: paper, food, writing, reading, homework, etc. It’s a question of
channelling their will and attention to make them capable of concentrating
voluntarily. If, at this point in their lives, we give children iPads, telephones or
tablets, their attention returns to the light-movement-sound stage of
development. This isn’t an advance for their prefrontal cortex but instead a clear
regression, and children are motivated and respond as they did when they were
babies. The only difference is that the sounds are more intense, and the lights
and movement change at a more vertiginous speed.
Young people’s brains need to learn to focus their attention, and to develop
the frontal area of the brain—responsible for will and self-control—in a healthy
way. An excessive exposure to screens inhibits correct functioning, leading to a
clear deficit in attention and concentration. Nowadays there’s a lot of emphasis
placed on the importance of meditation and mindfulness—paying complete
attention. We teach young people not to concentrate and as adults we struggle to
recover the capacity for self-control of our minds and attention. There’s
obviously something we’re not doing right.
Hyperconnectivity is intimately related to hyperactivity. ADHD—the well-
known attention deficit and hyperactivity disorder—has a strong link to it as
well. Young people diagnosed with ADHD have great difficulty with
concentration and attention and a low tolerance when faced with frustration. The
prolonged use of technology holds out gratifying, easy, attractive alternatives but
makes it more difficult to be capable of paying attention to any nondigital
stimulus.
We need offline education—above all on an emotional, social level. Face to
face communication is the best way to learn how to read others’ emotions, as
Nass has pointed out. We mustn’t forget that our much-discussed emotional
intelligence is one of the keys to success in life. The screen is a poor educator
when it comes to achieving this. It isolates and insulates the child from
everything that surrounds it. It slows the development of the capacity to
understand emotions and to connect with other people and their emotions, and it
denies the capacity to express what one feels while looking into someone’s eyes,
rather than at a keyboard or a screen. We must educate children to be capable of
savoring life, the emotions, and one-on-one relationships—and for that they
must look into our eyes.
Young people connect more easily to a screen, a social network, or a video
game than to nature, individuals, and reality. It’s not a question of rejecting
technology or of denying advances in the digital world but of knowing how to
introduce it into the lives of children and adolescents in a sensible, gradual way,
teaching them how to exert self-control over their access to apps and online
content. We must decide to educate them to connect first with the reality of
things, people’s emotions, and nature. Having done so, we’ll be ready to enter,
step by step, into the digital world.

* See Chapter 4 for more on personality charts.

 8

HOW TO LOWER CORTISOL LEVELS

EXERCISE
One of the most effective ways to combat stress, anxiety, and depression is to
exercise regularly. In this way, you encourage the production of serotonin and
dopamine, hormones that reduce anxiety and help combat depression.

Careful! Practicing very intense exercise can raise cortisol

levels, because the body interprets it as a threat.

In cases of extreme exercise, not only does cortisol not go down, it rises,
achieving a peak after 30 to 45 minutes of intense, prolonged exercise, after
which it descends little by little to normal levels. The problem is that many times
we don’t have enough time to get through the barrier where cortisol levels go
back down. For this reason, it can be more convenient to carry out gentle,
relaxed forms of exercise, like yoga or pilates, or simply walking. A study
carried out by biochemist Edward E. Hill, published in 2008 in the Journal of
Endocrinological Investigation, concluded that exercising at 40 percent intensity
was enough to reduce cortisol levels. In addition, if exercise takes place in
nature, in the open air, away from the noise and pollution of the big city, it has
even more beneficial effects for the body.
The environment in which one practices a sport matters, and quite a bit, too.
A study carried out in 2005 by Dr. Jules Pretty, of the biological sciences
department at the University of Essex, discovered various psychic benefits to
sports practiced in the open air in the countryside—what they called “green
sports practiced in the open air in the countryside—what they called “green
exercise”—as opposed to exercise carried out, for example, inside a gym on a
city street. The experiment consisted of projecting images on a wall while
groups of twenty subjects at a time exercised on treadmills. Four groups ran in
front of projections divided into four different categories: pleasant rural images,
unpleasant rural images, pleasant urban images, and unpleasant urban images. At
the same time, a control group ran without any accompanying projections. They
tested the subjects’ blood pressure and took note of two aspects of their
psychological state (mood and self-esteem) before and after each session. They
found that projections of pleasant images, both urban and rural, had a significant
positive effect on mood and self-esteem.
Nature and wildlife induce a state of well-being in the majority of people;
this is why it’s fundamental to mental health to have nearby access to green
spaces. Nature helps us to concentrate better, think with greater clarity, and
combat mental illnesses that we may have developed.
Merely contemplating nature creates beneficial effects, as Ernest O. Moore
demonstrated in 1981, based on the evidence that prisoners who had views of
farms in the area surrounding their prisons fell ill less frequently than those
whose cells looked into the courtyard of the jail. In a similar vein, Roger S.
Ulrich observed in 1984 that patients in a Pennsylvania hospital whose rooms
were furnished with windows giving a view of nature required shorter
postoperative stays. Contemplating nature is good, but exercise in natural
surroundings is better. In a 2014 study published in the journal Ecopsychology,
Dr. Sara Warber, professor of family medicine in the Medicine School at the
University of Michigan, discussed the beneficial effects of walking in a group in
the open air: It reduces stress, depression, and negative feelings while increasing
positive feelings and mental health.
Exercise helps to direct and balance the hippocampus. When you feel upset,
your hippocampus shrinks and the amygdala reacts in a more chaotic way.
In short, moderate exercise carried out in as natural a setting as possible
reduces cortisol levels, improves the immune system, and helps us to combat
stress, anxiety, and depression.
HANDLING TOXIC PEOPLE

Learn to manage your exposure to those people who have a

toxic effect on you. Surround yourself with “human vitamins.”

Almost all of us have to deal with someone whose mere presence or company—
even the simple act of calling them to mind—disrupts our mood.
You probably already know, without having to think too hard, who that
person is in your life. Normally the primary cause of this negativity is that, at
some point in your trajectory, that person had a perverse influence or a negative
impact on your life.
“I feel bad when I’m with him. I’m uncomfortable; he brings out the worst in
me. Whatever the subject of conversation, his comments, however subtly, give
off some measure of disdain. I don’t know if it’s all in my head or if there’s
really something there. I don’t know if there’s some jealousy or
envy . . . Whatever the reason, I feel vulnerable in his presence, and I can only
relax and breathe freely when he goes away. Even so, I can’t separate myself
from him, even though I think I should put some distance between us. This
situation is changing my character and creating anguish and sadness in me.”
This person might be your partner, your mother, a boss, a colleague, a
brother-in-law, a neighbor, a friend. Something about this person’s behavior,
presence, or way of relating is upsetting, and invariably disturbs your peace.
These are toxic people. There are many kinds: unstable, jealous, paranoid,
immature, or neurotic. In each case, they have the ability to destabilize us,
sometimes within seconds, offering opinions, gossiping, constantly evaluating
our lives, decisions, or comments. They turn themselves into spectators, with the
right to offer an opinion on everything we say or do, and, therefore it’s very
difficult to create healthy bonds with them. At times we’re guilty of letting
people who we know are like this into our inner circle.

A toxic person becomes a spectator of your life, with the right

to offer an opinion at any time.

They’re expert manipulators and they know how to detect the weak points of
 They’re expert manipulators and they know how to detect the weak points of
their victims with absolute precision. A toxic person, by definition, suffocates
the people who put up with him. At times it can be intentional; at others, they
might not be conscious of the terrible damage they’re causing to those around
him. Don’t confuse a person who is simply going through a bad time and
showing a certain temporary irascibility or cynicism with someone who
constantly and regularly exerts his toxic effect on anyone who puts up with it.
In principle, toxic people don’t bring us anything positive. In the case of a
romantic partnership or a family relationship, sometimes a codependent dynamic
emerges that can be difficult to see and acknowledge from the inside. We
convince ourselves that our inner equilibrium isn’t perturbed, and we insist on
maintaining the toxic relationship out of a fear of loneliness, which leads us to
put up with extreme situations that we shouldn’t tolerate.
The key to preventing toxic people from affecting us lies in the attitude we
take toward them. We need to make sure that they can’t invade our interior
world, avoiding, as far as possible, their meddling in our lives, and never
allowing them to negate our decision-making capacity. This last barrier, always
conserving our freedom to choose, can be impinged on by real or imaginary
obstacles that these “emotional vampires” deploy, playing with us in order, very
frequently, to break our wills.
Those who let themselves be taken over by toxic personalities may end up
with a set of anxious-depressive symptoms, feelings of guilt, dependency, and
consequent repercussions for their self-esteem.

SIX KEYS FOR MANAGING A TOXIC PERSON

1. Be discreet with them

At any moment, they might use the information that they have to
undermine you or do you harm. People who love you will celebrate your
successes and know how to support you in moments of difficulty. Having
identified a person who’s doing you harm, avoid giving them information
about your life.
2. Ignore the opinions of toxic people
In this way, you’ll be free, regardless of their remarks and behavior.
Have some perspective about what they do—don’t give their actions
importance. Whether they have influence over you depends on you.
Without confronting them directly, learn to put on a “mental raincoat” so
that disdainful looks, sarcastic comments, or incisive criticisms roll right
off you. You should ask yourself: Do I want this person to have
importance in my life?

3. Try to forget about them

Create distance, little by little, or—without being rude—directly. There
are people who come into our lives and improve them; and there are
others who improve them even more by leaving.

4. If you can’t create distance because they’re a big part of your life,
learn to live with them
If a person is always going to play some part in your life, learn to adapt,
and don’t make the same mistakes over and over. As time goes by, ask
yourself honestly if this person is “globally toxic,” creating toxicity and
unease with everyone, or “individually toxic,” for some reason only
having this effect on you.
After this first step, a second stage of analysis consists in uncovering
the cause of the toxicity. Try to analyze what’s causing you discomfort in
your relationship to this person. That is to say, what happens to you when
you see them? Do they bring up feelings of inferiority, weakness, rage,
fear, anger? Be your own therapist as much as you can, and make use of
pen and paper to progress toward a diagnosis. Try to understand the toxic
person: What’s happening to them? Why do they treat me this way?
I’ve always found it very helpful to remember a phrase already
mentioned in this book: understanding is alleviating. In many cases,
when we understand the situations that other people are going through,
their life stories, their traumas and problems, we can feel compassion for
them, and in this way relieve ourselves of suffering.
 5. Take a risk and forgive
A resentful heart cannot be happy, and many times forgiveness is the best
cure that exists. If a vehicle carries out a dangerous or aggressive
maneuver, we might think the driver is a lunatic, and start honking and
insulting him—something that won’t give us peace, but will increase our
cortisol levels—or we can see him as someone anxious and unhappy, feel
compassion, and forgive.

6. Keep your “human vitamins” close

These people produce the contrary effect to toxic people in our bodies
and brains. They’re capable of bringing joy to our hearts within seconds.
I recommend keeping good, joyful people within reach, people who have
healthy intentions, who activate and enrich your inner equilibrium.
“Human vitamins” are those people who always seem able to remind us
of the joy of living. We need to spend as much time with them as
possible.

Misery loves company, and bitterness is contagious. If you’re

at a vulnerable point, referring back to a person like that might
sink you and bring out your worst qualities. When you stop
feeling vulnerable around toxic people, you’ll have won an
important battle in the war for happiness.

POSITIVE THOUGHTS
Throughout this book, we’ve been discussing the importance of training your
thoughts. Now let’s look at some concrete guidelines for reining in the cascade
of negative thoughts and stopping or redirecting the torrent of worries that
engulfs us each day.
Enjoying life requires us to be capable of having perspective about its
negative aspects and of knowing how to take pleasure in the little things. Living
in a constant state of high alert, distress, or sadness prevents us from finding the
peace and balance necessary to happiness. The majority of the things that worry
us are an accumulation of “microworries” that, added together, disturb our inner
us are an accumulation of “microworries” that, added together, disturb our inner
world.
To avoid worries, we need to substitute constructive, positive occupations
and ideas for anxious ones. Occupy yourself with plans, hobbies,
people . . . whatever it takes to get out of the toxic cycle in which we all
unconsciously trap ourselves sometimes. I love this saying, attributed to Van
Gogh: “If you hear a voice within you say ‘you cannot paint,’ then by all means
paint, and that voice will be silenced.”
There is an inner voice I like to call the “thought commentator.” This is that
voice that comments on every throw in the game, on your environment, and the
people you encounter. It is intimately related to your personal judgments,
internal criticisms, and frustrations. Teaching this voice helps you to recover
equilibrium. In psychotherapy, I work a lot on this issue: finding a way to slow
down the devastating current of negative thoughts that engulf and block us.

Negative thoughts have a toxic impact, whose effects can last

in the body for several hours. Living stuck in a recurrent toxic
thought is distressing and disrupts the optimal functioning of
the body.

A SIMPLE GUIDE TO WORRYING LESS

The basis for these ideas is the notion that we can restructure the brain and the
automatisms that arise in the mind, blocking you each time you recur to them.
You should be aware that your thoughts are real. They exist. Even though you
can’t touch them or hear them out loud, they have strength and the capacity to
change you.

• Is the thing that’s worrying me significant, or does it lack importance?

Pause for a moment: could it be that my mind is tricking me, magnifying
or distorting this issue? Accept that thoughts don’t always tell the truth.
Sometimes they’re correct, but in many other cases they falsify reality.
• What emotion is coming up for me? Keeping in mind our schema of
 reality, what is my mood today? What’s the possible cause of this dip or
moment of vulnerability? Sleep, drugs, tiredness, external circumstances?
• Observe the impact that every negative thought has on your body. Become
aware of how a toxic or harmful thought can influence you physically
(tachycardia, sweating, headache, gastrointestinal discomfort, muscle
tightness, etc.)
• Don’t automatically translate every thought into words. We are the lords of
our silence and the slaves of our speech. Pause and reflect on what you’re
going to say, and the consequences it will have, before you express
yourself.
• Have I been able to successfully deal with what’s worrying me, or with a
similar issue, at another point in my life? What was the first step for
getting out of the locked groove?
• Don’t assume you know what other people are thinking: “I’m sure that
they think this about me . . .” Your suspicions might be unfounded. Don’t
prejudge.
• Speak kindly to yourself. Say something about yourself that is true and that
helps you to feel more secure.
• Feel the positive emotion, allowing it to bring you a sense of physical well-
being.
• Anchor yourself in the present and focus on your ability to act in the here
and now.
• Have a vision of the future. Decide if this battle is worth waging. Get
perspective. Ask yourself if what seems essential now will have so much
importance in a year.
• Don’t act or respond if you have automatic negative thoughts. Wait and
give yourself a chance. Be capable of changing your language, for
example, by replacing the word “problem” with “challenge,” or “mistake”
with “second chance.” Employ words that exude optimism, like “joy,”
“peace,” “hope,” “trust,” “passion,” or “excitement.”
• Look for the positive in every situation. Every situation can be looked at
from an angle that emphasizes either problems or solutions. Think of
Thomas Edison’s remark, “I have not failed. I’ve just found 10,000 ways
 that won’t work.”
• A little piece of advice for when you’re stuck in a thought loop: Write the
whirlwind of your thoughts down on a piece of paper and refute them. For
example: “My sister-in-law hates me.” Give that thought a reply: “She’s
having a bad day; she’s not usually this hard on me.” You might be
tricking yourself, but in the end, practicing this simple exercise will have
healthy consequences for your body and mind.

Your inner voice should support you, not undermine you. Be

careful not to get in your own way—you may make yourself
fail even before you’ve started.

MEDITATION/MINDFULNESS
In the depths of every human being, there are powerful sources of healing whose
mechanisms are still unknown. I’m referring to healthy introspection,
meditation, and prayer. The mind, thanks to these processes, can act on the body
and restore it. Here I’m going to offer a simple sketch of this discipline.

What Is Mindfulness?
Mindfulness means complete attention to the present moment. It is the art of
intentionally and attentively observing our consciousness. It’s a concept drawn
from Buddhist meditation. The core of mindfulness is attending exclusively to
the here and now.
Practicing it in Western society is no simple matter; it can be truly
counterintuitive, and requires an open mind. It invokes our spiritual dimension
and at times transcends the logic that generally guides our lives. However,
mindfulness is not religion in disguise. At its base, there’s nothing mystical or
magical about it; it’s simply common sense. It only requires a mental
examination, with the aim of discovering what is making your mind ill and what
can cure it. In recent decades, scientific studies on this practice have multiplied
revealing the benefits to body and mind that meditation and mindfulness in
particular can confer.
 The supernatural or spiritual dimension of a human being has an
extraordinary power over both mind and body. Among people who live out their
faith—whatever form it takes—with fidelity and peace, this translates, according
to some studies, into lower stress. This is due to multiple factors, but we can
intuit that having a sense of meaning in one’s life, a supportive community,
goals, and purpose accompanied by prayer or meditation as a mechanism for
grappling with problems and difficulties, contributes to that longed-for sense of
inner peace.
A few years ago I was working in London, in the psychiatry department of
King’s College. I was collaborating with and learning from Professor Andrea
Danese, a researcher who was, at that time, in the midst of investigating the
relationship between meditation and physical health, specifically inflammation. I
remember asking him one day, while eating lunch in the hospital cafeteria, if the
effects were similar across Buddhist meditation, mindfulness, and Christian or
Jewish prayer. His response was clear: yes, as long as the practice is carried out
under conditions of acceptance and surrender. He explained that the problem
with prayer and some meditation techniques is that the individual comes to the
practice requesting, demanding, imploring . . . in short, in a state of anguish,
which, rather than alleviating their distress, creates more of it.
Investing a little time in meditating with complete attention on what our
senses are experiencing in the present moment helps us gain time, increasing the
efficiency of everything we undertake, improving our attention and
concentration, our ability to learn new things, and our creativity. Practicing
mindfulness exercises the brain in the same way that practicing a sport exercises
the muscles.
Prayer adds another fundamental layer. In the case of mindfulness, the key
resides in releasing negative thoughts together with achieving a full awareness of
the senses and the here and now. When a spiritual vision of existence is also
present, as in prayer, faith in a superior being is added to the benefits of
mindfulness, along with an intimate trust that everything that happens to us has
meaning.
The belief system associated with most religions emphasizes caring for
personal relationships, promulgating empathy in an active way, and cultivating
love for others and the capacity to forgive.
Mindfulness and Business
The world of business currently gives enormous importance to mindfulness,
given that it has been demonstrated that the benefit of multitasking is nothing
more than a myth, and that carrying out various activities at a time has an
associated decrease in efficiency. When we undertake various tasks
simultaneously, we invest a lot more time, commit more errors, and struggle
more to remember things related to our work. On the other hand, when we are
totally present and intent on our work, our labor is more efficient, we make more
confident decisions, and we collaborate more effectively with colleagues.
Studies have also been carried out exploring the effectiveness of mindfulness
practice in the world of business. In 1979, working with the medical center of
the University of Massachusetts, the New Yorker Jon Kabat-Zinn developed a
program called Mindfulness-Based Stress Reduction, lasting eight weeks. The
results were conclusive: stress levels had gone down and participants felt they
had more energy at work. Furthermore, they observed that activity in the left
prefrontal area of the brain—which regulates the activation of the amygdala and
stimulates the parasympathetic nervous system—had increased, and participants
presented a greater production of antibodies when exposed to a flu virus than a
control group that hadn’t participated in the mindfulness course.
This practice is playing an ever-greater role in businesses around the world.
The benefits are obvious.

Mindfulness and the Immune System

In recent years, Dr. David S. Black, assistant professor of preventative medicine
at the Keck School of Medicine at the University of Southern California, has
published numerous studies on the health benefits of mindfulness. He carried out
the first exhaustive survey of randomly controlled testing that examined the
effects of mindfulness on five parameters of the immune system: stimulation and
circulation of inflammatory proteins, genetic expression and cellular
transcription factors, quantity of immune cells, the aging of these cells, and
antibody response. His findings suggested interesting effects from mindfulness:
a significant reduction in the specific markers of inflammation (whose harmful
effects we know well!), a high number of CD4 T lymphocytes—these are like
the “generals” of the immune system—and increased telomerase activity,
resulting in an elongation of the telomeres.* These studies are just the beginning,
but the results are encouraging.

Be proactive. Don’t be afraid to believe in the transcendent

meaning of your being and your life. First, learn to breathe
with attention in moments of calm, when you aren’t stressed
or in crisis. Train your mind little by little, gradually. Pay
attention to what’s around you, while also connecting in a
deep way with your essence; you’ll discover a wonderful
world.

OMEGA-3
All of my patients, family members, and random people who happen to cross my
path in life know that I’m an enthusiastic proponent of omega-3 supplements. It
all began a few years ago. I started suffering a severe problem with my gums,
and a dietician friend recommended that I start taking omega-3 every day. Much
to my surprise, after a few weeks, my problems cleared up all at once. I’ve
observed that after periods of intense stress, this discomfort returns, but fish oil
halts its harmful effects.
Ingesting omega-3 is a very healthy way of boosting your mood and
cognitive capacities. Although there are six types of omega-3 fatty acids, only
three of them connect to human physiology: α-Linolenic acid (ALA),
eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). We’ll
concentrate on the last two.
They’re usually referred to as essential fatty acids because they have vital
importance for certain bodily functions and because none of these fatty acids can
be produced autonomously inside the body, which is why it’s necessary to
include them in the diet.
EPA (eicosapentaenoic acid) is the precursor of certain eicosanoids. These
are lipid molecules—fats—that perform certain important anti-inflammatory and
immune functions. This fatty acid can be obtained by ingesting fish (salmon,
immune functions. This fatty acid can be obtained by ingesting fish (salmon,
sardines, tuna, mackerel, herring) and fish oil (cod liver oil). In internal
medicine, this fatty acid is employed as a lipid-lowering medication—it lowers
levels of cholesterol and triglycerides in the blood.
DHA (docosahexaenoic acid) is principally found in fish oil as well, but also
in certain algae, like spirulina. In reality, these algae are its origin point—fish
feed on the algae, and little by little it concentrates inside them, working its way
up the food chain. It’s particularly concentrated in the brain, retinas, and
reproductive cells. Neurons and the gray matter of the brain are composed
mostly of fat, which is why this component is key for their development and
correct functioning. The brain requires an adequate level of DHA for optimal
development. Where this is not the case, we’re faced with a deficit in
neurogenesis and the metabolism of neurotransmitters.

Omega-3 has an important anti-inflammatory function.

Studies carried out by the American nutritional biochemist William E. M.

Lands since 2005 have demonstrated that excess levels of omega-6 in relation to
the omega-3 levels are associated with heart attacks, arthritis, osteoporosis,
depression and mood swings, obesity, and cancer. An excess of omega-6 forms
the basis for multiple pathologies. In 2002, the Greek-born doctor Artemis P.
Simopoulos published evidence that not only is it important to ingest essential
fatty acids, it is even more crucial to maintain a healthy proportion of omega-6
to omega-3. We humans have evolved consuming them in a 1:1 ratio, but in
recent decades, due to the rise in meat consumption and processed foods, this
proportion has risen to 10:1 in Western diets—in the United States it can even
rise to 30:1. It has been demonstrated that diminishing the amount of omega-6
can help to prevent cardiovascular diseases, asthma, rheumatoid arthritis, and
colorectal cancer.
Breast milk contains DHA—as long as the mother has ingested it beforehand
—and it is vital to the neural and cerebral development of nursing babies;
mothers are also advised to ingest this fatty acid during the gestation period. But
DHA isn’t only vital during infancy; studies are beginning to emerge that link
adequate levels of omega-3 to a significant decrease in the likelihood of
developing dementia or Alzheimer’s. Conversely, low DHA levels in old age
developing dementia or Alzheimer’s. Conversely, low DHA levels in old age
have been associated with a rise in the probability of accelerated cognitive
decline. The brain is deeply dependent on this fatty acid, and low levels have
been related to depression, cognitive deterioration, and other disorders. Patients
with memory deficits, after ingesting one gram of DHA daily for six months,
have experienced an improvement in their memories. In addition, patients
diagnosed with Alzheimer’s, after ingesting omega-3 supplements, have
experienced a slower development of the disease. DHA is also pointed to as a
principal source of neuroprotectin, a substance implicated in the survival and
repair of brain cells.
Taking fish oil every day has healthy and beneficial effects at multiple
levels. A positive correlation has even been observed, in a study published in
2010 by Dr. Afshin Farzaneh-Far of the University of Illinois, between high
omega-3 levels and telomere length.
Finally, the benefits of fish oil include an improvement in attentive capacity
and ADHD symptoms. Young people who ingest omega-3 show an
improvement in test scores. Today, the American Psychiatric Association—and
many manuals of mental health—recommend ingesting omega-3 as a
preventative measure to slow or halt the development of certain mental illnesses,
such as schizophrenia, depression, and bipolar disorder; it has also been
recommended as part of their treatment of these illnesses.

I recommend taking one or two grams of omega-3 daily.

There are multiple studies that attest the beneficial effects—
both anti-depressive and anti-inflammatory—of this complex.

* Remember that telomere length acts as a measure of the number of times a cell
can divide, and therefore of our remaining lifespan.
 9

BEST POSSIBLE SELF

To achieve any kind of success or triumph in life, one must begin here, with a
process that might at first seem simple, but which isn’t easy to carry out
correctly.

WHO AM I?
Knowing oneself is the first step in overcoming oneself. To initiate an internal
process of self-overcoming and transformation, I usually follow these three steps
with my patients, and I recommend that you do the same:

1. Know myself
I need to know what I am like. What characterizes me? What do I like the
most about myself, or the least? I always say there are four facets to the
process of gaining self-knowledge:
•What others perceive about me: my image
•What I believe I am: my self-conception
•What I truly am: my essence
•What I show on online platforms: my digital image

2. Understand myself
This means knowing what has led me to respond as I do when faced with
certain situations, understanding my genes, my past, my way of relating
 certain situations, understanding my genes, my past, my way of relating
to others (bosses, friends, employees, partners). Recall your childhood
carefully. Avoid impossible therapies where you end up pitted against
your origins! When you’re conscious of your limitations, barriers, and
fears, and you understand where they come from, you’re making huge
steps forward in your inner work and expanding your capacity to manage
your emotions.

3. Accept myself
Assimilating certain things that are the way they are, and can’t be
modified, whatever I do. It’s important to accept that we have limitations,
make mistakes, and can be wrong. Succeeding in life doesn’t come from
being flawless and making no mistakes, but from learning to make the
most of our abilities and aptitudes.

There’s no reason your flaws should hold you back, as long

as you’re aware of them and know how to balance them out
with your strengths.

Life’s winners are those people who enjoy their work and are really excellent
at something in particular. They’re no different than you, it’s just that they’ve
devoted their time to polishing and refining their abilities and to trying to make
the most of them by focusing on something that they’re good at or that they love.
We don’t all have the luck to work in a field that excites us, but a happy,
successful person, a professional capable of leading the way, loves what they do
and does it well. As an old book says, “Love your work, and grow old in it.”

Talent + Passion = Vocation

If you call to mind people that you deeply admire, it doesn’t matter what
field they work in—they could be athletes, entrepreneurs, journalists, doctors,
spiritual leaders, writers—you’ll notice that all of them are individuals who
picked one thing to concentrate on, and strengthened their abilities in that area. I
don’t mean they can’t play well in many keys, as it were, but they know how to
don’t mean they can’t play well in many keys, as it were, but they know how to
focus on a particular thing that they do better than other people. Any person that
you bring to mind right now—really anyone!—has some degree of inner conflict
and has suffered to get to where they are.
I remember at a conference a few years ago, I met a very famous singer. He
had sold millions of albums and performed at packed concerts all over the world.
Something about him, beyond his music, inspired me and came across when I
met him. I was a real “fangirl,” and I came up to him to ask if I could take a
photo. He was someone who, one to one, showed a surprising amount of warmth
and attention, asking me about my family and my job. When I said I was a
psychiatrist, he told me, “I’ve been in therapy for a long time. I have panic
attacks in crowded places, and sometimes even on stage. It’s my daily struggle. I
hope to overcome it completely one day.”
A world-famous singer who panics in crowded places! I’ve seen concerts of
his on YouTube and in person; I’ve never forgotten that brief conversation, and
it makes me smile to think that, in spite of his debilitating fear, this man
triumphs wherever he appears.

ROGER FEDERER
Federer is a living legend, without a doubt the best and most elegant male
tennis player in history. He’s broken all the records in his sport and has fans
all over the world. In an interview published in July 2013 in the paper Marca,
his interviewer said, “You’ve always had a great serve, a better forehand, an
excellent volley, as well as variety in your slide. Your weak point seems to be
the backhand.”
“I had two options,” Federer replied, “make the most of my strengths or
improve my weaknesses. If I did the second, I would become a more
predictable tennis player. In the end, my virtues are what pays the bills. I can’t
see myself doing what lots of people do and hitting a thousand balls with a
backhand to try and get better.”

So, what is a leader? A leader needs three qualities: a message, the ability to
communicate it, and optimism about the results.
It’s difficult at the moment to find anyone who inspires in this way. The
politicians who occupy the airwaves often don’t know how to communicate, and
normally their messages are ambiguous and calculated, changing according to
the public they’re addressing or want to seduce. “Leaders” like that aren’t worth
anything. The people who make a mark, who can bring the rest of us along with
them, are the ones who radiate coherence, peace, and happiness.

BPS: BEST POSSIBLE SELF

A successful life requires reflection, knowledge, work, effort, a sense of
humor . . . it’s quite a list! I’ve formulated an equation that, to me, expresses
how to achieve your BPS for life.
Your BPS requires, above all, a zest for life! This means that, despite life’s
twists and turns, you always make the effort to be the best that you can. This
obviously can’t be learned in a book—it’s learned by living, enjoying, feeling,
and relishing your life, but above all by falling down and getting up again.
You are the result of your own decisions. You must realize that your
decisions condition your life, and you can’t just let yourself be swept along.

BPS = (Knowledge + Willpower + Life goals) x Passion

I’ve said that you’re the result of your decisions; with enough passion, and
by exerting and strengthening your willpower, you can achieve almost anything
you want. I say “almost” because there’s another factor—you can call it luck,
destiny, or providence—that may not always let you triumph or achieve your
goals, however realistic they are. But first, let’s look at the risks.
It’s like any equation:

• If you’re lacking knowledge . . . there’s nothing more dangerous than a

passionate, motivated fool!
• If you’re lacking willpower . . . you’ll start off full of knowledge and
excitement, but this will fade quickly!
 • If you’re lacking a life goal . . . you’ll be a slave of immediacy, in thrall to
instant gratification!
• If you’re lacking passion . . . you’ll never be a leader, you’ll never shine,
and you’ll spoil the other elements of the formula—plus you won’t enjoy
the benefits of passion that lead to a healthy old age!

KNOWLEDGE
Chance only favors the prepared mind.

—Louis Pasteur

This quotation from the French scientist always encourages me. Later, the writer
Isaac Asimov reiterated this thought, explaining that only he who prepares,
studies, and exerts himself with vigor and will can aspire to success in life.
This idea, applied to the questions that concern us here, possesses enormous
force. Maybe chance—or providence!—will come to meet us, but we won’t be
able to see it or take advantage of it in the right way. Fortune favors the prepared
and educated person, one who has acquired skills and knowledge sufficient to
seize luck when it arrives . . . if it arrives. We are all in possession of a powerful
tool for achieving our goals: Our capacity to study and cultivate ourselves. The
question is, are you ready to learn?
In treatment, we often apply “bibliotherapy.” We recommend books on
psychology and self-improvement at a certain level, to help patients understand
what’s happening to them or provide guidelines for overcoming it; and alongside
these, we recommend novels that suck them in or help them find a way out of
negative thoughts or toxic emotional states.

Avoid the idiot box, hours lost online, and YouTube. Go

outside, exercise, read—these are powerful antidepressants
and anxiolytics.

WILLPOWER
Don’t forget that your best possible self emerges when you focus on your
abilities, working hard on them in an ordered, disciplined, consistent way. You
have to learn to give everything you have, every day of your life . . . according to
the abilities you’ve got.

What Is Willpower?
Willpower is the ability to postpone gratification and reward. A person with
willpower has a long view of life, and is capable of setting concrete goals and
taking risks to achieve them. Willpower requires determination, decision, and
stamina.
The difference between wanting and desiring is rooted in willpower.
Wanting requires making a firm decision. Desire seeks possession or
gratification of the instant variety: food, drink, sex, or some other impulse. It has
a speed component and fulfills a person momentarily but doesn’t enhance them.
On the other hand, “wanting” seeks a further goal, which requires a concrete,
well-designed plan, and putting continual effort in to achieve it. It’s a fuller
process, because it helps us to grow as human beings.
Having a well-trained will is the result of continual personal work sustained
by effort and sacrifice, which transforms us into strong, consistent people,
capable of seeking not what’s easiest, but what is best for each of us. It isn’t
genetic, but acquired; you aren’t born with it, but you can conquer it.
Willpower is determination. It’s choosing a specific direction, having
previously reflected on it, evaluating the pros and cons and proceeding toward
your goal. One of the clearest indicators of a mature personality is having a
strong will. And the reverse is true too: one of the most obvious symptoms of an
immature personality is having a weak, fragile, breakable will, which quickly
abandons the struggle to reach a proposed goal.
This section could be expanded to fill an entire book (and such books do
exist). Order, constancy, perseverance, and effort are the motors that propel any
project or enterprise forward. Without them, however good your ideas are,
they’ll end up getting watered down and losing their force.

Having a well-trained will helps us to move toward the best

version of our life goals.
 version of our life goals.

SETTING GOALS AND OBJECTIVES

Goals are long-term, objectives short-term. Seneca the Younger said, “There is
no favorable wind for the sailor who doesn’t know where to go.” A person who
doesn’t have a plan is at the mercy of the moment. He reacts according to
impulses, emotions, or feelings, all of which—especially in our society—are
extremely malleable.
There are always people who have begun their projects in worse
circumstances than yours, but they’ve gotten where they wanted to go. Don’t be
afraid to change your goals and objectives if it’s necessary to do so for your
physical or mental health, or to improve your relationship with your partner,
family, or friends. The habits and customs that have built up around your way of
being have a huge influence on your life. People make the decision to create true
change during serious crises, whether personal, financial, familial, or medical.
As Dr. Valentín Fuster, cardiologist at Mount Sinai in New York, has aptly said:
“The best way to stop smoking is to have a heart attack.”

Let your heart soar, sketch out a plan of action, and execute
it.

One’s life project emerges from having a focus to hang on to and use for
support. Have a plan, be realistic, and go out and find it. I said at the beginning
of the book that few sentiments have done as much damage as the phrase, “It
will come when you least expect it.” This idea draws us into a passive, waiting
attitude, which is very dangerous—“it” might never come. Don’t be afraid to get
excited, imagine something great, make a plan, and carry it out! Having a plan
carries with it the personal satisfaction of being able to relish the different
achievements or milestones you reach. In those small steps you take lies the root
of true happiness—not in obsessing over a goal! It’s fundamental to know how
to revise your plans according to circumstances, or else you might end up
profoundly frustrated by failure.
PASSION
We should spend more time on what makes
us truly happy.

—Anonymous

Passion doesn’t add—it multiplies. It improves neural connections, fortifies

neurogenesis—the production of new neurons—and lengthens telomeres. We are
created to be happy, transmit that happiness to others, and share the good things
in life. An interesting fact: According to studies carried out at the Mayo Clinic,
life expectancy in pessimists is reduced by up to 19 percent.
What did Pep Guardiola say when he started coaching at Barcelona? “I give
you my word that we’ll try our hardest. I don’t know if we’ll win or lose, but
we’ll try. Fasten your seat belts. We’re gonna have a good time.” And it was
true; for years we—even Real Madrid fans!—got to enjoy some spectacular
football.
Can you learn to be an optimist?
Absolutely, you can. Israeli psychologist Tal Ben-Shahar leads the most
popular course at Harvard University, which teaches you how to be happy. We
can learn to be positive. It’s a slow job, but one that’s full of satisfaction and
opportunities to improve our physical and mental health. Optimism is a way of
holding on to the present moment, even though, as I’ve emphasized over the
course of this book, happiness isn’t what happens to us, but how we interpret
what happens. The people who have gone furthest in life had an optimistic vision
of the world and others and knew how to communicate it to those around them.
An optimist knows how to see their goals, while a pessimist always finds an
excuse not to go after them.

As Murray Butler aptly said, there are three kinds of people in

the world: those who make things happen, those who watch
things happen, and those who never know what happened.
What kind of person are you?
 IT’S NEVER TOO LATE TO START
AGAIN

The Case of Judith, the Porn Star

I met Judith at the end of a lecture on education and resilience I gave at a

college. She came up to speak to me and said, “I’m an actress. I saw online that
you were giving a talk at this college, and I decided to come. I don’t want to
keep living. I can’t do it anymore. I’m going to kill myself.”
I was completely frozen. I don’t know much about film, much less
international cinema (she had a light foreign accent). I asked her name, and just
at that moment, the director of the college came up to present me with a book
published in honor of the institution’s 50th anniversary. I took advantage of the
interruption to look her up on Google. She was a porn actress, with more than a
million online followers!
I turned back to her and asked her about the cause of her sadness. She
explained that her long-time boyfriend—they had known each other since
childhood—had asked her to marry him. She loved him, though she had a few
doubts (“I’m not sure I’m in love . . . or if I’m even capable of falling in love!”),
but she knew she didn’t have a future with him. She told me, “He wants me to
stop acting, and I’m ready to do it, but if we have children . . . you can’t
understand . . . if they looked me up online one day . . . I don’t have a future.”
Very delicately, still standing by the stage where I had given my talk, we
began to touch on the subject of pornography. I referred to it very carefully, to
avoid hurting her, and she noticed what I was doing.
“Thank you for not judging me. I need help . . . What worries me most is not
being able to erase my past, heal my wounds, and begin again.”
I fixed an appointment for early the following morning with her. I spent the
whole night turning the issue over and over in my mind—and then I called an
acquaintance who works in law enforcement to ask what’s required for someone
to change their identity.
The next morning I had all the necessary information. Her mother was
foreign and her father was Spanish, so she had dual nationality. We spoke about
the possibility of changing her name, even though she already used a pseudonym
for her work. We cautiously began to explore her past, discussing how she had
ended up shooting in different countries, occasionally intersecting with the world
of high-end prostitution and drug-dealing. She had many deep wounds that
needed healing.
She slowly revealed more of her life story to me. Very carefully, we dove
into her childhood, her mother’s abandonment of her, her father’s alcoholism
and later suicide. At the age of 10 she suffered sexual abuse at the hands of a
close relative. At 18, then a beautiful adolescent, she began to attract boys. That
was when she met Raúl, her long-time boyfriend. She didn’t want anything
serious, but he declared his undying love for her the first day they met and
promised to wait as long as she needed.
Soon, she was offered work as a model in a foreign country, and she
accepted. She needed money. At night she went partying, and that was where she
entered into contact with the world of drugs and high-end prostitution, both of
which paid very well. She stopped feeling anything. She faked everything. Every
night she wept without tears, lost in an internal void that did nothing but grow.
Raúl, who knew her situation, looked for her and tried to get her out of that
world, but without success. He gave her books and sent her recordings of
lectures, so that she would hear people talk about overcoming pain and trauma.
After a few weeks of therapy, she was much calmer. She was undertaking all
the steps necessary to change her life and appearance. She didn’t have a
the steps necessary to change her life and appearance. She didn’t have a
particularly distinctive face, and with a little bit of effort she was able to alter her
look.
A few months after I met her, she brought Raúl to a session. He was a
profoundly good man, who had always loved her and knew that she had
enormous potential, which had been damaged by the life she was leading.
A few months ago, I received this letter:

Dear Doctor,
I’ve just arrived in my new country. It’s not really new—my mother grew
up a hundred kilometers away from where we’ve set up house. I’ve
started a clothing business, which is going slowly, but I’m very excited
about it. I have my savings, and, if all goes well, we’ll get married next
spring. I’ve found my desire to live again, so thank you for your help!
[ . . . ]
It’s never too late to start again.

P.S. I sent your details to some of the girls I used to work with so that
you can help them too. Don’t tell them where I am.
Yours affectionately,
Judith
 AUTHOR’S NOTE TO THE 10TH
SPANISH EDITION

Dear Reader,

Medicine in general, and psychiatry in particular, are very vocational

professions. Ever since I was a girl, I felt a desire to help others and dedicate my
life to the training that would allow me to do so. The book that you have
between your hands is the result of many years of study, dozens of articles read,
hundreds or perhaps thousands of patients treated with care, common sense, and
a continuous willingness to learn.
The positive reception that has greeted this book gives me special joy. I’m
convinced that every person who has held this book in their hands had one
purpose, whether they were conscious of it or not: to know themselves. “Know
thyself”—this same phrase was written on the temple of Apollo at Delphi, the
epicenter of Greek civilization, and one of the roots of Western civilization.
Understanding ourselves, comprehending why what happens to us happens, is a
titanic undertaking, but it’s also the first step to achieving inner peace and
strengthening our relationship to those around us.
Since the publication of this book, I’ve received many messages from
readers that are pleased with having made progress in the difficult work of
knowing themselves, which has led them to improve their lives. Thanks to this
book and to my readers—thanks to you—I’ve discovered another way of putting
into practice my vocation of helping others.
I hope that this book, more than merely being enjoyable to read, is useful to
you in your life—and may good things happen to you!
 ACKNOWLEDGMENTS

My first thanks, without a doubt, go to Jesús, for his unconditional and untiring
support. Without him I would never have been able to write this book. To
Jesusín, for his endless joy; to Enrique, for bringing out my strength when I was
at my weakest; to Javier, for accompanying me from the first page to the last.
To my father, for being my teacher and guide in the science of the soul.
To my mother, for showing me that with effort and passion, anything can be
achieved.
To Cristina, for her loyalty and companionship throughout my life.
To Isabel, for walking hand in hand with me through the world of emotions
and in this exciting profession of helping others.
To the doctors and professors who have trained me over the years.
To my patients, true teachers, for allowing me to play a part in their lives
during difficult moments and for bringing me joy through their recovery.
To Planeta and Espasa for giving me the opportunity to pour into a book
everything I wanted to communicate.
To Fernando, for his patience in correcting the original text.
Finally, I want to give thanks to Almudena and Quique, united to a higher
power, for watching over me and being by my side every day.
 BIBLIOGRAPHY

Amen, Daniel. Change Your Brain, Change Your Life. St Louis, MO:
Turtleback, 2015.
American Psychiatric Association. DSM-5: Diagnostic and Statistical Manual of
Mental Disorders. Washington, DC: APA Publishing, 2013.
Aron, Elaine. The Highly Sensitive Person. New York: Birch Lane Press, 1996.
Ben-Shahar, Tal. Being Happy: You Don’t Have to Be Perfect to Lead a Richer,
Happier Life. New York: McGraw-Hill, 2010.
Bullmore, Edward. The Inflamed Mind: A Radical New Approach to Depression.
London: Shortbooks, 2018.
Carnegie, Dale. How to Win Friends & Influence People. New York: Simon &
Schuster, 2011.
Carr, Nicholas G. “Is Google Making Us Stupid?” The Atlantic, July-August
2008.
Cyrulnik, Boris. Resilience: How Your Inner Strength Can Set You Free From
the Past. New York: Tarcher, 2011.
Dyer, Wayne. Your Erroneous Zones. New York: HarperPerennial, 2001.
Frankl, Viktor. Man’s Search for Meaning. London: Rider, 2004.
Goleman, Daniel. Emotional Intelligence: Why It Can Matter More Than IQ.
New York: Bantam Books, 1996.
L’Ecuyer, Catherine. The Wonder Approach. London: Robinson, 2019.
Mam, Somaly. The Road of Lost Innocence. London: Virago, 2009.
Pert, Candace. Molecules of Emotion. New York: Scribner, 2012.
Puig, Mario. Reinventing Yourself. Singapore: Marshall Cavendish, 2011.
Rotella, Bob. How Champions Think. New York: Simon & Schuster, 2015.
Seligman, Martin. Learned Optimism: How to Change Your Mind and Your Life.
London: Nicholas Brealey Publishing, 2018.
Sonnenfeld, Alfred. How to Raise an Adult. Scotts Valley, CA: CreateSpace,
2017.
Tolle, Eckhart. Practising the Power of Now. London: Yellow Kite, 2016.
Wiesenthal, Simon. The Sunflower: On the Possibilities and Limits of
Forgiveness. New York: Schocken Books, 1998.
 INDEX

Page numbers listed correspond to the print edition of this book. You can use
your device’s search function to locate particular terms in the text.

A
addiction, 103, 169–71
adenosine triphosphate (ATP), 109
ADHD (attention deficit and hyperactivity disorder), 174, 189
adrenaline, 45, 51, 86, 145
agoraphobia, 157–58
ALA α-Linolenic acid, 188
Alberto (case study), 152–54
alcohol, 103
Alejandra (case study), 73
alert, 48, 50–51, 54, 86, 100, 135, 143, 181
Alzheimer’s disease, 8, 20, 59, 127, 189
ambiguity, 4
Amen, Daniel, 162
American Psychiatric Association, 189–90
amiability, 35–37
amygdala, 38, 43, 84, 86, 177, 186
amygdala hijack, 87–94. See also Guillermo (case study); Gustavo (case study)
analyzing triggers, 88
anger, 128
anti-cytokine pharmaceuticals, 60–61
anti-cytokine pharmaceuticals, 60–61
antidepressants, 60–61
anti-inflammatories applied to depression, 60–61
anti-inflammatory foods, 57
antisocial disorder, 131
Antonio (case study), 156–57
anxiety
and cancer, 142
constant, 49–50
and exercise, 175, 177
for the future, 63–64, 82–86
permanent, 54, 71
and psychosomatic illnesses, 137–38
and serotonin, 58
tools for confronting, 92–94
and worry, 63–64
See also Blanca (case study); John (case study)
anxious-depressive symptoms, 179
ARAS (Ascending Reticular Activating System), 113–20, 123
Aristotle, 3
The Art of Relaxing is Part of the Art of Working (Steinbeck), 164
Ascending Reticular Activating System (ARAS), 113–20, 123
Asimov, Isaac, 195
asking for forgiveness, 89–90
asking for help, 30–31
assertiveness, 33, 69, 146
ATP (adenosine triphosphate), 109
attention
and the brain, 173
on breathing, 92, 158
deficit, 172, 174
and mindfulness, 184–85
and multitasking, 172
neuroplasticity and, 123–24
and our ARAS, 119, 123
 and our ARAS, 119, 123
to surroundings, 119–20
and toxic thoughts, 56
and young people, 173–74
attention deficit and hyperactivity disorder (ADHD), 174, 189
attitude, 39, 112–13, 140–41, 163, 178
authenticity, 26
automatisms, 98, 99, 124, 182

B
bacterial flora, 57–58
basal tears, 135
Batty, David, 141–42
Beatriz and Luis (case study), 131–33
bedside manner, 13
behavioral medicine, 41
behavioral symptoms of depression, 69
behavioral symptoms of toxic cortisol, 54
belief system, 25–26, 39–40, 98–102, 185
Ben-Shahar, Tal, 199
Benson, Herbert, 41–42
benzodiazepines, 108
Best Possible Self (BPS), 102, 118, 146, 194–95, 196
bibliotherapy, 196
biochemical makeup of tears, 136
biochemistry, 103–4, 128–29
Black, David S., 186–87
Blackburn, Elizabeth, 148
Blanca (case study), 85–86
blushing, 135, 136–37
body. See mind-body relationship
body language, 128
borderline personality disorder, 104
brain
and adenosine, 109
and the ascending reticular activating system, 117–18
 and the ascending reticular activating system, 117–18
and attention, 173
and the cingulate system, 162
and cortisol levels, 54
and depression, 59–62
and DHA, 188–89
and emotions, 84, 87, 97
and exposure therapy, 157–58
and fear, 84, 86
and hyperstimulation, 172–73
and intestines, 57–59, 132
and mindfulness, 185–86
and multitasking, 172
and negative thoughts, 182
and neuropeptides, 129
and neuroplasticity, 123–24
and nun study, 127
and our inner equilibrium, 48
and oxytocin, 38
and positive attitude, 113
and remembering agreeable scenes, 41, 43
and remembering important information, 22
and response to threat, 45, 50
reward system, 169–70
and sleep, 108, 112
and stories, 32
and thoughts, 55–56
Brain, Behavior, and Immunity (journal), 59
breast milk, 189
breathing techniques, 92, 158–59
British Medical Journal (journal), 111
bruxism, 53
Buddhism, 77, 184–85
building proper relationships with others, 21–36
Buonarroti, Michelangelo, 70
business and mindfulness, 186

C
caffeine, 109
Cambodia, 8–9, 27, 74–76, 114–16
CaMKII (calmodulin-dependent protein kinase II), 42–43
cancer, 139, 141–45, 147
Carter-Scott, Chérie, 163
Catalina (case study), 65–66
Catholic nuns study, 126–27
CD4 T lymphocytes, 187
cellular behavior, 128–29
cellular division, 147–48
cellular environment, 143
cerebral cortex, 45
cerebral mapping, 97
child prostitution, 8–9, 74–76
children
depression in, 71
in the digital era, 170, 172–74
and guilt, 64–65
and hyperstimulation, 172–74
and stress, 60
and trauma, 8–9
chronic inflammation, 56, 59–62, 144–45
chronic negative emotions, 147
chronic stress
and cancer, 142, 145
physical symptoms of, 137
and rest, 168
symptomatology of, 52–55
and toxic cortisol, 51–55
chronopathy, 138, 164–68
cingulate system, 162
cingulate system, 162
cognitive decline, 189. See also Alzheimer’s disease
cognitive rigidity, 162. See also cingulate system
cognitive symptoms of depression, 69
compassion, 81–82
complexity, 4
concentration, 122–23, 124, 151, 173–74, 176
conflict, 20
constant anxiety, 49–50
contemplating nature, 176
control, 123–24, 154–59
coronary disease, 140–41
cortisol
and cancer, 142–43
and constant anxiety, 49–50
and crying, 136
and emotional memories, 86
and exercise, 112, 175–77
and forgiveness, 180
and friendliness, 36
how to lower, 175–90
introduction to, 46–48
and nutrition, 56–57
and response to threat, 45
and the sympathetic nervous system, 51
and telomerase, 149
and toxic cortisol symptoms, 51–55
and trauma, 48
triggers and attitudes that increase, 151–74
countertransference, 24
C-reactive protein (CRP), 60
criticisms, 31–32
criticisms of others, 31–32
crying, 135–36
Cyrulnik, Boris, 7–10
cytokines, 52, 62, 142
cytokines, 52, 62, 142

D
Dalai Lama, 79, 126
Danese, Andrea, 185
Danner, Deborah D., 126–27
Davidson, Richard J., 126
decision making, 99, 124, 178, 194–95, 196
depression, 68–73
behavioral symptoms of, 69
biochemistry or genetics, 103–4
and cancer, 139, 142
in children, 71
endogenous, 68
and exercise, 175, 177
exogenous, 68
famous sufferers of, 70
and guilt, 65
and inflammation, 59–62
and living in the past, 63–64
and loneliness, 148
neurobiological hypothesis of, 68–69
and nutrition, 57
and permanent anxiety, 54
postpartum, 130
and probiotics, 59
psychological symptoms of, 69
risk factors of, 69–70, 148
and serotonin, 58
social symptoms of, 69
symptomatology of, 69
therapeutic example of, 71–73
treatment of, 60–62, 71
See also Alejandra (case study)
Descartes, René, 167
Descartes, René, 167
desiring, 196
determination, 196–97
diabetes, 61
digestive system, 57–59, 132
digital era, 169–75
disgust, 128
docosahexaenoic acid (DHA), 188–89
dopamine, 38, 52, 55, 68, 169–71, 175
double blow, 9
drugs, 103, 169

E
Ecopsychology (journal), 176–77
education, 173–74
efficiency, 164, 172, 186
eicosapentaenoic acid (EPA), 188
Ekman, Paul, 127–28
EMDR (Eye Movement Desensitization), 80
Emilia (case study), 121–22
Emilio (case study), 134–35
Emotional Intelligence (Goleman), 87
emotional vampires, 18
emotions
and the amygdala, 84, 87
and cancer, 141–45
and crying, 135–36
defined, 125
and the digestive system, 57–58
and emotional intelligence, 174
and empathy, 32
expansive, 28
expression of, 131–33
and living in the past, 64
management of, 82–84, 87–88, 145–47
 and memories, 86–88
molecules of, 128–29
negative, 126, 130, 134, 146–47, 177
and nun study, 126–27
and oxytocin, 38
positive, 126–27, 134, 177, 183
and positive psychology, 125–26
principal, 127–28
and psychosomatic symptoms, 136–40
repressed, 129–30, 134–35, 136–40
and sleep, 108
and stimulation, 111
and thoughts, 97–100
See also fear; guilt
empathy, 14–15, 32–33, 37–38, 81, 106, 135, 185
endocrine system, 49
endogenous depressions, 68
enjoying life, 181
environment and anxiety, 83, 138
environment and exercise, 176–77
Eppinger, B., 172
Ernesto (case study), 105
essential fatty acids, 188–89
European Psychiatric Association, 34
eustress, 54–55, 151
exercise, 112, 175–77
exogenous depressions, 68
expansive emotions, 28
exposure therapy, 157–58
expressing emotions, 131–33. See also Beatriz and Luis (case study)
extreme exercise, 175
extremism, 40
Eye Movement Desensitization (EMDR), 80

F
F
Facebook, 169–70. See also digital era
face to face communication, 174
Facial Action Codification System (FACS), 128
facial expressions, 127–28
failures, 7, 67
faith, 184–85
falling in love, 18
famous sufferers from depression, 70–71
Farzaneh-Far, Afshin, 189
fast food, 57
fear, 82–86, 92–94, 102, 128, 157–58
Federer, Roger, 193–94
feeling too much, 81–82
Fehr, Ernst, 38
Fey, William, 136
first impressions, 20
fish oil, 187–89
focus. See attention
foods, 56–57
forgiveness, 73–81, 88, 89–90, 180, 185
foundations of good relationships, 20–21
Francisco (case study), 166–67
Frankl, Viktor, 39–41
Freud, Sigmund, 130
Friedman, Meyer, 141
friendliness, 35–37. See also Susana (case study)
friendship, 21, 26–27, 33
frustrations, 81, 104, 170–71, 182
functional magnetic resonance, 97
Fuster, Valentín, 197–98
future, 56, 63–64, 82–86, 183

G
Gascón, Pere, 142
Gascón, Pere, 142
generalized anxiety disorder, 86
genes, 103, 128–29
giving, 34, 38
globally toxic, 179–80
goals, 11–12, 40, 102, 117–19, 173, 195, 196–99
Goleman, Daniel, 87
a good cry, 136
good relationships, 19–21, 26–27
gratification, 96, 171, 196
green exercise, 176–77
Greider, Carol W., 148
group therapy, 136
growth system, 48
Guardiola, Pep, 198–99
Guillermo (case study), 87–88
guilt, 64–68. See also Catalina (case study)
Gustavo (case study), 90–92

H
happiness, 1–5
defined, 63
and facial expressions, 128
and having a plan, 198
and love, 18
and passion, 198–99
and positive thoughts, 181
and the present moment, 95–96
and self-esteem, 6
and state of mind, 102–3
study on, 19
and suffering, 7–9, 15
Waldinger study on, 19–20
Harvard University, 199
having a plan, 197–98
healthy romantic love, 18
healthy romantic love, 18
healthy routine, 112
heart attacks, 138, 141, 188
help, asking for, 30–31
helping others, 29. See also giving
Hemingway, Ernest, 70–71
high alert, 48, 50, 54, 181
highly sensitive person (HSP), 104–7. See also Ernesto (case study)
Hill, Edward E., 175–76
hippocampus, 22–23, 43, 54, 84–86, 108, 118, 177
Hiroki Terai, 136
hope, 8–9
hormones, 45, 53, 55, 103–4. See also cortisol; dopamine; oxytocin; serotonin
HSP (highly sensitive person), 104–7. See also Ernesto (case study)
human relations, 19–20
human vitamins, 180–81
humility, 30, 89–90
humor, 28
hyperactivity, 174
hyperconnectivity, 174
hyperstimulation, 171–73
hypothalamus, 45

I
“I Am Myself and My Circumstances” (Ortega y Gasset), 122–23
ideals, 26, 39–40
identifying emotions, 146
illnesses, 52, 59–62, 129, 134, 136–40. See also cancer
imagination, 55–56, 117–18, 143
immature personality, 197
immediacy, 165
immune system
and cancer, 142–43, 145
and chronic inflammation, 56
and constant anxiety, 49
 and constant anxiety, 49
and cortisol, 47
and depression, 61
and digestive system, 58
and lack of sleep, 108
mindfulness and, 186–87
and moderate exercise, 177
and toxic cortisol, 51–52
immunomodulatory pharmaceuticals, 59–61
imposition of views, beliefs, or values, 25–26
individually toxic, 180
inflammation
chronic, 56, 59–62, 144–45
and constant anxiety, 49–50
and cortisol, 47, 142–43
and depression, 59–62
and digestive system, 57–59
and foods, 56–57
and metastasis, 144–45
and mindfulness, 187
and stress, 49–50
and toxic cortisol, 51–53
inner equilibrium, 6, 48, 83, 130, 146–47, 178, 180–81, 182
inner freedom, 39
inner peace, 136, 146, 168, 185
inner strength, 12
inner voice, 93, 168, 181–82
insecurity, 101, 102
insulin, 47, 57
interactions with others, 18–20
intestines, 57–59, 132
involuntary functions, 45, 50, 98, 137
irritable bowel syndrome (IBS), 132
Isen, Alice, 28
isolation, 19, 54
J
Japan, 136
John (case study), 82
John Paul II, 81
Journal of Endocrinological Investigation (journal), 175–76
The Journal of Pain (journal), 13
Judaism, 77
judgments, 23–25, 67–68, 102, 181–82
Judith (case study), 201–3

K
Kabat-Zinn, Jon, 186
Khandaker, Golam, 60–61
A Kiss for All the World, 29
knowing oneself, 191–93
knowledge and our best possible self, 194–96
knowledge of people’s lives, interests, and professions, 23
know yourself, 111, 145–46
Kray, J., 172

L
Lancet (journal), 59
Lands, William E. M., 188–89
last thought of the day, 111
laughter, 28
leaders, 26, 194
Leclercq, Jacques, 167
LeShan, Lawrence, 139
life expectancy, 148, 198
life goals. See goals
likes, 169–70
limitations, acceptance of, 14
limiting beliefs, 98–99, 102
limits on the effect of others, 146
Livius, Titus, 83
Livius, Titus, 83
logotherapy, 41
Lola (case study), 160–61
loneliness, 19–20, 148
Lopizzo, Nicola, 59
Losin, Elizabeth, 13
losing control, 154–59. See also Alberto (case study); Antonio (case study)
love
for another person, 17–18
of ideals and beliefs, 39–40
of memories, 40–43
for others, 18–39
romantic, 18
and suffering, 15
Lucía (case study), 10–11

M
macrophages, 143
making a plan, 33
Mam, Somaly, 114–16
Mamen (case study), 5–6
managing a toxic person, 179–81
manners, 33–34
Marañón, Gregorio, 165
mature personality, 197
Mayo Clinic, 198
Mecklinger, A., 172
Medical Humanities (journal), 28
medication, 13, 73, 90–92, 108, 124, 153–54
meditation, 41, 173–74, 184–87
memories, 20, 39–43, 54, 84–88
memory, 22–23, 108, 189
mental barriers, 98
mental health, 28–29, 103, 125, 176–77, 189–90
mental illnesses, 1, 62, 176, 189–90. See also depression
metastasis, 144–45
Meyer, Jeff, 59
microbiota, 58–59
microworries, 181
mind-body relationship
and amygdala hijack, 89, 92
and anxiety, 83–84
and bacterial flora, 58–59
and body language, 128
and crying, 135
and emotional memories, 86–88
and love for others, 18
and mindfulness, 184–87
and negative thoughts, 182
and psychosomatic symptoms, 136–40
and state of mind, 143–44
and suppressed emotions, 129–30
and thoughts, 55–56
and trauma, 48
mindful breathing, 158–59
mindfulness, 173–74, 184–87
Mindfulness-Based Stress Reduction, 186
mirror neurons, 32
Mock, B., 172
moderate exercise, 175–77
modifying our mental and physical states, 55
Molecular Psychiatry (journal), 60
monoaminergics, 68
mood, 112–13, 176, 187
Moore, Ernest O., 176
Muller, Hermann Joseph, 147
multitasking, 172, 186
muscular pains, 53
muscular stiffness, 53
muscular stiffness, 53

N
Nass, Clifford, 172, 174
nature, 176–77
Nature (journal), 38, 42
negaholics, 162–63
negative emotions, 126, 130, 134, 146–47, 177. See also negaholics; pessimism
negative thoughts, 38, 181–83, 185, 196
nervous system, 50–51, 58, 137, 145. See also parasympathetic nervous system;
sympathetic nervous system
neural connections, 198
neurobiological hypothesis of depression, 68–69
neurogenesis, 118, 188, 198
neurohormonal system, 139, 143
neuroimaging techniques, 97
neuronal connections, 86, 123
Neuron (journal), 38
neurons, 32, 50, 118, 123–24, 188, 198
neuropeptides, 128–29
neuroplasticity, 69, 123
neuroprotectin, 189
neurotic personalities, 65, 134
neurotransmitters, 58, 129, 188
Newton, Isaac, 167–68
Nicomachean Ethics (Aristotle), 3
NSAIDs, 53
nucleus accumbens, 43
nutrition, 56–57, 93

O
objectives, 12, 117, 197–98
obsession, 162
offline education, 174
omega-3, 56–57, 187–90
omega-3, 56–57, 187–90
omega-6, 188–89
oncology, 139. See also cancer
opioid receptors, 128
optimism, 34, 80, 122, 199
Ortega y Gasset, José, 122–23
osmotic system, 47
oxytocin, 32, 36, 37–38, 55

P
pacifying feelings of guilt, 67–68
pain, 13, 14–15, 53, 81–82, 137–38
parasympathetic nervous system, 50–51, 52, 92, 100, 108, 159, 186
Parker, Sean, 169
passion, 118, 194–95, 198–99
perfectionism, 160–62. See also Lola (case study)
permanent anxiety, 54, 71
personality types, 104. See also highly sensitive person (HSP)
personal judgments, 181–82
personal work, 196–97
perspective, 80, 118, 179, 181, 183
Pert, Candace B., 128–29
pessimism, 122, 163, 198–99. See also negative emotions
pharmacological treatments, 60–62
physical health and state of mind, 104
physical symptoms, 53, 69, 89, 137
Pirfano, Íñigo, 29
placebo, 42
Plato, 168
positive emotions, 126–27, 134, 177, 183
positive psychology, 125–26
positive thoughts, 108, 111, 144–45, 181–82
posterior void, 170
postpartum depression, 130
post-tension moments, 12
post-traumatic stress disorder, 80, 86
post-traumatic stress disorder, 80, 86
prayer, 184–85
prefrontal cortex, 173
present moment, 11, 63–64, 67, 100, 124, 183, 184–85, 199. See also attention;
mindfulness
Pretty, Jules, 176
principal emotions, 127–28
prisoners, 176
probiotics, 59
productivity, 28, 164
pro-inflammatory food, 56–57
prosocial emotions or behaviors, 135
protective mode, 100
psychiatry, 4–5
psychological symptoms of depression, 69
psychological symptoms of toxic cortisol, 54
psychoneuroimmunology, 129
psychosomatic illnesses, 136–40. See also Tomás (case study)

Q
quality of social connections, 20

R
rancor, 79–80
reactive depressions, 68
reality, 72, 95–97, 99–100, 102–4, 120–23, 143–44. See also Emilia (case study)
redirecting thoughts and attention, 99, 124, 145, 181–82
reflex tears, 135
relaxation techniques, 41–42, 90–92, 158–59
remembered wellness, 41–43
remembering important information, 22–23
repressed emotions, 129–30, 134–35, 136–40. See also Emilio (case study)
reproductive system, 47
resentment, 77–79, 138. See also forgiveness
resilience, 7–10
resilience, 7–10
responsibility, 64
rest, 94, 108, 109, 111, 165–68. See also Francisco (case study); sleep
returning to site of traumatic event, 48
revenge, 79
risk factors of depression, 69–70, 148
Rizzolatti, Giacomo, 32
The Road of Lost Innocence (Mam), 114
Rockefeller, David, 22
role models, 25–26, 89
romantic love, 18
Rosenman, R. H., 141
rui-katsu therapy, 136
Runge, Friedlieb Ferdinand, 109

S
sadness, 69, 128, 135–36, 165, 170, 181. See also depression
safe space, 42
schema of reality, 72
screens, 110–11, 169–70, 173–74
Seidl, Karl, 77–78
self-absorption, 123
self-control, 12, 173–74
self-esteem, 5, 6, 80, 176, 179. See also Mamen (case study)
self-overcoming, 191–93
Seligman, Martin, 125
Seneca the Younger, 197
senile dementia, 127
serotonin, 58, 175
Shapiro, Francine, 80
shared interests, 26–27
Simopoulos, Artemis P., 188–89
singing, 28–29
Sing Your Heart Out, 28–29
sleep
cycles, 110
 cycles, 110
hygiene, 110–12
and light, 112
sleep onset latency (SOL), 111
and state of mind, 107–10
and toxic cortisol, 54
See also rest
Snowdon, David, 126–27
social connections, 19–20
social context of trauma, 9–10
social networks, 169–70, 174
social skills, 28–29, 33
social symptoms of depression, 69
speaking well of others, 31–32
spiritual dimension of a human being, 184–85
spiritual value of pain, 14
sports, 176
state of mind, 100, 102–13, 147. See also attitude
states of excitement, 118
Steinbeck, John, 164
stimulation, 87–88, 97, 111, 116–17, 123, 171–74
storytelling, 32–33
stress
and cancer, 141
childhood, 60
and constant anxiety, 49–50
and cortisol, 47–48
and eustress, 54–55, 151
and exercise, 175–77
and mindfulness, 186
and sympathetic nervous system, 51
See also chronic stress
stuck in the past, 11, 63, 64, 134
suffering
and avoidance, 96
 and avoidance, 96
and compassion, 81–82
and depression, 69
and forgiveness, 74, 76–77
and happiness, 7–9, 15
and inner strength, 12
meaning of, 14–15
and memories, 40–41
and negaholics, 163
and our belief systems, 102
and perfectionists, 161
and personality types, 104
suicide, 69
The Sunflower: On the Possibilities and Limits of Forgiveness (Wiesenthal), 77–
79
suprarenal glands, 45
surprise, 128
survival instincts, 50–51, 83
Susana (case study), 36–37
sympathetic nervous system, 50–51, 53, 100, 159
symptomatology of chronic stress, 52–55
symptomatology of depression, 69
Szostak, Jack W., 148

T
taking interest in people, 21–23
tears, 135–36
technology, 169–74
telomerase, 148–49, 187
telomeres, 147–49, 187, 189, 198
temporomandibular joint (TMJ), 53
tension, 12, 42, 92, 136, 143, 161–62
thalamus, 45
therapeutic example of depression, 71–73
thoughts
and emotions, 97–100
 and emotions, 97–100
last thought of the day, 111
and mind-body relationship, 55–56, 182
negative, 38, 181–83, 185, 196
and perfectionism, 161
positive, 108, 111, 144–45, 181–82
redirecting, 99, 124, 145, 181–82
and worry, 48, 182–83
thyroid system, 48
time, 12, 164–68
TMJ (temporomandibular joint), 53
Tomás (case study), 139–40
Tonegawa, Susumu, 42–43
toxic cortisol, 51–55
toxic people, 18, 146, 177–81
training thoughts and attention. See redirecting thoughts and attention
transformation, 191–93
trauma, 9–13
and cancer, 145
and forgiveness, 77
and ideals and beliefs, 40
and post-traumatic stress disorder, 80, 86
rebuilding from, 7–8
and relaxation techniques, 42
returning to site of, 48
See also Lucía (case study)
treatment of depression, 60–62, 71
trust, 37–38, 93

U
Ulrich, Roger S., 176
Unamuno, Miguel de, 6
uncertainty, 3–4, 83
unconscious beliefs, 101
understanding, 76, 88, 93, 98, 145–46, 168, 180, 192
understanding, 76, 88, 93, 98, 145–46, 168, 180, 192

V
vagus nerve, 52
values, 2–3, 25–26, 40, 68, 101
Van Gogh, Vincent, 70
vitamins, 56
volatility, 4
VUCA (volatility, uncertainty, complexity, and ambiguity), 4
vulnerability, 12, 30, 81, 83, 94, 103–4, 131

W
Waldinger, Robert, 19, 29, 148
wanting, 196
Warber, Sara, 176–77
warmth, 8
weeping, 136
Weil, Andrew, 159
Wiesenthal, Simon, 77–79
wildlife, 176
willpower, 195, 196–97
World War II, 39, 77–78
worry, 63–64, 111, 181–83
Names and potentially identifying characteristics of the patients described in this book have been changed
or omitted, and most patients are composites.

Copyright © 2018 by Marian Rojas Estapé

Translation copyright © 2021 by Sofia Smith-Laing
Copyright © 2018 by Editorial Planeta, S. A.
Espasa, sello de la Editorial Planeta, S. A.

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Entiende tu cerebro, gestiona tus emociones, mejora tu vida

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