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(Estimation of The Normal Range of Blood Glucose in Rats) - PubMed

The study evaluated the normal range of blood glucose levels in rats. Researchers collected data from nearly 500 rats to analyze factors affecting blood glucose. The average fasting blood glucose was 3.95 mmol/L and the post-prandial level was 5.65 mmol/L, with 95% upper limits of 6.2 mmol/L and 7.9 mmol/L respectively. Testing method, fasting duration, blood source, and time separating serum all significantly impacted results. The study established an expanded normal upper limit of 7.5 mmol/L for fasting blood glucose and 10.4 mmol/L for post-prandial blood glucose in rats.

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102 views2 pages

(Estimation of The Normal Range of Blood Glucose in Rats) - PubMed

The study evaluated the normal range of blood glucose levels in rats. Researchers collected data from nearly 500 rats to analyze factors affecting blood glucose. The average fasting blood glucose was 3.95 mmol/L and the post-prandial level was 5.65 mmol/L, with 95% upper limits of 6.2 mmol/L and 7.9 mmol/L respectively. Testing method, fasting duration, blood source, and time separating serum all significantly impacted results. The study established an expanded normal upper limit of 7.5 mmol/L for fasting blood glucose and 10.4 mmol/L for post-prandial blood glucose in rats.

Uploaded by

83. Monalisa Dewi C. Erang
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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6/15/22, 9:13 PM [Estimation of the normal range of blood glucose in rats] - PubMed

Comparative Study
Wei Sheng Yan Jiu. 2010 Mar;39(2):133-7, 142.

[Estimation of the normal range of blood glucose in


rats]
[Article in
Chinese]
Zhu Wang  1 , Yuexin Yang, Xuesong Xiang, Yuming Zhu, Jianhua Men, Mei He

Affiliations
PMID:
20459020

Abstract
Objective:
To evaluate the distribution and affecting factors of blood glucose in normal rats for the
criterion of hyperglycemia in animal model.

Methods:
The data of fast blood glucose (FBG) and 120 min postprandial blood glucose (PBG) of
nearly 500 Wistar and SD rats from different experiment in our laboratory were collected and
analyzed by multi-variable analysis and optimal scaling regression for the distribution and key
affecting factors of blood glucose. Comparing the blood glucose determined by different method
(glucose oxidase method or glucose monitor with strips), different duration (fasting for 5 h or 11 h),
different blood source (from abdominal aorta or tail), and different time for separating serum after
sampling (at once or till 120 min) was conducted in another 40-100 Wistar rats. A mathematical model
for the contribution of different components was evaluated and combined by parameters of half
width and range.

Results:
The average FBG and PBG of normal Wistar rats was (3.95 +/- 1.31) mmol/L and (5.65 +/-
Results:
The
1.63) mmol/L, and the 95% upper limit was 6.2 mmol/L and 7.9 mmol/L respectively. The differences

https://pubmed.ncbi.nlm.nih.gov/20459020/#:~:text=Results%3A The average FBG and,and 7.9 mmol%2FL respectively. 1/2


6/15/22, 9:13 PM [Estimation of the normal range of blood glucose in rats] - PubMed

of fasting duration, sample source, time before separating serum and testing methods, excepting for
rat species, were significant (P < 0.05). The results showed that the blood glucose tested by glucose
monitor method was not comparable with GOD method while the range of blood glucose was out of
7-11 mmol/L. The difference of blood glucose between fasting for 5h and 11 h was 0.8 mmol/L. Blood
glucose from abdominal aorta was 40% higher than that from tail. The reduction of blood glucose
was 8% in 60 min and over 50% in 120 min after blood being sampled. After the test requirement
being regulated, the upper limit for FBG and PBG was expanded to 7.5 mmol/L and 10.4 mmol/L,
respectively.

Conclusion:
The onset of diabetics in rat is judged as blood glucose being higher than the expanded
normal upper level. The criteria for rats are close to that for human.

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