Top 200 Pharmaceuticals by Retail Sales in 2021

Compiled and Produced by M. Haziq Qureshi from the Njarðarson Group (The University of Arizona)

1 Comirnaty 2 Humira 3 Spikevax 4 Keytruda 5 Eliquis 6 Revlimid 7 Imbruvica 8 Stelara 9 Eylea 10 Biktarvy 11 Opdivo 12 Xarelto 13 REGEN-COV 14 Trulicity 15 Enbrel 16 Darzalex 17 Ozempic 18 Jardiance 19 Prolia 20 Dupixent
(Bictegravir/Emtricitabine/
(COVID-19 Vaccine, mRNA) (Adalimumab) (COVID-19 Vaccine, mRNA) (Pembrolizumab) (Apixaban) (Lenalidomide) (Ibrutinib) (Ustekinumab) (Aflibercept) (Nivolumab) (Rivaroxaban) (Casirivimab/Imdevimab) (Dulaglutide) (Etanercept) (Daratumumab) (Semaglutide) (Empagliflozin) (Denosumab) (Dupilumab)
Tenofovir Alafenamide)

$36.781 Billion $21.874 Billion $17.675 Billion $17.186 Billion $16.732 Billion $12.898 Billion $9.777 Billion $9.54 Billion $9.005 Billion $8.624 Billion $8.431 Billion $7.651 Billion $7.582 Billion $6.757 Billion $6.211 Billion $6.023 Billion $5.875 Billion $5.829 Billion $5.798 Billion $5.779 Billion
Vaccine Immunology Vaccine Oncology Cardiovascular Diseases Oncology Oncology Immunology Ophthalmology Infectious Diseases Oncology Cardiovascular Diseases Infectious Diseases Diabetes Immunology Oncology Diabetes Diabetes Musculoskeletal Dermatology
21 Trikafta 22 Gardasil 23 Xtandi 24 Veklury 25 Ocrevus 26 Ibrance 27 Prevnar 13 28 Tagrisso 29 Insulin Glargine 30 Cosentyx 31 Remicade 32 Entyvio 33 Perjeta 34 Invega Sustenna 35 Vaxzevria 36 Actemra 37 Influenza Vaccines 38 Lucentis 39 Victoza 40 Tecentriq
(Pneumococcal 7-Valent Conju-
(Elexacaftor/Tezacaftor/Ivacaftor) (HPV Quadrivalent Vaccine) (Enzalutamide) (Remdesivir) (Ocrelizumab) (Palbociclib) (Osimertinib) (Insulin Glargine) (Secukinumab) (Infliximab) (Vedolizumab) (Pertuzumab) (Paliperidone Palmitate) (ChAdOx1-SARS-COV-2) (Tocilizumab) (Influenza Vaccine) (Ranibizumab) (Liraglutide) (Atezolizumab)
gate)

$5.697 Billion $5.673 Billion $5.636 Billion $5.565 Billion $5.44 Billion $5.437 Billion $5.272 Billion $5.015 Billion $4.92 Billion $4.718 Billion $4.494 Billion $4.267 Billion $4.256 Billion $4.022 Billion $3.917 Billion $3.833 Billion $3.812 Billion $3.616 Billion $3.575 Billion $3.568 Billion
Genetic Disorders Vaccine Oncology Infectious Diseases Neurology Oncology Vaccine Oncology Diabetes Immunology Immunology Gastrointestinal Disorders Oncology Neurology Vaccine Immunology Vaccine Ophthalmology Diabetes Oncology
41 Entresto 42 Xolair 43 Orencia 44 Herceptin 45 Simponi 46 Lynparza 47 Pomalyst 48 Januvia 49 Avastin 50 Farxiga 51 Hemlibra 52 Immunoglobulin 53 Skyrizi 54 Genvoya 55 Rituxan 56 Gilenya 57 Ofev 58 Symbicort 59 Insulin Aspart 60 Vyvanse
(Elvitegravir/Cobicistat/Emtricitabine/
(Sacubitril/Valsartan) (Omalizumab) (Abatacept) (Trastuzumab) (Golimumab) (Olaparib) (Pomalidomide) (Sitagliptin) (Bevacizumab) (Dapagliflozin) (Emicizumab) (Immunoglobulin) (Risankizumab) Tenofovir Alafenamide)
(Rituximab) (Fingolimod) (Nintedanib) (Budesonide/Formoterol) (Insulin Aspart) (Lisdexamfetamine)

$3.548 Billion $3.518 Billion $3.497 Billion $3.471 Billion $3.467 Billion $3.337 Billion $3.332 Billion $3.324 Billion $3.289 Billion $3.274 Billion $3.252 Billion $3.082 Billion $2.939 Billion $2.879 Billion $2.855 Billion $2.787 Billion $2.743 Billion $2.728 Billion $2.696 Billion $2.652 Billion
Cardiovascular Diseases Immunology Immunology Oncology Immunology Oncology Oncology Diabetes Oncology Diabetes Hematology Immunology Immunology Infectious Diseases Oncology Neurology Respiratory Disorders Respiratory Disorders Diabetes Neurology
61 Triumeq 62 Xeljanz 63 Insulin Lispro 64 Imfinzi 65 Polio/Pertussis/Hib 66 Fumarate 67 Shingrix 68 Zytiga 69 Otezla 70 COVID-19 Antibodies 71 Advate 72 Taltz 73 Aubagio 74 Lenvima 75 MMR Vaccines 76 Kadcyla 77 Tremfya 78 Cimzia 79 Sprycel 80 Prezcobix
(Antihemophilic Factor (Measles, Mumps, Rubella
(Abacavir/Dolutegravir/Lamivudine) (Tofacitinib Citrate) (Insulin Lispro) (Durvalumab) (DTaP - IPV - Hib Vaccine) (Diroximel Fumarate) (Zoster Vaccine) (Abiraterone Acetate) (Apremilast) (Bamlanivimab) (Ixekizumab) (Teriflunomide) (Lenvatinib) (Trastuzumab Emtansine) (Guselkumab) (Certolizumab pegol) (Dasatinib) (Darunavir/Cobicistat)
(Recombinant)) & Varicella Vaccines)

$2.547 Billion $2.455 Billion $2.453 Billion $2.412 Billion $2.377 Billion $2.362 Billion $2.329 Billion $2.297 Billion $2.249 Billion $2.239 Billion $2.229 Billion $2.213 Billion $2.152 Billion $2.149 Billion $2.135 Billion $2.133 Billion $2.127 Billion $2.12 Billion $2.117 Billion $2.083 Billion
Infectious Diseases Immunology Diabetes Oncology Vaccine Neurology Vaccine Oncology Dermatology Infectious Diseases Hematology Immunology Neurology Oncology Vaccine Oncology Immunology Infectious Diseases Oncology Infectious Diseases
81 Tysabri 82 Alimta 83 Tasigna 84 Neulasta 85 Yervoy 86 Promacta 87 Vyndamax 88 Janumet 89 Relvar 90 Spinraza 91 Soliris 92 Tivicay 93 Vimpat 94 Advair 95 Venclexta 96 Opsumit 97 Abilify Maintena 98 Latuda 99 Aranesp 100 Vraylar
(Natalizumab) (Pemetrexed) (Nilotinib) (Pegfilgrastim) (Ipilimumab) (Eltrombopag) (Tafamidis) (Sitagliptin/Metformin) (Fluticasone Furoate) (Nusinersen) (Eculizumab) (Dolutegravir) (Lacosamide) (Salmeterol) (Venetoclax) (Macitentan) (Aripiprazole) (Lurasidone) (Darbepoetin Alfa) (Cariprazine)

$2.063 Billion $2.061 Billion $2.06 Billion $2.027 Billion $2.026 Billion $2.016 Billion $2.015 Billion $1.964 Billion $1.92 Billion $1.905 Billion $1.874 Billion $1.869 Billion $1.851 Billion $1.836 Billion $1.82 Billion $1.819 Billion $1.769 Billion $1.764 Billion $1.756 Billion $1.728 Billion
Neurology Oncology Oncology Hematology Oncology Oncology Rare Disorders Diabetes Respiratory Disorders Genetic Disorders Hematology Infectious Diseases Neurology Respiratory Disorders Oncology Cardiovascular Diseases Neurology Neurology Hematology Neurology
101 Mavyret 102 Jentadueto 103 Spiriva 104 Descovy 105 Tafinlar 106 Rinvoq 107 Lupron 108 Trelegy Ellipta 109 Xifaxan 110 Lovenox 111 Jynarque 112 Jakavi 113 Odefsey 114 Interferon 115 Prograf 116 Nucala 117 Lixiana 118 RotaTeq 119 Juvederm 120 Bridion
(Emtricitabine/ (Fluticasone Furoate/Vilanterol (Emtricitabine/Rilpivirine/
(Glecaprevir/Pibrentasvir) (Linagliptin/Metformin) (Tiotropium) (Dabrafenib/Trametinib) (Upadacitinib) (Leuprolide) (Rifaximin) (Enoxaparin) (Tolvaptan) (Ruxolitinib) (Interferon Beta-1a) (Tacrolimus) (Mepolizumab) (Edoxaban) (Rotavirus Vaccine) (Hyaluronic Acid) (Sugammadex)
Tenofovir Alafenamide) Trifenatate/Umeclidinium) Tenofovir Alafenamide)

$1.71 Billion $1.709 Billion $1.704 Billion $1.7 Billion $1.693 Billion $1.651 Billion $1.648 Billion $1.647 Billion $1.645 Billion $1.636 Billion $1.624 Billion $1.595 Billion $1.568 Billion $1.566 Billion $1.566 Billion $1.545 Billion $1.545 Billion $1.539 Billion $1.535 Billion $1.532 Billion
Infectious Diseases Diabetes Respiratory Disorders Infectious Diseases Oncology Immunology Oncology Respiratory Disorders Infectious Diseases Hematology Cardiovascular Diseases Oncology Infectious Diseases Neurology Immunology Respiratory Disorders Hematology Vaccine Dermatology Neurology

121II Insulin Degludec 122 Brilinta 123 Epclusa 124 Alecensa 125 Rexulti 126 Pradaxa 127 NovoMix 128 Infanrix 129 Abraxane 130 Myrbetriq 131 Sandostatin 132IIIActivase/TNKase 133 Human Insulins 134 Afinitor 135 Zolgensma 136 Verzenio 137 Nexium 138 Somatuline 139 Xevudy 140 Erleada
(Diphtheria, Tetanus Acellular,
(Insulin Degludec) (Ticagrelor) (Sofosbuvir/Velpatasvir) (Alectinib) (Brexpiprazole) (Dabigatran Etexilate) (Biphasic Insulin Aspart) (Paclitaxel Protein Bound) (Mirabegron) (Octreotide) (Alteplase/Tenecteplase) (Human Insulin) (Everolimus) (onasemnogene abeparvovec-xioi) (Abemaciclib) (Esomeprazole) (Lanreotide) (Sotrovimab) (Apalutamide)
& Pertussis)

$1.483 Billion $1.472 Billion $1.462 Billion $1.459 Billion $1.457 Billion $1.451 Billion $1.447 Billion $1.44 Billion $1.423 Billion $1.42 Billion $1.413 Billion $1.412 Billion $1.38 Billion $1.369 Billion $1.351 Billion $1.35 Billion $1.326 Billion $1.324 Billion $1.296 Billion $1.291 Billion
Diabetes Cardiovascular Diseases Infectious Diseases Oncology Neurology Hematology Diabetes Vaccine Oncology Nephrology Oncology Cardiovascular Diseases Diabetes Oncology Neurology Oncology Gastrointestinal Disorders Oncology Infectious Diseases Oncology

141 Restasis 142 Mirena 143 Xyrem 144 Fasenra 145 Bexsero 146 Calquence 147 Uptravi 148IIInsulin Isophane 149 Trintellix 150 Creon 151 Benlysta 152 Kyprolis 153 Mvasi 154 Repatha 155 Crestor 156 Esbriet 157 Olumiant 158 Myozyme 159 NovoSeven 160 Linzess
(Cyclosporine) (Levonorgestrel) (Sodium Oxybate) (Benralizumab) (Meningococcal Vaccine) (Acalabrutinib) (Selexipag) (Insulin Isophane) (Vortioxetine) (Pancrelipase) (Belimumab) (Carfilzomib) (Bevacizumab-awwb) (Evolocumab) (Rosuvastatin) (Pirfenidone) (Baricitinib) (Alglucosidase Alfa) (Coagulation Factor VIIa) (Linaclotide)

$1.29 Billion $1.288 Billion $1.266 Billion $1.258 Billion $1.248 Billion $1.238 Billion $1.237 Billion $1.223 Billion $1.207 Billion $1.191 Billion $1.183 Billion $1.177 Billion $1.166 Billion $1.165 Billion $1.158 Billion $1.154 Billion $1.115 Billion $1.104 Billion $1.101 Billion $1.096 Billion
Immunology Urology Sleep Respiratory Disorders Vaccine Oncology Cardiovascular Diseases Diabetes Neurology Rare Disorders Rare Disorders Oncology Oncology Cardiovascular Diseases Cardiovascular Diseases Immunology Immunology Rare Disorders Hematology Gastrointestinal Disorders
161 Galvus Group 162 Nplate 163 Vectibix 164 Ingrezza 165 Keppra 166 Dovato 167 Adempas 168 Ilaris 169 Cyramza 170 Gleevec 171 Plavix 172 Nexgard 173 Copaxone 174 Inlyta 175 Epogen 176 Edurant 177 Ventolin 178 Pulmicort 179 Insulin Glulisine 180 Molnupiravir
(Vildagliptin) (Romiplostim) (Panitumumab) (Valbenazine) (Levetiracetam) (Dolutegravir/Lamivudine) (Riociguat) (Canakinumab) (Ramucirumab) (Imatinib) (Clopidogrel) (Afoxolaner) (Glatiramer acetate) (Axitinib) (Epoetin Alfa) (Rilpivirine) (Albuterol) (Budesonide) (Insulin Glulisine) (Molnupiravir)

$1.092 Billion $1.089 Billion $1.082 Billion $1.082 Billion $1.068 Billion $1.065 Billion $1.065 Billion $1.059 Billion $1.033 Billion $1.024 Billion $1.023 Billion $1.009 Billion $1.005 Billion $1.002 Billion $1 Billion $994 Million $972 Million $970 Million $966 Million $952 Million
Diabetes Immunology Oncology Neurology Neurology Infectious Diseases Cardiovascular Diseases Rare Disorders Oncology Oncology Cardiovascular Diseases Infectious Diseases Neurology Oncology Hematology Infectious Diseases Respiratory Disorders Respiratory Disorders Diabetes Infectious Diseases
181 Seloken 182 Zoladex 183 Kisqali 184 Fabrazyme 185 Velcade 186 Vemlidy 187 Vasostrict 188 Exforge Group 189 Pneumovax 23 190 Insulin Detemir 191 Adalat 192 Takhzyro 193 Takecab 194 YAZ 195 Austedo 196 Forteo 197 Evenity 198 Cialis 199 Diovan Group 200 Orkambi
(Pneumococcal Vaccine
(Metoprolol) (Goserelin) (Ribociclib) (Agalsidase Beta) (Bortezomib) (Tenofovir Disoproxil) (Vasopressin) (Amlodipine/Valsartan) (Insulin Detemir) (Nifedipine) (Lanadelumab-flyo) (Vonoprazan) (Drospirenone/Ethinyl Estradiol) (Deutetrabenazine) (Teriparatide) (Romosozumab-aqqg) (Tadalafil) (Hydrochlorothiazide/Valsartan) (Lumacaftor/Ivacaftor)
Polyvalent)

$951 Million $948 Million $937 Million $929 Million $925 Million $925 Million $902 Million $901 Million $893 Million $865 Million $840 Million $838 Million $837 Million $815 Million $802 Million $802 Million $776 Million $774 Million $773 Million $772 Million
Cardiovascular Diseases Oncology Oncology Rare Disorders Oncology Infectious Diseases Nephrology Cardiovascular Diseases Vaccine Diabetes Cardiovascular Diseases Genetic Disorders Gastrointestinal Disorders Urology Neurology Musculoskeletal Musculoskeletal Urology Cardiovascular Diseases Respiratory Disorders

Key Oncology CNS & Anesthesia Diabetes Cardiovascular Diseases Infectious Diseases Respiratory Disorders Immunology Miscellanious