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Quetiapine - Drug Study

Quetiapine (brand name Seroquel) is an antipsychotic drug used to treat schizophrenia, bipolar disorder, and dementia-related psychosis. It works by modulating dopamine and serotonin receptor activity in the brain. Common side effects include sedation, dry mouth, dizziness, and constipation. Care must be taken in elderly patients due to risks of dehydration, overheating, and diabetes. Dosage is variable depending on the condition being treated. Quetiapine interacts with several other drugs that can increase or decrease its metabolism and effects. Close monitoring of patients is important when using this medication.

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Jeran Henrich Busobuso
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166 views3 pages

Quetiapine - Drug Study

Quetiapine (brand name Seroquel) is an antipsychotic drug used to treat schizophrenia, bipolar disorder, and dementia-related psychosis. It works by modulating dopamine and serotonin receptor activity in the brain. Common side effects include sedation, dry mouth, dizziness, and constipation. Care must be taken in elderly patients due to risks of dehydration, overheating, and diabetes. Dosage is variable depending on the condition being treated. Quetiapine interacts with several other drugs that can increase or decrease its metabolism and effects. Close monitoring of patients is important when using this medication.

Uploaded by

Jeran Henrich Busobuso
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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Generic Name Quetiapine

Brand Name Seroquel

Classification Antibacterial, Fluoroquinolone

Mode of Action Quetiapine was used to treat seven elderly hospitalized


patients between 61 and 72 years of age who manifested
signs of psychosis related to schizophrenia, schizoaffective
disorder, or bipolar disorder

Dosage Not approved for dementia-related psychosis, because of


increased risk of cardiovascular or infectious-related deaths
Schizophrenia, Bipolar Disorder

Immediate release: 50-200 mg/day PO; may be increased


by 25-50 mg/day

Extended-release: 50 mg/day PO; may be increased by 50


mg/day

Psychosis, Agitation Related to Alzheimer’s Dementia (Off-


label)

12.5-50 mg/day PO initially; may be gradually increased as


tolerated; not to exceed 200-300 mg/day

Side Effects None known.


Adverse Effects Hypervitaminosis, chronic overdose produces malaise,
nausea, vomiting, drying or cracking of the skin or lips,
inflammation of tongue or gums, irritability, alopecia, night
sweats, bulging fontanelles in infants.
Indication  For the acute treatment of mania and maintenance
therapy following stabilization
 For Schizophrenia

Contraindication  Hypersensitivity, Hypokalemia, Hypomagnesemia,


Congenital QT prolongation, Arrhythmia hx

Drug Interaction  BARBITURATES, carbamazepine, phenytoin, rifampin, and


thioridazine may increase the clearance of quetiapine.
Quetiapine may potentiate the cognitive and motor effects
of alcohol, enhance the effects of ANTIHYPERTENSIVE
AGENTS, and antagonize the effects
of levodopa and DOPAMINE
AGONISTS. Ketoconazole, itraconazole, fluconazole, and
erythromycin may decrease the clearance of
quetiapine. Herbal: St. John's wort may
cause serotonin syndrome (headache, dizziness, sweating,
agitation).
Nursing Intervention  WARNING: Administer small quantities to any patient
with suicidal ideation.
 Monitor elderly patients for dehydration and institute
remedial measures promptly; sedation and
decreased sensation of thirst related to CNS effects
of drug can lead to severe dehydration.
 Monitor the patient closely in any setting that would
promote overheating.
 Regularly monitor patients for signs and symptoms of
patients diabetes mellitus.
 Consult physician about dosage reduction and use
of anticholinergic antiparkinsonians (controversial)
if extrapyramidal effects occur.
REFERENCES:
Kim ka, Joo Hj, Lee HM, Park JY (2018). Genetic polymorphisms on the
pharmacokinetics of quetiapine in healthy volunteers. Pharmacogenet Genomics.
Walder A, Greil W, Baumann P. (2017) Drug-induced Pisa syndrome under quetiapine.
Andrés PM, Vidal Formoso M. Priapism. (2017). Associated with quetiapine in an
elderly patient. 

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