MULTIPLE CHOICE QUESTIONS
1. Which of the following drugs can be administered by subcutaneous route?
(a) Albuterol
(b) Terbutaline
(c) Metaproterenol
(d) Pirbuterol
2. Mechanism of acion of theophylline in bronchial asthma
(a) Phosphodiesterase 4 inhibition
(b) Beta2 agontsm
(c) Anticholinergic action
(d) Inhibition of mucociliary clearance
3. To prevent exercise induced bronchial asthma drug used is:
(a) Sodium cromoglycate
(b) Ipratropium bromide
(c) Terbutaline
(d) Epinephrine
4. Which of the following drugs has been found to be useful in acute severe
asthma?
(a) Magnesium Sulphate (Recent NEE T Pattern Question)
(b) Anti-leukotrine
(c) Cromolyn Sodium
(d) Cyclosporine
5. Leukotriene receptor antagonist used for bronchial asthma is:
(a) Zafirlukast
(b) Zileuton
(c) Cromolyn sodium
(d) Aminophylline
6. Which enzyme is inhibited by aminophylline?
(a) Monoamine oxidase
(b) Alcohol dehydrogenase
(c) Phosphodiesterase
(d) Cytochrome P 450
7. With which of the following receptors theophylline has an antagonistic
interaction?
(a) Elistamine receptors
(b) Brady kinin receptors
(c) Adenosine receptors
(d) Imidazoline receptors
8. All of the following statements about theophylline are correct except:
(a) Increase in dose is required in cardiopulmonary disease
(b) Increases cAMP
(c) Increase in dose is required in smokers
(d) Inhibits phosphodiesterase
9. The loading dose of aminophylline is;
(a) 50-75 mg/kg
(b) 0.5-1 mg/kg
(c) 2-3.5 mg/ kg
(d) 5-6 mg/kg
10. Which of the following is NOT an adverse effect of salbutamol?
(a) Tachycardia
(b) Tolerance
(c) lypokalemia
(d) Hypoglycemia
11. Inhibition of 5-lipoxygenase is useful in:
(a) Cardiac failure
(b) Bronchial asthma
(c) Hepatic failure
(d) Arthritis
12. The drug not used in acute asthma is:
(a) Salbutamol
(b) Ipratropium
(c) Montelukast
(d) Hydrocortisone
13. Inflammation in the airways can be reduced by:
(a) Fluticasone
(b) Budesonide
(c) Theophylline
(d) Salbutamol
(e) Ipratropium
14. True about zafirlukast is:
(a) It inhibits lipooxygenase pathway
(b) It decreases the frequency of asthma attacks as compared to glucocorticoids
(c) It blocks LT receptor
(d) It is effective in acute bronchial asthma
(e) It can be administered orally
15. Drugs which increase level of theophylline include:
(a) Ciprofloxacin
(b) Barbtturates
(c) Cimetidine
(d) Allopurinol
(e) Phenytoin
16. The following drug is NOT useful during acute attack of bronchial asthma:
(a) Salbutamol
(b) lydrocorttsone
(c) Cromolyn sodium
(d) Theophylline
17. All of the following drugs useful in bronchial asthma are bronchodilators except:
(a) Theophylline
(b) Salmeterol
(c) Beclomethasone
(d) Ipratropium
18. All of the following are the adverse effects seen with the use of salbutamol
except:
(a) Tremors
(b) Palpitation
(c) Hypotension
(d) Hypokalemia
19. Which of the following is a bronchodilator?
(a) Corticosteroids
(b) Salmeterol
(c) Ketotifen
(d) Sodium cromoglycate
20. The drug that does not result in theophylline toxicity is:
(a) Ciprofloxacin
(b) Amoxicillin
(c) Erythromycln
(d) Cimetidine
21. All of the following drugs can precipitate acute attack of asthma except:
(a) Phenylbutazone
(b) Naproxen
(c) Glucocorticoids
(d) Aspirin
22. Ipratropium bromide used in bronchial asthma, is:
(a) β-Sympathomimetics
(b) .Methylxanthines
(c) Anticholinergics
(d) Mast cell stabilizers
23. Which of the following is long acting sympathomimetics used in bronchial
asthma?
(a) Salbutamol
(b) Terbutaline
(c) Bambuterol
(d) Salmeterol
24. Dextromethorphan is an:
(a) Antihtstarrunic
(b) Antitussive
(c) Expectorant
(d) Annallergic
25. Disodium cromoglycate is used by which of the following routes?
(a) Inhalation
(b) Oral
(c) IV
(d) IM
26. Which is a "Soft steroid" used in bronchial asthma?
(a) Budesonide
(b) Dexamethasone
(c) Ciclesonide
(d) Flunisolide
27. Omalizumab is administered in bronchial asthma by which route?
(a) Oral
(b) Intravenous
(c) Sulxutaneous
(d) Aerosol
28. Directly acting cough suppressant is:
(a) Dextromethorphan
(b) Bromhexjne
(c) Actyl cysteine
(d) Carbapentate
29. In a patient of chronic asthma on treatment with theophyline, which of the
following should not be used to treat his upper respiratory tract infection?
(a) Ampicillin
(b) Cephalexin
(c) Erythromycin
(d) All
30. Which of the following inhibits theophylline metabolism?
(a) INH
(b) Griseofulvin
(c) Prednisolone
(d) Ciprofloxacin
31. Longest acting β-agonist is:
(a) Salbutamol
(b) Terbutaline
(c) Salmeterol
(d) Theophylline
32. Common complication of aerosol steroids use include:
(a) Oral candidiasis
(b) Cushing's syndrome
(c) Decreased
(d) Systemic complications
33. The following drug is contraindicated in bronchial asthma:
(a) Propanolol
(a) Ipratropium bromide
(b) Theophylline
(c) Ketotifen
34. Release of histamine and leukotrienes from mast cells is prevented by:
(a) Zileuton
(b) Nedocrornil sodium
(c) Zaiirlukast
(d) Fexofenadine
35. Advantage of salmeterol over salbutamol is its:
(a) Shorter duration of action
(b) More potency
(c) la»nger duration of action
(d) Lesser cardiac effects
36. Interaction of theophylline with ciprofloxacin is:
(a) Ciprofloxacin increases theophylline metabolism
(b) Ciprofloxacin decreases theophylline metabolism
(c) Theophylline increases ciprofloxacin metabolism
(d) Theophylline decreases ciprofloxacin metabolism
37. Theophylline overdose causes:
(a) Bradycardia
(b) Seizures
(c) Drowsiness
(d) Bronchospasm
38. Therapeutic blood range of theophylline in microgram per mililitre is:
(a) 0-5
(b) 5-10
(c) 5-15
(d) 5-20
39. In theophylline metabolism, drug interactions occurs with all except:
(a) Cimetidine
(b) Phenobarbitone
(c) Rifamipine
(d) Tetracyclines
40. Mechanism of action of theophylline in bronchial asthma include all of the
following except:
(a) Phosphodiesterase inhibition
(b) Adenosine receptor antagonism
(c) Increased histone deacetylation
(d) Beta -2 rcceptor stimulation
41. Which of the following is a long acting beta 2 agonist?
(a) Salmeterol
(b) Orciprenaiine
(c) Penoterol
(d) Pexbaterol
42. Efficacy of salmeterol is increased if it is given along with:
(a) Theophylline
(b) Corticosteroid
(c) Ipratropium
(d) Sodium cromoglycate
43. Omalizumab is indicated for which of the following conditions:
(a) Multiple myeloma
(b) Psoriasis
(c) Bronchial asthma
(d) Rheumatoid arthritis
44. Most common dose related side effects of salbutamol is:
(a) Nervousness
(b) Palpitations
(c) Restlessness
(d) Tremors
45. Which of the following is a long acting beta 2 agonist?
(a) Salbutamol
(b) Salmeterol
(c) Terbutaline
(d) Levalbuterol
46. Mechanism of actions of montelukast is:
(a) Competitive antagonist of leukotriene receptors
(b) Inhibits alpha receptor
(c) Beta agonist
(d) Non-competitive inhibitor of leukotriene synthesis
47. Mechanism of action of zileuton is:
(a) Inhibits production of IgE
(b) Inhibits Lipoxygenase
(c) Inhibits Cyclooxygenase
(d) Inhibits activity of mast cells
48. Which of the following does not have a role in acute attack of asthma?
(a) Cromolyn sodium
(b) Ipratropium
(c) Steroids
(d) Salbutamol
49. Which of the following is not a bronchodilator?
(a) Beta 2 agonists
(b) Methylaxanthines
(c) Steroids
(d) Anticholinergic
50. Drug of choice for treatment of acute asthmatic attacks is:
(a) Leukotriene antagonists
(b) Lipoxygenase inhibitors
(c) Beta 2 agonists
(d) Anticholinergics
51. Which of the following class of drugs is a precipitant of acute asthma?
(a) Beta-adrenergic receptor agonists
(b) NSAlDs
(c) Calcium channel blockers
(d) blockers
52. Adverse effects of salmeterol include:
(a) Hyperkalemia
(b) Seizures
(c) Tremors
(d) Interstitial nephritis
53. A 34-year-old man with a long history of asthma is referred to pulmonologist.
The physician decides to prescribe zileuton. The mechanism of action of this
drug is to:
(a) Antagonize leukotriene D4 receptor
(b) Inhibits 5-lipoxygenase
(c) Inhibit phosphodiesterases
(d) Stimulate beta2 receptors
54. Select the correct statement regarding use of inhaled glucocorticoids in bronchial
asthma :
(a) They are used for acute attacks of asthma
(b) They have high systemic activity
(c) They are superior to agonists in symptom control
(d) Oral candidiasis can occur as a side effect
55. Which of the following drug is not used in the treatment of bronchial asthma?
(a) β2 agonists
(b) Corticosteroids
(c) Cholinesterase inhibitors
(d) Phosphodiesterase inhibitors
56. All of the following are useful in the management of acute asthma except:
(a) Hydrocortisone intravenously
(b) Salbutamol inhalation
(c) Salmeterol inhalation
(d) Terbutaline inhalation
57. Which of the following drugs prevents the release of leukotrienes and histamine
from mast cells?
(a) Lileuton
(b) Fexofenadine
(c) Nedocromil
(d) Tiotropium
58. Which of the following is a long acting B2 selective agonist?
(a) Formoterol
(b) Isoprenaline
(c) Salbutamol
(d) Ephedrine
59. In bronchial asthma the mechanism of action of corticosteroids is:
(a) Relax airway smooth muscle directly
(b) Inhibits mast cell deregulation
(c) Inhibits adenosine receptors
(d) Inhibits lymphocytic eosinophilic mucosal inflammation
60. Leukotrienes inhibitors are very effective in which one of the following
conditions:
(a) Exercise induced asthma
(b) Antigen induced asthma
(c) Aspirin induced asthma
(d) Occupational asthma
61. Inhaled sodium cromoglycate:
(a) Prevents the antigen antibody combination
(b) May cause cardiac arrhythmias
(c) Is of benefit in preventing exercise induced bronchial spasm
(d) Is effective in alleviating an acute episode of allergic asthma
62. Most common side effect of inhalational beclomethasone is:
(a) Adrenal suppression
(b) Oropharyngeal candidiasis
(c) Bronchoconstriction
(d) Hepatitis
63. Efficacy of inhaled steroids is maximum when particle size is:
(a) 1-5 µrn
(b) 5-10 µrn
(c) 10-15 µrn
(d) 15-20 µrn
64. Zileuton is:
(a) 5 lipooxygenase inhibitor
(b) TX A, inhibitor
(c) Leukotriene receptor antagonist
(d) Prostaglandin synthesis inhibitor
