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Drug Study Metronidazole

Metronidazole is an antibiotic, amebicide, and antiprotozoal drug used to treat anaerobic bacterial infections and amebiasis. It works by undergoing intracellular chemical reduction during anaerobic metabolism which damages bacterial DNA and inhibits nucleic acid synthesis, causing cell death. It is contraindicated in breastfeeding, hypersensitivity, and early pregnancy. Common side effects include gastrointestinal issues, neurological effects, and skin irritation. Nurses should monitor for adverse reactions and interactions, especially in patients with liver disease, and ensure proper administration such as slow IV infusion.

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4K views2 pages

Drug Study Metronidazole

Metronidazole is an antibiotic, amebicide, and antiprotozoal drug used to treat anaerobic bacterial infections and amebiasis. It works by undergoing intracellular chemical reduction during anaerobic metabolism which damages bacterial DNA and inhibits nucleic acid synthesis, causing cell death. It is contraindicated in breastfeeding, hypersensitivity, and early pregnancy. Common side effects include gastrointestinal issues, neurological effects, and skin irritation. Nurses should monitor for adverse reactions and interactions, especially in patients with liver disease, and ensure proper administration such as slow IV infusion.

Uploaded by

Jha Net
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Reno Jun M.

Nagasan , BSN-3J , Group 33 Name of Drug (Generic & Brand Names) Metronidazole (Brand Name: Anerobizol) Indications, Route, & Dosage >To treat systemic anaerobic infections caused by Bacteroides fragilis, Clostidium difficile, Clostridium perfingens, Eubacterium, Fusobacterium, Peptococcus, Peptostreptococcus, and Veillonella sp. Capsules, Tablets Children. 7.5 mg/kg q 6hr or 10 mg/kg q 8 hr >To treat amebiasis (Entamoeba histolytica) Capsules, Tablets Children. 11.6 to 16/7 mg/kg t.i.d. for 10 days

University of San Carlos, Cebu City

Classifications

Mechanism of Action Undergoes intracellular chemical reduction during anaerobic metabolism. After metronidazole is reduced, it damages DNA s helical structure and breaks its strands, which inhibits bacterial nucleic acid synthesis and causes cell death,

Contraindications Breast-feeding, hypersensitivity to metronidazole or its components, trichomoniasis during first trimester of pregnancy

Side & Adverse Effects CNS: Ataxia, dizziness, encephalopathy, fever, headache, lightheadedness, peripheral neuropathy, seizures (high doses) EENT: Dry mouth, lacrimation (topical form), metallic taste, pharyngitis GI: Abdominal cramps or pain, anorexia, diarrhea, nausea, pancreatitis, vomiting GU: Darkened urine, vaginal candidiasis (oral, parenteral, and topical forms); burning or irritation of sexual partener s penis, candidal cervicitis or vaginitis, dysuria, urinary frequency, vulvitis (vaginal form) HEME: Leukopenia MS: Back pain SKIN: burning sensation, stinging sensation, dry skin (topical form); erythema, pruritus, rash, urticaria (oral and parenteral forms) OTHER: injection site edema, pain, or, tenderness.

Nursing Responsibilities y If pt has adverse CNS reactions, such as seizures or peripheral neuropathy, tell prescriber and stop drug immediately. Monitor pt with severe liver disease because slowed metronidazole metabolism may cause drug to accumulate in the body and increase the risk of adverse effects. If skin irritation occurs, apply topical gel less frequently or discontinue it, as ordered. Monitor CBC and culture and sensitivity test if therapy lasts longer than 10 days or if second course of treatment is needed Give IV drug by slow infusion over 1 hr; don t give by direct IN injection

Antibiotic Amebicide Antiprotozoal

Reno Jun M. Nagasan , BSN-3J , Group 33

University of San Carlos, Cebu City

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