ISSN (Online) 2581-9429

IJARSCT
International Journal of Advanced Research in Science, Communication and Technology (IJARSCT)

Volume 3, Issue 2, March 2023

Impact Factor: 7.301

Role of Medicinal Plant in the Management of

Asthama
Omkar Dilip Bobade1, Shankar Ashok Dhage2, Nitin B. Kohale3, Suraj B. Rathod4
Students1,2, Principal2 and Assistant Professor4
Vardhman College of Pharmacy, Koli, Karanja (Lad), Washim, Maharashtra, India
[email protected]

Abstract: Asthma is a common disease that is rising in prevalence worldwide with the highest prevalence
in industrialized countries. Asthma affect about 300 million people worldwide and it has been estimated
that a further 100 million will be affected by 2025. Since the ancient times, plants have been exemplary
sources of medicine. Current asthma therapy lack satisfactory success due to adverse effect, hence patients
are seeking complementary and alternative medicine to treat their asthma. Ayurveda and other Indian
literature mention the use of plants in various human ailments. India has about 45,000 plant species and
among them several thousand are claimed to possess medicinal properties. Researches conducted in the
last few decades on the plants mentioned in ancient literature or used traditionally for asthma have shown
antiasthmatic, antihistaminic and antiallergic activity. This review reveals that some plants and their
extract have antiasthmatic, antihistaminic, anticholinergic and antiallergic activity.

Keywords: Asthma Antiasthmaticplants, Ayurveda, Herbalmedicines, Antiallergic Activity, Medicinal

property

I. INTRODUCTION
Asthma is a complex inflammatory disease that causes narrowing of the airways and is associated with altered levels of
eosinophils, mast cells, lymphocytes, cytokines, and other inflammatory cell products. It is well known that asthmatics
have elevated levels of certain IgE, which binds to receptors on mast cells and other inflammatory cells. Interactions
between IgE antibodies and antigens lead to the activation of many inflammatory cell responses, including the release
of mediators such as histamine, prostaglandins, and leukotrienes, which subsequently cause airway smooth muscle
contraction and bronchoconstriction. [1], [3]. Asthma is a widespread disease with highest prevalence in developed
countries and increasing prevalence worldwide. Asthma affects approximately 300 million people worldwide and is
estimated to affect another 100 million by 2025 [4],[5]. Since the 1970s, the global prevalence, morbidity, mortality and
economic burden of asthma, especially in children, have increased [6]. Medicinal plants for the treatment of asthma are
said to have anti-inflammatory, immunomodulatory, antihistamine, smooth muscle relaxant and allergic activities
[7].According to Ayurveda, anti-asthma drugs should possess properties such as anti-kapha and anti-vata [8].
Antioxidant supplements are effective in reducing the severity of bronchoconstriction by inhibiting pro-inflammatory
events by counteracting the effects of excess reactive oxygen and nitrogen species [9]. Asthma treatments are
inadequate due to side effects, so patients are looking for complementary and alternative medicines to treat asthma [10].
Quercetin is one of the most common flavonoids ingested by humans. Quercetin inhibits mast cellDegranulation and
subsequent histamine release.

II. ADVERSE EFFECT OF CURRENT TREATMENT USED IN ASTHMA[11]

IS OPRENA LINE
Causes tachycardia.

SALBUTAMOL
Muscle tremors (dose related), palpitation, restlessness, nervousness, throat irritation and ankle edema.

Copyright to IJARSCT DOI: 10.48175/IJARSCT-8690 246

www.ijarsct.co.in
 ISSN (Online) 2581-9429
IJARSCT
International Journal of Advanced Research in Science, Communication and Technology (IJARSCT)

Volume 3, Issue 2, March 2023

Impact Factor: 7.301
THEOPHYLINE
Convulsions, shock, arrhythmias, dependent) flushing, hypotension, diuresis, dyspepsia, insomnia etc. Increased muscle
tone, tachapnoea, (dose restlessness, tremors, vomiting, palpitation,

ANTICHOLINERGIC
Dry mouth, difficulty in swallowing and talking, scarlet rash, photophobia, blurring of near (Atropine and its
congeners) vision, palpitation, ataxia, delirium, hallucinations, hypotension, weak and rapid pulse, cardiovascular
collapse with respiratory depression, convulsions and coma (in severe poisoning).

KETOTIFEN
Sedation, dizziness, dry mouth, nausea and weight gain.

CORTICOSTEROIDS
Cushing’s habit, brittle skin, purple streaks, hyperglycemia, muscle weakness, susceptibility to infections, delayed
healing of wounds and surgical incisions, gastric ulcers, osteoporosis, glaucoma, growth retardation, psychiatric
disorders, hypothalamic-pituitary – Suppression of the adrenal gland (HPA) axis. Etc Therefore, the search for
effective, low-risk, non-drug strategies that offer valuable adjunctive or alternative treatments in asthma management is
clinically attractive and relevant. Complementary and alternative medicines are of great interest and their use in the
treatment and management of asthma is increasing [10]. The current review describes several plants that have
been pharmacologically studied for parameters involved in asthma.

III. SOME TRADITIONAL PLANTS WITH ANTIASTHAMATIC POTENTIAL

AERVA LANTA LINN (AMARANTHACEAE)
Aerva lanta (A. lanta) is an erect or deciduous herbaceous roadside weed identified by white axillary clusters of small
hairy flowers. Abundant in the plains of temperate regions of India. Ethanol extracts from the aerial parts of A. lanata
were tested at oral doses of 100 μg/ml in isolated goat tracheal chain preparation models and 30 and 60 mg/kg in
clonidine-induced catalepsy and mast cell degranulation in mice. , has anti-asthmatic.[12]

AGERATUM CONYZOIDES L.
Ageratum conyzoides, also known as A. conyzoides, is an upright, herbaceous annual plant that is native to tropical
America but has a distribution range throughout tropical and subtropical regions of the world. By preventing the
catalepsy that clonidine-induced in mice, a hydroalcoholic extract of the leaves of A. conyzoides at doses of 250, 500,
and 1000 mg/kg exhibits antihistaminic activity[13].

ARGEMONE MEXICANA
In India, Argemone mexicana (A. mexicana) is widespread in fields and roadside. It has antiallergic and antistress
properties when administered as an aqueous extract of A. mexicana stem at a dose of 50 mg/kg intravenously (i.v.)[14].

ASYSTASIA GANGETICA T. ADAMS (ACANTHACEAE)

In various regions of Nigeria, Asystasia gangetica (A. gangetica) is used to treat asthma. A. gangetica leaf extracts were
tested for antiasthmatic activity using guinea pig trachea, rat stomach strip, guinea pig ileal preparation, and egg
albumin-induced acute inflammation, according to Akah et al. According to the findings, the extracts did not have any
contractile or relaxing effects in isolated tissue preparations, although they did prevent spasmogen-induced
contractions[15]

BACOPA MONNIERI L. (SCROPHULARIACEAE)

Bacopa monnieri: Samiulla et al. tested the ability of B. monnieri leaf extracts to stabilise mast cells in rats using
petroleum ether, chloroform, methanol, and water extracts at doses of 10 g/mL. According to research findings, every
extract greatly reduces mast cell degranulation[16].

Copyright to IJARSCT DOI: 10.48175/IJARSCT-8690 247

www.ijarsct.co.in
 ISSN (Online) 2581-9429
IJARSCT
International Journal of Advanced Research in Science, Communication and Technology (IJARSCT)

Volume 3, Issue 2, March 2023

Impact Factor: 7.301
CASSIA SOPHERA (CAESALPINIACEAE)
Traditional uses of Cassia sophera (C. sophera) include the treatment of bronchitis and asthma. At doses of 250, 500,
and 750 mg/kg, the chloroform, ethyl acetate, and ethanol fractions isolated from the ethanol extract of C. sophera
leaves exhibit significant antiasthmatic activity in animal models of carrageenan-induced paw edoema, histamine-
induced bronchoconstriction, clonidine andHaloperidol-induced catalepsy, milk-induced leukocytosis, andand 750
mg/kg and this activity may be due to presence of flavonoids[17].

CASUARINA EQUISETIFOLIA LINN (CASUARINACEAE)

Evergreen Casuarina equisetifolia (C. equisetifolia) trees are grown along coastal regions from Gujarat to Orissa, in
some areas of West Bengal, and in the Andaman Islands. They typically reach heights of up to 50 metres. The trachea’s
constriction brought on by histamine (10–80 mcg/mL), catalepsy brought on by clonidine, and mast cell degranulation
at doses of 100 mg/kg are all inhibited by the methanol extract of wood and bark extracts [18].

CLERODENDRUM SERRATUM LINN (VERBENACEAE)

In traditional Ayurvedic medicine, Clerodendrum Serratum (C. serratum), also known as bharangi, is used to treat pain,
inflammation, rheumatism, respiratory illnesses, and malarial fever. With isolated goat tracheal chains, clonidine-
induced catalepsy, and milk-induced leucocytosis and eosinophilia in mice at doses of 50, 100, and 200 mg/kg, ethanol
extract of C. serratum roots demonstrated antiasthmatic activity[19].

CNIDIUM MONNIERI (UMBELLIFERAE)

As an antipruritogenic substance, Cnidium monnieri (C. monnieri) has been used in Chinese traditional medicine to
treat pain in the female genitalia, impotence, and suppurative dermatitis. In passive cutaneous anaphylaxis in rats,
Matsuda et al. reported that ethanol extract and Osthol, a chromane isolated from ethanol extract of C. monnieri fruits,
had antiallergic activity[20].

CRINUM GLAUCUM (AMARYLLIDACEAE)

South West Nigeria’s Yoruba people are fond of Crinum glaucum (C. glaucum). Practitioners of traditional medicine
said that it was a successful treatment for cough, asthma, and convulsions. At doses of 100–400 mg/kg, the aqueous
extract of C. glaucum exhibits antiallergic activity by reducing the area of dye leakage in passive cutaneous
anaphylactic reaction, protecting mast cell degranulation, and preventing histamine-induced bronchoconstriction in the
guinea pig[21].

CURCULIGO ORCHIOIDES GAERTN (AMARYLLIDACEAE)

A little herbal plant known as Curculigo orchioides (C. orchioides) is found in abundance in India, China, Malaya, and
Japan. Alcoholic extract of C. orchioides rhizomes exhibits antihistaminic and mast cell stabilising activity on
Compound 48/80-induced systemic anaphylaxis and mast cell degranulation[22]. Additionally, it prevented the
histamine-induced contraction of the goat trachea, guinea pig ileum, and bronchoconstriction in guinea pigs. It also
prevented theRat passive paw anaphylaxis caused by egg albumin, the mouse catalepsy caused by clonidine, and the
leucocytosis and eosinophilia caused by milk.milk induced leucocytosis and eosinophilia; clonidine induced catalepsy
in mice[23].

ECLIPTA ALBA LINN (ASTERACEAE)

At doses of 250 and 500 mg/kg on compound 48/80-induced mast cell degranulation, egg albumin-induced passive
cutaneous and paw anaphylaxis, bronchoalveolar lavage (BAL) study on gunea pig trachea, and histamine
determination, the 50% ethanol extract exhibits antianaphylactic and antihistaminic activity[24].

EUPHORBIA HIRTA (EUPHORBIACEAE)

Euphorbia hirta, a herbaceous wild plant that grows in India’s hotter regions, is sometimes referred to as asthma weed.
At dosages (100-1000 mg/kg), an ethanol extract of the entire aerial section of the plant exhibits antihistaminic and

Copyright to IJARSCT DOI: 10.48175/IJARSCT-8690 248

www.ijarsct.co.in
 ISSN (Online) 2581-9429
IJARSCT
International Journal of Advanced Research in Science, Communication and Technology (IJARSCT)

Volume 3, Issue 2, March 2023

Impact Factor: 7.301
antiallergic efficacy by preventing mast cell degranulation and suppressing passive cutaneous and paw anaphylactic
reactions[25].

FICUS BENGALENSIS LINN (MORACEAE)

The enormous Ficus bengalensis (F. bengalensis) tree grows to a height of around 30 m and spreads out many aerial
roots from its branches. When given to mice at a dose of 50 mg/kg of clonidine, ethyl acetate, ethanol, and aqueous
extracts ofThe bark of F. bengalensis exhibit antihistaminic activity by inhibiting the catalepsy that drug causes. These
effects could be a result of flavonoids[26],[27].

GAKANI
Gakani is a polyherbal medication that includes Syzygium aromaticum (L.) Merr, Securidaca iongipedunculata Tresen,
Piper guineense schum Thonn, Gramineae Olax subscorpioidea Oliv., and Gramineae Gramineae Olax subscorpioidea
Oliv (Myrtaceae). Gakani, a well-known herbal remedy, was tested for its ability to treat asthma using rat stomach
strips, guinea pig ileum preparations, and egg albumin-induced paw edoema. According to the results, the extract
prevented histamine and isoprenaline from having an effect on the guinea pig tracheal chain. It demonstrates how
histamine and 5-hydroxytryptamine decrease the contraction of an isolated guinea pig ileum and a rat stomach strip (5-
HT). Rats exposed to the extract showed good anti-inflammatory effects[28].

HEMIDESMUS INDICUS R. BR. (ASCLEPIADACEAE)

A twining shrub known as Hemidesmus indicus (H. indicus) is frequently seen in India. Using isolated goat tracheal
chain preparation, passive paw anaphylaxis in rats, and clonidine-induced catalepsy in mice, Bhujbal et al. reported
antiasthmatic activity of an ethanol extract of H. indicus roots at doses of 25, 50, and 100 mg/kg[29].

AMBURANA CEARENSIS (FABACEAE)

The Brazilian northeastern “caatinga” (savannah) is home to the medicinal plant Amburana cearensis (A. cearensis),
which is widely used to treat respiratory conditions including asthma. The guinea pig trachea’s KCl-induced contraction
was significantly relaxed by the flavonoid isokaempferide that was isolated from the trunk barks of A. cearensis[30].

PLANTS FROM ZINZIBERACEAE

According to Tewtrakul et al., ethanol and water extracts from a few plants in the Zinziberaceae family have
antiallergic properties[31].

LEPIDIUM SATIVUM LINN (CRUCIFERAE)

It is a glabrous, annual herb commonly referred to as “Asaliyo” that is grown as a salad plant all over India. Histamine
and acetylcholine-induced bronchospasm is inhibited by the ethanol extract and its fractions of ethyl acetate, n-butanol,
and methanol[32].

MENTHA SPICATA L
By suppressing antigen-stimulated rat basophile, the four novel flavonoids and three novel glycosides from M. spicata
leaves exhibit antihistaminic activity[33].

MOMORDICA DIOICA
Momordica dioica is a creeping plant that climbs. Its fruits and leaves are traditionally used as a treatment for
bronchitis, fever, tridosha, leprosy, and asthma. By preventing the 50 mg/kg clonidine-induced catalepsy in mice,
methanol and an aqueous pulp extract exhibit antihistaminic effect, which may be attributed to polar constituents[34].

MUCUNA PRURIENS
At doses of 50, 100, and 200 mg/kg, the L-DOPA extracted from the methanol extract of the seed has antihistaminic
action by reducing clonidine-induced catalepsy and mast cell degranulation in mice[35].

Copyright to IJARSCT DOI: 10.48175/IJARSCT-8690 249

www.ijarsct.co.in
 ISSN (Online) 2581-9429
IJARSCT
International Journal of Advanced Research in Science, Communication and Technology (IJARSCT)

Volume 3, Issue 2, March 2023

Impact Factor: 7.301
MYRICA ESCULENTA BUCH. HAM. (MYRICACEAE)
The common name for Myrica esculenta is Kaiphal. It is used in the ayurvedic medical system to treat bronchitis and
asthma. Using acetic acid-induced vascular permeability and allergic pleurisy in mice techniques, Patel et al. found
antiallergic and anti-inflammatory effects of ethanol extract of aerial parts[36]. By preventing acetylcholine-induced
bronchospasm in guinea pigs, egg albumin-induced anaphylaxis in guinea pigs at doses of 75 mg/kg, and by relaxing
guinea pig trachea and ileum caused by histamine and acetylcholine-induced bronchospasm, this plant’s stem bark has
bronchodilator and antianaphylacticActivity by inhibiting acetylcholine induced bronchospasm in guinea pigs, egg [37].

NYCTANTHES ARBORTRISTIS
It has a long history of usage in the management of asthma. At a dose of 50 mg/kg, the petroleum ether extract inhibits
the catalepsy that clonidine causes in mice, demonstrating antihistaminic activity[38].

OLEA EUROPEA (OLEACEAE)

It is a little evergreen tree that grows to a height of 12 to 20 feet, has aged, inflexible limbs, and a grey bark. By
preventing histamine-induced contraction of the goat trachea and the guinea pig ileum at concentrations of 100 g/mL
and 4 and 8 mg/kg/kg/kg, respectively, as well as catalepsy in mice, aqueous extract of ripe olives exhibits
antiasthmatic activity[39].

PHYMATODES SCOLOPENDRIA (BURM.) CHING (POLYPODIACEAE)

A crawling fern called Phymatodes scolopendria grows along Madagascar’s eastern coast in the sand. Inhibiting
histamine or carbachol-precontracted guinea pig trachea, Ramanitrahasimbola et al. showed bronchodilator activity of
1, 2-benzopyrone (coumarin) extracted from ethanol extract of aerial parts[40].

PIPER BETEL LINN

Traditionally, piper betel has been used to treat rheumatism, asthma, pruritis, cough, and colds. When histamine causes
bronchoconstriction in guinea pigs, as well as histamine-induced contraction of the guinea pig tracheal chain that is
dose dependent as well as isolated guinea pig ileum preparation, ethanol and an aqueous extract of the leaves at doses
of 100 and 200 mg/kg have antiasthmatic activity[41].

STRIGA OROBANCHIOIDES BENTH (SCROPHULARIACEAE)

A parasitic plant called Striga orobanchioides inhabits the roots of several plants. By inhibiting histamine-induced ileal
contractions in guinea pigs at concentrations of 2.5 to 25 g/mL in a dose-related manner and by inhibiting mast cell
degranulation at doses of 100 and 200 mg/kg, ethanol and aqueous extracts of the entire plant exhibit antihistaminic and
mast cell stabilising activity[42]-[49].

SPHAERANTHUS INDICUS KURZ (ASTERACEAE)

A significant plant used in folk medicine is called Sphaeranthus indicus. In comparison to the common medication
ketotifen, the ethanol extract at doses of 150 and 300 mg/kg and its ethyl acetate extract at doses of 100, 150, and 300
mg/kg demonstrated marginally superior protection against sheep serum and Compound 48/80-induced mast cell
degranulation[50].

III. CONCLUSION
Almost 70 percent of the prescription and OTC (Over the Counter) medicines that are being used for many diseases’
treatment is derived from plants and natural sources. Pharmacologists, Medical Doctors, Scientists and pharmaceutical
companies study the plants and herbs that are traditionally used for treatment of various diseases. After vigorous study
they identify the particular molecule that has therapeutic properties. These molecules do undergo various modifications
and mutations in laboratories. And then, it is mass produced in factories and systematically marketed. For example,
Digitalin which is a drug used to stimulate the heart. Well, Digitalin comes from an herb called foxglove. Another
example is the effective anti-clotting agent called Coumarol, that comes from a herb sweet clover. Another one is

Copyright to IJARSCT DOI: 10.48175/IJARSCT-8690 250

www.ijarsct.co.in
 ISSN (Online) 2581-9429
IJARSCT
International Journal of Advanced Research in Science, Communication and Technology (IJARSCT)

Volume 3, Issue 2, March 2023

Impact Factor: 7.301
Reserpine, which is one of the most popular tranquilizers. It is the first ever modern psychiatric drug. Most of the
modern tranquilizers are derived from Reserpine. Reserpine comes from a herb named snakeroot. In India they used
snakeroot for thousands of years to calm people down. Still another example is Quinine. It is very efficient in reducing
fever, especially malarial fever. This drug comes from the Peruvian bark in South America. Another example is Asprin
which was derived from white willow bark. Let us see the herbs connection to Asthma. The first ever modern
prescription medicine used to treat asthma is ephedrine. It is derived from the Chinese plant known as Ma Huang.
Chinese have been using Ma Huang to treat breathing disorders, wheezing etc. for the past 2000 years. The molecule
ephedrine was isolated from Ma Huang in1940 and was widely prescribed since then. Cromolyn Sodium is another
popular medicine used for the treatment of asthma. Cromolyn was derived from a plant knows as Khellin (Ammi
Visnaga) commonly found in Egypt. It was used as a muscle relaxant by Egyptians for many centuries. Dr. Roger
Altouynan (the discoverer of Cromolyn molecule), an asthmatic, tried Khellin on himself and found it to be very
beneficial. Today cromolyn sodium is one of the first lines of treatment for asthma. Cromolyn sodium has weaned great
number of patients away from harmful corticosteroids. Cromolyn effectively prevents asthma attack before it occurs.
Prescription medicines Codeine, atropine, hyoscyamine, digoxin, digitoxin, pilocarpine, and quinidine are all derived
from plants. Asthma and Allergy are lifestyle diseases and herbs are extremely effective. The goals of medicine no
matters to which group it belongs, are the same i.e. welfare of patients. One can look towards a future of integrated
medicine and hope that research in alternative medicine will help to cure asthma safe and effectively rather than
managing.

REFERENCES
[1]. Holgate ST, Polosa R. Treatment strategies for allergy and asthma. Nat Rev Immunol. 2008;8:218–230.
[2]. Donno DM, Bittesnich D, Chetta A, Olivieri D, Lopez-Vidriero MT. The effect of inflammation on
mucociliary clearance in asthma. Chest. 2000;118(4):1142–1149. .
[3]. Tattersfield AE, Knox AJ, Britton JR, Hall IP. Asthma. Lancet. 2002;360:1313–1322. .
[4]. Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of the GINA
Dissemination Committee report. Allergy. 2004;59:469–478. .
[5]. Bousquet J, Bousquet PJ, Godard P, Daures JP. The public health implications of asthma. Bull World Health
Organ. 2005;83:548–554. [PMC free article] .
[6]. Braman SS. The global burden of asthma. Chest. 2006;130:4S–12S. .
[7]. Greenberger PA. Therapy in management of rhinitis asthma complex. Allergy Asthma Proc. 2003;24:403–
407. .
[8]. Lyengar MA, Jambaiah KM, Rao GM. Studies on an anti-asthma kada: A Proprietary Herbal Combination
Part-I Clinical Study. Indian Drug. 1994;31(5):183–186. .
[9]. Henricks PA, Nijkamp FP. Reactive oxygen species as mediators in asthma. Pulm. Pharmacol. Ther.
2001;14:409–420.
[10]. Slader CA, Reddel HK, Jenkins CR, Armour CL, Bosnic Anticevich SZ. Complementary and alternative
medicine use in asthma: who is using what? Respirol. 2006;11:373–387. .
[11]. Tripathi KD. 4th ed. New Delhi, India: Jaypee brothers medical Publishers Ltd; 2001. Essentials of medical
pharmacology.
[12]. Kumar D, Prasad DN, Parkash J, Bhatnagar SP, Kumar D. Antiasthmatic activity of ethanolic extract of
Aerva lanata Linn. Pharmacologyonline. 2009;2:1075–1081. .
[13]. Tote MV, Mahire NB, Jain AP, Bose S, Undale VR, Bhosale AV. Effect of Ageratum conyzoides Linn on
clonidine and haloperidol induced catalepsy in mice. Pharmacologyonline. 2009;2:186–194.
[14]. Bhalke RD, Gosavi SA. Antistress and antiallergic effect of Argemone mexicana stem in asthma. Arch.
Pharm Sci Res. 2009;1(1):127–129.
[15]. Akah PA, Ezike AC, Nwafor SV, Okoli CO, Enwerem NM. Evaluation of the anti-asthmatic property of
Asystasia gangetica leaf extracts. J Ethnopharmacol. 2003;89:25–36. .
[16]. Samiulla DS, Prashanth D, Amit A. Mast cell stabilising activity of Bacopa monnieri. Fitoterapia.
2001;72:284–285. .

Copyright to IJARSCT DOI: 10.48175/IJARSCT-8690 251

www.ijarsct.co.in
 ISSN (Online) 2581-9429
IJARSCT
International Journal of Advanced Research in Science, Communication and Technology (IJARSCT)

Volume 3, Issue 2, March 2023

Impact Factor: 7.301
[17]. Nagore DH, Ghosh VK, Patil MJ. Evaluation of antiasthmatic activity of Cassia sophera Linn. Phcog Mag.
2009;5(19):109–118. .
[18]. Aher AN, Pal SC, Patil UK, Yadav SK, Bhattacharya S. Evaluation of anthistaminic activity of Casuarina
equisetifolia frost (Casuarinaceae) Pharmacologyonline. 2009;1:1144–1149. .
[19]. Bhujbal SS, Kewatkar SM, Kumar D, Mudgade SC, Patil MJ. In vivo and in vitro antiasthmatic studies of
Clerodendrum serratum Linn. Pharmacologyonline. 2009;2:745–752. .
[20]. Matsuda H, Tomohiro N, Yasuko, Kubo M. Anti-allergic effects of cnidii monnieri fructus (Dried Fruits of
Cnidium monnier) and Its major component, osthol. Bio Pharm Bull. 2002;25(6):809–812. .
[21]. Okpo SO, Adeyemi OO. The anti-allergic effects of Crinum glaucum aqueous extract. Phytomedicine.
2002;9:438–441. .
[22]. Venkatesh P, Mukherjee PK, Satheesh Kumar N, Neelesh K Nema, Bandyopadhyay A, Hiroyuki Fukui, et
al. Mast cell stabilization and antihistaminic potentials of Curculigo orchioides rhizomes. J Ethnopharmacol.
2009;126:434–436. .
[23]. Pandit P, Singh A, Bafna AR, Kadam PV, Patil MJ. Evaluation of antiasthmatic activity of Curculigo
orchioides Gaertn. Rhizomes. Indian J Pharm Sci. 2008;70(4):440–444. [PMC free article] .
[24]. Patel MB, Panchal SJ, Patel JA. Antianaphylactic activity of alcoholic extract of Eclipta alba. J Young
Pharm. 2009;1(3):244–250. .
[25]. Youssouf MS, Kaiser P, Tahir M, Singh GD, Singh S, Sharma VK, et al.et al. Anti-anaphylactic effect of
Euphorbia hirta. Fitoterapia. 2007;78:535–539. .
[26]. Taur DJ, Nirmal SA, Patil RY. Effect of various extracts of Ficus bengalensis bark on clonidine and
haloperidol-induced catalepsy in mice. Pharmacologyonline. 2007;3:470–477. .
[27]. Taur DJ, Patil RY. Effect of bio-fractions isolated from Ficus bengalensis bark on clonidine induced
catalepsy. J Pharmacy Res. 2009;2(11):1676–1677. .
[28]. Akah PA, Gamaniel KS, Samson A, Wambebe CO. Evaluation of Nigerian traditional medicine: effects of
Gakani, a herbal anti-asthmatic drug. J Ethnopharmacol. 1997;55:87–92. .
[29]. Bhujbal SS, Kumar D, Deoda RS, Deore TK, Patil MJ. Antiasthmatic activity of roots of Hemidesmus
indicus R. Br. Pharmacologyonline. 2009;1:209–216. .
[30]. Luzia KAM Leal, Melina F Costa, Márcia Pitombeira, Viviane M Barroso, Edilberto R Silveira, Kirley M.
Canuto, et al. Mechanisms underlying the relaxation induced by isokaempferide from Amburana cearensis in
the guinea-pig isolated trachea. Life Sci. 2006;79:98–104. .
[31]. Tewtrakul S, Subhadhirasakul S, Kummee S. Anti-allergic activity ofCompounds from Kaempferia
parviflora. J Ethnopharmacol. 2008;116:191–193. Mali RG, Mahajan SG, Mehta AA. Studies on
bronchodilatory effect of Lepidium sativum against allergen induced bronchospasm in guinea pigs. Phcog
Mag. 2008;4(15):189–192. .
[32]. Satoshi Yamamura, Koichiro Ozawa, Kazuhiro Ohtani, Ryoji Kasai, Kazuo Yamasak. Antihistaminic
flavones and aliphatic glycosides from Mentha spicata. Phytochemistry. 1998;48(1):131–136. .
[33]. Rakh MS, Raut DN, Chavan MJ, Chaudhari SR. Effect of various extracts of Momordica dioica pulp on
clonidine and haloperidol-induced catalepsy in mice. Pharmacologyonline. 2010;1:1–11.
[34]. Pathan AA, Kasture SB, Mahalaxmi M. Residue of Mucuna pruriens potentiates haloperidol and clonidine-
induced catalepsy in mice. Pharmacologyonline. 2009;3:652–658. .
[35]. Patel KG, Rao NJ, Gajera VG, Bhatt PA, Patel KV, Gandhi TR. Antiallergic activity of stem bark of Myrica
esculenta Buch. Ham. (Myricaceae) J Young Pharm. 2010;2(1):74–78. [PMC free article] .
[36]. Patel KG, Bhalodia PN, Patel AD, Patel KV, Gandhi Evaluation of bronchodilator and anti-anaphylactic
activity of Myrica sapida. Iranian Biomedical Journal. 2008;12(3):191–196. .
[37]. Nirmal SA, Pal SC, Mandal SC. Antihistaminic activity of NyctanthesArbortristis Bark.
Pharmacologyonline. 2009;3:924–928. .
[38]. Chandak R, Devdhe S, Changediya V. Evaluation of anti-histaminic activity of aqueous extract of ripe olives
of Olea-europea. J Pharm Res. 2009;2(3):416–420. .

Copyright to IJARSCT DOI: 10.48175/IJARSCT-8690 252

www.ijarsct.co.in
 ISSN (Online) 2581-9429
IJARSCT
International Journal of Advanced Research in Science, Communication and Technology (IJARSCT)

Volume 3, Issue 2, March 2023

Impact Factor: 7.301
[39]. Ramanitrahasimbola D, Rakotondramanana DA, Rasoanaivo P, Randriantsoa A, Ratsimamanga S, Palazzino
G, et al.et al. Bronchodilator activity of Phymatodes scolopendria (Burm.) Ching and its bioactive
constituent. J Ethnopharmacol. 2005;102:400–407. .
[40]. Jawale NM, Shewale AB, Nerkar GS, Patil VR. Evalution of antihistaminic activity of leaves of Piper betel
Linn. Pharmacologyonline. 2009;3:966–977. .
[41]. Harish MS, Nagur M, Badami S. Antihistaminic and mast cell stabilizing activity of Striga orobanchioide. J
Ethnopharmacol. 2001;76:197–200. .
[42]. Dilkash NA, Tripathi T, Khan AA, Shahid M, Khan HM, Siddiqui M, et al.et al. Effects of histamine H1R—
H4R—agonist on the airway epithelium of rabbits. Asian Pac J Trop Med. 2010;3(5):367–370. .
[43]. Jung JY, Lee KY, Lee MY, Jung D, Cho ES, Son HY. Antioxidant and antiasthmatic effects of saucerneol D
in a mouse model of airway inflammation. Int Immunopharmacol. 2011 .
[44]. Boskabady MH, Mohsenpoor N, Takaloo L. Antiasthmatic effect of Nigella sativa in airways of asthmatic
patients. Phytomedicine. 2010;17(10):707–713. .
[45]. Jin M, Yang JH, Lee E, Lu Y, Kwon S, Son KH, et al.et al. Antiasthmatic activity of luteolin-7-O-glucoside
from Ailanthus altissima through the downregulation of T helper 2 cytokine expression and inhibition of
prostaglandin E2 production in an ovalbumin-induced asthma model. Biol Pharm Bull. 2009;32(9):1500–
1503. .
[46]. Pandit P, Singh A, Bafna AR, Kadam PV, Patil MJ. Evaluation of antiasthmatic activity of Curculigo
orchioides Gaertn. Rhizomes. Indian J Pharm Sci. 2008;70(4):440–444. [PMC free article] .
[47]. Agrawal B, Mehta A. Antiasthmatic activity of Moringa oleifera Lam: a clinical study. Indian J Pharmacol.
2008;40(1):28–31. [PMC free article] .
[48]. Li PB, Ma Y, Wang YG, Su WW. Experimental studies on antitussive, expectorant and antiasthmatic effects
of extract from Citrus grandis var. tomentosa. Zhongguo Zhong Yao Za Zhi. 2006;31(16):1350–1352. .
[49]. Mathew JE, Srinivasan KK, Dinakaran V, Joseph A. Mast cell stabilizing effects of Sphaeranthus indicus. J
Ethnopharmacol. 2009;122:394–396. [PubMed]

Copyright to IJARSCT DOI: 10.48175/IJARSCT-8690 253

www.ijarsct.co.in