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Solvent Evaporations:: Step 1

The document describes the process of solvent evaporation for producing polymeric microparticles. It involves three steps: 1) Forming a solution or dispersion of the active ingredient in an organic polymer phase. 2) Emulsifying the polymer phase into an aqueous phase containing a stabilizer to form an oil-in-water emulsion. 3) Removing the organic solvent from the dispersed phase by extraction or evaporation, causing the polymer to precipitate and form microspheres. The microparticles are then recovered.

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173 views5 pages

Solvent Evaporations:: Step 1

The document describes the process of solvent evaporation for producing polymeric microparticles. It involves three steps: 1) Forming a solution or dispersion of the active ingredient in an organic polymer phase. 2) Emulsifying the polymer phase into an aqueous phase containing a stabilizer to form an oil-in-water emulsion. 3) Removing the organic solvent from the dispersed phase by extraction or evaporation, causing the polymer to precipitate and form microspheres. The microparticles are then recovered.

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SOLVENT EVAPORATIONS:

Active Polymer
Ingredient + Volatile organic solvent Step 1:
Formation of a solution/dispersion of
the drug into an organic polymer
Organic Polymeric Phase
phase.
Addition into an aqueous
phase (+o/w stabilizer) Step 2:
Formation of Oil-in-Water
Emulsification of the polymer phase
Emulsion into an aqueous phase containing a
suitable stabilizer, thus, forming a o/w
Temperature increase
emulsion.
Solvent Evaporation
Step 3:
Removal of the organic solvent from
Particle Formation by
the dispersed phase by extraction or
Polymer Precipitation
evaporation leading to polymer
precipitation and formation of the
microspheres.
RECOVERY OF POLYMERIC
MICROPARTICLES
Pan Coating:
The coating solution is applied
as atomized spray to the solid
core material in the coating pan.

To remove the coating solvent


warm air is passed over the
coated material.

 By using this technique larger sized particles


will be coated effectively.
Rotational Suspension Separation:

 In this process, core material


dispersed in a liquid shell
formation is fed onto a rotating
disk.

A flat disk is shown, but conical


or bowl shaped disks can be used.

Individual core particles coated with a film of shell formation are flung off the
edge of the rotating disk along with droplets of pure coating material.

 When the shell formation is solidified,(e.g.. by cooling) microcapsules are


produce.
EXTRUSION:
 This method was first patented in 1957.

 The process involves forcing a core material dispersed in a molten


carbohydrate mass through a series of dies, into a bath of dehydrating
liquid.

 When contact with the liquid is made, the carbohydrate case hardens to
entrap the core material.

 The extruded filaments are separated from the liquid bath, dried using an
anti-caking agent such as calcium tripolyphosphate .

 This process is particularly useful for heat labile substances such as flavors,
vitamin C and colors.
Multi-orifice Centrifugal Process

 SWRI develop a mechanical


process that utilizes centrifugal
forces to hurl, a core material
particle through an enveloping
membrane.

 Production rate of 50 to 75
pound/hr have been achieved
with this process.

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