12/1/2020 Pharmacodynamics and Pharmacokinetics Quiz
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Question 1
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As a clinical consultant for the BreathRight drug research firm, you are given the task of using an in vitro assay to screen ten
thousand drug analogs to find the most potent beta-2 agonist. When analyzing your data, which
pharmacodynamics/pharmacokinetic parameter would you be most interested in?
A. Maximal effect
B. EC50
C.
Half-life
D. Bioavailability
Clear my choice
Question 2
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A 54-year-old patient is on warfarin (an anticoagulant) to treat atrial fibrillation and reduce the risk of thromboembolism. He
appears pale and complains of weakness. His blood pressure is much lower than normal and he mentions that he recently started
taking over-the-counter cimetidine for an ulcer. He complains of black and bloody stool over the past 2 days. The MOST LIKELY
explanation for your patient’s symptoms is:
A.
Cimetidine interfering with warfarin absorption
B. Cimetidine induction of warfarin metabolism
C.
Cimetidine inhibition of warfarin metabolism
D. An overdose of cimetidine
Clear my choice
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12/1/2020 Pharmacodynamics and Pharmacokinetics Quiz
Question 3
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Regarding the pharmacokinetic characteristics of drugs, which of the following statements is INCORRECT:
A. For drugs that bind with high affinity to plasma proteins, the volume of distribution is close to total body water volume
B. Hepatic drug metabolism often involves conversion of a non-polar drug to a polar metabolite
C. Non-polar drugs are more likely to cause central nervous side effects than polar drugs
D. Gastrointestinal absorption of hydrophobic drugs occurs more readily than hydrophilic drugs
Clear my choice
Question 4
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An experimental infusable drug, X729, is currently being studied to determine its pharmacokinetics. The drug was found to have a
half-life of 1.5 hours and is eliminated by first order kinetics. What is the minimum number of hours required to reach a steady state
concentration of >90%?
A. 3
B. 1.5
C. 4.5
D. 6
Clear my choice
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12/1/2020 Pharmacodynamics and Pharmacokinetics Quiz
Question 5
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If the volume of distribution (Vd) for gentamicin is equal to a patient’s extracellular fluid volume (0.2L/kg) and the patient weight
80kg, what loading dose would you give to achieve a therapeutic plasma concentration of 4 ug/mL?
A. 80mg
B. 320mg
C. 64mg
D. 16mg
Clear my choice
Question 6
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Dose response data was collected during the preclinical testing of four drugs for the treatment of acute heart failure. Which of the
following statements is INCORRECT?
A. Drug A has the highest potency
B.
Drug B has lesser efficacy than Drug C
C. Drug C has greater potency than Drug B
D. Drug A has greater efficacy than Drug D
Clear my choice
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12/1/2020 Pharmacodynamics and Pharmacokinetics Quiz
Question 7
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An ICU patient received 500 mg of a drug X by intravenous infusion at 8.00 PM on the night of admission. This drug has a half-life of
6 hours. What is the expected amount of drug left in the body at 8.00 AM next day morning? Assume that the drug follows first-
order rate kinetics.
A. 100 mg
B. 125 mg
C. 175 mg
D. 150 mg
Clear my choice
Question 8
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Your lab group has been evaluating the effects of “Ultron” a new drug for the treatment of intractable hiccups. When administered
over a wide concentration range, three dose response relationships were defined in test subjects. Using facial flushing as an
unwanted side effect, what would be the estimated therapeutic index for “Ultron”?
A. 10
B. 100
C.
0.01
D.
1
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12/1/2020 Pharmacodynamics and Pharmacokinetics Quiz
Question 9
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For the weakly acidic drug HA with pka = 5.4, the [HA]:[A-] ratio at gastric pH=2.4 is:
A. 100:1
B. 10:1
C. 1000:1
D. 10,000:1
Clear my choice
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12/1/2020 Pharmacodynamics and Pharmacokinetics Quiz
Question 10
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The graph below illustrates the dose-response relationship for the effect of the beta agonist isoproterenol on an isolated perfused
heart, both alone and in the presence of different fixed concentrations of Drug X.
Based on the data shown, which one of the following statements is correct? Drug X:
A. decreases the intrinsic activity of isoproterenol
B. has no affinity for the beta receptor
C. is an allosteric antagonist
D. has no intrinsic activity of its own
Clear my choice
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12/1/2020 Pharmacodynamics and Pharmacokinetics Quiz
Question 11
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Your pediatric patient is suffering from a bacterial infection and requires maintenance dosing with gentamicin. Gentamicin’s
elimination clearance is 5.0L/hr. What maintenance intravenous dose of gentamicin should you give every 8 hours to maintain an
average steady state of 5mg/L?
A. 100mg
B. 25mg
C. 200mg
D.
50mg
Clear my choice
Question 12
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Concerning the effect of pH on the urinary excretion of drugs, it can be correctly stated that urinary:
A. alkalization accelerates excretion of weak acids and bases
B. acidification accelerates excretion of weak acids
C. alkalization has no effect on excretion of weak bases
D. alkalization accelerates excretion of weak acids
Clear my choice
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12/1/2020 Pharmacodynamics and Pharmacokinetics Quiz
Question 13
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A pharmaceutical company is calculating the bioavailability of a new Drug X. For the intravenous formulation administration of 50
mg yielded an area under the curve (AUC) of 60 mg hr/L. For the oral formulation 100 mg yields an AUC of 80 mg hr/L. Which of the
following is the bioavailability of Drug X?
A. 67%
B. 74%
C. 70%
D. 64%
Clear my choice
Question 14
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Assume that a cell expresses 100 receptors on its surface and that binding of 40 of these receptors by a drug are required to achieve
a maximal biological response. How many receptors would have to be removed or irreversibly antagonized on this cell before you
would observe a change in the maximal response to the drug (assume that you can add as much drug to the cell as you want to
induce the biological response):
A. 20
B. 10
C. 80
D. 50
Clear my choice
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12/1/2020 Pharmacodynamics and Pharmacokinetics Quiz
Question 15
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The Area-Under-the-Curve (AUC) and Cmax can change based on changes in either the rate of absorption after an oral dose of a
drug or the terminal rate of elimination. Drug Y has 100% absolute bioavailability. If you administered the same dose of Drug Y as
an oral solution rather than a tablet what do you expect would happen to the AUC and Cmax?
A. AUC is increased, but Cmax is decreased
B. Both AUC and Cmax would be unchanged
C. Both AUC and Cmax are increased
D. AUC is unchanged, but Cmax is increased
Clear my choice
Question 16
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Brian is a 15- year-old patient who has been admitted to hospital with a severe case of bacterial septicemia caused by a gram-
negative organism that has been determined to be sensitive to gentamicin. Gentamicin’s volume of distribution (Vd) = 20L. What i.v.
loading dose would you give Brian to rapidly achieve a therapeutic plasma level of 5mg/L?
A. 50mg
B. 25mg
C. 20mg
D. 100mg
Clear my choice
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12/1/2020 Pharmacodynamics and Pharmacokinetics Quiz
Question 17
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Drug A has an EC50 of 10 nM and a maximum effect of 95%. Drug B has an EC50 of 75 nM and a maximum effect of 100%. Drug C
has an EC50 of 190 nM and a maximum effect of 34%. Which of the following is correct?
A. Drug A is the most potent drug.
B. Drug A has the highest efficacy.
C. Drug C has the lowest efficacy but highest potency.
D. Drug B is the most potent drug.
Clear my choice
Question 18
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You decide to switch a patient’s medication from intravenous drip to oral formulation (tablets three times a day) prior to discharge
from hospital. The intravenous dose regimen he was being given was 10mg/hr. What maintenance dose should be given when
switching to oral tablets (three times a day) assuming 100% bioavailability?
A. 20mg tablets
B. 120 mg tablets
C. 80 mg tablets
D. 40 mg tablets
Clear my choice
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12/1/2020 Pharmacodynamics and Pharmacokinetics Quiz
Question 19
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Regarding the relationship between the interaction of an agonist drug with its receptor and the potency of the drug, which of the
following statements is CORRECT?
A. The greater the agonist potency, the higher is the drug/ receptor dissociation constant, K
D
B. The greater the number of receptors occupied by the agonist drug, the greater is its potency
C. The presence of competitive antagonist decreases the agonist potency
D. Agonist drugs with high potencies have high ED50
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12/1/2020 Pharmacodynamics and Pharmacokinetics Quiz
Question 20
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The graph below represents the dose-response relationships for Drugs A, B, C and D. Which of the following statement is CORRECT?
A.
Drug B is an inverse agonist
B. Drug A dose-response would shift to the right in the presence of Drug B
C.
Drug A has a larger EC50 than Drug B
D. Drug D is more potent than Drug B
Clear my choice
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