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Bioprocess Technology 2022

This document contains instructions and questions for a summer examination on the module "Bioprocess Technology" for postgraduate and master's students. The exam is 2 hours and students must answer 3 of the 5 questions provided. The examiners are Dr. Donal Eardly (internal) and Prof. Cormac Murphy and Dr. AnnaMarie Rogers (external). The questions cover topics like single-use bioprocessing technologies, bioreactor design and operation modes, downstream processing unit operations, real-time bioprocess monitoring techniques, and future bioproduction facility design.

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81 views3 pages

Bioprocess Technology 2022

This document contains instructions and questions for a summer examination on the module "Bioprocess Technology" for postgraduate and master's students. The exam is 2 hours and students must answer 3 of the 5 questions provided. The examiners are Dr. Donal Eardly (internal) and Prof. Cormac Murphy and Dr. AnnaMarie Rogers (external). The questions cover topics like single-use bioprocessing technologies, bioreactor design and operation modes, downstream processing unit operations, real-time bioprocess monitoring techniques, and future bioproduction facility design.

Uploaded by

sheronjosephait
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
You are on page 1/ 3

TECHNOLOGICAL UNIVERSITY OF THE SHANNON: MIDLANDS MIDWEST

SUMMER EXAMINATIONS 2021/2022

MODULE: BIOT09003-26021 - Bioprocess Technology


PROGRAMME(S):
AL_SBPMT_9 Postgraduate Diploma in Science in Biopharmaceutical
Technology
AL_SBIOP_9 Master of Science in Biopharmaceutical Technology

YEAR OF STUDY: 1,5

EXAMINER(S):
Dr. Donal Eardly (Internal)
Prof. Cormac Murphy (External)
Dr. AnnaMarie Rogers (External)

TIME ALLOWED: 2 Hours

INSTRUCTIONS: Answer 3 questions. All questions carry equal marks.

MAKE SURE YOU HAVE RECEIVED THE CORRECT EXAM PAPER. PLEASE DO NOT TURN
OVER THIS PAGE UNTIL YOU ARE INSTRUCTED TO DO SO.
The use of programmable or text storing calculators is expressly forbidden.
Please note that where a candidate answers more than the required number of questions, the
examiner will mark all questions attempted and then select the highest scoring ones.

There are no additional requirements for this paper.

BIOT09003-26021 – Bioprocess Technology


Summer Examinations 2021/2022 Page 1 of 3
QUESTION 1 [TOTAL MARKS: 33.33]
Review the rise of single-use technologies in biopharmaceutical manufacturing,
including the advantages that they offer- and the problems that may occur- over
traditional systems.

[End of Question 1]

QUESTION 2 [TOTAL MARKS: 33.33]


Discuss the advantages and disadvantages of the various types of bioreactor design
and modes of operation (batch, fed-batch, continuous, perfusion) in the production of
biopharmaceuticals in mammalian cell lines.

[End of Question 2]

QUESTION 3 [TOTAL MARKS: 33.33]


Write an essay on a typical downstream process flow for the unit operations required
for the isolation, purification and concentration of a recombinant protein drug
product.

[End of Question 3]

QUESTION 4 [TOTAL MARKS: 33.33]


Review the benefits of in-line probes for real-time monitoring of bioprocesses
compared to off-line sampling, and explain the different types of spectroscopy that
can be used for this type of monitoring.

[End of Question 4]

BIOT09003-26021 – Bioprocess Technology


Summer Examinations 2021/2022 Page 2 of 3
QUESTION 5 [TOTAL MARKS: 33.33]
Write an essay on the future design of bioproduction facilities.

[End of Question 5]

[END OF EXAM]

BIOT09003-26021 – Bioprocess Technology


Summer Examinations 2021/2022 Page 3 of 3

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