5.
DUCTAL SYSTEM
o Consists of hollow tubes connected initially with the acinus
than with other ducts.
eProgressively grows larger, each Lined by different kind of
epithelium lining
" 1. intercalated duct Intralobular ducts
2. striated duct
: 3. excretory duct Interlobular
Minor glands have single duct which secretethe saliva
directly into the salivary gland.
Apart from carrying the saliva the ducts in major glands,
play a vital role in modification of saliva. h
A. INTERCALATED DUCT
Lined by single layer of cuboidal cells, with less cytoplasm
Small amount of RER is in the basal cytoplasm
o Intercalated ducts do not acts as a simple conducting unit
but they modify the saliva through secretory and absorptive
process.
They contribute components like lysozyme,
lactoferin to saliva.(stored in secretory
granules)
They also contain some undifferentiated cells - which
can undergo differentiation to replace damaged cells
At the periphery of the duct, processes and cell bodies of
myoepi cells, attached by desmosomes toduct cells.
. They are compressed between the secretory unit, it is
difficult to identify them in light microscopy.
B. STRIATED DUCTS
They receive saliva from intercalated ducts.
Intralobular ducts
oIntercalated Striated ducts
Striatedducts are lined by layer of tall columnar epicells,
having large centrally placed nuclei.
oAbundant cytoplasm showing prominent striations at the
basal part of cell.
Serous
acini
Fatcell
Striated
duct
Copyrght 2003, Mosby lnc., Aa rgts eevd
e Basal cytoplasm of striated cells is partitioned by deep
infoldings of plasma membrane, producing numerous sheet
like folds.
Striations are large mitochondria which are radially
oriented in between the infoldings of cell.
Infoldings with large amount of mitochondria provides a
larger surface area -cell is involved in active transport.
o Striated ducts - are the site of electrolyte reabsorption
especially of Na and Cl and secretion of Kand
Hco3 ions
This reabsorption is against the concentration gradient
hence requires a lot of energy
(abundant mitochondria)
Small secretory granules secrete kallikerein, peroxidases
Secrets epidermalgrowth factor
Ducts appear impermeable to water
MOTON EYa
C. EXCRETORY DUCTS
o Striated ducts join each other to form large intralobular duct.
" These ducts progressively enlarge and form -excretory duct -
saliva into oral cavity
pseudo stratified columnar epi
Stratified cuboidal
Stratified squamous epi (when it merges with epi of
oral cavity)
eAs excretory duct enlarges it contains 2layers - epithelium
and outer connective tissue.
CT has collagen and elastic fibers which allow passive
stretching of duct to allow and accommodate varying
volumes of saliva.
Some other type of cells are also present in the
excretory ducts -
Receptor cells for the nerve endings, few lymphocytes
and macrophages, dendritic cells. Involved in processing
and presentation of foreign antigens to T cells.
CLASSIFICATION AND STRUCTURE OF
MAJOR SALIVARY GLANDS
Classification -
1. size
Major and minor glands
O 2..location
o Labial, lingual, palatal.
3. Histochemical nature
O Serous and mucous
MAJOR SALIVARY GLANDS
1. Parotid gland
e Largest salivary gland, bilaterally paired.
© Lies in front of the external ear, its secretion reach the
mouth by ducts.
Main excretory duct- Stensens duct- opens at the buccal
mucosa opposite the maxillary second molar.
Parotid gland is a pure serous gland.
Blood supply by branches of ext carotid artery
tytily
2. Submandibular gland / sub maxillary gland
Second largest gland
@Lies on the medial aspect of the body of the mandible in
submandibular triangle
Omain excretory duct - Wharton's duct- opens at the
Sublingual papillae (lateral to lingual frenum)
Bloodsupply - via lingual and facial arteries.
eMixed gland, with both serous and mucus secretory units
(predominantly serous)
3. Sublingual gland -
o Smallest gland, almond shape
o Lies below the tongue between the floor of the mouth.
Composed of one main gland with several small glands.
O Main duct Bartholin duct - opens near the submandibular
duct.
e Smaller ducts - Duct of Rivinus - opens independently along
the sublingual fold.
" Mixed gland, predominantly mucus.
o Intercalated and striated ducts r poorly developed
oBlood supply -sublingual and submental arteries.
MINOR SALIVARY GLANDS
Located beneath the epithelium in almost all the parts of oral
cavity.
600-1000 minor SG
o These glands consists of several small groups of secretory
units opening via short ducts directly into mouth.
SONY
Not present in gingiva, ant raphe region of hard
palate.
Classified acc to their anatomic location --
O 1. labial and buccal
" 2. glossopalatine
" 3. palatine
4. lingual
SONY
