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Synthesis of Methamphetamine from P2P and NaBH4 Reduction
 GhostChemist ·  Jan 21, 2024 ·  methamphetamine methamphetamine from p2p methamphetamine hydrochloride nabh4 powder p2p
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Jan 21, 2024  #1

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Reactions proceed according to Scheme 1.

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Scheme 1​
Reagents and Materials:
10 g of pure P2P (steam distillation purified)
45-55 g of silica gel d=2.5-4 mm (NOT powder)
3 g of sodium borohydride (equivalent in moles)
65 ml of absolute isopropyl alcohol
18.1 – 20 ml of 35-40% aqueous methylamine
50-100 g of anhydrous sodium sulfate Na2SO4
200-250 ml of dichloromethane
50-100 g of ammonium chloride NH4Cl
50 ml of concentrated sulfuric acid (88%)
10-15 ml of diethyl ether
200-300 ml of distilled water
5-10 g of sodium hydroxide
500-1000 g of ice
cool packs
1 L three-neck flask
Distillation setup
Vacuum filtration setup
Chemical beakers
Glass adapters
2 L separating funnel
Heater
  Download Video

Methamphetamine Synthesis via NaBH4

 Novator ·  Sunday at 1:37 AM ·  12 ·  meth methamphetamine
methamphetamine synthesis nabh4 p2p

Synthesis of Methamphetamine via NaBH4 From P2P...

Synthesis​

Stage 1

Prepare the mixture in the container one day before the synthesis by combining 20 ml of methylamine, 65 ml of
absolute isopropyl alcohol, and 15 g of anhydrous sodium sulfate. Add 2-5 g of silica gel to the mixture and
periodically stir the mixture with vigorous shaking. Fig 1​

Fig 1

Add 40 g of silica gel into a three-necked flask, connect the absorbers (a calcium chloride tube with silica gel
and hygroscopic cotton), and let it stand for 0.5-1 hour for drying. Fig 2​

Fig 2
Pour the pre-prepared and dried methylamine solution in alcohol into the reactor, additionally rinsing the
sodium sulfate with portions of isopropyl alcohol. In the case where P2P was not pre-dried, set up a separating
funnel with a layer of silica gel and introduce P2P into the reactor in portions. After adding all of P2P, rinse the
remaining residue with several portions of isopropyl alcohol. Stir the resulting reaction mass for 2 hours, during
which the temperature increases from 22 to 30°C, which should be considered for larger synthesis volumes.
Fig 3​

Fig 3

The next step is to cool the reaction mixture (RM) to 0-5°C. Fig 4​

Fig 4

Sodium borohydride is added to the reaction mixture (RM) in small portions to prevent the temperature from
rising above +15°C (for about 3 hours). After adding all the sodium borohydride, the RM is stirred for 1-1.5
days at a temperature not exceeding +20°C. The temperature is maintained using cold accumulators. Fig 5​
Fig 5

Reaction mass after the reaction. Fig 6​

Fig 6

Stage 2​
The reaction mass (RM) in a three-necked flask is filled with water to dissolve the precipitate, then transferred
to a separating funnel, and a sodium hydroxide solution is added. The reaction mass should have an
appropriate pleasant odor, sometimes with a trace of unreacted methylamine.
Water added to RM. Fig 7​
Fig 7

The silica gel is washed with additional portions of water to extract all of the RM. Then, extraction is performed
by adding dichloromethane (DCM). The process is repeated by adding DCM and water for better separation.
Fig 8​

Fig 8

The DCM layer is drained into a 1-liter beaker, and anhydrous sodium sulfate is added. Fig 9​

Fig 9

Dried extract of methamphetamine in DCM. Fig 10​

Fig 10

Stage 3​
The dried extract in DCM is introduced into a 500 ml flask (the drying agent is washed with additional portions
of DCM!). Fig 11​

Fig 11

The distillation setup is assembled. DCM is distilled off at the temperature 90-100°C. Complete distillation of
DCM is not important. Fig 12​
Fig 12

The oil after DCM distilled off, should have a pleasant amine-like odor, significantly different from the smell of
methylamine. Fig 13​

Fig 13​

Stage 4​

The oil obtained in Stage 3 is transferred to a beaker, and an additional 10-20 ml of ethanol is rinsed from the
distillation flask. Fig 14​
Fig 14

A hydrogen chloride generator is assembled. Fig 15​

Fig 15

The methamphetamine free base should have an alkaline reaction until it is saturated with hydrogen chloride.
Fig 16​

Fig 16

After the beginning of hydrogen chloride evolution from the tube, you can gradually immerse it in the solution to
prevent it from getting sucked in! After full saturation, the solution should have a pink, raspberry, or dark red
color depending on the purity of the reagents used during the synthesis. Fig 17​
Fig 17

Next, the obtained solution is evaporated until crystallization occurs. Fig 18​

Fig 18

Fully crystallized reaction mass. Fig 19​

Fig 19

The crystallized methamphetamine hydrochloride is mixed with diethyl ether and thoroughly stirred into a
paste-like mass. The resulting paste is transferred onto a vacuum filter. Fig 20​

Fig 20
22  #2
Jan
The methamphetamine thank you for your effort
hydrochloride is filtered, if necessary, washed with additional portions of ether
(ethylacetate or Et2O) (in case of heavy contamination, acetone is also added). Fig 21​
Mo0odi
Don't buy from me
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Joined: Aug 26, 2022
Messages: 138
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Points: 28

22  #3
Jan
The most awaited synthesis in my life

jasper
Don't buy from me
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Joined: Nov 4, 2023
Messages: 15
Reaction score: 5
 Points: 3

19  #4
Feb
Can this synthesis be done in larger scale, like 1-2 kilo

hunter12
Don't buy from me By Throw-off

T
Resident
19 Feb  #5
Joined: Jan 18, 2023
hunter12 Yes easily
Messages: 20
Reaction score: 3
GhostChemist
Points: 3

20  #6

T
Feb
Is the sodium sulfate just used as a drying agent for the DCM? Is there a reason to use Sodium sulfate over magnesium sulfate?
By GhostChemist
02 Mar  #9

Throw-off Throw-off no, you can use any drying agent as sodium sulfate or magnesium sulfate. but don`t use MgClO4 as drying agent
Don't buy from me
Throw-off
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By Throw-off
Joined: Feb 18, 2024
Messages:
Reaction score:
43
17
T 02 Mar  #10

GhostChemist Thought so, tried it with magnesium sulfate and it worked a treat
Points: 8

02  #7

J
Mar
How to use methylamine hcl in this process?
By GhostChemist

02 Mar  #8

jotoy convert methylamine into dry alcohol solution

jotoy
Don't buy from me
Mo0odi
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Joined: Dec 20, 2023 ↑View previous replies…
Messages: 12
Reaction score: 1 By jotoy
Points: 3
J 03 Mar  #11

GhostChemist Ofc yes but what way and what mesurements

By Throw-off

T 04 Mar  #12

jotoy If you can't work out simple molecular weight and ratios you can't make meth. That's the rules

The-Hive

By jotoy

J 06 Mar  #13

Throw-off You cant just disolve methylamine into alchohol to make a solution

Fig 21 Throw-off
By Throw-off

T 07 Mar  #16
The obtained methamphetaminejotoy
hydrochloride.
Are you dyslexic?Fig
When22
did​ I state methylamine HCl could be dissolved in alcohol? Freebase the hcl and it
releases the gas and makes water and salt as bi-product.. I swear some of you retards shouldn't be messing with
chemicals.

The-Hive

By WillD
06 Mar  #14

jotoy methylamine hcl + tea (triethylamine) in methanol (if u use NaBH4, in some other cases, other solvents are used)

Mo0odi

06  #15
Mar
Can we please have the secret to big nice shards of meth crystals. Tried almost all the recrystalization on the forum but non of them
give big crystals.

hunter12
Don't buy from me
Resident
By lalalander
Joined: Jan 18, 2023
Messages: 20 15 Apr  #17
Reaction score: 3 hunter12 You need to separate the isomers. The D and L isomers form large rocks on their own, but not together.
Points: 3

15  #18
Apr
Hi, gentlemen, you need to dry the reagent before production, but you need to use 40% methylamine aqueous solution, which
contains water. What's the use of drying like this?

Fig 22 hacke8
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Joined: Feb 26, 2024
 Messages:
The product yield 22is
Reaction score: 2
60 - 79 %
Points: 3

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 reagents
   and  glassware
 must be dry.​
A small
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portion of silica gel
Synthesis Technologies and Analysis
can be added to sodium borohydride.​
Amphetamines (Phenylethylamines)
The size of the silica gel is 2.5-4 mm.​
Do not use silica gel in powder form.​
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