SAFETY DATA SHEET Page 1 / 9

Creation Date 15-Mar-2010

Revision Date 13-Dec-2020
Version 3

ACR12064

1,6-Hexanediamine
SECTION 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

产品说明: 己二胺
Product Description: 1,6-Hexanediamine

Cat No. : 120640000; 120640010; 120640050; 120641000; 120645000

Synonyms 1,6-Diaminohexane; Hexamethylenediamine
CAS No 124-09-4
Molecular Formula C6 H16 N2

Supplier UK entity/business name

Fisher Scientific UK
Bishop Meadow Road,
Loughborough, Leicestershire LE11 5RG, United Kingdom
General info; Tel: +44 (0)1509 231166

EU entity/business name
Acros Organics BVBA
Janssen Pharmaceuticalaan 3a, 2440 Geel, Belgium
General Info; Tel: +32-14-57 52 11 ([email protected])
Technical Support; Tel +32-14-56 56 00 ([email protected])

Emergency Telephone Number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11
Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99
CHEMTREC Tel. No.US:001-800-424-9300 / Europe:001-703-527-3887

E-mail address [email protected]

Recommended Use Laboratory chemicals.

Uses advised against No Information available

SECTION 2. HAZARD IDENTIFICATION

Physical State Appearance Odor

Solid Colorless Amine compounds

Emergency Overview
Causes severe skin burns and eye damage. May cause respiratory irritation. Combustible liquid. Harmful if swallowed. Harmful in
contact with skin. Hygroscopic.

Classification of the substance or mixture

Flammable liquids. Category 4

Acute Oral Toxicity Category 4
Acute Dermal Toxicity Category 4
Skin Corrosion/Irritation Category 1 B
Serious Eye Damage/Eye Irritation Category 1
Specific target organ toxicity - (single exposure) Category 3

Label Elements

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Signal Word Danger

Hazard Statements
H227 - Combustible liquid
H314 - Causes severe skin burns and eye damage
H335 - May cause respiratory irritation
H302 + H312 - Harmful if swallowed or in contact with skin

Precautionary Statements
Prevention
P210 - Keep away from heat/sparks/open flames/hot surfaces. - No smoking
P264 - Wash face, hands and any exposed skin thoroughly after handling
P270 - Do not eat, drink or smoke when using this product
P271 - Use only outdoors or in a well-ventilated area
P280 - Wear protective gloves/protective clothing/eye protection/face protection
Response
P303 + P361 + P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower
P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing
P310 - Immediately call a POISON CENTER or doctor/physician
P330 - Rinse mouth
P331 - Do NOT induce vomiting
P363 - Wash contaminated clothing before reuse
P370 + P378 - In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction
Storage
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed
Disposal
P501 - Dispose of contents/ container to an approved waste disposal plant

Physical and Chemical Hazards

Combustible material. Hygroscopic.
Health Hazards
Corrosive. Causes skin and eye burns. Causes serious eye damage. May cause respiratory irritation. Harmful if swallowed.
Harmful in contact with skin.
Environmental hazards
Contains no substances known to be hazardous to the environment or not degradable in waste water treatment plants. . Will likely
be mobile in the environment due to its water solubility. The product is water soluble, and may spread in water systems.

Toxicity to Soil Dwelling Organisms. Toxic to terrestrial vertebrates.

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS

Component CAS No Weight %

Hexamethylenediamine 124-09-4 >95

SECTION 4. FIRST AID MEASURES

Eye Contact
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required.

Skin Contact
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Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required.

Inhalation
Remove to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth method if victim ingested or inhaled the
substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory
medical device. Immediate medical attention is required.

Ingestion
Do NOT induce vomiting. Call a physician or poison control center immediately.

Most important symptoms and effects

Causes burns by all exposure routes. Ingestion causes severe swelling, severe damage to the delicate tissue and danger of
perforation: Product is a corrosive material. Use of gastric lavage or emesis is contraindicated. Possible perforation of stomach or
esophagus should be investigated

Self-Protection of the First Aider

Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and prevent spread of
contamination.

Notes to Physician
Treat symptomatically.

SECTION 5. FIRE-FIGHTING MEASURES

Suitable Extinguishing Media

CO 2, dry chemical, dry sand, alcohol-resistant foam. Water mist may be used to cool closed containers.

Extinguishing media which must not be used for safety reasons

No information available.

Specific Hazards Arising from the Chemical

Combustible material. Containers may explode when heated. Keep product and empty container away from heat and sources of
ignition. Thermal decomposition can lead to release of irritating gases and vapors.

Protective Equipment and Precautions for Firefighters

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear. Thermal decomposition can lead to release of irritating gases and vapors.

SECTION 6. ACCIDENTAL RELEASE MEASURES

Personal Precautions
Use personal protective equipment as required. Remove all sources of ignition. Evacuate personnel to safe areas. Keep people
away from and upwind of spill/leak. Avoid dust formation.

Environmental Precautions
Should not be released into the environment. See Section 12 for additional Ecological Information. Do not flush into surface water
or sanitary sewer system.

Methods for Containment and Clean Up

Sweep up and shovel into suitable containers for disposal. Avoid dust formation.

Refer to protective measures listed in Sections 8 and 13.

SECTION 7. HANDLING AND STORAGE

Handling
Wear personal protective equipment/face protection. Keep away from open flames, hot surfaces and sources of ignition. Do not get
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in eyes, on skin, or on clothing. Avoid dust formation. Do not breathe (dust, vapor, mist, gas). Do not ingest. If swallowed then seek
immediate medical assistance.

Storage
Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat, sparks and flame. Corrosives area.

Specific Use(s)
Use in laboratories

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Control Parameters

Component ACGIH TLV OSHA PEL NIOSH IDLH European Union

Hexamethylenediamine TWA: 0.5 ppm

Monitoring methods
BS EN 14042:2003 Title Identifier: Workplace atmospheres. Guide for the application and use of procedures for the assessment of
exposure to chemical and biological agents. MDHS14/3 General methods for sampling and gravimetric analysis of respirable and
inhalable dust

Exposure Controls

Engineering Measures
Use only under a chemical fume hood. Ensure that eyewash stations and safety showers are close to the workstation location. Use
explosion-proof electrical/ventilating/lighting equipment. Wherever possible, engineering control measures such as the isolation or
enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly
designed ventilation systems, should be adopted to control hazardous materials at source.

Personal protective equipment

Eye Protection Goggles (European standard - EN 166)

Hand Protection Protective gloves

Glove material Breakthrough time Glove thickness EU standard Glove comments

Butyl rubber < 45 minutes 0.35 mm EN 374 (minimum requirement)
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger
of cuts, abrasion.
Remove gloves with care avoiding skin contamination.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure

Respiratory Protection When workers are facing concentrations above the exposure limit they must use
appropriate certified respirators.
To protect the wearer, respiratory protective equipment must be the correct fit and be used
and maintained properly

Large scale/emergency use Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits
are exceeded or if irritation or other symptoms are experienced
Recommended Filter type: Particulates filter conforming to EN 143

Small scale/Laboratory use Use a NIOSH/MSHA or European Standard EN 149:2001 approved respirator if exposure
limits are exceeded or if irritation or other symptoms are experienced.
Recommended half mask:- Valve filtering: EN405; or; Half mask: EN140; plus filter, EN
141
When RPE is used a face piece Fit Test should be conducted

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Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.

Environmental exposure controls Prevent product from entering drains.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance Colorless
Physical State Solid

Odor Amine compounds

Odor Threshold No data available
pH 12 1% aq. solution
Melting Point/Range 38 - 41 °C / 100.4 - 105.8 °F
Softening Point No data available
Boiling Point/Range 204 - 205 °C / 399.2 - 401 °F @ 760 mmHg
Flash Point 81 °C / 177.8 °F Method - No information available
Evaporation Rate Not applicable Solid
Flammability (solid,gas) No information available
Explosion Limits Lower 0.7 Vol%
Upper 6.3 Vol%
Vapor Pressure 2 mbar @ 50 °C
Vapor Density Not applicable Solid
Specific Gravity / Density No data available
Bulk Density No data available
Water Solubility 490 g/l (20°C)
Solubility in other solvents No information available
Partition Coefficient (n-octanol/water)
Component log Pow
Hexamethylenediamine 0.02
Autoignition Temperature 310 °C / 590 °F
Decomposition Temperature No data available
Viscosity Not applicable Solid
Explosive Properties No information available
Oxidizing Properties No information available

Molecular Formula C6 H16 N2

Molecular Weight 116.21

SECTION 10. STABILITY AND REACTIVITY

Stability Hygroscopic.

Hazardous Reactions None under normal processing.

Hazardous Polymerization Hazardous polymerization does not occur.

Conditions to Avoid Incompatible products. Avoid dust formation. Exposure to moist air or water. Heat, flames
and sparks.

Materials to avoid Strong oxidizing agents.

Hazardous Decomposition Products Carbon monoxide (CO). Carbon dioxide (CO2). Nitrogen oxides (NOx).

SECTION 11. TOXICOLOGICAL INFORMATION

Product Information

(a) acute toxicity;

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Component LD50 Oral LD50 Dermal LC50 Inhalation
Hexamethylenediamine LD50 = 750 mg/kg ( Rat ) LD50 = 1110 mg/kg ( Rabbit )

(b) skin corrosion/irritation; Category 1 B

(c) serious eye damage/irritation; Category 1

(d) respiratory or skin sensitization;

Respiratory Based on available data, the classification criteria are not met
Skin Based on available data, the classification criteria are not met

(e) germ cell mutagenicity; Based on available data, the classification criteria are not met

(f) carcinogenicity; Based on available data, the classification criteria are not met
There are no known carcinogenic chemicals in this product

(g) reproductive toxicity; Based on available data, the classification criteria are not met

(h) STOT-single exposure; Category 3

Results / Target organs Respiratory system

(i) STOT-repeated exposure; Based on available data, the classification criteria are not met

Target Organs None known.

(j) aspiration hazard; Not applicable

Solid

Other Adverse Effects See actual entry in RTECS for complete information

Symptoms / effects,both acute and Ingestion causes severe swelling, severe damage to the delicate tissue and danger of
delayed perforation: Product is a corrosive material. Use of gastric lavage or emesis is
contraindicated. Possible perforation of stomach or esophagus should be investigated

SECTION 12. ECOLOGICAL INFORMATION

Ecotoxicity effects Do not empty into drains.

Component Freshwater Fish Water Flea Freshwater Algae Microtox

Hexamethylenediamine Leuciscus idus: LC50: EC50: = 23.4 mg/L, 48h EC50: = 14.8 mg/L, 96h EC50 = 85 mg/L 2 h
62 mg/L/96h (Daphnia magna) (Pseudokirchneriella
subcapitata)
EC50: = 15 mg/L, 72h
(Pseudokirchneriella
subcapitata)

Persistence and Degradability

Persistence Soluble in water, Persistence is unlikely, based on information available.
Degradation in sewage No inhibition of bacteria is expected if properly introduced into a biological treatment facility.
treatment plant

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Bioaccumulative Potential Bioaccumulation is unlikely

Component log Pow Bioconcentration factor (BCF)

Hexamethylenediamine 0.02 No data available

Mobility in soil The product is water soluble, and may spread in water systems Will likely be mobile in the
environment due to its water solubility Highly mobile in soils

Endocrine Disruptor Information This product does not contain any known or suspected endocrine disruptors
Persistent Organic Pollutant This product does not contain any known or suspected substance
Ozone Depletion Potential This product does not contain any known or suspected substance

SECTION 13. DISPOSAL CONSIDERATIONS

Waste from Residues/Unused Waste is classified as hazardous. Dispose of in accordance with the European Directives
Products on waste and hazardous waste. Dispose of in accordance with local regulations.

Contaminated Packaging Dispose of this container to hazardous or special waste collection point.

Other Information Do not flush to sewer. Waste codes should be assigned by the user based on the
application for which the product was used. Do not empty into drains. Large amounts will
affect pH and harm aquatic organisms. Solutions with high pH-value must be neutralized
before discharge.

SECTION 14. TRANSPORT INFORMATION

Road and Rail Transport

UN-No UN2280
Proper Shipping Name HEXAMETHYLENEDIAMINE, SOLID
Hazard Class 8
Packing Group III

IMDG/IMO

UN-No UN2280
Proper Shipping Name HEXAMETHYLENEDIAMINE, SOLID
Hazard Class 8
Packing Group III

IATA

UN-No UN2280
Proper Shipping Name HEXAMETHYLENEDIAMINE, SOLID
Hazard Class 8
Packing Group III

Special Precautions for User No special precautions required

SECTION 15. REGULATORY INFORMATION

International Inventories
X = listed, China (IECSC), Europe (EINECS/ELINCS/NLP), U.S.A. (TSCA), Canada (DSL/NDSL), Philippines (PICCS), Japan (ENCS), Japan
(ISHL), Australia (AICS), Korea (KECL).

Component The List of TCSI IECSC EINECS TSCA DSL PICCS ENCS ISHL AICS KECL
Inventory of dangerous
Hazardous goods GB
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Chemicals 12268 -
(2015 2012
Edition)
Hexamethylenediamin X X X X 204-679-6 X X X X X X KE-18611
e

National Regulations

SECTION 16. OTHER INFORMATION

Creation Date 15-Mar-2010

Revision Date 13-Dec-2020
Revision Summary Not applicable.

Training Advice
Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and
hygiene.
Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit
and standards.
First aid for chemical exposure, including the use of eye wash and safety showers.

Legend

CAS - Chemical Abstracts Service TSCA - United States Toxic Substances Control Act Section 8(b)
Inventory
EINECS/ELINCS - European Inventory of Existing Commercial Chemical DSL/NDSL - Canadian Domestic Substances List/Non-Domestic
Substances/EU List of Notified Chemical Substances Substances List
PICCS - Philippines Inventory of Chemicals and Chemical Substances ENCS - Japanese Existing and New Chemical Substances
IECSC - Chinese Inventory of Existing Chemical Substances AICS - Australian Inventory of Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances NZIoC - New Zealand Inventory of Chemicals

WEL - Workplace Exposure Limit TWA - Time Weighted Average

ACGIH - American Conference of Governmental Industrial Hygienists IARC - International Agency for Research on Cancer
DNEL - Derived No Effect Level Predicted No Effect Concentration (PNEC)
RPE - Respiratory Protective Equipment LD50 - Lethal Dose 50%
LC50 - Lethal Concentration 50% EC50 - Effective Concentration 50%
NOEC - No Observed Effect Concentration POW - Partition coefficient Octanol:Water
PBT - Persistent, Bioaccumulative, Toxic vPvB - very Persistent, very Bioaccumulative

ADR - European Agreement Concerning the International Carriage of ICAO/IATA - International Civil Aviation Organization/International Air
Dangerous Goods by Road Transport Association
IMO/IMDG - International Maritime Organization/International Maritime MARPOL - International Convention for the Prevention of Pollution from
Dangerous Goods Code Ships
OECD - Organisation for Economic Co-operation and Development ATE - Acute Toxicity Estimate
BCF - Bioconcentration factor VOC (volatile organic compound)

Key literature references and sources for data

https://echa.europa.eu/information-on-chemicals
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS

Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text
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End of Safety Data Sheet

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