PRINCIPLES OF INHERITANCE AND VARIATION
1. When two genes are located on the same chromosome, the proportion of parental gene combination is
A) higher than non-parental B) lower than non-parental
C) equal to non-parental D) None of these
2. Refer to the given figure showing meiosis and germ cell formation in a cell with four chromosomes.
Which law of Mendel can be effectively explained by this figure?
A) Law of dominance B) Law of segregation
C) Law of independent assortment D) All of these
3. The term used to describe the generation of nonparental gene combination is
A) linkage B) recombination C) mutation D) none of these
4. Refer to the given figure which is followed by few statements. Choose the incorrect statement about
it.
A) It shows male heterogamety.
B) Both possess same types of autosomes.
C) The sex of progeny is determined by females.
D) This type of sex determination is different from humans.
5. Select the incorrect statement.
A) Male fruit fly is heterogametic.
B) In male grasshoppers, 50% of sperms have no sex chromosome.
C) In domesticated fowls, sex of progeny depends on the type of sperm rather than egg.
D) Human males have one of their sex chromosomes much shorter than the other.
6. Match the items of Column I with Column II.
7.Chromosomal aberrations are commonly observed in
A) cardiac cells B) cancer cells C) skeletal cells D) none of these
8. A classical example of point mutation is
A) gout B) night blindness C) sickle cell anaemia D) Turner’s syndrome
9. Assertion: Grasshoppers show male heterogamety.
Reason: Male grasshoppers produce two types of gametes.
A) Both assertion and reason are true and the reason is the correct explanation of assertion.
B) Both assertion and reason are true but the reason is not the correct explanation of assertion.
C) Assertion is true but reason is false.
D) Both assertion and reason are false.
10. In a pedigree analysis, the given symbol represents
A) affected individuals B) mating C) consanguineous mating D) unspecified sex
11. Mendelian disorders are mainly determined by alteration or mutation in the
A) chromosomes B) single gene C) array of genes D) none of these
12. Among the following which one is a Mendelian disorder?
A) Haemophilia B) Sickle cell anaemia C) Cystic fibrosis D) All of these
13.A genetic disease transmitted from a carrier female that is phenotypically normal to only some male
progeny is
A) sex-linked dominant B) sex-linked recessive
C) autosomal dominant D) autosomal recessive
14. Refer to the given pedigree analysis. It is related to the analysis of
A) autosomal dominant trait B) autosomal recessive trait
C) sex-linked dominant trait D) sex-linked recessive trait
15. Haemophilia A and B are due to deficiencies of respectively clotting factor
A) VIII and IX B) IX and VIII C) VII and IX D) X and VII
16. In sickle cell anaemia, valine replaces glutamic acid. This valine is coded by the triplet,
A) AAG B) GAG C) GUG D) GAA
17. Sickle Cell Anaemia (SCA) is transferred from parents to offspring when
A) father is affected, and mother is normal. B) father is normal, and mother is carrier.
C) father is normal, and mother is affected. D) both mother and father are carrier.
18. If a colourblind man marries a woman who is homozygous for normal colour vision, the probability
of their son being colour blind is
A) 0.75 B) 1 C) 0 D) 0.5
19. The chromosomal disorders are
A) absence of one or more chromosomes
B) excess of one or more chromosomes
C) abnormal arrangement of chromosomes
D) all of these
20. Condition of having 2n ± 1 or 2n ± 2 chromosomes is called
A) polyploidy B) aneuploidy C) allopolyploidy D) monosomy
21. Thalassemia and sickle cell anaemia are caused due to a problem in globin molecule synthesis.
Select the correct statement.
A) Both are due to a quantitative defect in globin chain synthesis.
B) Thalassemia is due to less synthesis of globin molecules.
C) Sickle cell anaemia is due to quantitative problem of globin molecules.
D) Both are due to qualitative defect in globin chain synthesis
22. Phenylketonuria is an inborn error in which affected individual lacks an enzyme that converts
A) phenylalanine into tyrosine B) tyrosine into phenylalanine
C) glutamic acid into valine D) valine into glutamic acid
23. A disease caused by an autosomal primary nondisjunction is
A) Klinefelter’s syndrome B) Turner’s syndrome C) Sickle cell anaemia D) Down’s syndrome
24. Refer to the given figure. It is showing the characteristic features of
A) Down’s syndrome B) Turner’s syndrome C) Klinefelter’s syndrome D) None of these
25. The disease caused by the trisomy of chromosome number 21 is
A) Turner’s syndrome B) Haemophilia C) Klinefelter’s syndrome D) Down’s syndrome
26. What is the genetic disorder in which an individual has an overall masculine development,
gynaecomastia and is sterile?
A) Turner’s syndrome B) Klinefelter’s syndrome
C) Edward’s syndrome D) Down’s syndrome
27. What map unit (centimorgan) is adopted in the construction of genetic maps?
A) A unit distance between two expressed genes, representing 10% cross over.
B) A unit distance between two expressed genes, representing 100% cross over.
C) A unit distance between genes on chromosomes, representing 1% cross over.
D) A unit distance between genes on chromosomes, representing 50% cross over.
28. What type of relationship is found between the distance of genes and percentage of recombination?
A) Inverse B) Parallel C) Direct D) None of these
29. Match Column-I with Column-II and choose the correct option from the codes given below.
30. Match Column-I with Column-II and choose the correct answer from the codes given below.
Answer the following:
1. Explain the mechanism of sex determination in Human and Honeybees.
2. Write short notes on the following:
a. Sickle cell anaemia
b. Thalassemia
c. Phenylketonuria
d. Haemophilia
3. Write the chromosomal compliment and the symptoms of the following:
a. Down’s syndrome
b. Klinefelter’s syndrome
c. Turner’s syndrome
4. Explain the advantages of Drosophila as experimental organism in genetics.
5. Name the scientists who proposed Chromosomal theory of inheritance and state their
observations.
6. Differentiate between linkage and recombination.
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