Material Safety Data Sheet

Miconazole MSDS

Section 1: Chemical Product and Company Identification

Product Name: Miconazole Contact Information:

Catalog Codes: SLM4270 Sciencelab.com, Inc.

14025 Smith Rd.
CAS#: 22916-47-8 Houston, Texas 77396
US Sales: 1-800-901-7247
RTECS: NI4770000
International Sales: 1-281-441-4400
TSCA: TSCA 8(b) inventory: No products were found. Order Online: ScienceLab.com
CI#: Not available. CHEMTREC (24HR Emergency Telephone), call:
1-800-424-9300
Synonym: 1H-Imidazole,
1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-; International CHEMTREC, call: 1-703-527-3887
Imidazole,
1-(20(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- For non-emergency assistance, call: 1-281-441-4400

Chemical Name:
Imidazole,1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)-

Chemical Formula: C18H14Cl4N2O

Section 2: Composition and Information on Ingredients

Composition:
Name CAS # % by Weight
Miconazole 22916-47-8 100

Toxicological Data on Ingredients: Miconazole: ORAL (LD50): Acute: 500 mg/kg [Rat]. 519 mg/kg [Mouse].

Section 3: Hazards Identification

Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of
inhalation (lung irritant).

Potential Chronic Health Effects:

CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate medical condition.

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 Section 4: First Aid Measures
Eye Contact:
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Get medical attention if irritation occurs.

Skin Contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.

Serious Skin Contact: Not available.

Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention if symptoms appear.

Serious Inhalation: Not available.

Ingestion:
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature.

Auto-Ignition Temperature: Not available.

Flash Points: Not available.

Flammable Limits: Not available.

Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated
compounds.

Fire Hazards in Presence of Various Substances:

Slightly flammable to flammable in presence of heat.
Non-flammable in presence of shocks.

Explosion Hazards in Presence of Various Substances:

Slightly explosive in presence of open flames and sparks.
Non-explosive in presence of shocks.

Fire Fighting Media and Instructions:

SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

Special Remarks on Fire Hazards: As with most organic solids, fire is possible at elevated temperatures

Special Remarks on Explosion Hazards:

Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust
explosion hazard.

Section 6: Accidental Release Measures

Small Spill:
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.

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Large Spill:
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.

Section 7: Handling and Storage

Precautions:
Keep away from heat. Keep away from sources of ignition. Do not ingest. Do not breathe dust. Wear suitable
protective clothing. If ingested, seek medical advice immediately and show the container or the label.

Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area.

Section 8: Exposure Controls/Personal Protection

Engineering Controls:
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.

Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.

Personal Protection in Case of a Large Spill:

Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.

Exposure Limits: Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Powdered solid. Crystalline powder.)

Odor: Odorless.

Taste: Bitter.

Molecular Weight: 416.13 g/mole

Color: White. Off-white.

pH (1% soln/water): Not applicable.

Boiling Point: Not available.

Melting Point: 170°C (338°F)

Critical Temperature: Not available.

Specific Gravity: Not available.

Vapor Pressure: Not applicable.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

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Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water, acetone.

Solubility:
Easily soluble in acetone.
Insoluble in cold water, hot water.
Soluble in Dimethylformamide

Section 10: Stability and Reactivity Data

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: Excess heat, incompatible materials

Incompatibility with various substances: Not available.

Corrosivity: Non-corrosive in presence of glass.

Special Remarks on Reactivity: Sensitive to light.

Special Remarks on Corrosivity: Not available.

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Inhalation. Ingestion.

Toxicity to Animals: Acute oral toxicity (LD50): 500 mg/kg [Rat].

Chronic Effects on Humans: Not available.

Other Toxic Effects on Humans: Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation (lung irritant).

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans:

May affect genetic material (mutagenic).
May cause adverse reproductive effects. based on animal test data

Special Remarks on other Toxic Effects on Humans:

Acute Potential Health Effects:
Skin: May cause irritation. May cause allergic (sensitivity) reactions such as itching, rash, cutaneous pruritus,
flushes
Eyes: May cause irritation.
Inhalation: May cause respiratory tract irritation.
Ingestion: May cause gastrointestinal tract irritation or upset with nausea, vomiting, diarrhea, anorexia. May
affect the cardiovascular system (tachycardia, arrhythmias), blood (aggregation of erythrocytes, anemia,
thrombocytopenia, thrombocytosis), behavior/central nervous system (drowsiness, convulsions, acute psychosis),
respiration (respiratory stimulation). It may also cause hyperlipidemia, febrile reactions, arthralgia, and anaphylxis

Section 12: Ecological Information

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Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.

Toxicity of the Products of Biodegradation: The products of degradation are as toxic as the product itself.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:
Waste must be disposed of in accordance with federal, state and local environmental
control regulations.

Section 14: Transport Information

DOT Classification: Not a DOT controlled material (United States).

Identification: Not applicable.

Special Provisions for Transport: Not applicable.

Section 15: Other Regulatory Information

Federal and State Regulations: No products were found.

Other Regulations:
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.

Other Classifications:

WHMIS (Canada): Not controlled under WHMIS (Canada).

DSCL (EEC):
R22- Harmful if swallowed.
S2- Keep out of the reach of children.
S46- If swallowed, seek medical advice
immediately and show this container or label.

HMIS (U.S.A.):

Health Hazard: 1

Fire Hazard: 1

Reactivity: 0

Personal Protection: E

National Fire Protection Association (U.S.A.):

Health: 1

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 Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment:
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.
Safety glasses.

Section 16: Other Information

References:
Registry of Toxic Effects of Chemicals (RTECS).
-Manufacturer's Material Safety Data Sheet.

Other Special Considerations: Not available.

Created: 10/10/2005 08:41 PM

Last Updated: 10/10/2005 08:41 PM

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