e298 Journal of Hypertension Vol 35, e-Supplement 2, September 2017

Design and method: This observational program (held in the Russian Federation) Objective: The role of regular physical activity on blood pressure (BP) and in-
involved 392 doctors (internists and GPs) which included 1969 patients whose hy- flammatory process have been investigated in hypertension. This study aims to
pertension was uncontrolled on combination antihypertensive treatment. Patients evaluate the acute effects of either aerobic, resistance or both combined exercises
were previously treated with free-dose or fixed-dose combinations in 86% and on inflammatory markers IL-10 and IL-1ra in resistant (RH) and controlled hyper-
14% of cases, respectively. Implementation of the Programme had been approved tensive (HT) subjects. Secondly, we will assess those effects on BP levels.
at a meeting of the Inter-University Ethics Committee, protocol number 06–14 of
Design and method: This randomized, single-blind, crossover non-pharmacologi-
06/20/2014 (Moscow).
cal intervention study will include 20 patients, 10 RH and 10 HT, who are regularly
Results: Switching to a fixed-dose combination of perindopril arginine/indapamide followed at the Outpatient Resistant Hypertension Clinic (UNICAMP, Brazil). This
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10/2.5 mg resulted in a mean reduction of 39.5 mm Hg in systolic BP and 18.7 mm study will comprise two parts: (1) to determine the type and duration of each exer-
Hg in diastolic BP after 3 months. The target BP (<140/90 mm Hg) was achieved cise individually for each volunteers, and (2) to perform all the three types of exer-
in 76% patients. Patient adherence to treatment (assessed by the Morisky-Green cise in a crossover way in all subjects, which will consist of: 1) aerobic exercise: ac-
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scale) and well-being (assessed by a visual-analogue scale) increased significantly. tivity on a treadmill lasting 45 minutes with intensity of 50–60% of maximum heart
The change in treatment was not only effective, but also safe. Adverse events were rate obtained from ergometer test; 2) resistance exercise: 4 series of 12 repetitions of
recorded in 28 patients (1.4% of the general study population), and down-titration resistance exercises at moderate intensity (until moderate fatigue), for 45 minutes;
was required in only 1 case, due to symptomatic hypotension. The magnitude of BP 3) combined exercise: aerobic (25 minutes) + resistance (20 minutes), with an inter-
reduction and the rate of achievement of target BP were similar whether or not free- val of 2 minutes between sessions totalizing 45 minutes. We will perform blood test
or fixed-dose combinations were used previously, and whether or not additional before and after the interventions to assess inflammatory biomarkers IL-10 and IL-
education of doctors and patients was provided; however, they were correlated with 1ra. Also, we will determine the beat-to-beat BP levels (using the Finometer device).
BP at baseline and duration of treatment. Predictors of failure to achieve target BP
included: age, male sex, low adherence to treatment at baseline, a high score on the
well-being scale, a higher BP level at baseline, high total cholesterol, body mass,
heart rate, and low glomerular filtration rate.
Conclusions: Treatment regimen simplification using fixed-dose perindopril argi-
nine/indapamide combination at full doses plays a major role in increasing treat-
ment efficacy in hypertensive patients.

PP.25.05 EFFECT OF MEDITATION UPON ARTERIAL BLOOD

PRESSURE

R. Gasser, L. Veigl. Dept. of Cardiology, Medical University, Graz, Austria

Objective: Regarding the guidelines of the American Heart Association 2013
on the treatment of hypertension, meditation constitutes a „level of evidence B“,
which means that “it may be considered as a therapeutic strategy for (pre)hyper-
tensive patients’’. In order to prove this, however, further research is required. The
American Heart Association’s conclusion along with other case-studies listed in
the bibliography, reflect the growing interest in meditation as an easy and afford-
able technique with few side effects.
Design and method: Here, we studied 113 publications related to meditation and
it´s effect upon arterial hypertension. Firstly, research reveales that stress plays an
important role in the development of essential hypertension. Therefore, stress-re-
lief is directly linked to lower blood pressure. Stress-reducing effects of mediation
were demonstrated in studies by measuring levels of stress hormones, skin resis-
tance, heart rate variability and EEG. Patients reactions to stressful situations also
showed improvements after the implementation of meditation as a coping strategy
due to a decrease in blood pressure as response to stress tests. Thus, stress-reduc- Results: We expect that the acute practice of exercise modulates the inflammatory
ing effects of meditation have been argued to play an important role in treatment biomarkers, IL-10 and IL-1ra, and secondly, the BP levels.
of hypertension. In addition, it has been claimed that both, decreased sympathetic
Conclusions: This study may provide a better understanding of the acute mecha-
tone and changes in hormone levels, could lead to blood pressure lowering effects.
nisms of this non-pharmacologic treatment in RH, in order to make this more
Results: On the one hand, published data of numerous studies show a significant effective in this high-risk population.
reduction of blood pressure in pre-hypertensive and hypertensive patients through
meditation. On the other hand, the majority of studies suffered from small patient PP.25.07 EFFECTIVENESS OF A SMARTPHONE
numbers, poor study design and insufficient statistical analyses. Moreover, some APPLICATION IN INCREASING PHYSICAL ACTIVITY
of the results were inconsistent and, in some cases, even contradictory. Interest- AND DECREASE SEDENTARY LIFESTYLE. THE
ingly, descriptions of side effects of meditative practices were also found. We shall EVIDENT II STUDY
present a complete review of the available literature.
Conclusions: In conclusion, the effectiveness and safety of meditation as a sole L. Garcia-Ortiz1, Ji Recio-Rodriguez1, C. Agudo-Conde1, I. Repiso-Gento2,
Y. Schmolling-Guinovart3, N. González-Viejo4, C. Martín-Cantera5, Ms Arietale-
therapeutic measure to lower blood pressure in (pre)hypertensive patients could
anizbeaskoa6, C. Rodriguez Martin1, Mc Castaño Sanchez1, P. Martinez Perez1,
not be proven at this point as distinct from the recommendations of the AHA.
M. Del Rio Garcia1, C Montero Sánchez1, M. Gómez-Marcos1, The Evident
However, mediation could be accepted as a component of life-style modifications Investigators1. 1Primary Health Care Research Unit, La Alamedilla Health Center.
suggested like physical exercise, weight loss, reduction of sodium absorption and, Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain, 2Casa
if necessary, additional medication. de Barco Health Center, Health Service of Castilla y León, Valladolid, Spain, 3Río
Tajo Health Center, Health Service of Castilla-La Mancha. University of
PP.25.06 ACUTE EFFECTS OF AEROBIC AND RESISTANCE Castilla-La Mancha, Talavera de la Reina, Spain, 4Torre Ramona Health Center,
EXERCISES IN INFLAMMATORY MARKERS IL- Health Service of Aragón, Zaragoza, Spain, 5Primary Health Care University
10 AND IL-1RA IN PATIENTS WITH RESISTANT Research Institute IDIAP-Jordi Gol, Barcelona, Spain, 6Primary Health Care
Research Unit of Bizkaia, Basque Health Service-Osakidetza, Bilbao, Spain
HYPERTENSION: RATIONALE OF A RANDOMIZED,
CONTROLLED TRIAL Objective: The present study evaluates the effects of adding an APP in support
of standardized counselling in order to increase physical activity and decrease
C. Gasparetti1,N. Fraccari1,
A.M. Ritter1,
R. Modolo1,
V. Brunelli1,
N. Correa1, sedentary lifestyle.
H. Coelho-Junior2, B. Rodrigues2, H. Moreno1, A.P. De Faria1. 1Laboratory of
Cardiovascular Pharmacology, Faculty of Medical Sciences, University of Design and method: A randomized, controlled, multicenter clinical trial was car-
Campinas (UNICAMP), Campinas, Brazil, 2Faculty of Physical Education, Uni- ried out. Six primary care centers in Spain. A total of 833 subjects from family prac-
versity of Campinas (UNICAMP), Campinas, Brazil tice offices were recruited through random sampling: 415 in the APP + counseling

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