Printed on: Fri Jan 05 2024, 09:45:49 PM(EST) Status: Currently Official on 06-Jan-2024 DocId: GUID-0440C3A0-4F04-440C-84FE-A3FF66D6CC25_1_en-US
Printed by: USP NF Official Date: Official Prior to 2013 Document Type: USP @2024 USPC
Do Not Distribute DOI Ref: 5sjl1 DOI: https://doi.org/10.31003/USPNF_M89740_01_01
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B: Shake 1 g of it with 10 mL of water, and filter. To the
Zinc Oxide and Salicylic Acid Paste filtrate add 1 mL of ferric chloride TS: an intense reddish violet
color is produced. To this solution add 1 mL of acetic acid: the
» Zinc Oxide and Salicylic Acid Paste contains not color is not dispersed. To this solution add 2 mL of 2 N
hydrochloric acid: the color is dispersed and a white crystalline
less than 23.5 percent and not more than 25.5 precipitate is formed.
percent of zinc oxide (ZnO), and not less than 1.9 Minimum fill á755ñ: meets the requirements.
percent and not more than 2.1 percent of salicylic Assay for zinc oxide—Weigh accurately in a tared porcelain
acid (C7H6O3). crucible about 500 mg of Paste, heat gently until melted, and
continue the heating, gradually raising the temperature until
It may be prepared as follows: the mass is thoroughly charred. Ignite the mass strongly until
all of the carbonaceous material has been dissipated, the
Salicylic Acid, in fine powder................ 20 g residue is uniformly yellow, and the weight of the cooled
residue is constant. The weight of the residue represents the
Zinc Oxide Paste, a sufficient quantity quantity of ZnO in the weight of the Paste taken for the assay.
Assay for salicylic acid—Transfer to a suitable beaker about
to make................................................ 1000 g 5 g of Paste, accurately weighed. Add 40 mL of alcohol,
previously neutralized with 0.1 N sodium hydroxide to a
Thoroughly triturate the Salicylic Acid with a phenol red endpoint, and heat on a water bath for 5 minutes,
with frequent swirling. While still hot, add phenol red TS, and
portion of the paste, then add the remaining paste, titrate with 0.1 N sodium hydroxide VS to a red endpoint. Each
and triturate until a smooth mixture is obtained. mL of 0.1 N sodium hydroxide is equivalent to 13.81 mg of
salicylic acid (C7H6O3).
al
Packaging and storage—Preserve in well-closed
containers.
Identification—
A: The residue obtained in the Assay for zinc oxide is yellow ci
when hot and white when cool.
ffi
O
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