SDS (Safety Data Sheet)

Argireline Amplified
Safety Data Sheet according to Federal Register / Vol. 77, No. 58 / Revision Date: 05-Nov-2021
March 26, 2012 / Rules and Regulation Supersedes: Feb-2021

1 PRODUCT & COMPANY IDENTIFICATION

Product Name: Argireline Amplified Distributor: MakingCosmetics Inc.

Synonyms: No data available Address: 10800 231st Way NE
INCI Name: Acetyl hexapeptide-8 Redmond, WA 98053 (USA)
CAS Number: 616204-22-9, 7732-18-5, 532-32-1 Phone / Fax: 425-292-9502 / 425-292-9601
Formula: No data available Web: www.makingcosmetics.com
Product Form: Liquid
Product Use: Cosmetic use Emergency Telephone Number: 1-800-424-9300 (Chemtrec)

2 HAZARDS IDENTIFICATION

GHS Classification: Not classified

GHS Labeling: Not a dangerous substance according to GHS
GHS Hazard Pictograms: None
GHS Hazard Statements: None
GHS Precautionary Statements: None
Potential Health Hazards: Eyes: Not expected to be irritant.
Inhalation: Not expected to be irritant.
Skin: Not expected to be irritant.
Ingestion: Not expected to be irritant.
NFPA Ratings (704): Health N/A N/A
Flammability N/A N/A
Reactivity N/A N/A
Specific Hazard N/A

3 COMPOSITION/INFORMATION ON INGREDIENTS

Component CAS No. Weight % Molecular Weight

Water 7732-18-5 Q.S. 100% Not Available
Acetyl Hexapeptide-8 616204-22-9 0.0455-0.055% Not Available
Sodium Benzoate 532-32-1 0.45-0.55% Not Available

4 FIRST AID MEASURES

Eyes: Rinse immediately with plenty of water. If eye irritation persists, get medical advice/attention.
Inhalation: Not a direct hazard. Remove from area of exposure; seek medical attention for coughing or choking.
Skin: Remove contaminated clothing and wash with water. Rinse with water. If discomfort or symptoms persist, seek
medical attention.
Ingestion: Not toxic. If discomfort symptoms appear, call a physician. Do Not Induce Vomiting! Never give anything by
mouth to an unconscious person.

5 FIRE-FIGHTING MEASURES

Suitable (and unsuitable) May be combustible at high temperature. Use appropriate media (dry powder, foam, carbon
extinguishing media: dioxide, water) for adjacent fire. Do not use direct water jet.
Special protective equipment & Wear self-contained, approved breathing apparatus and full protective clothing, including eye
precautions for firefighters: protection and boots.
Flash Points: >95°C
Specific hazards arising from the May emit toxic fumes under fire conditions. See also Stability and Reactivity section.
chemical:

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 SDS (Safety Data Sheet)

6 ACCIDENTAL RELEASE MEASURES

Personal precautions, protective Avoid direct eye contact. Do not try to clean up the leak without proper protective
equipment & emergency procedures: equipment. See section 8 for recommendations on the use of personal protective
equipment.
Environmental precautions: Avoid liquid release into sewers/public water. Notify environmental authorities in case of
large leaks.
Methods and material for Spills can be contained by capping the container. For cleaning up a spill, use a suitable
containment and cleaning up: absorbent material and pump it into the correct container.

7 HANDLING & STORAGE

Precautions for safe Handle in accordance with good industrial hygiene and safety practices. Avoid spills. Do not eat, drink, or
handling: smoke in work areas. See section 8 for recommendations on the use of personal protective equipment. Keep
container closed when not in use.
Conditions for safe Store in clean, cool, and dark place. Avoid extreme environmental conditions. Keep away from heat and
storage, incl. any incompatible materials (see section 10 for incompatibilities). If stored as recommended, shelf life is 18
incompatibilities: months.

8 EXPOSURE CONTROLS / PERSONAL PROTECTION

Component Exposure Limits Basis Entity

Argireline Amplified Not available

TWA: Time Weighted Average over 8 hours of work. STEL: Short Term Exposure Limit during x minutes.
TLV: Threshold Limit Value over 8 hours of work. IDLH: Immediately Dangerous to Life or Health
REL: Recommended Exposure Limit WEEL: Workplace Environmental Exposure Levels
PEL: Permissible Exposure Limit CEIL: Ceiling

Personal Protection:
Eyes: Safety glasses should be worn.
Inhalation: Local exhaust. Provide adequate ventilation.
Body: Protective gloves made of rubber or neoprene. Suitable protective clothing should be worn.
Other: Use good personal hygiene practices. Provide eyewash stations, quick-drench showers and washing facilities
accessible to areas of use and handling.

9 PHYSICAL AND CHEMICAL PROPERTIES

Appearance: Transparent solution Vapor Pressure: No data available

Odor: No data available Vapor Density: No data available
Odor Threshold: No data available Evaporation Rate: No data available
Color: Colorless Flammability: No data available
Molecular Weight: No data available Upper/lower Explosive Limit: No data available
pH: 4.0-5.5 Flash Point: >95°C
Boiling Point: No data available Specific Gravity: 0.95-1.05
Melting Point: No data available Solubility in Water: No data available
Relative Density: No data available Auto-Ignition Temperature: No data available
Partition Coefficient: n- No data available Decomposition Temperature: No data available
octanol/water:
Viscosity: No data available Explosive Properties: No data available
Oxidizing Properties: No data available Freezing Point: No data available
Refractive Index: 1.314-1.354 Identification (HPLC): Similar retention time as in-
house reference standard

10 STABILITY AND REACTIVITY

Reactivity: No reactivity hazards known.

Chemical Stability: The substance/mixture is stable if stored and handled as recommended.
Hazardous Polymerization: No hazardous reactions known if stored and handled as recommended.

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 SDS (Safety Data Sheet)
Conditions to Avoid: None known if stored and handled as recommended.
Incompatible Materials: None known.
Hazardous Decomposition Products: No hazardous decomposition products known if stored and handled as recommended.

11 TOXICOLOGICAL INFORMATION

Acute Toxicity: No data available

Skin: Not considered irritant.
Eyes: Classified as non-irritating at 25 mg/L in a HET-CAM test.
Respiratory: No data available
Ingestion: No data available
Carcinogenicity: No data available
Teratogenicity: No data available
Germ Cell Mutagenicity: Did not induce gene mutations under the experimental conditions (AMES test).
Embryotoxicity: No data available
Specific Target Organ Toxicity: No data available
Reproductive Toxicity: No data available
Respiratory/Skin Sensitization: No data available
Corrosivity: No data available
Sensitization: Not considered sensitizing.
Irritation: No data available
Repeated Dose Toxicity: No data available

12 ECOLOGICAL INFORMATION

Ecotoxicity
Aquatic Vertebrate: No data available
Aquatic Invertebrate: No data available
Terrestrial: No data available
Persistence and Degradability: Readily biodegradable (28d, DOC die-away test, OECD 301A).
Bioaccumulative Potential: No bioaccumulation is expected.
Mobility in Soil: Not determined.
PBT and vPvB Assessment: Not determined.
Other Adverse Effects: Not determined.

13 DISPOSAL CONSIDERATIONS

Waste Residues: Users should review their operations in terms of the applicable federal/national or local regulations and
consult with appropriate regulatory agencies, if necessary, before disposing of waste product container.
Product Containers: Users should review their operations in terms of the applicable federal/national or local regulations and
consult with appropriate regulatory agencies, if necessary, before disposing of waste product container.

The information in section 13 is for the product as shipped. Use and/or alterations to the product may change the characteristics of
the material and alter the waste classification and proper disposal methods

14 TRANSPORT INFORMATION

DOT (Dept. of Transportation, USA): Not applicable

TDG (Transportation of Dangerous Goods, Canada): Not applicable
IMDG (International Maritime Dangerous Goods): Not applicable
IATA (International Air Transport Association): Not applicable
ICAO (International Civil Aviation Organization): Not applicable

15 REGULATORY INFORMATION

TSCA Inventory Status: No ingredients restricted by applicable cosmetic regulations.

DSCL (EEC): No data available
WHMIS (Canada): No data available

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 SDS (Safety Data Sheet)
DSL (Canada): No data available
Canada: No ingredients listed in HOTLIST schedule.
EU EINECS/ELINCS/NLP: No data available
China IECSC: No data available
China IECIC (06.30.2014): All ingredients listed in IECIC schedule.
All ingredients listed in AICS schedule.
Australia AICS:
Exception: Acetyl Hexapeptide-8*
Australia SUSMP: No ingredients listed in SUSMP.
Japan: No ingredient restrictions known on the Standards for Cosmetics, Notification No. 331/2000, as
amended in April 2016.
Exception: Sodium Benzoate (maximum permitted amount: 1.0g per 100g)
Philippines PICCS: No data available
Korea KECI: No data available
New Zealand NZIoC: No data available
European Union: In accordance with Regulation 1223/2009 on cosmetic products.
Brazil: In accordance with article 11 from Resolution RDC No. 7 of February 10, 2015.
CA Prop. 65: No ingredients listed in California's Proposition 65.
Water: Exempt (Annex IV)
REACH: Acetyl Hexapeptide-8: Exempt (<1 ton/year)
Sodium Benzoate: Registered (01-2119460683-35-XXXX)

*The obligation to notify to NICNAS applies only to import volumes over 10kg of substance/year.

16 OTHER INFORMATION

Revision Date: 05-Nov-2021

Compliance: This document has been prepared in accordance with the SDS requirements of the OSHA Hazard Communication
Standard 29 CFR 1910.1200
Disclaimer: This information relates only to the specific material designated and may not be valid for such material used in
combination with any other materials or in any other process. Such information is to be the best of the
company’s knowledge and believed accurate and reliable as of the date indicated. However, no representation,
warranty or guarantee of any kind, express or implied, is made as to its accuracy, reliability or completeness
and we assume no responsibility for any loss, damage or expense, direct or consequential, arising out of use. It
is the user’s responsibility to satisfy himself as to the suitableness & completeness of such information for his
own particular use.

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