ACKNOWLEDGEMENT

Dear Sir/Madam,
I am, A. Sreesivasakthi, a Final year student pursuing a Bachelor of
Pharmacy (B.Pharm) degree, would like to express my sincere gratitude to
Tablets [India] Limited and our esteemed Principal and Dean Dr. R.
Srinivasan sir, Faculty of Pharmacy, Bharath Institute of Higher Education
and Research.
I am profoundly thankful to Tablets [India] Limited for providing me with
the opportunity to engage in an enriching industrial training program. The
experience gained during my internship at their esteemed organization
has been invaluable in broadening my understanding of the
pharmaceutical industry. The exposure to their company's operations,
commitment to quality, and dedication to innovation have significantly
contributed to my professional growth and knowledge in the field of
pharmacy.
I would also like to extend my heartfelt gratitude to Dr. R. Srinivasan sir,
our Principal, and all my Faculty staff for their unwavering support and
guidance throughout my academic journey. Their mentorship and
encouragement have been instrumental in shaping my academic and
professional aspirations.
I consider myself fortunate to have had the privilege of learning from
Tablets [India] Limited, I am committed to applying the knowledge and
skills I have acquired to make a positive impact in the pharmaceutical
field.
Once again, thank you for the invaluable opportunities and support
provided to me during my academic and professional development.

Sincerely,
A.SREESIVASAKTHI.
 ABSTRACT
This internship report provides a comprehensive overview of my
experiential learning journey at Tablets [India] Limited, a prominent
pharmaceutical company. The report delves into the pharmaceutical
industry's intricate dynamics and explores the specific functions and
operations of the company. It also highlights the roles and responsibilities I
undertook during my internship as a Final year B.Pharm student, shedding
light on the practical applications of pharmaceutical knowledge.
The report begins with an introduction to Tablets [India] Limited, detailing
its history, mission, and core values. It then proceeds to offer insights into
the pharmaceutical industry, discussing the critical role it plays in
healthcare and the global economy. The pharmaceutical industry's
regulatory framework and quality control standards are elucidated to
underscore the significance of compliance and safety.
The main body of the report provides an in-depth analysis of Tablets
[India] Limited's organizational structure, departments, and key functions.
Specific focus is given to the production, quality control, and research and
development departments, showcasing the company's commitment to
innovation and product excellence. Furthermore, the report presents a
detailed account of my internship experience, illustrating the tasks I
performed, challenges encountered, and lessons learned during my
tenure.
A critical aspect of the report is the exploration of Tablets [India] Limited's
dedication to pharmaceutical research and development. This section
highlights the company's contribution to the development of novel drug
formulations, its investment in cutting-edge technology, and its
commitment to improving patient healthcare outcomes.
Throughout the report, emphasis is placed on the pharmaceutical
industry's role in addressing global health challenges, and Tablets [India]
Limited's efforts to align with sustainable and ethical business practices.
This internship report serves as a comprehensive document that not only
outlines my practical exposure to the pharmaceutical industry but also
provides a broader understanding of Tablets [India] Limited's commitment
to quality, innovation, and patient welfare. It is a testament to the valuable
experiences gained during my internship, underscoring the importance of
bridging academic knowledge with real-world applications in the
pharmaceutical sector.
 INTERNSHIP OBJECTIVES
Learning objectives for an internship at Tablets [India] Limited in the
pharmaceutical industry:
1.Understanding Pharmaceutical Operations: Gain a comprehensive
understanding of Tablets [India] Limited's pharmaceutical
operations, including drug manufacturing, quality control, research
and development, and distribution.
2.Compliance and Regulatory Knowledge: Learn about the regulatory
requirements and compliance standards governing the
pharmaceutical industry, including Good Manufacturing Practices
(GMP), FDA guidelines (or equivalent in your region), and other
relevant regulations.
3.Quality Control and Assurance: Develop skills in quality control and
assurance by participating in laboratory testing, quality checks, and
quality documentation processes to ensure the production of safe
and effective pharmaceutical products.
4.Pharmaceutical Research and Development: Gain exposure to
pharmaceutical research and development activities, including the
development of new drug
formulations, clinical trials, and the drug development life cycle.
5.Clinical Trial Management: Understand the processes involved in clinical
trials, including patient recruitment, data collection, trial
documentation, and the ethical considerations in human research.
6.Product Formulation: Learn about pharmaceutical formulation
techniques, including the development of solid dosage forms, liquid
formulations, and other drug delivery systems.
7.Documentation and Regulatory Affairs: Gain proficiency in maintaining
accurate and compliant documentation for pharmaceutical products,
including batch records and regulatory submissions.
8.Supply Chain Management: Learn about pharmaceutical supply chain
processes, including procurement, inventory management, and
distribution, to understand the flow of pharmaceutical products.
9.Laboratory Techniques: Develop laboratory skills, such as analytical
chemistry, microbiology, or molecular biology, depending on your
role and department.
10.Data Analysis: Gain proficiency in data analysis tools and techniques
for interpreting pharmaceutical research and clinical trial data.
11.Ethical and Regulatory Awareness: Understand and adhere to ethical
standards in pharmaceutical research and ensure compliance with
industry regulations and guidelines.
12.Problem-Solving and Critical Thinking: Enhance problem-solving and
critical-thinking skills by addressing real-world challenges in drug
development and manufacturing.
13.Professional Communication: Improve written and oral communication
skills through interactions with colleagues, superiors, and clients within
the pharmaceutical industry.
14.Team Collaboration: Collaborate effectively with cross-functional
teams, including
research scientists, pharmacists, regulatory experts, and quality
assurance professionals.
15.Professional Networking: Build a professional network within the
pharmaceutical industry by connecting with colleagues, mentors,
and industry professionals.
16.Continuous Learning: Embrace a culture of continuous learning by
attending relevant training sessions, workshops, and seminars offered
by the company.
17.Adaptation to Technology: Stay updated with emerging technologies
and trends in the pharmaceutical industry, especially in areas like
biotechnology and digital health.
18.Contributing to Innovation: Participate in brainstorming sessions and
contribute
innovative ideas or solutions that could benefit Tablets [India]
Limited and the pharmaceutical industry as a whole.
 TABLETS[INDIA] LIMTED

Tablets India Ltd, the flagship company of the closely held JHAVER GROUP
is one of the leading companies in the Indian Pharmaceutical industry.
They are recognized as the Pioneers in revolutionizing Probiotics, Amino
Acids, and GI Lavage therapy in India and currently are ranked among the
leaders in India and Nepal in these segments.
Tablets (India) Limited was one of the early pharma ventures in India and
was founded in 1938 by Mr. Sri Krishna Jhaver.
Tablets India Ltd is one of the leading companies in India and operates via
9 divisions across the human health & and animal health business with a
combined field force strength of 2000 dedicated and loyal employees
positioned across India.
With an objective of increasing its presence in the global market, Tablets
India Ltd has established geography-specific partnerships with leading
export houses and has established focused JVs under the names of Tablets
MedoPharm Pvt Limited and Tablets Global Care Pvt Limited
nts

Tablets India enjoys a substantial market share in its chosen therapeutic

segments like

PROBIOTIC GI LAVAGE NUTRACEUTICAL FERTILITY SUPPORT RESPIRATORY

HEMATINICS
HEMATINICS PHYTOCHEMICALS PARENTERAL SOLUTIONS
INTERNATIONAL COLLABRATIONS:
Tablets [India] Limited has established itself as a prominent player in the
pharmaceutical
industry, not only within the domestic market but also on the global stage.
Their commitment
to innovation, quality, and patient care extends beyond borders, as
evidenced by our strategic international collaborations .
Benefits of International Collaborations
 Knowledge Exchange: International collaborations promote the
exchange of
knowledge and best practices, allowing Tablets [India] Limited to
leverage global expertise.
 Market Expansion: Our collaborations
facilitate market expansion,
 enabling us to reach patients in
diverse regions and markets.

 Innovation Acceleration: Partnerships

with global innovators accelerate
our product development and

technological advancements.
Compliance and Quality: Collaborations
LIST OF COLLABRATED COMPANIES:
Ajinomoto Pharma Co Ltd., Japan – 1971
Ajinomoto Co. Inc, Japan – 1991
F.Hoffmann La Roche, Switzerland – 1991
Kotobuki Pharmaceuticals Co. Ltd, Japan –
1998 TOA Pharmaceutical Co. Ltd, Japan –
2000
Chr. Hansen A/S Denmark – 2005
Taradon Laboratory., Belgium – 2006
Nitta Gelatin Inc. Japan – 2009
Pharmavista, USA – 2011
Lesaffre International S.A.R.L, France – 2014
MANREMYC, Spain – 2015
Ganeden Biotech, USA – 2015
UAS Labs LLC, USA – 2016
Morinaga Nutritional Foods Pte Ltd , JAPAN –
2016 DuPont Nutrition & Health, USA – 2019
Kerry Inc. Ireland – 2020

Tablets [India] Limited's commitment to international collaborations

reflects our dedication to
 improving global healthcare through innovation, quality, and accessibility.
The above
collaborations serve as a testament to our vision of a healthier world,
where patients everywhere have access to safe and effective
pharmaceutical solutions.
 INTERNSHIP SCHEDULE
Myself and my nine classmates had a great opportunity to get an
internship from a well-known pharmaceutical industry situated in
Tondriapet, TABLETS [INDIA] LIMITED for eight days [21/08/2023-
30/08/2023], where we are separated into two groups to experience the
work in the pharmaceutical industry.

The departments visited during our internship program were listed below:
Quality control unit
Small Volume Parenterals
[SVP]
Large Volume Parenteral
[LVP]
Liquid orals productions
Tablets production unit

Both groups were perfectly organized by the industry to experience each

department of the company to gain our practical knowledge by directly
visualizing the manufacturing, production, packing, and visual inspection
process and staff were very accessible to providethe required knowledge
of the complete process and equipment usage in the pharmaceutical
industry.
Let me share my observations in each department I visited for training in
the form report below:
 QUALITY CONTROL
The Quality Control (QC) Department stands as a steadfast guardian of
quality, precision, and excellence. With an unwavering commitment to
upholding rigorous standards and ensuring the utmost customer
satisfaction, the QC Department plays a pivotal role in the journey from
concept to completion.

Quality Control is more than just a department; it is a philosophy deeply

ingrained in the organizational DNA. It encompasses a systematic
approach to monitor, assess, and enhance the quality of products,
processes, and services. The QC Department serves as the final frontier
where meticulous scrutiny, rigorous testing, and unwavering attention to
detail combine to deliver products that not only meet but often exceed
customer expectations.
In Tablets[India], the QC department has four instrumental rooms
equipped with high-tech equipment, Wet and dry areas, a Microbiology
area, a QC for packaging materials desk, QA desk.
QC staff members were assigned as chemists, analysts, senior chemists,
managers, head managers, and general managers of the QC department. I
found everyone was very easy to communicate with and query about the
instrument techniques used in the department for pharmaceutical
products.
DRY AREA:
All instrumental rooms were maintained in hygienic condition to prevent
microbial contamination and pressure and the temperature was checked
accordingly based on the condition required for the sample, The whole
department was floor mopped thrice a day to maintain a clean
environment, and staff were directed to follow the guidelines like wearing
a clean apron, gloves, head cap, and shoe covers.
Each and every instrument was demonstrated and explained practically by
the staff members.
Equipment which I experienced by learning their respective methods and
principle are listed below:
INSTRUMENTATION ROOM 1:
Ph probe: The pH probe contains two electrodes (a sensor electrode and a
reference electrode) to measure the hydrogen ion activity in the solution.
The ion exchange generates a voltage, which is measured by a pH meter
that converts the voltage to a readable pH value. It is a water quality
sensor that measures the pH level of a liquid. pH (hydrogen potential)
measures the interaction between hydrogen and hydroxide ions in a
water-based solution. Solutions with large amounts of hydrogen ion
activity are acids. Conversely, a solution with a large amount of hydroxide
ion activity is a base. The use of pH probes in measuring pH is important
for a wide range of industries, which is why there are different pH sensors
for different applications.

Fig 1: ph probe
Observation: A heavy metal limit test was observed, Chemists were
adjusting the pH of Ferrous Glycine Sulphate.
PARTICLE COUNTER:
A particle counter is used for monitoring and diagnosing particle
contamination within specific clean media, including air, water, and
chemicals. Particle counters are used in a variety of applications in support
of clean manufacturing practices, Industries include electronic components
and assemblies, pharmaceutical drug products and medical devices, and
industrial technologies such as oil and gas.
Fig 2: Particle counter
Observations: I was able to go through the liquid particle counter of both SVP
and LVP

SVP LVP
2ml – 10ml products 100 ml – 500ml products
10 microns – 6000 microns 10 particles – 25 particles

PROCEDURE:
Before injecting the sample, the instrument is set to run in water for the
cleaning process

Sample is injected

With 5ml of HPLC water

The process is repeated three consecutive times to obtain the mean value

Everything was directed in the configuration software

DISSOLUTION APPARATUS:
Dissolution, in the context of pharmaceuticals, refers to the process by
which a solid dosage form, such as a tablet or capsule, disintegrates and
disperses into solution when exposed to a specific solvent under controlled
conditions. This dissolution process is a key determinant of how a drug is
absorbed by the body and ultimately exerts its therapeutic effect.

Fig 3: Dissolution apparatus

In the realm of pharmaceuticals and quality control, the Dissolution
Apparatus stands as a critical instrument of scientific precision, playing a
pivotal role in ensuring the efficacy and safety of oral medications. As a
remarkable innovation in the field of pharmaceutical testing,
the dissolution apparatus has revolutionized the way pharmaceutical
formulations are evaluated and regulated.

GAS CHROMATOGRAPHY:
Gas chromatography is the process of separating compounds in a mixture
by injecting a gaseous or liquid sample into a mobile phase, typically
called the carrier gas, and passing the gas through a stationary phase. The
mobile phase is usually an inert gas or an unreactive gas such as helium,
argon, nitrogen, or hydrogen. The stationary phase can be solid or liquid,
although most GC systems today use a polymeric liquid stationary phase.
The stationary phase is contained inside of a separation column.

Fig 4: Gas chromatography

A gas chromatograph is made of a narrow tube, known as the column,
through which the vaporized sample passes, carried along by a continuous
flow of inert or nonreactive gas. Components of the sample pass through
the column at different rates, depending on their chemical and physical
properties and the resulting interactions with the column lining or filling,
called the stationary phase. The column is typically enclosed within a
temperature-controlled oven. As the chemicals exit the end of the column,
they are detected and identified electronically.
Observation:
I was able to witness the automated GC of Ethylene Glycol syrup, chemist
explained the complete process of the instrument. In the industry, they
were using both the thermal and flame ionization conductor, and the gas
supplied was inert gases the carrier gas used was nitrogen gas, and had
an opportunity to visualize the column[ capillary] and the headspace to
collect the residue.
INSTRUMENTATION ROOM 2:
STABILITY CHAMBER:
Stability chambers in the pharmaceutical industry are controlled
environments designed to assess the long-term stability of drugs and other
products. These chambers replicate varying temperature, humidity, and
light conditions to predict potential reactions and degradation. Equipped
with precise monitoring systems, they ensure uniform conditions and
security. Pharmaceutical stability testing involves subjecting samples to
these controlled environments,
and the results are crucial for regulatory compliance. Overall, stability
chambers play a vital role in determining shelf life, storage
recommendations, and maintaining the quality and efficacy of
pharmaceuticals

.
FIG 5: STABILITY CHAMBER
OSMOMETER:
An osmometer is a laboratory instrument used to measure the osmotic
concentration of a solution, reflecting the number of solute particles
dissolved in it. It is particularly valuable in the pharmaceutical and clinical
settings for assessing the osmolality of biological fluids and
pharmaceutical formulations. By determining osmolality, which is the
measure of the solution's osmotic potential, osmometers contribute to
quality control in drug manufacturing and aid in diagnosing conditions
related to abnormal fluid balance or renal function in clinical settings. This
information is crucial for ensuring the safety and efficacy of
pharmaceutical products and assessing patient health.
FLAME PHOTOMETER:
A flame photometer is a scientific instrument used for the qualitative and
quantitative analysis of metal ions based on their characteristic emission
spectra when introduced into a flame. It is commonly employed in
analytical chemistry, particularly for measuring the concentration of alkali
and alkaline earth metal ions in a sample. The instrument works by
aspirating a sample into a flame, where the metal ions are vaporized and
then emit light at specific wavelengths. By measuring the intensity of the
emitted light, the concentration of specific metal ions can be determined.
Flame photometry finds applications in various fields, including
environmental analysis, clinical chemistry, and research laboratories.
INSTRUMENTATION ROOM 3:
DISINTEGRATION APPARATUS:
A disintegration apparatus is a pharmaceutical testing instrument used to
evaluate the disintegration time of oral solid dosage forms, such as tablets
and capsules. The disintegration process assesses how quickly a dosage
form breaks down into smaller particles when exposed to a specified fluid
environment, typically water.
 FIG 6: DISINTEGRATION APPARATUS
This test helps ensure that the pharmaceutical product will disintegrate
appropriately in the gastrointestinal tract, allowing for optimal drug
absorption.
MELTING POINT APPARATUS:A melting point apparatus is a laboratory
instrument used to determine the temperature at which a substance
transitions from a solid to a liquid state.

FIG 7: MELTING POINT APPARATUS

This measurement is known as the melting point and is a crucial
parameter for identifying and characterizing chemical compounds. The
apparatus typically consists of a sample holder, a heating block, and an
observation system.
HPLC:
High-Performance Liquid Chromatography (HPLC) is a powerful analytical
technique widely used in the separation, identification, and quantification
of components in a mixture. It operates on the principle of liquid
chromatography, where a liquid mobile phase passes through a stationary
phase, separating components based on their interactions with the
stationary phase.
 FIG 8: HPLC
Key components of an HPLC system include a pump to deliver the mobile
phase, a sample injector, a column where separation occurs, a detector to
measure the analyte concentration, and a data analysis system. HPLC is
extensively applied in pharmaceuticals, environmental analysis, food and
beverage testing, and various research fields due to its high sensitivity and
precision.
KARL FISHNER TITRATION:
Karl Fischer titration is a widely used method in analytical chemistry for
determining the moisture content in a sample. Named after the German
chemist Karl Fischer who developed the technique, it is particularly
effective for measuring low levels of water in various substances, including
chemicals, pharmaceuticals, and food products.

FIG 9: KARL FISHNER TITRATION

ATOMIC ABSORPTION SPECTROMETER:

An Atomic Absorption Spectrometer (AAS) is a sophisticated analytical
instrument used in chemistry to quantify the concentration of specific
elements in a sample. It operates based on the principle of atomic
absorption spectroscopy, where the absorption of light by atomic vapor is
measured at a specific wavelength
 .
FIG 10: ATOMIC ABSORPTION SPECTROMETER
WORKING: The sample is introduced into a flame or other atomization
source, causing the atoms of the target element to absorb light at a
characteristic wavelength when exposed to a light source. The absorption
is then quantified, and the concentration of the element in the sample is
determined.
AAS is highly sensitive and selective, making it valuable in various fields
such as environmental analysis, clinical chemistry, and materials science.
It is particularly useful for detecting trace elements in samples and is an
essential tool in quality control, research, and regulatory compliance in
industries like pharmaceuticals and metallurgy.

INSTRUMENTATION ROOM 4:
WEIGHING MACHINE:
A weighing machine, also commonly referred to as a scale, is a device
used to measure the mass or weight of an object. It typically consists of a
platform or pan where the object is placed and a system of levers, springs,
or electronic components that respond to the force exerted by the mass.
Weighing machines come in various types, including mechanical (analog)
scales and electronic (digital) scales. Digital scales are more prevalent
today, providing accurate and easy-to-read measurements.
TAP DENSITY TESTER:
A tap density tester is a laboratory instrument used to measure the tapped
density of a powder or granular material. The tapped density is a key
parameter in pharmaceutical, food, and powder metallurgy industries,
providing information about the packing characteristics of a powder under
defined conditions. The instrument operates by repeatedly tapping a
container filled with the powder, compacting it over time

.
FIG 11: TAP DENSITY TESTER
WET AREAS:
In a Quality Control (QC) laboratory, a wet area refers to a designated
space equipped and designed for performing analytical procedures that
involve liquid reagents, solutions, or other wet chemicals. This area is
specifically set up to handle sample preparation, wet chemistry
techniques, and other processes that involve the use of liquids.
We are allowed to visualize the Moffler, hot air oven, water bath, water
supply equipment.
Three stone benches were allocated for the titrations and QC analyst
demonstrated the titrations and thoroughly explained the QC process of :
FEVASTIN IP [Paracetamol
injection]
ASTYFER XT TABLET
ASTYFER Z SYRUP
PEGLAC – G.I LAVAGE
PEGLAC PLUS
MULTI VITAMIN INFUSION
The above titrations were completely performed by the staff members
following the SOP designed be the company.
MICROBIOLOGY AREA:
The microbiology area within a pharmaceutical or biotechnology facility is
a specialized zone dedicated to ensuring the sterility and quality of
products. Maintained under controlled conditions, this environment
employs cleanrooms, laminar flow hoods, and rigorous protocols to
prevent contamination

.
FIG 12: MICROBIOLOGY AREA
Microbiologists conduct a range of tests, including microbial identification,
environmental monitoring, bioburden and endotoxin testing, and sterility
testing. Culturing and incubation processes help quantify and identify
microorganisms, while method validation ensures testing accuracy. Strict
training and gowning procedures, coupled with comprehensive
documentation, contribute to compliance with regulatory standards such
as Good Manufacturing Practices (GMP). The microbiology area plays a
pivotal role in upholding the safety and efficacy of pharmaceutical and
biotechnological products through meticulous microbial analysis.
 QC FOR PACKAGING
Quality Control (QC) for packaging in various industries involves rigorous
processes to ensure
that packaging materials and methods meet specified standards and
requirements. Here are
some key aspects of QC for packaging:
1.Material Inspection: QC starts with the inspection of packaging
materials. This
includes checking the quality and specifications of materials such as
paper, cardboard, plastic, glass, or metal used for packaging.
2.Print Quality: If the packaging involves printing, QC assesses the print
quality, accuracy, and legibility of labels, instructions, and other
printed information.
3.Dimensional Checks: Ensuring that the packaging dimensions meet the
specifications to accommodate the product properly.
4.Seal Integrity: Verifying the integrity of seals, closures, and joints to
prevent leakage or contamination during transportation and
storage.
5.Barcoding and Labeling: Checking the accuracy and readability of
barcodes and labels for traceability and regulatory compliance.
6.Physical Durability: Assessing the physical durability of the packaging to
withstand handling, transportation, and environmental conditions.
7.Regulatory Compliance: Ensuring that the packaging meets relevant
regulatory
requirements and standards, including those related to safety,
environmental impact, and product information.
8.Compatibility: Verifying that the packaging is compatible with the
product, preventing any interactions that might affect product quality.
9.Batch Consistency: Maintaining consistency in packaging across different
batches or production runs.
10.Functionality Checks: Verifying features such as child-resistant
closures, tamper- evident seals, and other functionalities, especially
in industries like pharmaceuticals.
11.Environmental Impact: Considering sustainability factors, such as
recyclability and eco-friendly materials, in accordance with industry
and regulatory trends.
I am able to witness every QC procedure for packaging material done by
the staff members.
Through this, I’m able to understand the quality of medicine plays a vital
role in every aspect of providing safety to the patient
 SMALL VOLUME PARENTERAL UNIT
A Small Volume Parenterals (SVP) unit in the pharmaceutical industry is a
specialized manufacturing facility that focuses on the production of sterile
injectable drug products in small volumes. SVP typically refers to injectable
drug formulations with volumes less than or equal to 100 milliliters. These
products are administered through various routes, including intravenous
(IV), intramuscular (IM), and subcutaneous (SC).

FIG 13: SVP PRODUCT

Outline process:
Washing

Recycling

Supply of compressed air

Washing with sterile water

Repeat the process for 3 more times

Sterilization

Dry zone Sterile room

Cooling zone
 Filling

6 Stokes 4 Stokes
8 Stokes

Sealing
In the SVP unit, we are able to visualise every process via the allocated
see-through transparent window as every process took place under sterile
conditions, and every staff member was strictly following their respective
guidelines. The air supply from the Laminar air flow chamber is 98.3%
fresh air which has no contamination and filling of SVP [1,2,3,4] is done by
grading system [A, B, C, D] of 100ml, 1000ml, 10000ml, 100000ml.
Filling 1: This process is ON-LIVE, ie. One day process of washing,
sterilizing, and filling
Filling 2, 3, 4: This process is OFF-HAND, ie.[two days process] The
process of washing and sterilizing is done on day 1 and filling is done on
day 2. Vial filling follows this type.
After the filling process, the ampoules or vials are sent to the Labelling
section which is labeled with the respective details with mfg date, batch
no, and exp date.
After labeling the ampoules or vials are sent to Visual checking, This visual
checking is done twice by machine as well as manual checking, if found
any fiber particles or any impurities the product is immediately rejected
and discarded. Accepted products are packed accordingly and dispatched.
The SVP products manufactured byTablets India are :

Neostigmine injection I.P – 1ml

Fevastin [ amber color] – 2 ml,
10ml
Multi vitamin infusion – 10 ml
Small Volume Parenterals (SVP) production encompasses a comprehensive
understanding of sterile injectable drug manufacturing processes.
 LARGE VOLUME PARENTERAL
Large-volume parenterals (LVP) refer to sterile injectable drug products
with volumes typically exceeding 100 milliliters. These formulations are
administered intravenously and are commonly used for fluid and
electrolyte replacement, as well as the delivery of large doses of
medication. Large Volume Parenterals play a critical role in healthcare,
especially in situations requiring significant fluid replacement or the
administration of large doses of medications. The production of LVPs
demands a high level of expertise, precision, and adherence to regulatory
guidelines to ensure the safety and efficacy of these injectable drug
products.

FIG 14: LVP PRODUCT

OUTLINE OF LVP PROCESS:
Starting from the Production schedule the raw materials are approved and
stored and the solution is prepared which is then passed to the membrane
filtration process and end membrane then moved to bottle washing, bottle
brushing, filling accordingly, and closed with proper sterilization of the
stopper then sealed and completely sterilized at last it is moved to
quarantine unit which next led to the visual inspection, then approved
bottles are moved to labeling, and packaging unit.

FIG 15: STERILIZER

Washed bottles are placed in the conveyor belt and filled with the I.V
sample via 6 stokes with the end membrane and the other 6 stokes by
passing nitrogen gas, sterilized plugs and poly pick rings are sealed then
all set for sterilization, Sterilization is done by superheated water spray
sterilizer for 2.30hrs by passing water steam after sterilization it is passed
to the labeling and packaging section then dispatched accordingly.
The regulatory landscape governing LVP manufacturing, emphasizing the
paramount importance of compliance with Good Manufacturing Practices
(GMP) and other industry standards. This reflects on the broader
implications of LVP production in healthcare, particularly in scenarios
requiring significant fluid replacement or the administration of large drug
doses.
It touches upon the collaborative and multidisciplinary nature of the LVP
manufacturing unit, emphasizing the synergy required among various
departments for successful operations. Large Volume Parenterals adhere
to stringent quality control measures, aseptic processing, and regulatory
compliance. The production process includes considerations for container
closure systems, compatibility testing, and documentation of each batch.
LVPs play a vital role in various healthcare settings, necessitating precision
and expertise in their production to ensure safety and efficacy.
 LIQUID ORAL DEPARTMENT
The Liquid Oral Department in pharmaceutical manufacturing is a
specialized unit focused on the production of liquid oral dosage forms,
which include solutions, suspensions, and syrups that are administered
orally. This department plays a crucial role in providing an alternative
dosage form for patients who may have difficulty swallowing tablets or
capsules. Here are key aspects of the Liquid Oral Department:
1.Formulation: Pharmaceutical scientists and formulators in this
department develop formulations for liquid oral drugs, ensuring
proper solubility, stability, and palatability.
2.Batch Manufacturing: The actual production involves compounding the
ingredients according to the formulation, often in larger batches.
This process includes precise measurements and mixing to achieve
uniformity.
3.Quality Control: Rigorous quality control measures are implemented to
ensure the consistency, purity, and safety of the liquid oral products.
This includes testing for active ingredients, stability, and microbial
contamination.
4.Filling and Packaging: Liquid oral products are filled into bottles or other
suitable containers and then appropriately labeled and packaged.
The packaging must ensure product integrity and compliance with
regulatory requirements.
5.Flavoring and Coloring: Since these formulations are meant for oral
administration, flavoring agents and coloring may be added to
enhance palatability and improve patient acceptance, especially for
pediatric formulations.
6.Regulatory Compliance: Adherence to Good Manufacturing Practices
(GMP) and other regulatory guidelines is essential to ensure the
safety and efficacy of liquid oral products. Regulatory bodies
typically scrutinize the processes and facilities to ensure compliance.
7.Documentation: Detailed documentation of each batch, including the
manufacturing process, quality control tests, and any deviations
from standard procedures, is maintained for traceability and
regulatory purposes.
The Liquid Oral Department contributes significantly to pharmaceutical
manufacturing, providing a versatile and patient-friendly form of
medication. The production of liquid oral formulations requires a careful
balance of scientific formulation, precise manufacturing processes, and
stringent quality control to ensure the production of safe, effective, and
palatable pharmaceutical products.
 FIG 16: LIQUID ORAL
Astymin Liquid contains essential amino acids and multivitamins. Amino
acids are building blocks of protein which are a vital part of our nutrition
and are associated with numerous functions in the human body. Vitamins
are organic nutrients that are essential for life. The human body requires
these nutrients to ensure normal metabolism, growth, and physical well-
being. Essential amino acids and most vitamins are not made in the body,
or only in insufficient amounts (Vitamins) to meet our needs and hence
supplementation with ASTYMIN LIQUID becomes necessary.
In the Liquid orals department, we are able to see batch manufacturing
records, this BMR contains the Datasheet, filling process, sealing process,
visual inspection, stamping, and packing instructions, materials used
sheet, and stereo impression sheet for cartons. Overall the process was
clearly explained by the staff.
 TABLETS MANUFACTURING UNIT
A Tablets Manufacturing Unit is a specialized facility in the pharmaceutical
industry focused on the production of tablet dosage forms. Tablets are one
of the most common and widely used forms of medication, offering
convenience, accurate dosing, and ease of administration. The
manufacturing process involves several key stages:
1.Formulation Development: Pharmaceutical scientists and formulators
develop tablet formulation, which includes active pharmaceutical
ingredients (APIs) and various excipients. Excipients can include
binders, disintegrants, lubricants, and other materials that contribute
to the tablet's properties.
2.Granulation: Granulation is a process where the blended powder
mixture is agglomerated to form granules. This step improves the
flowability of the powders and aids in the compression process.
3.Tablet Compression: The granules are compressed into tablets using a
tablet press machine. The machine applies pressure to form the
tablets, and it can have multiple punches and dies to produce tablets
of different shapes and sizes.
4.Coating (if applicable): Some tablets undergo a coating process to
provide taste masking, protect the tablet from environmental
factors, or control the release of the drug. Coating can be done using
film-coating or sugar-coating techniques.
5.Quality Control: Rigorous quality control measures are implemented
throughout the manufacturing process. This includes testing raw
materials, in-process checks, and final product testing for attributes
such as hardness, friability, disintegration, and dissolution.
6.Packaging: The final tablets are packaged into blister packs, bottles, or
other suitable containers. Packaging is designed to protect the
tablets from environmental factors, ensure stability, and provide
patient information.
7.Regulatory Compliance: Adherence to Good Manufacturing Practices
(GMP) and other regulatory guidelines is crucial to ensure the safety,
efficacy, and quality of the manufactured tablets. Regulatory bodies
conduct inspections to verify compliance.
8.Documentation: Detailed documentation of each batch is maintained,
including the manufacturing process, quality control test results, and
any deviations from standard procedures. This documentation is
essential for traceability and regulatory purposes.
The Tablets Manufacturing Unit operates in a controlled environment to
prevent contamination and ensure the quality of the final product. Modern
tablet manufacturing processes often involve automation and advanced
technologies to enhance efficiency and consistency. The unit is a critical
component of the pharmaceutical industry, producing a wide range of
tablets to meet the diverse needs of patients and healthcare providers.
 FIG 17: TABLET MANUFACTURING UNIT AREA

SOME PRODUCTS WE VISUALIZED IN THE TABLETS MANUFACTURING UNIT

:
 CONCLUSION
In conclusion, my internship at Tablets India has been an enriching and
insightful experience, providing a firsthand understanding of the intricate
workings of the pharmaceutical industry. Throughout my tenure, I had the
privilege of working alongside dedicated professionals in a dynamic and
cutting-edge environment, contributing to my growth both professionally
and personally.
The exposure to the Tablets India manufacturing unit has allowed me to
witness the meticulous processes involved in the production of
pharmaceutical tablets. From formulation development to quality control
measures, every stage is executed with precision and in strict adherence
to regulatory standards. The emphasis on Good Manufacturing Practices
(GMP) is not just a regulatory requirement but a testament to Tablets
India's commitment to producing safe and efficacious medications.
Moreover, my interactions with the team at Tablets India have instilled in
me a profound appreciation for the significance of collaboration,
innovation, and attention to detail in the pharmaceutical field. I witnessed
the dedication of the professionals involved in ensuring that each tablet
meets the highest standards of quality and efficacy.
In the words of Henry Ford, "Coming together is a beginning; keeping
together is progress; working together is success." This ethos echoes the
collaborative spirit at Tablets India, where diverse talents converge to
achieve a common goal — delivering pharmaceutical solutions that impact
lives positively.
This internship has not only enhanced my technical skills but has also
nurtured my understanding of the ethical responsibilities associated with
pharmaceutical manufacturing. As I move forward in my academic and
professional journey, the experiences gained at Tablets India will
undoubtedly serve as a strong foundation, shaping my commitment to
excellence and adherence to ethical practices in the pharmaceutical
domain.
In the words of Steve Jobs, "Your work is going to fill a large part of your
life, and the only way to be truly satisfied is to do what you believe is great
work." My time at Tablets India has fueled my aspiration to contribute to
the pharmaceutical industry by upholding the principles of quality,
integrity, and continuous improvement. I am immensely grateful for this
opportunity and look forward to leveraging the knowledge gained during
my internship in my future endeavors.