j [+ PURBANCHAL UNIVERSITY iy Me 2018 Bachelor of Pharmacy /First Semester/ Final Time: 03:00 hrs. Full Marks: 80/Pass Marks: 40 PHAR111: Pharmaceutical Inorganic Chemistry (New Course) Candidates are required to give their answers in their own words as far as practicable. Figures in the margin indicate full marks. Group A: Multiple Choice Question (Sheet Attached-20)’ Group B Answer the question. 1x15=15 1. Problem based question. A white, fine, water insoluble powder of an inorganic compound is“used both as a’ non-systemic antacid and_dentifrice. The compound produces effervescence when a few drops of acetic Ce (OK Aeid is added on it. Foy eee, the compound, write its molecular formula, Pe and its properties. Explain how it works as an antacid and dentifrice. ean sseeeoa (b) Describe a chemical method for the preparation of above compound. What cause the effervescence when the above compound is reacted with acetic acid? ()_ The above compound is usually given in combination with other | antacids. Give the justification for combination antacid therapy? Wri les of combined antacid preparations. roup C Answer TWO questions. 2x10=20 Define radioisotopes and radiopharmaceuticals. Mention some examples of radiopharmaceutical preparations. What are the yb safety measures to be taken during handling and storage of radio isotopes. 3. Define and classify dental products with example. Explain the role of fluoride as anti carries agent. Write and draw chemical formula of any ‘wo fluorides used in toothpaste. “+ conta...(2) 4(a) Define limit test. Write down the principle and procedure, ere of Chloride. (b) Write the concept of acids and bases with examples. Explain ethods for the purification of water used in pharmaceutical preparation. Group D Answer FIVE questions. 5x5=25 “5. What do you mean by electrolyte replacement therapy? What are the roles of ingredients that are used in ORS. 6. Define inorganic anesthetics. Write about preparation, storage and use of Nitrous Oxide. a . ) Explain the mechanism of complexation, How do activated charcoal. Show antagonist effect against heavy metal poisoning. 8-~ Define adsorbent and mention their uses. Write a short note on activated charcoal. 9. How do KMnO, act as local anti-infective agents? What are the advantages of Povidone Iodine over Iodine? 10. Explain the functions of iron in body. Describe the preparation and assay of Ferrous gluconate. eee 8PURBANCHAL UNIVERSITY —™ 2023 Bachelor of Pharmacy /First Semester/ Final Time: 03:00 hrs. Full Marks: 80/Pass Marks: 40 PHAR114: Mathematics (New Course) Candidates are required to give their answers in their own words as far as practicable. Figures in the margin indicate full marks. Group A: Multiple Choice Question (Sheet Attached-20) Group B Problem based question. 1«15=15 i Prove that continuity of a function is necessary but not sufficient condition for the existence of the derivative of the function at the ay int. Find — if x? + y? = x2y?. Pe dx Group C Answer TWO questions. 2x10=20 2. Define Bernoulli’s differential equation of first order and first dy tany 1 x J a —-—— =(1+ x)e secy. degree. Solve tig ¢ ) lim xsina juate: 2 Eval xa x-a@ 4, Solve the differential equation y +2y'+2y = Ssint. y(0)=Oand y'(0)=0 by using Laplace transform method. Group D ‘5=25 Answer FIVE questions. 5x! 5. Test continuity of f(x)= 0 for x=2 Contd. ... at point x = 2.(2) Solve the differential equation 22) _, dy arg tay= 20 #~ PURBANCHAL UNIVERSITY 2023 Bachelor of Pharmacy /First Semester/Final ‘Time: 03:00 hrs. Full Marks: 80/Pass Marks: 40 PHARL13: Physical Chemistry (New Course) Candidates are required to give their answers in their own words as far as practicable, Figures in the margin indicate full marks. Group A: Multiple Choice Ques: Group B Problem based question. 1x15=15 1. Ina first order reaction n (Sheet Attached-20) A—> product It takes 50 minutes to change 10 mole/L reactant into 5 mole/L at 25°C. The analyst increases the temperature to 40°C so that rate constant found to be increased by 10 times. (a) Find the half life period of reaction. (b) Find the activation energy of the reaction. (c) What happens in half life period if the initial concentration of reactant is changed? (d) Find the time required to change 80% reactant into product. (c) How do you change the activation energy of this reaction? (9 Find the change in rate of reaction on increasing temperature 25°C to 40°C. Group C Answer TWO questions. 2x10=20 2. Describe Faradaya’s law of electrolysis and Explain Debye- Huckel theory. 3. Write the postulate of kinetic gas theory. Prove the kinetic gas equation for ideal gas. 4. Define adsorption. Explain Freundliah adsorption isotherm and Langmuir adsorption Isotherms. Group D Answer FIVE questions. 5x8=25 5. Describe the relation between Cp and Cv, Contd. ...10. (2) State Lambert Beer’s law. Prove this equation. How can you determine surface tension of liquid? How can you determine the molecular weight of solute by elevation of boiling point? Explain the phase diagram of one component system with example. Prove that decrease in free energy of a system is equal to the RTIAK. BPURBANCHAL UNIVERSITY 2023 Bachelor of Pharmacy /First Semester/ Final Time: 03:00 hrs. Full Marks: 80/Pass Marks: 40 PHAR115: Basic Computer Applications (New Course) Candidates are required to give their answers in their own words as far as practicable. Figures in the margin indicate full marks. Group A: Multiple Choice Question (Sheet Attached-20) Group B Problem based question. 1x15=15 l(a) Consider the following table which contains roll numbers and marks of a student in five subjects. A B c D E F ¢ 7) Rot | eno | mamas | science | compurer | nepatt | Net Total No. 2) 102 | 45 | 56 | 67 were couse. \3 Grade sents he 2, (i) Write formula using function to calculate the Total Marks obtained. (i) Write formula to calculate the Grade as per the following Marks Grade 0-40 4 40-50 3 50-60 2 60 and above 1 (b) Write the MS-DOS command (i) To create a directory i) To remove a directory (iii) To rename a file or files (iv) To display the content of a text file Contd. ...(2) {v) To copy one or more files to another location Group € Answer TWO questions. 2x10=20 2. What is computer language? Briefly explain the usefulness of a computer language. Compare high level language and low level language with suitable example. 3. What do you mean by DBMS? What according to you are the objectives of any DBMS. Briefly explain any DBMS package like DBASE-III. 4. Answer FIVE questions. 5. Describe the importance of algorithm and flowchart in program development. Write an algorithm and draw corresponding flowchart to find minimum among three given integers. Group D 5x5=25, With the help of a block diagram, Explain the major hardware components of a simple computer system. What do you mean by computer Network? Explain briefly about network topologies. Explain the software development life cycle. What is SPSS? Explain its features. Why is computer security system is gaining popularity in recent time? Explain with example. Write short notes on (Any Two): (a) UNIX operating system (b) Power Point (c) RAM Vs ROM #Bachelor of Pharmacy /First Se Time: 03:00 hrs. PURBANCHAL UNIVERSITY | 2023 mester/ Final Full Marks: 80/Pass Marks: 40 PHAR111: Pharmaceutical Inorganic Candidates are required to give their a Chemistry (New Course) nswers in their own words as far as practicable, Figures in the margin indicate full marks, Group A: Multiple Choice Question (Sheet Attached-20) Group B Problem based. question. as 1x15=15 A white, fine, water insoluble powder of inorganic compound which is used as antacid and dentifrices. The compound Produces effervescence when a few drops of acetic acid is added on it. Answer the following questions, (a) Identify the compound and its properties in detail. (b) Explain the mechanism of action as antacid and dentifrices. (c) Write a chemical method for the preparation of the above compound. (4) Explain about the reaction with acetic acid for the above compound. (e) Why the above compound is usually given in combination with other antacids? Group C Answer TWO questions. 2. 2x10=20 Write brief note on protective, adsorbent and acidifiers with example. Define buffer solution with its types. Explain the role and mechanism of action of buffer. Derive the Handerson Haselbalch equation. Write about the Anti oxidant and Preservatives. Give the ideal properties of antioxidant. Write a detail note on sodium nitrite and Hypophosphorous acid, Contd. ...(2) Group D Answer FIVE questions. 5x5=25 5. Write about complexing agent. List out the ideal properties of complexing agent with its use in Pharmaceuticals. 6. Explain the role of Oxygen and carbon dioxide in our body. Write short note on preparation and storage of oxygen gas. 7. Classify topical agent with examples. Write about the advantages of povidone iodine over iodine. 8. Write a note on Heavy metal poisoning and their antagonist. 9. Explain about the electrolyte replacement therapy. Write a note on importance of sodium and chloride ion in the body. 10. Discuss about the different types of water. Explain about the methods for purification of water used in pharmaceutical preparation. #2023 achelor of Pharmacy /First Semester/Back ‘Time: 03:00 hrs. Full Marks: 80/Pass Marks: 40 PHAR113: Physical Chemistry (New Course) Candidates are required to give their answers in their own words as far as practicable. Figures in the margin indicate full marks. Answer THREE questions. i. Answer FIVE questions. 6. ‘Te Group A 3x10=30 Derive Kinetic gas equation. Derive Boyle's law and Granhm's law of diffusion form kinetic gas equation. Discuss Langmuir adsorption isotherm. Mention the importance and limitations of this theory. Describe the variation of heat of reaction with temperature. Write the postulates of Debye Huckel theory. Write short notes on any TWO: (a) Raoult's law and its limitations. (b) Michaelis Menten equation (c) Elevation of boiling point (d) Time independent schrodinger's equation Explain the factors that affect the rate of chemical reaction. Derive the integrated rate law expression of zero order reaction. Group B 5x5=25 State and explain the first law of thermodynamics. Define surface tension. How is the surface tension of liquid measured? Define free energy function. Derive the relationship between free energy and net useful work. State and explain Hess’s law of constant heat summation. Point out its application. Contd. ...~™ (2) i : i ion. Show that half-life periog of If-life of chemical reaction. wth r Er anor. reaction is independent of initial concentration of irs : reactant. Write down the importance of half life in pharmacy. 11. What is catalysis? Give the important characteristics of catalysis. i i Ss 12(a) Explain why water forms the concave meniscus on capillary glas: tube, 2 (b) What are the Significances of Van der Waals constants, a &b? | Group C Answer TEN questions, 10x2.5=25 13. What are the refractive index and optical rotation? 14.” Define the term (a) Parachor (©) dipole moment 15. The resistance of zx solution of salt is found to be 2.5*103Q, Calculate equivalent conductance. Cell constant ()= 1.15em-} 16. What do you mean by real an 17. Show your familiarity with 18. 19, id ideal Solutions? What are the extensive and intensive Properties of system 20. State the enthalphy. 21. State Stark-Rinstein’s law of Photochemicaj equiv, What is ‘quivalence, meant by quantum yield? 22. A first order Teaction is 75% Completed in 60 mi - 6 i j ; minutes. Fing half- 23, State third law of thermodynamics, 24, Define the viscosity and its importance in Pharmacy‘PURBANCHAL UNIVERSITY ~~ 2023 Bachelor of Pharmacy /First Semester/ Back Time: 03:00 hrs. Figures in the margin indicate full marks, Group A Answer THREE questions, 1 Define Pharmacognosy and write its scope, climatic zones of Nepal. Write the common and of two vegetations occurring in each zone, 3x10=30 Describe various botanical names 2. List and explain the various factors influencing cultivation, Describe sexual method of propagation. Write about different ‘ypes of soil and fertilizers of common use. 3. Give a description of key character of Rubiaceae and Myrtaceae family with floral formula and floral diagram. 4. Detail the general morphological and anatomical features of leaf with a neat diagram. Write about the biological source, morphology and microscopic characteristic, chemical constituents, adulteration and uses of cinchona bark. the various types of adulteration mples. Write down WHO guidelines al raw materials. Group B 5S. Define adulteration. Discuss found in crude drugs with exai of the standardization of herb; Answer FIVE questions. 5x5=25 6. Explain about the Preparation method of herbarium specimen, 7. Write about the principle of Ayurvedic and Amchi system of medicine. 8. Write short note on Pest man: agement and natural Pest control agents. 9. Give the key characteristics, the wu ame of two plants and floral diagram of Solonaceae family. Contd,(2) 10. Discuss the morphological and anatomical characters of bark, 11. Write the biological source and uses of fennel fruit, and explain its test for identification. 12. Write about WHO guide lines of the standardization of Herbal finished products. Group C Answer TEN questions. 10x2.5=25, 13, Write the principle of Homoeopathy and Traditional Chinese system of medicine. 14. Write short note on importance of herbarium. 15. Write about the application of plant tissue culture. 16. Differentiate natural drying and artificial drying of crude drugs. 17. Give the key characters of Labiatate family. 18. Give the advantages and disadvantages of Morphological and taxonomical classification. 19. Differentiate organized and unorganized crude drugs with examples. 20.. List and explain various types of stomata with a neat diagram. 21. Define palisade ratio and stomatal index. 22. Give the biological source and uses of Cinchona. 23. Write the different reasons of adulteration of crude drugs. 24. Write about any one physical method of evaluation of crude drugs.Medical & Allied Sciences/B. Pharmacy/First Semester Group A: Multiple Choice Questions Time: 20 minutes Full Marks: 20 PHAR114: Mathematics (New Course) Exam. Roll No. Tick (Vv) the best answer. 20x1=20 . SingXx 1. him 22 = 5 the value of gis... x90 tan2x (a) 2 (b)5 () 10 (ao 2. The value of jim3275* +2 is .... ee od (a) 2 {b) 3 (1 (a) = o 3. The points of discountinuity of the function f(x) = —2*=5 _ is =5x+6 (a)-2and-3 (b)2and3 © ()-2and3_ (4) Zand -3 4. The derivative of _ with respect to x is () DY SIEDS ON (ey Tin ae See ye ds ax xx vx 2xvx 5. Ifx=asec@ and y=6 tandthen is (a) escco (0) dosed (€) 2 seca (A) ~2coseco 6. The derivative of tan-*(—$i02%_\is 1+cos2x fa) 1 (b) ()--!_ — @) none 1437 i 7. I y=%, then £2 is equal to Cas (a) 1 (b) x () x (a) 1 6 6 8. The slope of tangent to the curve y = x3 - 2x? - 3x + 4 at (1,-2) is (a) 0 (b) -4 (ce) 17 (a) 4 Contd.10. ll. 12. 13. 14, 15. 16, 17. 18. (2) 7? then 82 is vce axdy (a) 2xyz, (b) 4xyz (c) 4yz (d) 4zx The value of fin dris @ly. (b) x(1-Inx) +e (c) eX +e (d) x(Inx-1)+e x Integration [ 1 xis x -9 (a) sm( 23) (b) 1 (223 © 1 23) @ tu( 22) 3d 3 x43 6 (x43 ‘The value of fone is a+b (@) alnar+s) (by) -__1_ _@ I@t+) @__a (a+b)? a (a+b)? 6 (m, n) is equals to... (a) [ix ta-x de () Ley © [eq-n™ ae @) fx" G-2™ ae The solution of differential equation xdy — ydx = 0 is fa)y=cx (b) x= cy () xy=¢ (d) none A differential equation Mdx + Ndy = 0 is exact if (a) OM ON (uy AM _ ON) BM__ AN Gy none a ay a If the auxiliary equation has ey roots @ + if then complementary function (C.F.) is . (a) ce* +c,e" (b) ‘M(Aonan Baie) (c) ce* —c,e* (a) e*(Acos Ax + Bsin Bx) The expansion of (1-D)? is (a) 1+D+D2+ D3 (1+ 2D + 3D?+ 4D3...... (b) 1-D+ D2-Ds..... (a) 1- 2D + 3D2- 4s ‘The integrating factor of gt Lys is toes at mot “te e @ 2 ; x Contd. ...(3) . The Laplace transform of f(1)=e cosbt is .* e) aa —— (s-ay 4b? (say 4b* () —$t4 @ —4__ (s-a)’ +b" (stay +b? 20. The inverse Laplace transform of sa is s’-a (a) Sinh at (b) t sinh at (c) cosh at (d) t cosh atMedical & Allied Sciences/B. Pharmacy/First Semester Group A: Multiple Choice Questions Time: 20 minutes Full Marks: 20 PHAR115: Basic Computer Applications (New Course) Exam. Roll N Tick (“) the best answer. 20x1=20 1. The brain of computer system is ..... (a) ALU (b) Register (c) CU (4) CPU 2. Which of the following is fastest memory? (a) Register. (b) Cache —(c) RAM (4) ROM 3. Which of the followings is a smallest memory? {a) KiloByte (b) MegaByte (c) Nibble (d) Byte 4. Which network. topology is based on linear architecture........ (a) Ring (b) Star (c) Bus (d) None of above 5. Arrange in descending order the units of memory TB, KB, GB, MB: (a) TB>MB>GB>KB (b) MB>GB>TB>KB (c) TB>GB>MB>KB (@) GB>MB>KB>TB 6. Printerisa {a) Input Device (b) Output Device (c) Storage Device {d) None of above 7. Type of Network that cover school or college (a) LAN (b) MAN (c) WAN (d) None 8. The output in a computer screen is called ............. (a) Copy (b) Soft copy (c) Hard copy (d) Paper 9. Identify the device through which data and instructions are entered into a computer (a) Software (b) Output device (c) Input device (4) Memory 10. Computer Moniter is also known as ... (a) DVU (b) UVD () VU (@) ccTV 11, Who is the father of computer? (a) John Napier (b) Blaise Pascal (c) Lady Ada Lovelace (d) Charles Babbage Contd. ...12. 13. 14, 15. 16. 1% 18. 19. 20. (2) Biochips are used in which generation computers ......... (a) Third Generation (b) Second Generation (c) Fifth Generation (a) Fourth Generation The two kinds of main memory are esses (a) Primary and secondary _(b) Random and sequential (c) ROM and RAM (a) All of above OS isa. : (a) System Software (b) Application Software (c) Purbanchal University Software _(d) All of above Ms-Word is .... (a) Spreadsheet Software (b) Presentation Software () Word Processing Software (4) Operation System Software How to remove your computer virus (check the false statement): (@) Using Antivirus (b) Using Firewall (c) Using Scandisk (4) Using Pirated Software Which of the following is not a Function is MS Excel? (a) SUM (b) AVG. (c) MAX (a) MIN To start Microsoft PowerPoint application (a) Click on Start>> Programs >> All Programs>> Microsoft PowerPrint (b) Hit Alt+ Ctrl + R then type ppoint.exe and Enter (c) Click Start>> Run then type powerpnt then press Enter (d) All of above WWW is an example of a . {a) WAN (b) MAN () LAN () PAN DEL command is used to ... (a) Delete files (b) Delete directory (c) Delete labels (a) Delete contents of fileMedical & Allied Sciences/B. Pharmacy/First Semester Group A: Multiple Choice Questions Time: 20 minutes Full Marks: 20 Tick (v) the best answer. 20x1=20 1, 2 PHAR113: Physical Chemistry (New Course) Dual nature of particle explained by... ii (a) De Broglie equation (b) Broglie plank's equation (c) Schrodinger equation (d) Eienstein equation Rate of reaction increases by sixteen times on increasing concentration four times, then the order of reaction is ..........-- (a) zero order —(b) first order (c) half order (d) second order Langmuir adsorption isotherm explain the isotherm of .......- (a) Type first (b) Type second (c) Type third(d) Type fourth Second law of photochemistry is applied if quantum yield is. (a) zero (b) greater than zero (c) equal to one (d) less than one Falling liquid drop in air is spherical in shape is due to .... (a) surface tension (b) viscosity (c) refractive index (d) osmosis Highest molecular velocity of gas molecule is ... (a) root mean square velocity _(b) average velocity (c) most probable velocity (d) none Degree of freedom of aqueous solution of glucose is (a) zero {b) one () two (d) three Rheochor is related to ......-.--1+++ (a) Viscosity (b) Surface tension (c) Internal energy (4) Enthalpy Spontaneity of reaction is explained by change in .... (a) enthalpy (b) internal energy (c) gibb’s free energy (d) entropy Contd. ...10. ll 12, 14, 15. 16. 17. 18. 19. 20. (2) Change in volume of system is constant in process. (a) Isochoric _(b) Isobaric (c) adiabatic (d) isothermal Work done in isothermal reversible expansion is (a) 2.303 nRT In v2/V1 (b) 2.303 nRT log V1/V2 (c) 2.303nRT log P1/P2 (d) none The unit of equivalent conductance is {a) Mhocm-eqv-} (b) mho cm? eqv () mho cm? equ! (d) none Ideal solution obey the .... : : {a) Ideal gas equation (b) Nernst equation {c) Raoult’s law (4) Vander Waal’s equation The distribution oj solute between two immiscible solvent is explained by ............. (a) Henry’s Law () Nernst distribution law (c) Raouit’s law (4) Law of mass action Vant Hoff factor helps to measure the (@) Molecular weight (b) ionization constant (€) fraction of solute ionized (a) none Depreesion in freezing point of a solution is directly proportional to (a) Molarity of solution (b) elevation of boiling point (c) atmospheric pressure (4) none Specific conductance increases with ... (@) Decrease in concentratio nm (b) decrease in dilution (c) increase in dilution (@) none Kinetic gas equation shows the relationship with . (a) Average velocity (b) most probable velocity (c) root mean square velocity (4) mean square velocity Critical temperature is directh ¥ Proportional to the vander waal constant ............. (aja (b) b ()e Initial order of enzyme catalyzed reaction is ...,.., (a) first order —(b) zero order (c) second order (d) none (a) none _ a> Medical & Allied Sciences/B. Pharmacy/First Semester Group A: Multiple Choice Questions Time: 20 minutes Full Marks: 20 1. PHAR111: Pharmaceutical Inorganic Chemistry (New Course) Tick (V) the best answer. 20x1=20 Strong acid is «20... (a) Ca2* (b) Hg* (Qt (d) Cut ZNO is used as ........002. (a) antacid (b) astringent (c) antiseptic (d) antidote Hydrogen peroxide is used as .......... {a) antiseptic (b) acidifying agent (c) protective (d) antioxidant In Wilson disease a condition of excess storage of ..... (a) Cadmium —_(b) Zine (c) Copper —(d) Arsenic Flumazenil is classified as .. (a) chemical antidote (b) physiological antidote (c) mechanical antidote (d) All of the above 1 Becqurel is equivalent to (a) 2.7 x 10-1! curie (b) 2.7 x 10° curie (c) 1.7 x 10-1! curie (d) 1.7 x 10°! curie Gamma rays are electromagnetic radiations with a wave length (a) much larger than light (b) much shorter than light (c) equal to light (d) None of these Gold-198 used in the treatment of ......... (a) pemicious anaemia (b) rheumatoid arthritis (c) detection of tumours (d) thyroid functioning Cathartics are the drugs used to (a) relieve acidity (b) relieve constipation (c) reduce gastrointestinal irritations (d) all of the above Contd. ...10. i. 12. 13. 14. 15. 16. ihe 19. 20. (2) In metabolic acidosis .......+++ (a) HCO3 excess (b) CO2 decreased (c) HCOS deficit (a) All of above Calcium gluconate is prepared by . {a) lactic acid and CaCO3_—_(b) oxallic acid and CaCO3 (c) gluconic acid and CaCO3_—_ (A) gluconic acid and Ca(OH)2 Drug of choice to combat systemic acidosis: (a) KHCO; (b) NaHCO; (c) NavCO3_—(d) K2COs This ion is used very effectively as astringent, protective and antiperspirant: (a) Mg (b) Al (c) Zn (@) Cu Strong iodine solution contains KI for the purpose of: (a) preservation (b) reducing agent (c) preventing precipitation _ (4) complex formation Blue vitriol, an effective astringent and emetic is chemically: (a) FeSOs.7H20 (b) CaCly (c) MgSO4.H20 (d) CuSO4.SH20 The substance which improve the flow of granule is ........ (a) Disintegrant (b) Suspending agent (c) Lubricant (d) Binder The most abundant extracellular ion .............. (a) Na (b) K (c) Mg (a) Ca D-penicillamine is also used for the treatment of .. (a) Gout (b) Respiratory infection (c) Rheumatoid arthritis (d) Cancer Antidote for cynide poisoning is . (a) Flumazenil (b) Naloxone (a Dittreaprol (d) Sodium nitrite The reagent used for the limit test of sulphate is ..... (a) Silver nitrate (b) Barium chloride (c) Sulphuric acid (d) Magnessium sulphate