USMLE Step 1 Prep Syllabus

(Microbiology and Biochemistry will be done daily as drills)

Week 1 Cardiology
● Day 1 Cardiology
○ Physiology
○ Fetal circulation
○ Cardiac action potentials
○ EKG
○ Frank-Starling curve
○ Cardiac output graphs
● Day 2 Cardiology
○ Coronary Artery Disease
○ Myocardial infarction/Heart Failure and complications
○ Shock
○ Associated pharmacology: MI, HF and anginal therapy
● Day 3 Cardiology
○ Congenital Cardiac Defects
○ Hypertension
○ Hyperlipidemia
○ Associated pharmacology: antihypertensives and lipid lowering agents
● Day 4 Cardiology
○ Arrhythmias
○ Murmurs
○ Valvular diseases
○ Associated pharmacology: antiarrhythmic classes
● Day 5 Cardiology
○ Drills
○ Questions

Week 2 Respiratory
● Day 1 Respiratory
○ Anatomy
○ Physiology
○ Flow-volume loops
● Day 2 Respiratory
 ○ Ventilation/Perfusion
○ Cancers
○ Associated Pharmacology
● Day 3 Respiratory
○ COPD/Cystic Fibrosis
○ Restrictive/Pneumoconioses
○ Associated Pharmacology
● Day 4 Respiratory
○ Transudates vs. Exudates
○ Pulmonary infections
○ Associated pharmacology
● Day 5 Cardiology Review

Week 3 Endocrine/Reproductive
● Day 1 Endocrine/Reproductive
○ Anatomy/Embryo/Physiology
○ Aortic arch, Pharyngeal arch/cleft/pouch derivatives
○ Endocrine pathways
○ Hormone functions
● Day 2 Endocrine/Reproductive
○ Menstrual cycle/Pregnancy
○ Pituitary/Pineal/Hypothalamic disorders
○ Cancers (MEN, ovarian/breast/cervical, etc)
○ Associated pharmacology
● Day 3 Endocrine/Reproductive
○ Diabetes Mellitus/Insipidus/SIADH
○ Thyroid/Parathyroid Disorders
○ Adrenal disorders
○ Associated pharmacology
● Day 4 Endocrine/Reproductive
○ Sex development disorders
○ Sex chromosone disorders
○ Menstrual cycle/Pregnancy
○ Pregnancy complications
● Day 5 Respiratory/Cardiology Review
● Day 6 Exam 1 (covers weeks 1-3)

Week 4 Renal
● Day 1 Renal
○ Anatomy/Physiology
○ Renal Clearance/Glomerular Filtration
 ○ Nephron transport/hormones
○ RAAS
● Day 2 Renal
○ Acid/Base disorders, Renal tubular acidosis
○ Electrolytes
○ Associated pharmacology
● Day 3 Renal
○ Nephritic/Nephrotic
○ Stones
○ Cancers
○ Associated pharmacology
● Day 4
○ AKD and pathologies
○ Diuretics
○ Stones
○ Associated pharmacology
● Day 5 Endocrine Review

Week 5 Gastrointestinal
● Day 1 GI
○ Embryology
○ Anatomy
○ Physiology
○ Secretory products
● Day 2 GI
○ Gastric pathologies
○ Intestinal pathlogies
○ Associated pharmacology
● Day 3 GI
○ Liver pathologies
○ Biliary tree pathologies
○ Cancers
○ Associated pharmacology
● Day 4 Renal Review
● Day 5 Respiratory/Endocrine Review
Week 6 Neurology
● Day 1 Neuro
○ Embryology/Anatomy
○ Cranial Nerves
○ Spinal tract
● Day 2 Neuro
○ Common brain lesions
○ Strokes/hemorrhage
○ Seizures
○ Headaches
○ Associated pharmacology
● Day 3 Neuro
○ Movement disorders
○ Neurodegenerative disorders
○ Neurocutaneous disorders
○ Associated pharmacology
● Day 4 Neuro
○ Brain tumors
○ Spinal cord lesions
○ CN lesions
○ Ophthalmology
○ Associated pharmacology
● Day 5 GI/Renal review
● Day 6 Exam 2 (Covers weeks 1-6)

Week 7 Hematology/Pathology
● Day 1 Hematology/Oncology
○ Anatomy/Physiology
○ Pathways
○ Cellular injury
○ RBC pathology
● Day 2 Hematology/Oncology
○ Anemias
○ Iron studies
○ Platelet disorders
 ○ Associated pharmacology
● Day 3 Hematology/Oncology
○ Leukemias/lymphomas
○ Blood thinners
○ Oncogenes
○ Cancer medications
● Day 4 Cardio/Resp/Endo/Renal review
● Day 5 GI/Neuro review

Week 8 Musculoskeletal, Skin and Connective Tissue

● Day 1 Musculoskeletal, Skin and Connective Tissue
○ Anatomy/physiology
○ Injuries
○ Musculoskeletal conditions
○ Associated pharmacology
● Day 2 Musculoskeletal, Skin and Connective Tissue
○ Bone disorders
○ Bone tumors
○ Fractures
○ Associated pharmacology
● Day 3 Musculoskeletal, Skin and Connective Tissue
○ Arthritis disorders
○ Connective tissue diseases
○ Associated pharmacology
● Day 4 Musculoskeletal, Skin and Connective Tissue
○ Skin disorders
○ Skin cancers
○ Skin infections
○ Blistering disorders
○ Associated pharmacology
● Day 5 Review Hematology/Neurology

Week 9 Biochemistry/Pharmacology
● Day 1 Biochemistry/Pharmacology
○ Regulatory steps/enzymes
○ Enzyme deficiencies
○ Collagen diseases
○ Lab Techniques (ELISA, Western blots, PCR etc)
 ● Day 2 Biochemistry/Pharmacology
○ Genetics (Terms, Modes of inheritance)
○ Hereditary pathologies
○ Nutrition
○ Lysosomal/Glycogen/lipid disorders
● Day 3 Biochemistry/Pharmacology
○ Pharmacokinetics
○ Autonomic drugs
○ Toxins
○ Drug reactions
● Day 4 Review Cardio/Resp/Renal/Endo
● Day 5 Review Musculoskeletal/Heme/GI/Neuro
● Day 6 Exam 3 (Covers weeks 1-9)

Week 10 Psychiatry/Biostats
● Day 1 Psych/Biostats
○ Ego defenses
○ Childhood disorders
○ Personality disorders
○ Mood disorders
○ Psychosis
○ Other disorders
○ Associated pharmacology
● Day 2 Psych/Biostats
○ Biostats
● Day 3 Review TBA
● Day 4 Review TBA
● Day 5 Review TBA
● Day 6 Final Assessment Exam