COURSE FILE

OF
Medicinal Chemistry-II
B. PHARM SEM- V
(Based on Outcome Based
Education)
FACULTY DETAILS
Name of the Faculty: Sudipta Modak
Designation: Assistant Professor
Department: Department of Pharmaceutical Sciences

COURSE DETAILS

Program: B. Pharm
Semester: 5th semester
Course: Medicinal Chemistry-II
Course Code: BP501T
Category of Course: Professional Core

1
INDEX

S. No Topic Page No. Remarks

Mission and Vision of the University 2

Graduate Attributes 3
Mission and Vision of the Department 4
Program Education Objectives 5
Program Outcomes 6-7
Mapping of PEO with PO
Correation of course component with PEO
Course Scheme
Course Objective & Course Outcome
Mapping of PO & CO
Course Content
Course delivery method
Assessment pattern
Sessional Question Paper
Assessment I
Assessmnet II

Assignment I

Assignment II

End Semester Question Paper

2
Vision of the University

The vision envisages augmenting the cause of education at all levels. As a catalyst for
developing engaged and employable workforce, JRU envisions making a compelling
transformation to the world through education, research and innovation that will make
difference to the society and mankind.

Mission of the University

We endeavour to create the best possible learning environment for our students through
dynamic research, rigorous training and efficient mentorship and are committed to the cause
of making higher education accessible to all irrespective of caste, color or creed. To create an
atmosphere of rigor and discipline through innovative education that helps students to
understand all aspects of societal challenges and enable them to works in team to tackle
multifarious problems that directly benefit society.

3
Department of Pharmaceutical Sciences

About the department

The Department of Pharmacy was established in the year 2019 and recognized by the Govt.
of Jharkhand & approved by Pharmacy Council of India, New Delhi. The Department has
been a front runner in the field of pharmacy education with highly qualified, experienced and
research-oriented faculty. The curriculum philosophy aims to provide ability to design &
evaluates various dosage forms, Regulatory & Ethics to be followed in Pharmaceutical
Manufacturing Processes, in-depth adequate knowledge, scientific research updates including
basic principles & advances in Pharmaceutics, Pharmaceutical chemistry, Pharmacology &
Phytomedicines. The Department of Pharmacy has excellent laboratory setup to ensure
experiential learning for a better grasp of the theoretical aspects of pharmaceutical sciences.
The Department provides B. Pharm and D. Pharm courses which enables students with
comprehensive knowledge of medical drugs and aids along with in-depth study of Pharmacy.
The prime focus is always laid on skill enhancement and inculcate the culture of research to
solve emerging challenges towards a successful career ahead.

4
Vision

To evolve as a leading centre for excellence by synergizing knowledge, skill, research and
technology in pharmaceutical care and develop skilled professionals in the area of
pharmaceutical sciences to aid global healthcare with value ethics.

Mission
To excel in Pharmacy education with interdisciplinary approach in the emerging area
of Science and Technology with focus on industry academia interaction, patient
centered care, community engagement and research.
To inspire and inculcate pharmacy graduates with ethical values, entrepreneurship
skill, leadership and effective communication.
To nurture graduates with utmost competence, professionalism and skill to solve
emerging challenges in the field of Pharmacy.

Programme Educational Objectives (PEO)

PEO 1: To develop conceptual and practical knowledge in the various fields of
pharmaceutical sciences in order to build technical skill for analytical aspects in research and
design of Pharmaceutical products.
PEO 2: To prepare the students to enter careers in the pharmaceutical industries, clinical
research companies, government sectors, community and hospital Pharmacy in the field of
pharmaceutical sciences, pharmaceutics, pharmaceutical chemistry, pharmacology,
pharmacovigilance & pharmacognosy.
PEO 3: To develop professional ethics and moral values amongst the students in context to
social pharmacy and health sciences.
PEO 4: To inculcate high order thinking to realise the market potential and explore
entrepreneurship skills to grab the opportunities.
PEO 5: To create enthusiasm among graduates to upgrade themselves in the context of
technological advancement in the field of pharmaceutical sciences seeking higher studies.
PEO 6: To develop communication, team spirit, leadership skills, analytical skills and shall
be self-motivated for lifelong learning to achieve excellence in all spheres of pharmacy.

5
Programme Outcome (PO)

PO 1: Pharmacy knowledge: Apply the knowledge of basic molecular biology, drug

mechanism, science of various systems of human body, fundamental principles of analytical
chemistry, preparation of different dosage forms, natural drugs and monographs of inorganic
drugs in pharmacy.
PO 2: Planning abilities: Demonstrate effective planning abilities in pharmaceutical
industry through resource & time management, delegation skills and organizational skills to
achieve goal.
PO 3: Problem analysis: Develop ability for in-depth analytical and critical thinking in
order to identify, formulate, solve the issues related to Pharmaceutical Industry, Regulatory
Agencies, Hospital and Community Pharmacy.
PO 4: Modern tool usage: Apply the foundation of pharmaceutical science in formulation
technology, synthetic knowledge of modern pharmacy computing tools uses as per the
requirement of pharmaceutical sectors within the constraints.
PO 5: Leadership skills: Exhibit leadership quality, team spirit with motivational capability
when planning for fulfilment of professional and social responsibilities to facilitate
improvement in health and wellbeing.
PO 6: Professional identity: Understand, analyze and communicate the value of their
professional roles in society (e.g. health care professionals, educators, managers, employers,
employees).
PO 7: Pharmaceutical ethics: Demonstrate behaviour that recognizes cultural and personal
variability in values, communication and lifestyles. Honour personal values and apply ethical
principles in professional and social contexts. Use ethical frameworks; apply ethical

6
principles while making decisions and take responsibility for the outcomes associated with
the decisions.
PO 8: Communication: Demonstrate effective communication with the pharmacy
community and with society at large such as being able to comprehend and write effective
reports, make effective presentations and documentation to give and receive clear
instructions.
PO 9: The Pharmacist and society: Apply reasoning informed by the contextual knowledge
to assess societal, health, safety and legal issues and the consequent responsibilities relevant
to the professional pharmacy practice.
PO 10: Environment and sustainability: Understand the impact of the professional
pharmacy solutions in societal and environmental contexts, and demonstrate the knowledge
of, and need for sustainable development.
PO 11: Entrepreneurial skill: Exhibit effective entrepreneurial skills in the field of
pharmacy to analyse the market potential and grab opportunities.
PO 12: Lifelong learning: Develop an aptitude for lifelong learning in the broadest context
of technological change. Develop the decision-making ability for selection of higher studies
in pharmaceutical sciences and allied fields.

Mapping of PO & PEO

POs PEOs
PEO 1 PEO 2 PEO 3 PEO 4 PEO 5 PEO 6
PO 1 √ √ √
PO 2 √ √ √
PO 3 √ √ √
PO 4 √ √
PO 5 √ √
PO 6 √ √
PO 7 √ √
PO 8 √ √
PO 9 √ √
PO 10 √
PO 11

7
 √
PO 12 √ √ √

Correlation of course component with PEO

Course Component of B. Pharm program having 212 Credits in Theory Courses

Curriculum Content % of total number

(Total no. of credits of credits of the
Category of Course PEOs Contact Hours
of the programme) program
1

Professional Core PEO 1, 1080 hrs 128 60.37%

Courses PEO 2,
PEO 5

Basic 345 hrs 40 18.86%

Pharmacy/Science
PEO 1,
courses focused on
PEO 2
skill development

Courses focused on PEO 3, 135 hrs 12 5.66%

entrepreneurship PEO 4

Elective Courses PEO 1, 210 hrs 20 9.43%

PEO 2

Value-added 30 hrs 12 5.66%

courses imparting
PEO 6,
transferable and
PEO 3
life skills

Total credit 212

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B. PHARM COURSE SCHEME- SEMESTER V

Course No. of Credit

Name of the course Tutorial
code hours points
BP501T Medicinal Chemistry II – Theory 3 1 4
BP502T Industrial PharmacyI– Theory 3 1 4
BP503T Pharmacology II – Theory 3 1 4
BP504T Pharmacognosy and Phytochemistry II– Theory 3 1 4
BP505T Pharmaceutical Jurisprudence – Theory 3 1 4
BP506P Industrial PharmacyI – Practical 4 - 2
BP507P Pharmacology II – Practical 4 - 2
BP508P Pharmacognosy and Phytochemistry II – 4 - 2
Practical
Total 27 5 26

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MEDICINAL CHEMISTRY -II

Course Code: BP501T

Continuous Internal Evaluation (CIE): 25
Semester End Examination (SEE): 75
Credit Point: 04
Course hours: 45 Hrs
Course Objective:
Upon completion of the course student shall be able:

1. Understand the chemistry of drugs with respect to their pharmacological activity

2. Understand the drug metabolic pathways, adverse effect and therapeutic value ofdrugs
3. Know the Structural Activity Relationship of different class of drugs
4. Study the chemical synthesis of selected drugs.
5. Moleculer modelling and docking of different compounds and study their activity.

Course Outcomes:
After the successful completion of the course, students should be able to:
CO1: Understand the chemistry of drugs with respect to their pharmacological activity

CO2: Understand the drug metabolic pathways, adverse effect and therapeutic value
ofdrugs

CO3: Know the Structural Activity Relationship of different class of drugs

CO4: Study the chemical synthesis of selected drugs.

CO5: Moleculer modelling and docking of different compounds and study their activity.

Mapping of Course Outcome to Program Outcome:

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COs POs
PO PO PO 3 PO PO PO PO PO PO PO PO PO
1 2 4 10 12
5 6 7 8 9 11
CO 1 √
CO 2 √ √
CO 3 √
CO 4 √
CO 5 √ √

Course Program Level of Assessing Level of

Outcome (CO) Outcome (PO) Bloom’s Tools can be Correlation
Taxonomy used to
measure CO
CO 1 P0 2 Remember,
Understand
CO 2 PO 3, PO 4 Understand,
Apply
CO 3 PO 6 Apply, Analyse
CO 4 PO 6 Analyse,
Evaluate
CO 5 PO 3, PO 5 Evaluate,
Create

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COURSE CONTENT
Sl. Content of the Course Hr Course
N s. Outco
o. mes
(CO)
1. Unit I CO 1

Antihistaminic agents: Histamine, receptors and their distribution in the

humanbody

H1–antagonists: Diphenhydramine hydrochloride*,

Dimenhydrinate, Doxylamines cuccinate, Clemastine fumarate,
Diphenylphyraline hydrochloride, Tripelenamine hydrochloride,
Chlorcyclizine hydrochloride, Meclizine hydrochloride, Buclizine
hydrochloride, Chlorpheniramine maleate, Triprolidine
hydrochloride*, Phenidamine tartarate, Promethazine
hydrochloride*, Trimeprazine tartrate, Cyproheptadine
hydrochloride, Azatidine maleate, Astemizole, Loratadine, 10
Cetirizine, Levocetrazine Cromolyn sodium

H2-antagonists: Cimetidine*, Famotidine, Ranitidin.

Gastric Proton pumpinhibitors: Omeprazole, Lansoprazole,Rabeprazole,

Pantoprazole

Anti-neoplastic agents:
Alkylating agents: Meclorethamine*, Cyclophosphamide, Melphalan,
Chlorambucil, Busulfan, Thiotepa
Antimetabolites: Mercaptopurine*, Thioguanine,
Fluorouracil, Floxuridine, Cytarabine, Methotrexate*,
Azathioprine
Antibiotics: Dactinomycin, Daunorubicin, Doxorubicin,
Bleomycin Plant products: Etoposide, Vinblastin
sulphate, Vincristin sulphate Miscellaneous: Cisplatin,
Mitotane.

12
2. Unit II 10 CO 2
Anti-anginal:

Vasodilators: Amyl nitrite, Nitroglycerin*, Pentaerythritol tetranitrate,

Isosorbide dinitrite*, Dipyridamole.
Calcium channel blockers: Verapamil, Bepridil hydrochloride, Diltiazem
hydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine,
Nimodipine.

Diuretics:

Carbonic anhydrase inhibitors: Acetazolamide*,

Methazolamide,
Dichlorphenamide.
Thiazides: Chlorthiazide*, Hydrochlorothiazide,
Hydroflumethiazide,
Cyclothiazide,
Loop diuretics: Furosemide*, Bumetanide, Ethacrynic acid.

Potassium sparing Diuretics: Spironolactone, Triamterene, Amiloride.

Osmotic Diuretics: Mannitol

Anti-hypertensive Agents: Timolol, Captopril, Lisinopril, Enalapril,

Benazepril hydrochloride, Quinapril hydrochloride, Methyldopate
hydrochloride,* Clonidine hydrochloride, Guanethidine monosulphate,
Guanabenz acetate, Sodium nitroprusside, Diazoxide, Minoxidil,
Reserpine, Hydralazine hydrochloride.

3. Unit III 10 CO 3
Anti-arrhythmic Drugs: Quinidine sulphate, Procainamide
hydrochloride, Disopyramide phosphate*, Phenytoin sodium,
Lidocaine hydrochloride, Tocainide hydrochloride,
Mexiletine hydrochloride, Lorcainide hydrochloride, Amiodarone,
Sotalol.

Anti-hyperlipidemicagents: Clofibrate, Lovastatin,

Cholesteramine and Cholestipol

Coagulant & Anticoagulants: Menadione,Acetomenadione,

Warfarin*,
Anisindione, clopidogrel

Drugs used in Congestive Heart Failure: Digoxin, Digitoxin, Nesiritide,

Bosentan, Tezosentan.

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4. Unit IV 8 CO 4
Drugs acting on Endocrine system
Nomenclature, Stereochemistry and metabolism of steroids
Sex hormones: Testosterone, Nandralone, Progestrones, Oestriol,
Oestradiol,
Oestrione, Diethyl stilbestrol.
Drugs for erectile dysfunction: Sildenafil, Tadalafil.
Oral contraceptives: Mifepristone, Norgestril, Levonorgestrol
Corticosteroids: Cortisone, Hydrocortisone,Prednisolone,
Betamethasone, Dexamethasone
Thyroid and antithyroid drugs: L-Thyroxine, L-Thyronine,
Propylthiouracil, Methimazole.

5. Unit V 7 CO 4,
CO5
Antidiabetic agents:
Insulin and its preparations
Sulfonyl ureas: Tolbutamide*, Chlorpropamide, Glipizide, Glimepiride.
Biguanides: Metformin.
Thiazolidinediones: Pioglitazone, Rosiglitazone.
Meglitinides: Repaglinide, Nateglinide.
Glucosidase inhibitors: Acrabose, Voglibose.

Local Anesthetics: SAR of Local anesthetics

Benzoic Acid derivatives; Cocaine, Hexylcaine, Meprylcaine,

Cyclomethycaine, Piperocaine.
Amino Benzoic acid derivatives: Benzocaine*, Butamben, Procaine*,
Butacaine, Propoxycaine, Tetracaine, Benoxinate.
Lidocaine/Anilide derivatives: Lignocaine, Mepivacaine, Prilocaine,
Etidocaine.

Miscellaneous: Phenacaine, Diperodon, Dibucaine.*

Recommended Books (Latest Editions)

14
1. Wilson and Giswold’s Organic medicinal and Pharmaceutical Chemistry.
2. Foye’s Principles of Medicinal Chemistry.
3. Burger’s Medicinal Chemistry, Vol I to IV.
4. Introduction to principles of drug design- Smith and Williams.
5. Remington’s Pharmaceutical Sciences.
6. Martindale’s extra pharmacopoeia. 129 7. Organic Chemistry by I.L. Finar, Vol. II.
8. The Organic Chemistry of Drug Synthesis by Lednicer, Vol. 1-5.
9. Indian Pharmacopoeia.
10. Text book of practical organic chemistry- A.I.Vogel.

COURSE PLAN
DELIVERY METHODS:
Power Point Presentation, Tutorials, Video Lectures, Design exercises, assignments,
Interactive session, viva voce.

COVERAGE:
Unit 1 by: - Power Point Presentation, Hand notes, Chart Video Lectures, assignments.

Unit 2 by: - Power Point Presentation, Hand notes, Video Lectures, assignments, Interactive
session.

Unit 3 by: - Power Point Presentation, Hand notes, Video Lectures, assignments, Design
exercises, assignments.

Unit 4 by: - Power Point Presentation, , Video Lectures, assignments, Interactive session.

Unit 5 by: - Power Point Presentation, , Video Lectures, assignments, Interactive session

BEYOND SYLLABUS:
Principle value of industrial set up.

15
 Principle & construction & working of the quality assurance & quality control basis
laboratory.

Method of Evaluation

3.3. Teacher Assessment (AT1-3)

3.4. Semester End Examination
3.5. Others (Quiz,Group Discussion)

TARGET:
Percentage Pass in the course should be 100%
Percentage of Students with A and above grade 60%

ASSESSMENT PATTERNS

CIE- Continuous Internal Evaluation (30 Marks)

Bloom’s Sessional Exam (15) (Average Class Participation Marks (10) (Average of
Category marks of best of any 2 sessional) Assessment 1 & 2)
Marks (out
of 25) Sessional Sessional Sessional Assessment 1 (20) Assessment 2 (20)
1 (30) 2 (30) 3 (30)

Remember

Understan
d

Apply

Analyse

Evaluate

Create

SEE- Semester End Examination (75 Marks)

Remember

16
Understand

Apply

Analyse

Evaluate

Create

Lecture Plan UNIT: 01

17
Sr. No Topics/Sub Topics Refere CO D Si
No . of nces Cove at gn
. Pe Books red e
rio
ds

1 1 Antihistaminagent Histami recept thei (4), CO1

ic s: ne, ors andr distribution in (7)
humanbody

2 1 H1–antagonists: Diphenhydramine hydrochloride*, (4), CO1

Dimenhydrinate, Doxylamines cuccinate, Clemastine (7)
fumarate, Diphenylphyraline hydrochloride, Tripelenamine
hydrochloride, Chlorcyclizine hydrochloride
3 1 Meclizine hydrochloride, Buclizine hydrochloride, (4), CO1
Chlorpheniramine maleate, Triprolidine hydrochloride*, (7)
Phenidamine tartarate, Promethazine hydrochloride
4 1 Trimeprazine tartrate, Cyproheptadine hydrochloride, (4), CO1
Azatidine maleate, (7)
5 1 Astemizole, Loratadine, Cetirizine, Levocetrazine (4), CO1
Cromolyn sodium. (7)

6 1 H2-antagonists: Cimetidine*, Famotidine, Ranitidin. (4), CO1

(7)

7 1 Gastric Proton pump (4), CO1

Pantoprazole (7)

8 1 Alkylatingagents:Meclorethamine*, Melphal (4), CO1

Cyclophosphamide, an, (7)
Chlorambucil, Busulfan, Thiotepa

9 1 Antimetabolites: Mercaptopurine*, (4), CO1

Thioguanine, Fluorouracil, Floxuridine, (7)
Cytarabine, Methotrexate*, Azathioprine

10 1 Antibiotics: Dactinomycin, (4), CO1

Daunorubicin, Doxorubicin, Bleomycin
(7)

Plant products: Etoposide, Vinblastin

sulphate, Vincristin sulphate
Miscellaneous: Cisplatin, Mitotane.

18
 Name & Sign. of Faculty Sign. of H.o.D
SUDIPTA MODAK

Lecture Plan UNIT :02

Sr. No. of Topics/Sub Topics References CO Date Sign

No. Periods Books Covered

1 1 Anti-anginal: (2),(3) CO2

Vasodilators: Amyl nitrite,
Nitroglycerin*, Pentaerythritol
tetranitrate, Isosorbide
dinitrite*, Dipyridamole.

2 1 Calcium channel blockers: (2),(3) CO2

Verapamil, Bepridil
hydrochloride, Diltiazem
hydrochloride, Nifedipine

3 1 Amlodipine, Felodipine, (2),(3) CO2

Nicardipine, Nimodipine.

4 1 Diuretics:Carbonic (2),(3) CO2

anhydrase
inhibitors:
Acetazolamide*,

5 1 Methazolamide, (2),(3) CO2

Dichlorphenamide.

6 1 Thiazides: Chlorthiazide*, (2),(3) CO2

Hydrochlorothiazide,
Hydroflumethiazide,

19
 Cyclothiazide,
Loop diuretics: Furosemide*,
Bumetanide, Ethacrynic acid.

7 1 Potassium sparing Diuretics: (2),(3) CO2

Spironolactone, Triamterene,
Amiloride.

Osmotic Diuretics: Mannitol

8 1 Anti-hypertensive Agents: (2),(3) CO2

Timolol, Captopril, Lisinopril,
Enalapril, Benazepril
hydrochloride, Quinapril
hydrochloride

9 1 Methyldopate hydrochloride,* (2),(3) CO2

Clonidine hydrochloride,
Guanethidine monosulphate,
Guanabenz acetate
10 1 Sodium nitroprusside, (2),(3) CO2
Diazoxide, Minoxidil,
Reserpine, Hydralazine
hydrochloride.

Name & Sign. of Faculty Sign. of H.o.D

Sudipta Modak

Lecture Plan UNIT :03

Sr. No. of Topics/Sub Topics References CO Date Sign

No. Periods Books Covered

20
1 1 Anti-arrhythmic Drugs: (4), (7) CO3
Quinidine sulphate,
Procainamide
hydrochloride,
Disopyramide phosphate*,

2 1 Phenytoin sodium,Lidocaine (4), (7) CO3

3 1 hydrochloride, Tocainide (4), (7) CO3

hydrochloride

4 1 Mexiletine hydrochloride, (4), (7) CO3

Lorcainide hydrochloride,
Amiodarone, Sotalol.

5 1 Anti-hyperlipidemic agents: (4), (7) CO3

Clofibrate, Lovastatin

6 1 Cholesteramine and Cholestipol (4), (7) CO3

7 1 Coagulant & (4), (7) CO3

Anticoagulants:
Menadione,
Acetomenadione,

8 1 Warfarin*, (4), (7) CO3

Anisindione, clopidogrel

9 1 Drugs used in Congestive Heart (4), (7) CO3

Failure: Digoxin, Digitoxin,

10 1 Nesiritide, Bosentan, (4), (7) CO3

Tezosentan.

21
Name & Sign. of Faculty Sign. of H.o.D

Sudipta Modak

Lecture Plan UNIT :04

Sr. No. of Topics/Sub Topics References CO Date Sign

No. Periods Books Covered

1 1 Drugs acting on (4), (7) CO4

Endocrine system
Nomenclature,
Stereochemistry and
metabolism of steroids

2 1 Sex hormones: (4), (7) CO4

Testosterone, Nandralone,
Progestrones, Oestriol,
Oestradiol

3 1 Oestrione, Diethyl (4), (7) CO4

stilbestrol.
Drugs for erectile
dysfunction: Sildenafil,
Tadalafil.

4 1 Oral contraceptives: (4), (7) CO4

Mifepristone, Norgestril,
Levonorgestrol

5 1 Corticosteroids:Cortisone, (4), (7) CO4

Hydrocortisone,
6 1 Prednisolone, (4), (7) CO4
Betamethasone,
Dexamethasone

7 1 Thyroid and antithyroid (4), (7) CO4

drugs: L-Thyroxine, L-
Thyronine,

22
8 1 Propylthiouracil, (4), (7) CO4
Methimazole.

Name & Sign. of Faculty Sign. of H.o.D

Sudipta Modak

Lecture Plan UNIT :05

Sr. No. of Topics/Sub Topics References CO Date Sign

No. Periods Books Covered

1 1 Antidiabetic agents: (4), (7) CO5

Insulin and its
preparations
Sulfonyl ureas:
Tolbutamide*,
Chlorpropamide,
Glipizide, Glimepiride.
Biguanides: Metformin.

2 1 Thiazolidinediones: (4), (7) CO5

Pioglitazone,
Rosiglitazone.
Meglitinides:
Repaglinide, Nateglinide.

3 1 Glucosidase inhibitors: (4), (7) CO5

Acrabose, Voglibose.

4 1 Local Anesthetics: SAR (4), (7) CO5

of Local anesthetics

23
5 1 Benzoic Acid (4), (7) CO5
derivatives; Cocaine,
Hexylcaine, Meprylcaine,
Cyclomethycaine,
Piperocaine.

6 1 Amino Benzoic acid (4), (7) CO5

derivatives:
Benzocaine*, Butamben,
Procaine*, Butacaine,
Propoxycaine,
Tetracaine, Benoxinate.

7 1 Lidocaine/Anilide (4), (7) CO5

derivatives: Lignocaine,
Mepivacaine, Prilocaine,
Etidocaine.

Miscellaneous:
Phenacaine, Diperodon,
Dibucaine.*

Name & Sign. of Faculty Sign. of H.o.D

Sudipta Modak

24
25