ELTE Biology MSC Entrance Interview Topics 2024 2
ELTE Biology MSC Entrance Interview Topics 2024 2
Program in English
(at Eötvös Loránd University) – 2024
Specialization in Molecular Genetics, Cell- and Developmental Biology
(MGCDB)
GENETICS
1. Gene and regulation of gene activity. Mendelian laws. Main characteristics of primary
transcript, exon, intron, allele, co-linearity of gene and transcript. Exceptions of Mendelian
laws (linkage, gene conversion, gene interactions).
2. Mutation and structure of chromosomes. Mutations on DNA and chromosomal level, ploidity,
balancer chromosomes, mutagen agents, Ames test, mutation repair, pleiotropy, DNA
polymorphic markers, DNA diagnostics. Chromatin structure, specific chromosomes (e.g.,
polytene chromosomes in Drosophila), sex-linked inheritance.
3. Recombination. Linkage, gene conversion and crossing over, chiasm. Holliday structure,
tetrad analysis, the molecular mechanism of recombination. Gene transfer and gene mapping
in phages, bacteria and eukaryotes, determination of gene order, map distance, crossover
interference, mapping (Haldane) rule. Haplotype.
4. Developmental genetics. Genetic and biochemical pathways, epistasis (double mutant)
analysis, genetic interactions, main signal transduction (genetic) pathways, sex determination
and dosage compensation, early development in Drosophila, mosaic analysis, maternal effect
genes, maternal inheritance.
CELL BIOLOGY
5. Structure of the plasma membrane and membrane transport processes.
6. Compartmentalization of the eukaryotic cell. Targeting of specific protein and RNA molecules.
Internal connections of the endomembrane system: vesicular transport, membrane fluidity.
7. The features of cell cycle and cell cycle control. Extrinsic regulation: mode of action of growth
factors, cell signaling pathways (Ras - MAP-kinase pathway). Intrinsic regulation: checkpoints
(cyclin - CDK complexes, mode of action of retinoblastoma and p53 proteins).
8. Role of intercellular connections in multicellular organisms. General characteristics of cell
signaling pathways upon an example. Basic tissue types, examples of cellular communication
on the molecular level.
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5. Major metabolic pathways, their characteristics, and control. Fundamentals of bioenergetics,
relevance of ATP. Mechanism of biological oxidation. Function of ATP synthase.
6. Principles of prokaryotic metabolism. Cultivation of microorganisms.
7. General characteristics of biogeochemical cycles. The role of microbes in biogeochemical
cycles.
8. Organization of the bacterial cell.
9. Cellular components and function of the native immune system; its connections with the
adaptive immune system.
10. Cellular components and function of the adaptive immune system; its connections with the
native immune system.
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7. Global biodiversity patterns. Organization and function of ecological communities. Fluxes of
energy and matter in ecosystems.
8. Elements of climate, changes in time. Climate of the earth. Climatic effects on soil and
vegetation.
9. Soils, soil formation, physical, chemical and biological characteristics of soils. Processes in the
soil profile, soil classification.
10. Geographic distribution of organisms, dynamics in space and time, biological invasion.
Refuges, relicts and endemisms. Island biogeography. Conservation biology.
11. Characteristics, stratification and communities of the freshwater biotope. Structure and
function of freshwater communities, freshwater ecological systems.
PLANT TAXONOMY
12. Classification of plants: from artificial systems to cladistics. Chloroplast symbiogenesis and the
phylogenetic system of photosynthetic eukaryotes before the invasion of land.
13. Traditional and molecular taxonomic characters in plant taxonomy, theoretical principles of
molecular phylogenetics. Recent phylogenetic system of terrestrial plants (Embryophyta).
ANIMAL TAXONOMY
14. Theories of taxonomy. Relationship of taxonomy and systematics. Schools of classification,
phylogenetic systems. Comparative analysis of morphological and molecular trees of life.
Phylogeny of invertebrates, characteristics of main groups.
15. Origin of Chordata, hypotheses. Main evolutionary steps in the phylogeny of Vertebrates,
characteristics of major taxa