Acute Poisoning with

Organophosphate Pesticide
PHAR-312 SEMESTER WORK
Subtitle:Case Report from Journal of Clinical Toxicology
Authors: Jane Doe, John Smith
Publication year:2022

Ege Sert No:20201100076

 INTRODUCTION
Abstract

• In impoverished n tions like Ethiopi , org nophosph te compounds re commonly used s pesticides nd suicide gents due to their inhibitory
e ects on the cetylcholinester se enzyme. This c se involves 21-ye r-old Ethiopi n fem le university student who ttempted suicide. She
experienced symptoms such s n use , vomiting, incre sed s liv tion, chills, swe ting, di iculty bre thing, nd dizziness. Upon dmission to the
emergency dep rtment, she received tre tment including intr n s l oxygen nd intr venous tropine to counter ct the e ects of the poisoning

• P tient Det ils:

• Age: 21 ye rs

• Gender: Fem le

• Medic l History: No signi ic nt p st medic l history

• Exposure Det ils:

• Subst nce: Org nophosph te pesticide

• Amount: Approxim tely 50 mL

• Route of Exposure: Or l
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 CLINICAL PRESENTATION AND DIOGNOSIS

• Symptoms:She rrived t the hospit l with two-hour history of n use nd spor dic
vomiting s well s n hour of persistent vomiting, incre sed s liv tion through the mouth,
chills, progressive swe ting, bre thing di iculties, nd dizziness.

• Di gnosis:Clinic l evidence of her susceptibility to the poison, clinic l fe tures, nd the

presence of g rlic-like odor frequently round out the di gnosis. G stric l v ge w s done
right w y fter she w s dmitted without ny vit l signs, l bor tory testing, or physic l
ex min tion.
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 DISCUSSION

• Org nophosph te pesticides re widely used in f rming nd homes in Ethiopi . They re v il ble over-the-
counter nd c n be leth l if ingested in suicide ttempts. The poisoning c n c use unusu l c rdi c toxicity,
including myoc rditis nd peric rditis. The he rt toxicity goes through three ph ses: initi l ph se
(ch r cterized by mild symp thetic ction), extended cholinergic toxicity ph se, nd the prolonged ph se
ssoci ted with long QT interv l nd polymorphic VT. In this c se, the p tient experienced the irst two
ph ses but received prompt tre tment, preventing the prolonged ph se. Org nophosph te poisoning c n
result in three m jor syndromes: cute cholinergic syndrome, intermedi te syndrome, nd org nophosph te
poisoning-induced del yed polyneurop thy. The p tient in this c se h d cute cholinergic syndrome nd
intermedi te syndrome but did not experience del yed polyneurop thy. Common symptoms of
org nophosph te poisoning include br dyc rdi , miosis, bronchosp sm, incre sed s liv tion, l crim tion,
urine, muscul r p r lysis, di rrhe , nd incre sed s liv tion. Tre tment involves resuscit tion, oxygen
dministr tion, tropine sulf te, electrolyte b l ncing luids, nd oxime. Due to limit tions in equipment nd
unknown ingestion mount, the severity of the p tient's condition upon rriv l could not be determined.
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 CONCLUSION

• Org nophosph te poisoning in ctiv tes cetylcholinester se

nd le ds to n excess of nicotinic nd musc rinic receptors,
c using v rious symptoms. Atropine sulf te is the
recommended tre tment. To reduce poisonings, the Ethiopi n
government should restrict vendors of poisoned goods nd
involve m nuf cturers, regul tory gencies, nd poison control
centers. Governments should r ise w reness by using w rning
l bels nd promoting prim ry prevention methods. The uthor
emph sizes pe ceful problem-solving inste d of resorting to
suicide.
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REFERENCES

• https://www.ncbi.nlm.nih.gov/pmc/ rticles/PMC9630056/