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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER– 3 EXAMINATION – SUMMER -2019
Subject Code: BP301TP Date: 28-05-2019
Subject Name: Pharmaceutical Organic Chemistry II
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Explain molecular orbital structure and resonance energy of benzene. 06
(b) Explain effect of substituent on acidity of benzoic acid. 05
(c) Notes on Sachse Mohr’s theory. 05
Q.2 (a) Why benzene undergoes electrophilic substitution reaction? Explain 06
halogenation reaction of benzene with mechanism.
(b) Write down important reaction involve in benzoic acid in detail. 05
(c) Discuss about reaction of cyclopropane and cyclobutane. 05
Q.3 (a) Notes on Haworth synthesis for naphthalene and Anthracene. 06
(b) Discuss about Coulson and Moffitts modification of cycloalkanes. 05
(c) Write down structure and medicinal use of Anthracene, diphenylmethane 05
triphenylmethane derivatives.
Q.4 (a) Write a notes on acidicity and effect of substituents of phenol. 06
(b) Discuss the molecular orbital structure of naphthalene? 05
(c) What happen when 05
(a) Naphthalene is treated with concentrated sulphuric acid at 1650C.
(b) Anthracene is treated with sodium dichromate and sulphuric acid.
Q.5 (a) Write down significance and principle involve in determination of 06
(a) RM value (b) Acetyl value
(c) Ester value (d) Iodine value
(b) Notes on synthetic use of aryl diazonium salts. 05
(c) Explain 05
(a) Why phenol is more acidic than ethyl alcohol?
(b) Why o-nitrophenol is steam volatile whereas p-nitrophenol is not?
Q. 6 (a) How will you synthesise the following compounds from benzene 06
(a) Benzene hexachloride (b) Ethylbenzene
(c) Isopropylbenzene (d) Cyclohexane
(b) Write down structure and use of following compounds 05
(a) DDT (b) Saccharin (c) Cresol
(c) Notes on inductive group and its directing effect in monosubstituated benzene. 05
Q.7 (a) Explain hydrogenation of oil with diagram. Discuss significance and principal 06
of acid value and saponification value.
(b) Notes on a Fridel crafts alkylation and acylation of benzene 05
(c) Discuss Bayer’s strain theory with suitable examples. 05
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER– 3 EXAMINATION – WINTER -2019
Subject Code: BP301TP Date: 14-11-2019
Subject Name: Pharmaceutical Organic Chemistry II
Time: 10:30AM TO 01:30PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Write down the methods of preparation and uses of benzoic acid. 06
(b) Halogens are deactivators but o, p- directors. Justify with suitable examples. 05
(c) Write the principle and significance of Iodine number. 05
Q.2 (a) Write a short note Fries Rearrangement and Carbylamines reaction. 06
(b) Write the mechanism Friedal Craft alkylation with its limitations. 05
(c) Enumerate the influence of substituents on acidity of Aromatic acids. 05
Q.3 (a) Convert these followings: 06
I. Phenol to Phenyl acetic acid
II. p- cresol to p-NO2 benzyl tolyl ether
III. o- cresol to N- nitroso 2- methyl Phenol
(b) Describe in detail about Bayer’s strain theory with its limitation 05
(c) Write an informative note on Huckel’s rule of aromaticity. 05
Q.4 (a) Comment these followings: 06
I. Why Benzene undergoes Substitution reaction instead of addition
reaction? Justify
II. Why reactivity of NO2 benzene is slow in comparison to Benzene.
(b) Why animal fats are solids and Vegetable oils are Liquids? Justify with 05
examples
(c) Describe three different reactions of fatty acids with examples. 05
Q.5 (a) What happens when Anthracene reacts with these following? Write the 06
reaction.
I. Maleic anhydride
II. Na/C2H5OH
III. Na2Cr2O7
(b) Write down any five methods of Preparation of Phenol 05
(c) Write down methods of Preparation of Naphthalene. 05
Q. 6 (a) Convert these followings: 06
I. Chloro benzene to Benzene
II. Styrene to 2-Phenyl Ethanol
III. Benzene to m- nitro benzaldehyde
(b) Write the synthesis and utility of Diazonium salts.
www.remixeducation.in 05
(c) What do you mean by Rancidity? Explain in detail with example. 05
Q.7 (a) Describe the various qualitative tests of phenol. 06
(b) Write down the structure and uses of these followings: 05
a) DDT b) Saccharin c) Diphenylmethane d) Phenanthrene e) Cresol
(c) Write a short note on Sachse Mohr’s theory. 05
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER– 3 EXAMINATION – SUMMER -2019
Subject Code: BP302TP Date: 30-05-2019
Subject Name: Physical Pharmaceutics I
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Describe Raoult’s law with its application. 06
(b) Define following terms 05
(i) Solution (ii) Solute (iii) Solvent (iv) Saturated solution (v) supersaturated
solution.
(c) Enumerate factors affecting solubility and discuss common ion effect in detail. 05
Q.2 (a) Discuss the factors affecting solubility of gas in liquids. 06
(b) What is polymorphism? Discuss it with suitable examples. 05
(c) Briefly explain (i) Glassy state and (ii) Liquid crystals. 05
Q.3 (a) Explain sublimation with suitable diagram. 06
(b) What is the significance of specific rotation in pharmacy? 05
(c) Write a note on Du Nouy Tensiometer. 05
Q.4 (a) Explin spreading coefficient. 06
(b) Give the range of HLB value of (i) Detergents (ii) wetting agents (iii) o/w 05
emulsifying agents (iv) Antifoaming agents (v) Solubilizing agents
(c) What is physisorption? Differentiate physisorption and chemisorptions. 05
Q.5 (a) Explain the significance of protein binding. 06
(b) Write a short note on Clathrates. 05
(c) Write a short note on ligands. 05
Q. 6 (a) Classify the complexes and explain chelates in detail. 06
(b) Explain Sorensen’s pH scale. 05
(c) Write a note on pH determination. 05
Q.7 (a) Explain Henderson-Hasselbalch equation. 06
(b) What are the methods of adjusting tonicity? Discuss freezing point method in 05
detail.
(c) Explain the limitation of distribution law. 05
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER– 3 EXAMINATION – WINTER -2019
Subject Code: BP302TP Date: 16-11-2019
Subject Name: Physical Pharmaceutics I
Time: 10:30AM TO 01:30PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Define solubility. Explain the factors affecting on solubility of drug with 06
suitable example.
(b) Discuss in detail Raoult’s low and its deviations. 05
(c) Write a note on distribution law with its limitations and applications. 05
Q.2 (a) Explain in brief (1) Eutectic mixture (2) Sublimation. 06
(b) Write a note on liquid crystals. 05
(c) Define refractive index. Explain the method used to determine refractive index. 05
Q.3 (a) Enlist the methods used to measure the surface and interfacial tensions. Explain 06
any one in detail.
(b) Write a note on HLB scale. 05
(c) Explain in detail about surface active agents. 05
Q.4 (a) Define and classify the complexation. Write in detail about “chelates” 06
(b) Describe the applications of complexation in field of pharmacy. 05
(c) Write a note on Protein drug binding kinetics. 05
Q.5 (a) Enlist the methods used to determine the pH. Discuss any one in detail. 06
(b) Discus in detail about Sorensen’s pH scale. 05
(c) Write a short note on “Buffer Equation” 05
Q. 6 (a) What is White – Vincent method of making isotonic solution? Discuss with 06
suitable example.
(b) Discuss in detail about Aerosols. 05
(c) Give a note on spreading coefficient 05
Q.7 (a) Classify the crystals. Discuss about crystal habit. 06
(b) Explain in detail freundlich adsorption isotherm. 05
(c) Discuss in brief about buffer capacity. 05
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER– 3 EXAMINATION – SUMMER -2019
Subject Code: BP303TP Date: 01-06-2019
Subject Name: Biochemistry
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Enlist unsaturated fatty acids and discuss oxidation of omega-3 fatty acid 06
(b) Discuss amphibolic nature of citric acid cycle. 05
(c) Explain β-oxidation of fatty acid 05
Q.2 (a) Explain the properties and identification tests of carbohydrate 06
(b) Define: Iodine number, Saponification number, Acid number, 05
Rancidity, Mutarotation
(c) Write a note on TCA cycle 05
Q.3 (a) Discuss importance of Cori’s cycle 06
(b) Discuss the Synthesis of Glucose from Non-Carbohydrate sources 05
(c) Write a note on regulation of enzyme activites 05
Q.4 (a) Write a note on galactose and fructose 06
(b) Write a note on cholesterol biosynthesis 05
(c) Discuss the transport mechanism across cell membrane 05
Q.5 (a) Describe the structures and function of mucopolysaccharides 06
(b) Describe the Watson and Crick Model of DNA Structure 05
(c) Discuss enzyme kinetics in brief and its mechanism of action 05
Q. 6 (a) Explain Metals and Vitamins as Co-enzyme and their Significance 06
(b) Write a note on protein synthesis and inhibitors. 05
(c) Write a note on Lipid Storage Diseases 05
Q.7 (a) Explain the genetic code with its characteristics 06
(b) Explain in detail the process of RNA synthesis. 05
(c) Describe significance of melatonin and dopamine. 05
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. - SEMESTER–III • EXAMINATION – WINTER -2019
Subject Code: BP303TP Date: 19/11/2019
Subject Name: BIOCHEMISTRY
Time:10:30AM TO 01:30PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Define and classify carbohydrate with suitable examples. Also explain 06
biological role of carbohydrates.
(b) Define bioenergetics and give relationship between free energy, enthalpy and 05
entropy and redox potential.
(c) Draw flow chart of Glycolysis – Pathway and discuss its energetics and 05
significance
Q.2 (a) Write a note on Electron transport chain (ETC) and its mechanism 06
(b) Explain Oxidative phosphorylation & its mechanism. 05
(c) Give brief note on β-Oxidation of saturated fatty acid. 05
Q.3 (a) Discuss Biological significance of cholesterol and conversion of cholesterol 06
into bile acids and vitamin D.
(b) Give a brief note on De novo synthesis of fatty acids 05
(c) Give a detail note on urea cycle and its disorders 05
Q.4 (a) Write a brief note on catabolism of heme and discuss hyperbilirubinemia 06
(b) Give brief note on Protein synthesis and inhibitors 05
(c) Draw the Structure of DNA and RNA and discuss their functions. 05
Q.5 (a) Give detail on regulation of enzymes. 06
(b) Define and classify enzyme. 05
(c) Discuss Enzyme inhibitors with examples 05
Q. 6 (a) Give Therapeutic and diagnostic applications of enzymes 06
(b) Give hormonal regulation of blood glucose level. 05
(c) Write in brief Gluconeogenesis- Pathway. 05
Q.7 (a) Define energy rich compounds and give its classification and biological 06
significance.
(b) Give a brief note on Uncouplers. 05
(c) Write a brief on Enzyme kinetics 05
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER– 3 EXAMINATION – SUMMER -2019
Subject Code: BP304TT Date: 04-06-2019
Subject Name: Pathophysiology
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Define alzheimer disease. Write about pathophysiology and symptoms of 06
alzheimer and its treatment.
(b) Write a short note on 05
i. Asthma
ii. Ulcerative colitis
(c) Write in detail about electrolyte imbalance. Explain the role of electrolytes in 05
the electrophysiology of heart.
Q.2 (a) Define atherosclerosis. Write in detail about pathophysiology of atherosclerosis 06
causes and medications used.
(b) What is schizophrenia. Explain the process of occurrence of schizophrenia 05
symptoms.
(c) Write about clinical signs of Inflammation. Explain mechanism of 05
inflammation and mediator’s of inflammation.
Q.3 (a) Enumerate types of sickle cell anemia. Write about pathophysiology of sickle 06
cell anemia and its treatment.
(b) Define Homeostasis. Explain about Feedback systems. 05
(c) Write a short note on 05
i. Chronic renal failure
ii. Gout
Q.4 (a) Explain in brief about thyroid disorders. Write about etiology and 06
pathophysiology of goiter.
(b) Explain types of peptic ulcer. Write about pathogenesis and treatment of peptic 05
ulcer.
(c) Write a short note on malignant tumor. 05
Q.5 (a) Define gonorrhea. Write about pathophysiology of gonorrhea, diagnosis and its 06
treatment.
(b) Write about pathogenesis of B.P. Explain in detail about role of kidney in 05
hypertension.
(c) Write a short note on meningitis. 05
Q. 6 (a) Define UTI. Write in detail about etiology, pathophysiology and its treatment. 06
(b) Write a short notewww.remixeducation.in
on PCOS. 05
(c) Write about cell injury. Explain in detail about cellular adaptive changes. 05
Q.7 (a) Classify diabetic mellitus. Discuss the causes, symptoms and treatment of 06
diabetic mellitus.
(b) Write in detail about types of Hepatitis and its causes. 05
(c) Define AIDS. Write about pathogenesis, diagnosis and its prevention. 05
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER– 3 EXAMINATION – WINTER -2019
Subject Code: BP304TT Date: 21-11-2019
Subject Name: Pathophysiology
Time: 10:30AM TO 01:30PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Classify types of hypertension. Write a note on risk factors and management of 06
hypertension
(b) Write signs and symptoms and complications of Diabetes mellitus. 05
(c) Define Atrophy, Hypertrophy, Hyperplasia, Metaplasia and Dysplasia 05
Q.2 (a) Explain pathophysiology of Peptic ulcer diseases. 06
(b) Explain the pathogenesis of asthma. Write differences between Bronchial 05
asthma and COPD.
(c) Explain diagnosis and management of Tuberculosis. 05
Q.3 (a) Write pathophysiology of Rheumatoid arthritis. 06
(b) Explain causes of acute renal failure. 05
(c) Describe the signs and symptoms of various forms of epilepsy. 05
Q.4 (a) Write clinical manifestation and pathophysiology of Parkinsonism. 06
(b) Write etiology and pathogenesis of cancer 05
(c) Write mechanism of different type of inflammation 05
Q.5 (a) Explain the pathogenesis and clinical manifestations of AIDS. 06
(b) Describe basic principles of wound healing in the skin. 05
(c) Write about various types of arrhythmia 05
Q. 6 (a) Classify anemia. Write detailed note on Iron deficiency anemia. 06
(b) Define hepatitis. What are signs and symptoms of hepatitis? Write causes of 05
hepatitis.
(c) Describe in details the signs and symptoms of schizophrenia. 05
Q.7 (a) Discuss signs and symptoms and complications of urinary tract infections. 06
(b) Write etiology, clinical manifestation and treatment of Depression. 05
(c) Explain pathophysiology of Atherosclerosis 05
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER– 3 EXAMINATION – SUMMER -2019
Subject Code: BP305TP Date: 07-06-2019
Subject Name: Pharmacognosy and Phytochemistry I
Time: 02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Define Pharmacognosy. Discuss its scope and development in brief. 06
(b) “Physicochemical evaluation is extremely important for quality control of crude 05
drugs”. - Justify.
(c) Discuss the sexual and asexual methods of vegetative propagation in brief. 05
Q.2 (a) What is evaluation of the crude drugs? Explain quantitative microscopic 06
evaluation of the crude drugs.
(b) How can you classify the crude drugs? Give a short note on Chemical and 05
Taxonomical type of classification.
(c) Define adulteration of crude drug? Discuss unintentional adulteration of crude 05
drugs.
Q.3 (a) Explain -“Plant tissue culture is fundamental concept of Pharmacognosy”. 06
(b) Enlist various plant tissue culture techniques. Discuss Micropropogation and 05
somatic hybridization in very brief.
(c) Give a note on composition of nutrient media in plant tissue culture. 05
Q.4 (a) Elaborate the fundamental principles of Homeopathic system of medicine. 06
(b) Discuss the Tridoshas as basic principles of Ayurvedic system of medicine. 05
(c) Discuss plant hormones and their applications in plant growth and 05
development.
Q.5 (a) Define secondary metabolite? Give classification, properties and identification 06
tests of Alkaloids.
(b) Classify Glycosides as secondary metabolites. Write any two qualitative 05
phytochemical tests of them.
(c) Write the following chemical tests: 05
(i) Gold beater’s skin test (ii) Modified Borntrager’s test (iii) Match stick test
Q. 6 (a) Define pharmaceutical aids. Discuss Gelatin and Papain as pharmaceutical aids 06
in brief.
(b) Write biological source, chemical constituents and uses of the following: 05
(i) Agar (ii) Tragacanth (iii) Guar gum
(c) Write a note on Natural allergens. 05
Q.7 (a) Give a brief report on factors affecting cultivation of medicinal plants. 06
(b) Write biological source, chemical constituents and identification tests of Castor 05
oil and Bees wax.
(c) Describe the novel medicinal agents obtained from marine sources. 05
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER– 3 EXAMINATION – WINTER -2019
Subject Code: BP305TP Date: 25-11-2019
Subject Name: Pharmacognosy and Phytochemistry I
Time: 10:30 TO 01:30PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Define Pharmacognosy. Discuss in brief about scope and development of 06
Pharmacognosy.
(b) Enlist sources of crude drugs. Describe in brief about marine and animal 05
sources of crude drugs.
(c) Name different traditional system of medicine. Discuss Ayurvedic system of 05
medicine in details.
Q.2 (a) What is drug evaluation? Write down different types of evaluation of crude 06
drugs. Explain physical evaluation of crude drugs in details.
(b) Differentiate organized and unorganized crude drug with examples. 05
(c) Explain plant growth regulators in details. 05
Q.3 (a) Define crude drug. Enlist different method of classification. Discuss 06
pharmacological classification of crude drug with examples.
(b) Define following : 05
1. Resin 2. Gum
3. Stomata 4. Trichome 5. Mucilage
(c) Write down biological source, properties, uses and method of preparation of 05
honey.
Q.4 (a) Differentiate following: 06
1. Hydrolysable tannin and condensed tannin
2. Gum acacia and gum tragacanth
3. Fixed oil and Volatile oil
(b) What is adulteration of crude drug? Discuss different types of adulteration with 05
suitable example.
(c) Give biological source, chemical constituent, uses of castor oil and wool fat. 05
Q.5 (a) Enlist factor affecting cultivation of crude drugs. Explain in details extrinsic 06
factors.
(b) Define Glycoside. Discuss its classification and properties in details. 05
(c) Write a note on mutation and hybridization. 05
Q. 6 (a) Define plant tissue culture. Explain composition of nutrient media in details. 06
(b) Write a note on different types of culture. 05
(c) Write down short note on Natural allergen. 05
Q.7 (a) Define alkaloid. Discuss classification and properties in details. 06
(b) Define Carbohydrate. Write a note on starch and Guar gum. 05
(c) Write a note on plant fibers. 05
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