NIPAGUARD CG
Technical Data Sheet
NIPAGUARD CG Publisher
Rothausstrasse 61
4132 Muttenz
Switzerland
Preservative for the cosmetic industry Copyright ©
Clariant International Ltd, 2022
Chemical name Mixture of isothiazolinones Contact
BU INDUSTRIAL & CONSUMER
SPECIALTIES
INCI Name: Methylchloroisothiazolinone, Methyl
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isothiazolinone www.clariant.com
Chemical structure
Issue
October 2022
Product properties 1
Appearance (20°C) Clear liquid
Colorless to slightly yellowish
Chemical and physical data
Active ingredients Total 1.50
5-chloro-2-methyl-4- Approx. 1.15%
isothiazolin-3-one
2-methyl-4-isothiazolin-3- Approx. 0.35%
one
Inert Ingredients
Magnesium salts Approx 23.0%
Water Approx 75.5%
pH (as is) 1.7-3.7
1 These characteristics are for guidance only and not to be taken as product specifications. The tolerances
are given in the product specification sheet. For further product properties, specifications, safety, and ecologi-
cal data, please refer to the MSDS.
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Publisher
Profile Rothausstrasse 61
4132 Muttenz
Characteristics Switzerland
Nipaguard CG is a mixture of active ingredients and inert salts in aqueous solution. It is Copyright ©
readily miscible in water, glycol and alcohol and presents low solubility in hydrocarbons. Clariant International Ltd, 2022
Nipaguard CG exhibits a wide range of antimicrobial activity against gram positive and Contact
gram negative bacteria, fungi and yeasts. BU INDUSTRIAL & CONSUMER
SPECIALTIES
Nipaguard CG provides protection in a wide range of products. It is heat stable up to www.ics.clariant.com
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50 °C and should be added to formulations which need a hot process during the cooling
stage.
Applications
Typical use concentration of NIpaguard CG in cosmetic formulations ranges from 0.05-
0.1%.
The presence of calcium and magnesium ions in hard water provides a significant positive
influence on Nipaguard CG stability. The presence of amine impurities in raw materials
has a deleterious effect on the stability of Nipaguard CG; a simple reduction in pH to below
7, converting the amine to its salt will normally solve the problem.
Some reducing agents like sulfated and sulfonated surfactants (due to their residual sulfite
or bisulfite contents), strong nucleophiles and secondary amines can decompose
Nipaguard CG.
General recommendations that will enhance stability and improve the performance of
Nipaguard CG during the formulation development:
• Use slightly acidic pH values especially when the formulation has free DEA
• Eliminate residual SO2 when present with a suitable oxidizing agent
• Avoid high temperatures (above 50°C).
• Use preferable hard water
• To improve viscosity, use MgCl2 rather than NaCl
• Some fillers such as talc, titanium oxides, kaolin could absorb or degrade
Nipaguard CG
Since the components of cosmetic and toiletry formulations vary considerable and may
have an impact on the effect of preservatives, we recommend each manufacturer to
confirm the efficacy and stability of Nipaguard CG in formulations challenging them with
microorganisms commonly found in cosmetics products.
Microbial Activity
Nipaguard CG exhibits antimicrobial activity against a wide range of bacteria, yeasts and
molds. This is illustrated by the following table which shows the minimum inhibitory
concentration (MIC) of Nipaguard CG against examples of different groups of
microorganisms.
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Microorganisms MIC level (ppm) Active ingredient (ppm) Publisher
Rothausstrasse 61
Gram Negative Bacteria 4132 Muttenz
Pseudomonas aeruginosa 500 7,5 Switzerland
Gram Positive Bacteria
Copyright ©
Staphylococcus aureus 500 7,5 Clariant International Ltd, 2022
Yeasts
Candida albicans 200 3 Contact
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Molds
SPECIALTIES
Aspergillus brasiliensis 200 3 www.ics.clariant.com
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Regulatory Status
According to Cosmetic Regulation ((EC) 1223/2009 Annex V) Nipaguard CG can be used
up to a maximum concentration of 0.097% by weight of product as supplied (15 ppm active
ingredient) in rinse-off products. Nipaguard CG is not permitted for leave on products.
These information is for guidance only. Please check local requirements carefully as they
might vary.
Storage and Shelf Life
Nipaguard CG has a shelf life of 2 years
Safety
Further information on handling, storage and dispatch is given in the material safety data
sheet.
This information corresponds to the present state of our ٭For sales to customers located within the United States and
knowledge and is intended as a general description of our Canada the following applies in addition:
products and their possible applications. Clariant makes no NO EXPRESS OR IMPLIED WARRANTY IS MADE OF THE
warranties, express or implied, as to the information’s MERCHANTABILITY, SUITABILITY, FITNESS FOR A
accuracy, adequacy, sufficiency or freedom from defect and PARTICULAR PURPOSE OR OTHERWISE OF ANY
assumes no liability in connection with any use of this PRODUCT OR SERVICE.
information. Any user of this product is responsible for
determining the suitability of Clariant’s products for its © 2022 Clariant International Ltd,
particular application. ٭Nothing included in this information Rothausstrasse 61, 4132 Muttenz, Switzerland
waives any of Clariant’s General Terms and Conditions of
Sale, which control unless it agrees otherwise in writing. Any
existing intellectual/industrial property rights must be
observed. Due to possible changes in our products and
applicable national and international regulations and laws,
the status of our products could change. Material Safety
Data Sheets providing safety precautions, that should be
observed when handling or storing Clariant products, are
available upon request and are provided in compliance with
applicable law. You should obtain and review the applicable
Material Safety Data Sheet information before handling any
of these products. For additional information, please contact
Clariant.
Page 3 of 3 NIPAGUARD CG Issue: October 2022
