Hemoglobina
Nombre:
Homo sapiens hemoglobin subunit alpha 1 (HBA1)
Secuencia gen:
1 tagctgggat tacaggcgtg caccaccaca cccagctaat ttttgtattt ttagtagaga
61 cggggtttct ccatgttggt cagcctggtc tcgaactccc gacctcagct gatccacccg
121 ccttggcctc ccaaagtgct gggattacag gcgtgagcca ccgagcctgg ccaaaccatc
181 acttttcatg agcagggatg cacccactgg cactcctgca cctcccaccc tccccctcgc
241 caagtccacc ccttccttcc tcaccccaca tcccctcacc tacattctgc aaccacaggg
301 gccttctctc ccctgtcctt tccctaccca gagccaagtt tgtttatctg tttacaacca
361 gtatttacct agcaagtctt ccatcagata gcatttggag agctgggggt gtcacagtga
421 accacgacct ctaggccagt gggagagtca gtcacacaaa ctgtgagtcc atgacttggg
481 gcttagccag cacccaccac cccacgcgcc accccacaac cccgggtaga ggagtctgaa
541 tctggagccg cccccagccc agccccgtgc tttttgcgtc ctggtgtttg ttccttcccg
601 gtgcctgtca ctcaagcaca ctagtgacta tcgccagagg gaaagggagc tgcaggaagc
661 gaggctggag agcaggaggg gctctgcgca gaaattcttt tgagttccta tgggccaggg
721 cgtccgggtg cgcgcattcc tctccgcccc aggattgggc gaagccctcc ggctcgcact
781 cgctcgcccg tgtgttcccc gatcccgctg gagtcgatgc gcgtccagcg cgtgccaggc
841 cggggcgggg gtgcgggctg actttctccc tcgctaggga cgctccggcg cccgaaagga
901 aagggtggcg ctgcgctccg gggtgcacga gccgacagcg cccgacccca acgggccggc
961 cccgccagcg ccgctaccgc cctgcccccg ggcgagcggg atgggcggga gtggagtggc
1021 gggtggaggg tggagacgtc ctggcccccg ccccgcgtgc acccccaggg gaggccgagc
1081 ccgccgcccg gccccgcgca ggccccgccc gggactcccc tgcggtccag gccgcgcccc
1141 gggctccgcg ccagccaatg agcgccgccc ggccgggcgt gcccccgcgc cccaagcata
1201 aaccctggcg cgctcgcggg ccggcactct tctggtcccc acagactcag agagaaccca
1261 ccatggtgct gtctcctgcc gacaagacca acgtcaaggc cgcctggggt aaggtcggcg
1321 cgcacgctgg cgagtatggt gcggaggccc tggagaggtg aggctccctc ccctgctccg
1381 acccgggctc ctcgcccgcc cggacccaca ggccaccctc aaccgtcctg gccccggacc
1441 caaaccccac ccctcactct gcttctcccc gcaggatgtt cctgtccttc cccaccacca
1501 agacctactt cccgcacttc gacctgagcc acggctctgc ccaggttaag ggccacggca
1561 agaaggtggc cgacgcgctg accaacgccg tggcgcacgt ggacgacatg cccaacgcgc
1621 tgtccgccct gagcgacctg cacgcgcaca agcttcgggt ggacccggtc aacttcaagg
1681 tgagcggcgg gccgggagcg atctgggtcg aggggcgaga tggcgccttc ctctcagggc
1741 agaggatcac gcgggttgcg ggaggtgtag cgcaggcggc ggctgcgggc ctgggccgca
1801 ctgaccctct tctctgcaca gctcctaagc cactgcctgc tggtgaccct ggccgcccac
1861 ctccccgccg agttcacccc tgcggtgcac gcctccctgg acaagttcct ggcttctgtg
1921 agcaccgtgc tgacctccaa ataccgttaa gctggagcct cggtagccgt tcctcctgcc
1981 cgctgggcct cccaacgggc cctcctcccc tccttgcacc ggcccttcct ggtctttgaa
2041 taaagtctga gtgggcagca gcctgtgtgt gcctgggttc tctctatccc ggaatgtgcc
2101 aacaatggag gtgtttacct gtctcagacc aaggacctct ctgcagctgc atggggctgg
2161 ggagggagaa ctgcagggag tatgggaggg gaagctgagg tgggcctgct caagagaagg
2221 tgctgaacca tcccctgtcc tgagaggtgc caggcctgca ggcagtggct cagaagctgg
2281 ggaggagaga ggcatccagg gttctactca gggagtccca gcatcgccac cctcctttga
2341 aatctccctg gttgaaccca gttaacatac gctctccatc aaaacaaaac gaaacaaaac
2401 aaactagcaa aataggctgt ccccagtgca agtgcaggtg ccagaacatt tctctcattc
2461 ccaccccttc ctgccagagg gtaggtggct ggagtgaggg tgctggccct actcacactt
2521 cctgtgtcac ggtgaccctc tgagagcagc ccagtcagtg gggaaggagg aaggggctgg
2581 gatgctcaca gccggcagcc cacacctggg gagactcttc agcagagcac cttgcggcct
2641 tactcctgca cgtctcctgc agtttgtaag gtgcattcag aactcactgt gtgcccagcc
2701 ctgagctccc agctaattgc cccacccagg gcctctggga cctcctggtc ttctgcttcc
2761 tgtgctgcca gcaacttctg gaaacgtccc tgtccccggt gctgaagtcc tggaatccat
2821 gctgggaagt tgcacagccc atctggctct cagccagcct aggaacatga gcagcacttc
2881 caacccagtc cctgccccac agcaagcctc cccctccaca ctcacagtac tggattgagc
2941 tttggggagg gtggagagga ccctgtcact gctttccttc tggacatgga cctctctgaa
3001 ttgttgggga gttccctccc ctctccacca cccgctcttc ctgcgcctca cagcccagag
3061 cattgttatt tcagcagaaa cactttaaaa aataaactaa aatccgacag gcacggtggc
3121 tcacgcctgt aatcccagca ctttgggagg ccgaggtggg aggatcacct gaggtcggga
3181 gtttgagacc accctgatca acatgtagaa accccatcta tactaaaaat acaaaatcag
3241 ccgggcatgg tggcccatgc ctgtaaaccc acctactccg gaggctgagg caggagaatc
3301 attttaacca aggaggcaga ggttgcagtg agctaagatc acaccattgc actccagcct
3361 ggaaaacaac agcgaaactc cgcctcaaaa aaaaaaaagc ccccacatct tatctttttt
3421 ttttccttca ggctgtgggc agagtcagaa gagggtggca gacagggagg ggaaatgaga
3481 agatccaacg ggggaagcat tgctaagctg gtcggagcta cttccttctc tgcccaaggc
3541 agcttaccct ggcttgctcc tggacaccca gggcagggcc tgagtaaggg cctggggaga
3601 cagggcaggg agcaggctga agggtgctga cctgatgcac tcctcaaagc aagatcttct
3661 gccagacccc caggaaatga cttatcagtg atttctcagg ctgttttctc ctcagtacca
3721 tccccccaaa aaacatcact tttcatgcac agggatgcac ccactggcac tcctgcacct
3781 cccacccttc cccagaagtc caccccttcc ttcctcaccc tgcaggagct ggccagcctc
3841 atcaccccaa catctcccca cctccattct ccaaccacag ggcccttgtc tcctctgtcc
3901 tttcccctcc ccgagccaag cctcctccct cctccacctc ctccacctaa tacatatcct
3961 taagtctcac ctcctccagg aagccctcag actaaccctg gtcaccttga atgcctcgtc
4021 cacacctcca gacttcctca gggcctgtga tgaggtctgc acctctgtgt gtacttgtgt
4081 gatggttaga ggactgccta cctcccagag gaggttgaat gctccagccg gttccagcta
4141 ttgctttgtt tacctgttta accagtattt acctagcaag tcttccatca gatagcattt
4201 ggagagctgg gggtgtcaca gtgaaccacg acctctaggc cagtgggaga gtcagtcaca
4261 caaactgtga gtccatgact tggggcttag ccagcaccca ccaccccacg cgccacccca
4321 caaccccggg tagaggagtc tgaatctgga gccgccccca gcccagcccc gtgctttttg
4381 cgtcctggtg tttattcctt cccggtgcct gtcactcaag cacactagtg actatcgcca
4441 gagggaaagg gagctgcagg aagcgaggct ggagagcagg aggggctctg cgcagaaatt
4501 cttttgagtt cctatgggcc agggcgtccg ggtgcgcgca ttcctctccg ccccaggatt
4561 gggcgaagcc tcccggctcg cactcgctcg cccgtgtgtt ccccgatccc gctggagtcg
4621 atgcgcgtcc agcgcgtgcc aggccggggc gggggtgcgg gctgactttc tccctcgcta
4681 gggacgctcc ggcgcccgaa aggaaagggt ggcgctgcgc tccggggtgc acgagccgac
4741 agcgcccgac cccaacgggc cggccccgcc agcgccgcta ccgccctgcc cccgggcgag
4801 cgggatgggc gggagtggag tggcgggtgg agggtggaga cgtcctggcc cccgccccgc
4861 gtgcaccccc aggggaggcc gagcccgccg cccggccccg cgcaggcccc gcccgggact
4921 cccctgcggt ccaggccgcg ccccgggctc cgcgccagcc aatgagcgcc gcccggccgg
4981 gcgtgccccc gcgccccaag cataaaccct ggcgcgctcg cggcccggca ctcttctggt
5041 ccccacagac tcagagagaa cccaccatgg tgctgtctcc tgccgacaag accaacgtca
5101 aggccgcctg gggtaaggtc ggcgcgcacg ctggcgagta tggtgcggag gccctggaga
5161 ggtgaggctc cctcccctgc tccgacccgg gctcctcgcc cgcccggacc cacaggccac
5221 cctcaaccgt cctggccccg gacccaaacc ccacccctca ctctgcttct ccccgcagga
5281 tgttcctgtc cttccccacc accaagacct acttcccgca cttcgacctg agccacggct
5341 ctgcccaggt taagggccac ggcaagaagg tggccgacgc gctgaccaac gccgtggcgc
5401 acgtggacga catgcccaac gcgctgtccg ccctgagcga cctgcacgcg cacaagcttc
5461 gggtggaccc ggtcaacttc aaggtgagcg gcgggccggg agcgatctgg gtcgaggggc
5521 gagatggcgc cttcctcgca gggcagagga tcacgcgggt tgcgggaggt gtagcgcagg
5581 cggcggctgc gggcctgggc cctcggcccc actgaccctc ttctctgcac agctcctaag
5641 ccactgcctg ctggtgaccc tggccgccca cctccccgcc gagttcaccc ctgcggtgca
5701 cgcctccctg gacaagttcc tggcttctgt gagcaccgtg ctgacctcca aataccgtta
5761 agctggagcc tcggtggcca tgcttcttgc cccttgggcc tccccccagc ccctcctccc
5821 cttcctgcac ccgtaccccc gtggtctttg aataaagtct gagtgggcgg cagcctgtgt
5881 gtgcctgagt tttttccctc agcaaacgtg ccaggcatgg gcgtggacag cagctgggac
5941 acacatggct agaacctctc tgcagctgga tagggtagga aaaggcaggg gcgggaggag
6001 gggatggagg agggaaagtg gagccaccgc gaagtccagc tggaaaaacg ctggacccta
6061 gagtgctttg aggatgcatt tgctctttcc cgagttttat tcccagactt ttcagattca
6121 atgcaggttt gctgaaataa tgaatttatc catctttacg tttctgggca ctcttgtgcc
6181 aagaactggc tggctttctg cctgggacgt cactggtttc ccagaggtcc tcccacatat
6241 gggtggtggg taggtcagag aagtcccact ccagcatggc tgcattgatc ccccatcgtt
6301 cccactagtc tccgtaaaac ctcccagata caggcacagt ctagatgaaa tcaggggtgc
6361 ggggtgcaac tgcaggcccc aggcaattca ataggggctc tactttcacc cccaggtcac
6421 cccagaatgc tcacacacca gacactgacg ccctggggct gtcaagatca ggcgtttgtc
6481 tctgggccca gctcagggcc cagctcagca cccactcagc tcccctgagg ctggggagcc
6541 tgtcccattg cgactggaga ggagagcggg gccacagagg cctggctaga aggtcccttc
6601 tccctggtgt gtgttttctc tctgctgagc aggcttgcag tgcctggggt atcagaggga
6661 gggttcccgg agctggtagc cataaagccc tggccctcaa ctgataggaa tatcttttat
6721 tccctgagcc catgaatcac ccttggtaaa cacctatggc aggccctctg cctgcgtttg
6781 tgatgtcctt cccgcagcct gtgggtacag tatcaactgt caggaagacg gtgtcttcgt
6841 tatttcatca ggaagaatgg aggtctgacc taaaggtaga aatatgtcaa atgtacagca
6901 gagggctggt tggagtgcag cgctttttac aattaattga tcagaaccag ttataaattt
6961 atcatttcct tctccactcc tgctgcttca gttgactaag cctaagaaaa aattataaaa
7021 attggccggg cgcggtggct cacacctgta attgcagcac tttgccaggc ttaggcaggt
7081 ggatcacctg aagtcagggg ttcgagacca gcctagccaa catagtgaaa ccctgtctct
7141 actaaaaaga caaaaattgt ccaggtgtga tgactcatgc ctgtaaacct ggcactttgg
7201 gaggcggagg ttgtagtgag tcaagatcgc gccatcgcac tccagcttgg gcaacaagag
7261 cgaaactctg tctcaaaaaa aaatttaatc taatttaatt taatttaaaa attagcacgg
7321 tggttgggca cagtggctca cgcctgtaat cccagcactt tgggaagcca aggtgggcag
7381 atcacaaggt caggaattcg agaccagcct ggccaatatg gggaaacccc atctctacta
7441 aaaatacaaa aaattagccg ggtgtggtgg cgcacgcctg taatcccagc tactcgggag
7501 gttgaggtag gagaatcact tgaacccagg aggcagaggt tgcagtgacc cgagatcaca
7561 ccattgcact ctagcctggg caacaagagc aaaactccat ctcaaaaaaa attataaaaa
7621 ttatacatca gtagatgaat gggtaaacaa aatgtggtgg tctatacaca caatggaata
7681 ttatttggcc acaaaaagaa atgaagcact gataggatgt agctgcaccc tgaaaatatt
7741 tgacaagtaa aagaagccgg acaccaaagg tcacaaactg catgacccca tctatatgca
7801 atatccgcta cagccaaatc catagggacc aaaagcggat tagtggctgc cggggccaga
7861 gttactgtta at
Intrones:
Gen 1:
1201 actct tctggtcccc acagactcag agagaaccca
1261 ccatggtgct gtctcctgcc gacaagacca acgtcaaggc cgcctggggt aaggtcggcg
1321 cgcacgctgg cgagtatggt gcggaggccc tggagaggtg aggctccctc ccctgctccg
1381 acccgggctc ctcgcccgcc cggacccaca ggccaccctc aaccgtcctg gccccggacc
1441 caaaccccac ccctcactct gcttctcccc gcaggatgtt cctgtccttc cccaccacca
1501 agacctactt cccgcacttc gacctgagcc acggctctgc ccaggttaag ggccacggca
1561 agaaggtggc cgacgcgctg accaacgccg tggcgcacgt ggacgacatg cccaacgcgc
1621 tgtccgccct gagcgacctg cacgcgcaca agcttcgggt ggacccggtc aacttcaagg
1681 tgagcggcgg gccgggagcg atctgggtcg aggggcgaga tggcgccttc ctctcagggc
1741 agaggatcac gcgggttgcg ggaggtgtag cgcaggcggc ggctgcgggc ctgggccgca
1801 ctgaccctct tctctgcaca gctcctaagc cactgcctgc tggtgaccct ggccgcccac
1861 ctccccgccg agttcacccc tgcggtgcac gcctccctgg acaagttcct ggcttctgtg
1921 agcaccgtgc tgacctccaa ataccgttaa gctggagcct cggtagccgt tcctcctgcc
1981 cgctgggcct cccaacgggc cctcctcccc tccttgcacc ggcccttcct ggtctttgaa
2041 taaagtctga gtgggcagca
Exones:
Exon 1: 4981 a ctcttctggt
5041 ccccacagac tcagagagaa cccaccatgg tgctgtctcc tgccgacaag accaacgtca
5101 aggccgcctg gggtaaggtc ggcgcgcacg ctggcgagta tggtgcggag gccctggaga
5161 g
Exon 2: ga 5281 tgttcctgtc cttccccacc accaagacct acttcccgca cttcgacctg agccacggct
5341 ctgcccaggt taagggccac ggcaagaagg tggccgacgc gctgaccaac gccgtggcgc
5401 acgtggacga catgcccaac gcgctgtccg ccctgagcga cctgcacgcg cacaagcttc
5461 gggtggaccc ggtcaacttc aag
Exon 3: 5581 ctcctaag
5641 ccactgcctg ctggtgaccc tggccgccca cctccccgcc gagttcaccc ctgcggtgca
5701 cgcctccctg gacaagttcc tggcttctgt gagcaccgtg ctgacctcca aataccgtta
5761 agctggagcc tcggtggcca tgcttcttgc cccttgggcc tccccccagc ccctcctccc
5821 cttcctgcac ccgtaccccc gtggtctttg aataaagtct gagtgggcgg ca
Sitios de restricción (enzimas):
1. HindIII: Reconoce y corta secuencias específicas, como 5’-AAGCTT-3’. El gen HBA1
puede tener sitios de restricción para HindIII en su secuencia.
2. BamHI: Reconoce y corta secuencias específicas, como 5’-GGATCC-3’. Puede
haber sitios de restricción para BamHI en el gen HBA1.
3. EcoRI: Reconoce y corta secuencias específicas, como 5’-GAATTC-3’.
También puede haber sitios de restricción para EcoRI en el gen HBA1.
Longitud de pares de bases:
1,120 pares de bases (pb) en su secuencia de ADN.
Tamaño en kilodaltons (kDa):
El tamaño de la cadena alfa-1 de la hemoglobina, codificada por el gen HBA1, puede ser
estimado por el número de aminoácidos que contiene y su composición molecular. La
cadena alfa-1 de la hemoglobina tiene una longitud de alrededor de 142 aminoácidos.
Cadena RNAm:
