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The document consists of a series of multiple-choice questions related to lipid-lowering medications and their management in various clinical scenarios. It covers topics such as treatment options for hypertriglyceridemia, safety of drugs in pregnancy, side effects of statins and fibrates, and monitoring requirements for different drug classes. The questions also address specific patient cases and the appropriate therapeutic approaches for managing lipid disorders.

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Karan Praba
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19 views4 pages

5

The document consists of a series of multiple-choice questions related to lipid-lowering medications and their management in various clinical scenarios. It covers topics such as treatment options for hypertriglyceridemia, safety of drugs in pregnancy, side effects of statins and fibrates, and monitoring requirements for different drug classes. The questions also address specific patient cases and the appropriate therapeutic approaches for managing lipid disorders.

Uploaded by

Karan Praba
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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73.

A patient with severe hypertriglyceridemia and a history of pancreatitis is best treated with:
A) Fibrates
B) Ezetimibe
C) PCSK9 inhibitors
D) Statins

74. Which lipid-lowering drug is safest in pregnancy?


A) Statins
B) Bile acid sequestrants
C) Fibrates
D) Niacin

75. A patient with statin intolerance should consider:


A) PCSK9 inhibitors
B) Omega-3 fatty acids
C) Fibrates
D) Niacin

76. A 70-year-old patient on statins has elevated liver enzymes. The next step is to:
A) Continue the statin
B) Discontinue the statin
C) Reduce the dose
D) Switch to fibrates

77. What is the MOST serious side effect of statins?


A) Rhabdomyolysis
B) Constipation
C) Flushing
D) Hypertension

78. Statins should be taken at night because:


A) They cause drowsiness
B) Cholesterol synthesis is highest at night
C) They work better with food
D) They increase metabolism overnight

79. Which drug class requires monitoring of liver function tests?


A) Statins
B) Bile acid sequestrants
C) Omega-3 fatty acids
D) PCSK9 inhibitors

80. What is the MOST serious side effect of fibrates?


A) Rhabdomyolysis
B) Hypertension
C) Bradycardia
D) Hypoglycemia

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81. A patient is started on simvastatin but reports muscle aches and weakness. Which alternative statin has the
lowest risk of myopathy?
A) Lovastatin
B) Pravastatin
C) Atorvastatin
D) Fluvastatin

82. Which of the following statins is primarily metabolized by the CYP2C9 enzyme, reducing its risk of drug
interactions?
A) Simvastatin
B) Rosuvastatin
C) Atorvastatin
D) Lovastatin

83. Statins should be avoided in patients with:


A) Diabetes
B) Hypertension
C) Liver disease
D) Atherosclerosis

84. Which of the following should be monitored periodically in patients taking statins?
A) Serum sodium
B) Serum potassium
C) Liver enzymes (ALT, AST)
D) Hemoglobin

85. The combination of statins and fibrates increases the risk of:
A) Hepatic encephalopathy
B) Myopathy
C) Peptic ulcer disease
D) Hyperglycemia

86. Bile acid sequestrants work by:


A) Inhibiting HMG-CoA reductase
B) Blocking NPC1L1 transporter
C) Binding bile acids in the intestine
D) Activating PPAR-α receptors

87. Which of the following is a contraindication for bile acid sequestrants?


A) Hypercholesterolemia
B) Chronic constipation
C) High LDL cholesterol
D) Diabetes mellitus

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88. Which lipid-lowering drug class is the safest for use in children and pregnant women?
A) Statins
B) Fibrates
C) Bile acid sequestrants
D) PCSK9 inhibitors

89. PCSK9 inhibitors primarily function by:


A) Blocking LDL receptor degradation
B) Increasing bile acid synthesis
C) Reducing triglyceride levels
D) Inhibiting lipoprotein lipase

90. Which of the following is a potential side effect of PCSK9 inhibitors?


A) Hepatotoxicity
B) Injection site reactions
C) Severe constipation
D) Bradycardia

91. PCSK9 inhibitors are best suited for:


A) Patients with mild hyperlipidemia
B) Patients with statin intolerance
C) Patients with low triglycerides
D) Patients with low cardiovascular risk

92. Which of the following is the MOST common side effect of niacin?
A) Myopathy
B) Flushing
C) Hypercalcemia
D) Bradycardia

93. Niacin increases the risk of:


A) Hypoglycemia
B) Hyperuricemia
C) Hypotension
D) Vitamin B12 deficiency

94. The lipid parameter most significantly increased by niacin is:


A) LDL cholesterol
B) HDL cholesterol
C) Triglycerides
D) VLDL cholesterol

95. Omega-3 fatty acids primarily lower:


A) LDL cholesterol
B) Triglycerides
C) HDL cholesterol
D) Total cholesterol

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96. Which of the following is an anti-inflammatory effect of omega-3 fatty acids?
A) Increased platelet aggregation
B) Decreased production of pro-inflammatory cytokines
C) Increased LDL oxidation
D) Activation of PPAR-γ receptors

97. A 50-year-old man with type 2 diabetes has high triglycerides and normal LDL levels. Which drug class is
the best initial treatment?
A) Statins
B) Fibrates
C) PCSK9 inhibitors
D) Bile acid sequestrants

98. A patient on statin therapy develops severe muscle pain and an elevated creatine kinase (CK) level. What is
the next step?
A) Continue statin therapy and monitor CK
B) Reduce the statin dose
C) Discontinue the statin immediately
D) Switch to a PCSK9 inhibitor

99. A 45-year-old woman with familial hypercholesterolemia is not achieving LDL reduction with statins alone.
Which drug should be added?
A) Fibrates
B) Niacin
C) Ezetimibe
D) Omega-3 fatty acids

100. A 55-year-old patient on atorvastatin and warfarin has an elevated INR. What is the most likely reason?
A) Atorvastatin increases warfarin metabolism
B) Atorvastatin displaces warfarin from plasma proteins
C) Warfarin inhibits statin metabolism
D) Warfarin induces cytochrome P450 enzymes

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