Insulin Products Last Updated 01/2025

Rapid-Acting Intermediate-Acting Long-Acting

100 U/mL vial (3 or 10 mL) 100 U/mL vial (3 or 10 mL)
100 U/mL pen (3 mL) - 5 pens/box 100 U/mL pen (3 mL) - 5 pens/box 100 U/mL pen (3 mL) - 5 pens/box

Admelog [SoloStar, Vial] Humulin N (U-100) [KwikPen, Vial] Basaglar [KwikPen, Tempo Pen]
Insulin lispro (analog, conventional) Insulin isophane or NPH (human)
Insulin glargine (analog)
Duration: 4-6 hours (or 3-5 hours) Duration: 14-18 hours
Duration: 24-30 hours
4 U/INH
(single-dose
8 U/INH 500 U/mL vial (20 mL)
cartridges)
12 U/INH 500 U/mL pen (3 mL) - 2 pens/box
100 U/mL vial (10 mL)
100 U/mL pen (3 mL) - 5 pens/box
Afrezza
Inhaled powdered Insulin (human, ultra-rapid) Humulin R (U-500) [KwikPen, Vial]
Duration: 2.5-3 hours Regular insulin (human) Lantus [SoloStar, Vial]
Duration: ~21 hours (13-24 h) Insulin glargine (analog)
Duration: 24-30 hours
100 U/mL vial (10 mL)
100 U/mL pen (3 mL) - 5 pens/box
100 U/mL vial (10 mL)
100 U/mL pen (3 mL) - 5 pens/box
Apidra [SoloStar, Vial] 100 U/mL pen (3 mL) - 5 pens/box

Insulin glulisine (analog)

Novolin N (U-100) [FlexPen, Vial]
Duration: 5-6 hour (or 3-5 hours)
Insulin isophane or NPH (human)
Rezvoglar [KwikPen]
Duration: 14-18 hours
100 U/mL vial (10 mL) Insulin glargine-aglr (analog, biosimilar^)
100 U/mL pen (3 mL) - 5 pens/box
100 U/mL cart. (3 or 1.6 mL)
Duration: 24-30 hours

Fiasp [FlexTouch, Vial, PenFill, PumpCart]

Insulin aspart (analog, ultra-rapid) Intermediate + Rapid-Acting 100 U/mL vial (10 mL)
Duration: 4-6 hours (or 3-5 hours) 100 U/mL pen (3 mL) - 5 pens/box

50/50 U/mL pen (3 mL) - 5 pens/box

100 U/mL vial (3 or 10 mL) Semglee [Pen, Vial]
100 U/mL pen (3 mL) - 5 pens/box
200 U/mL pen (3 mL) - 2 pens/box Insulin glargine-yfgn (analog, biosimilar^)
Humalog Mix 50/50 [KwikPen] Duration: 24-30 hours
Humalog [KwikPen, Jr, Tempo Pen, Vial]
Insulin lispro protamine (50%)/lispro (50%)
Insulin lispro (analog, conventional)
Duration: Up to 24 hours (analog)
Duration: 4-6 hours 300 U/mL pen (1.5 mL) - 3 pens/box
300 U/mL pen (3 mL) - 2 pens/box
75/25 U/mL vial (10 mL)
100 U/mL vial (10 mL) 75/25 U/mL pen (3 mL) - 5 pens/box
100 U/mL pen (3 mL) - 5 pens/box
200 U/mL pen (3 mL) - 2 pens/box Toujeo [SoloStar, Max]
Humalog Mix 75/25 [KwikPen, Vial] Insulin glargine (analog)
Lyumjev [KwikPen, Jr, Tempo Pen, Vial] Insulin lispro protamine (75%)/lispro (25%) Duration: Up to 36 hours
Insulin lispro-aabc (analog, ultra-rapid) Duration: 16-20 hours (analog)
Duration: 4-6 hours
70/30 U/mL vial (10 mL) 100 U/mL vial (10 mL)
100 U/mL vial (10 mL) 70/30 U/mL pen (3 mL) - 5 pens/box 100 U/mL pen (3 mL) - 5 pens/box
100 U/mL pen (3 mL) - 5 pens/box 200 U/mL pen (3 mL) - 3 pens/box
100 U/mL cart. (3 mL)

NovoLog Mix 70/30 [FlexPen, Vial] Tresiba [FlexTouch, Vial]

NovoLog [FlexPen, Vial, PenFill]
Insulin aspart protamine (70%)/aspart (30%) Insulin degludec (analog, ultra-long)
Insulin aspart (analog, conventional)
Duration: Up to 24 hours (analog) Duration: 36-42 hours
Duration: 4-6 hours

Short-Acting Intermediate + Short-Acting Long-Acting + GLP-1 RA

(glucagon-like peptide 1 receptor agonist)

100 U/mL vial (3 or 10 mL) 70/30 U/mL vial (3 or 10 mL) 100 U/3.6 mg per mL pen (3 mL) -
70/30 U/mL pen (3 mL) - 5 pens/box 5 pens/box

Humulin R (U-100) [Vial] Humulin 70/30 [KwikPen, Vial] Xultophy [Pen]

Regular insulin (human) Insulin isophane (70%)/regular insulin (30%) Insulin degludec + liraglutide (analog)
Duration: 6-8 hours Duration: Up to 24 hours (analog/human) Duration: Up to 42 hours (degludec)

100 U/mL vial (10 mL) 70/30 U/mL vial (10 mL) 100 U/33 mcg per mL pen (3 mL) -
100 U/mL pen (3 mL) - 5 pens/box 70/30 U/mL pen (3 mL) - 5 pens/box 5 pens/box

Novolin R [FlexPen, Vial] Novolin 70/30 [FlexPen, Vial] Soliqua [SoloStar]

Regular insulin (human) Insulin isophane (70%)/regular insulin (30%) Insulin glargine + lixisenatide (analog)
Duration: 6-8 hours Duration: Up to 24 hours (analog/human) Duration: 24-30 hours (glargine)

1 U/mL single-dose container (100 mL)

Insulin Biosimilars
Myxredlin At the time of writing (April 2023), there are two insulin biosimilars available in the United States:
Regular insulin (human) IV solution 1. Rezvoglar® (insulin glargine-aglr)
2. Semglee® (insulin glargine-yfgn)
Both are interchangeable biosimilars of Lantus®. It should be noted that these two products are not biosimilars of
Basaglar (another distinct insulin glargine reference product), nor are they interchangeable with each other. Refer to the
FDA's Purple Book for the most up-to-date list of approved biosimilars.

More clinical pearls at pyrls.com Page 1 of 2 ® 2025 Cosmas Health, Inc. and/or its affiliates. All rights reserved.
Insulin Products Storage Last Updated 01/2025

All products are good until their expiration date* when kept unopened and refrigerated (36°F-46°F [2°C-8°C]).

DAYS GOOD AT ROOM TEMP

BRAND GENERIC STORAGE WHEN OPENED/IN-USE
(≤86º F [30ºC]) WHEN IN-USE
Admelog SoloStar pen Insulin lispro 28 days Do not refrigerate
Admelog vial Insulin lispro 28 days Room or Refrigerate (≤86º F [30ºC] )
Afrezza* Insulin human (inhaled) 10 days (sealed blisters & strips); 3 days (opened strips) 77°F (25°C) (excursion permitted 59-86°F [15-30°C])
Apidra SoloStar pen Insulin glulisine 28 days (≤77º F [25ºC] ) ≤ 77°F (25°C), but do not refrigerate
Apidra vial Insulin glulisine 28 days (≤77º F [25ºC] ) Room or Refrigerated (≤77°F [25°C])
Basaglar KwikPen/Tempo Pen Insuline glargine 28 days Do not refrigerate
Fiasp FlexTouch pen Insulin aspart 28 days Room or Refrigerated (≤86°F [30°C])
Fiasp PenFill cartridge Insulin aspart 28 days Do not refrigerate
Fiasp vial Insulin aspart 28 days Room or Refrigerated (≤86°F [30°C])
Humalog KwikPen and cartridge Insulin lispro 28 days Do not refrigerate
Humalog vial Insulin lispro 28 days Room or Refrigerated (≤86°F [30°C])
Humalog Junior KwikPen Insulin lispro 28 days Do not refrigerate
Humalog TempoPen Insulin lispro 28 days Do not refrigerate
Humalog Mix 50/50 KwikPen Insulin lispro protamine/lispro 10 days Do not refrigerate
Humalog Mix 75/25 KwikPen Insulin lispro protamine/lispro 10 days Do not refrigerate
Humalog Mix 75/25 vial Insulin lispro protamine/lispro 28 days Room or Refrigerated (≤86°F [30°C])
Humulin N KwikPen NPH 14 days Do not refrigerate
Humulin N vial NPH 31 days Room or Refrigerated (≤86°F [30°C])
Humulin R vial Insulin human (regular) 31 days Room or Refrigerated (≤86°F [30°C])
Humulin R U-500 KwikPen Insulin human (regular) 28 days Do not refrigerate
Humulin R U-500 vial Insulin human (regular) 40 days Room or Refrigerated (≤86°F [30°C])
Humulin 70/30 KwikPen NPH/regular 10 days Do not refrigerate
Humulin 70/30 vial NPH/regular 31 days Room or Refrigerated (≤86°F [30°C])
Lantus SoloStar pen Insulin glargine 28 days Do not refrigerate
Lantus vial Insulin glargine 28 days Room or Refrigerated (≤86°F [30°C])
Lyumjev pen Insulin lispro-aabc 28 days Do not refrigerate
Lyumjev vial Insulin lispro-aabc 28 days Room or Refrigerated (≤86°F [30°C])
Novolin N FlexPen NPH 28 days Do not refrigerate
Novolin N vial NPH 42 days (≤77º F [25ºC]) ≤77°F (25°C), but do not refrigerate
Novolin R FlexPen Insulin human (regular) 28 days Do not refrigerate
Novolin R vial Insulin human (regular) 42 days (≤77º F [25ºC]) ≤77°F (25°C), but do not refrigerate
Novolin 70/30 FlexPen NPH/Regular 28 days Do not refrigerate
Novolin 70/30 vial NPH/Regular 42 days (≤77º F [25ºC]) ≤77°F (25°C), but do not refrigerate
NovoLog FlexTouch/FlexPen Insulin aspart 28 days Do not refrigerate
NovoLog vial Insulin aspart 28 days Room or Refrigerated (≤86°F [30°C])
NovoLog PenFill Cartridge Insulin aspart 28 days Do not refrigerate
NovoLog Mix 70/30 FlexPen Insulin aspart 14 days Do not refrigerate
NovoLog Mix 70/30 Vial Insulin aspart 28 days Room or Refrigerated (≤86°F [30°C])
Rezvoglar KwikPen Insulin glargine-aglr 28 days Do not refrigerate
Semglee pen Insulin glargine-yfgn 28 days Do not refrigerate
Semglee vial Insulin glargine-yfgn 28 days Room or Refrigerated (≤86°F [30°C])
Soliqua 100/33 Insulin glargine + lixisenatide 28 days (≤77º F [25ºC]) ≤77°F (25°C), but do not refrigerate
Toujeo (Max) SoloStar pen Insulin glargine 56 days Do not refrigerate
Tresiba FlexTouch pen Insulin degludec 56 days Room or Refrigerated (≤86°F [30°C])
Tresiba vial Insulin degludec 56 days Room or Refrigerated (≤86°F [30°C])
Xultophy 100/3.6 Insulin degludec + liraglutide 21 days Room or Refrigerated (≤86°F [30°C])

*For Afrezza: Unopened, refrigerated foil packages may be stored until the expiration date. Unopened, refrigerated blister cards and strips must be used within 1 month.

Priming Insulin Pens

Insulin Classes and Action Profiles*

Rapid-Acting Short-Acting Long-Acting

Prime insulin pens prior to each injection with 2 units except
Plasma Insulin Levels

Aspart (4-6 h) Regular (6-8 h) Glargine (24-30 h)

Glulisine (5-6 h) Intermediate Degludec (36-42 h) the following:
Lispro (4-6 h) NPH (14-18 h)
Inhaled (2.5-3 h)
Humulin® R U-500 Kwikpen 5 units
Toujeo® SoloStar 3 units
Toujeo® Max SoloStar 4 units

Xultophy® Pen Select priming symbol

Reference: [1] Hirsch IB. Insulin analogues. N Engl Med. 2005 Jan 13;352(2): 174-83. https//
www.ncbi.nlm.nih.gov/pubmed/15647580. [2] Wong EY, Kroon L. Ultra-Rapid-Acting Insulins:
How Fast Is Really Needed?. Clin Diabetes. 2021;39(4):415-423. doi:10.2337/cd20-0119. [3]
Individual manufacturer product labels.

Time (hours)

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