Management of Positive Patch Test Reactions - 1st Edition
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Library of Congress Cataloging-in-Publication Data
ISBN 978-3-540-44347-6 Management of positive patch test reactions / Jan E. Wahlberg … [et al.].
p. cm.
Includes bibliographical references.
ISBN 978-3-540-44347-6 ISBN 978-3-642-55706-4 (eBook)
DOI 10.1007/978-3-642-55706-4
1. Contact dermatitis–Handbooks, manuals, etc. I. Wahlberg, Jan E.
RL244.M36 2003 616.97¢3–dc21 2003045728
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Preface
The International Contact Dermatitis Research
Group (ICDRG) updated their standard series
in “Proposal for a revised international standard
series of patch tests” 1 ; 34 allergens/test preparations
from three standard series from Europe (EECDRG),
from USA (NACDG), and from Japan (JSDS) were
compared. They were divided in a modified interna-
tional standard series (20 allergens), and an extend-
ed international standard series and additional
useful allergens (8+6, respectively). These 34 aller-
gens/test preparations are reviewed in this booklet.
To aid the reader, we provide an abbreviated expo-
sure sheet which we hope will be of practical value.
The editors welcome comments, additions, correc-
tions, and suggestions for future editions.
We would like to thank all our contributors for their
excellent work.
Jan E. Wahlberg, Peter Elsner,
Lasse Kanerva, Howard I. Maibach,
for the ICDRG
1 Contact Dermatitis (1997) 36: 121–123
Addresses
Editors Wahlberg, Jan E.
National Institute for Working Life
113 91 Stockholm
Sweden
Elsner, Peter
Department of Dermatology
Universitätsklinikum Jena
Erfurter Straße 35
07740 Jena
Germany
Kanerva, Lasse
Institute of Occupational Health
Section of Dermatology
Topeliuksenkatu 41 a
00250 Helsinki
Finland
Maibach, Howard I.
Department of Dermatology
University of California
San Francisco School of Medicine
San Francisco, CA 94143-0989
USA
VIII Addresses
Contributors Alanko, Kristiina
Finnish Institute of Occupational Health
Topeliuksenkatu 41 aA
00250 Helsinki
Finland
Andersen, Klaus E.
Department of Dermatology
Odense University Hospital
5000 Odense C
Denmark
Avnstorp, Christian
Klinik for Hudsygdomme
Roskildevej 264
2610 Rödovre
Denmark
Bruynzeel, Derk P.
Department of Dermatology
Free University Hospital
De Boelelaan 1117
1081 HV Amsterdam
The Netherlands
Bruze, Magnus
Department of Occupational
and Environmental Dermatology
Malmö University Hospital
205 02 Malmö
Sweden
Chowdhury, Mahbub M.U.
Department of Dermatology
University Hospital of Wales
Box 100, Heath Park
Cardiff CF14 4XW
United Kingdom
Addresses IX
Färm, Gunilla
Department of Dermatology
Örebro University Hospital
701 85 Örebro
Sweden
Fischer, Torkel
Hensvik 253
760 49 Herräng
Sweden
Flyvholm, Mari-Ann
National Institute of Occupational Health
Lersö Parkallé 105
2100 Copenhagen
Denmark
Freeman, Susanne
Skin and Cancer Foundation
Contact and Occupational Clinic
277 Bourke Street, Darlinghurst
2101 Sydney
Australia
Goh, Chee Leok
National Skin Centre (S)
1 Mandalay Road
Singapore 308205
Singapore
Goossens, An
Department of Dermatology
UZKU Leuven
3000 Leuven
Belgium
X Addresses
Gruvberger, Birgitta
Department of Occupational
and Environmental Dermatology
Malmö University Hospital
205 02 Malmö
Sweden
Guin, Jere D.
18 Corporate Hill Drive, Suite 100
Little Rock, AR 72205
USA
Hannuksela, Matti
South Karelia Central Hospital
Laihiankatu 6,
53100 Lappeenranta
Finland
Hansson, Christer
Department of Dermatology
University Hospital
221 85 Lund
Sweden
Hindsén, Monica
Department of Occupational
and Environmental Dermatology
Malmö University Hospital
205 02 Malmö
Sweden
Isaksson, Marléne
Department of Occupational
and Environmental Dermatology
Malmö University Hospital
205 02 Malmö
Sweden
Addresses XI
Jolanki, Riitta
Finnish Institute of Occupational Health
Topeliuksenkatu 41 aA
00250 Helsinki
Finland
Lachapelle, Jean-Marie
Department of Dermatology
Louvain University, UCL 3033,
30 Clos Chapelle-aux-Champs
1200 Brussels
Belgium
Lidén, Carola
Department of Occupational
and Environmental Dermatology
Norrbacka
171 76 Stockholm
Sweden
Maibach, Howard I.
Department of Dermatology
University of California
San Francisco School of Medicine
San Francisco, CA 94143-0989
USA
Möller, Halvor
Department of Dermatology
Malmö University Hospital
205 02 Malmö
Sweden
Paulsen, Evy
Department of Dermatology
Odense University Hospital
5000 Odense C
Denmark
XII Addresses
Seidenari, Stefania
Department of Dermatology
University of Modena
Via del Pozzo 71
41100 Modena
Italy
Shaw, Stephanie
Culverton, 110, Wycombe Road
Princes Risborough
Bucks HP27 OEY
United Kingdom
Wilkinson, John
Culverton, 110, Wycombe Road
Princes Risborough
Bucks HP27 OEY
United Kingdom
Contents
Metals Cobalt Chloride 3
Torkel Fischer
Nickel Sulfate 7
Carola Lidén
Potassium Dichromate 11
Christian Avnstorp
Rubber Chemicals Thiuram Mix, Mercapto Mix,
and Mercaptobenzothiazole 15
Christer Hansson
Preservatives Diazolidinyl Urea, Imidazolidinyl Urea,
and Quaternium 15 23
John Wilkinson, Stephanie Shaw
Formaldehyde 29
Mari-Ann Flyvholm
Methylchloroisothiazolinone
and Methylisothiazolinone 37
Birgitta Gruvberger
Methyldibromoglutaronitrile 41
Birgitta Gruvberger, Magnus Bruze
XIV Contents
Parabens 45
Susanne Freeman
Thimerosal 47
Halvor Möller
Perfumes Balsam of Peru (Myroxylon pereirae) 53
and Fragrances Derk P. Bruynzeel
Fragrance Mix 57
Derk P. Bruynzeel
Corticosteroids Budesonide, Tixocortol Pivalate,
and Hydrocortisone-17-Butyrate 63
Marléne Isaksson
Additional Benzocaine 73
Topical Remedies Stefania Seidenari
Cetylstearyl Alcohol 75
Matti Hannuksela
Clioquinol 79
Jean-Marie Lachapelle
Ethylenediamine Dihydrochloride 81
Susanne Freeman
Neomycin Sulfate 83
An Goossens
Propylene Glycol 85
Mahbub M.U. Chowdhury, Howard I. Maibach
Wool Alcohols 89
An Goossens
Contents XV
Plants Colophony 93
Gunilla Färm
Primin 95
Monica Hindsén
Sesquiterpene Lactone Mix 97
Evy Paulsen, Klaus E. Andersen
Urushiol 101
Jere D. Guin
Miscellaneous Epoxy Resin 105
Riitta Jolanki, Kristiina Alanko
para-Phenylenediamine Free Base 111
Stefania Seidenari
p-Tertiary-Butylphenol Formaldehyde Resin 113
Chee Leok Goh
Tosylamide/Formaldehyde Resin 115
Carola Lidén
Alphabetized Listing of Contents
Balsam of Peru (Myroxylon pereirae) 53
Benzocaine 73
Budesonide 63
Cetylstearyl Alcohol 75
Clioquinol 79
Cobalt Chloride 3
Colophony 93
Diazolidinylurea 23
Epoxy Resin 105
Ethylenediamine Dihydrochloride 81
Formaldehyde 29
Fragrance Mix 57
Hydrocortisone 17-Butyrate 63
Imidazolidinyl Urea 23
Mercaptobenzothiazole 15
Mercapto Mix 15
Methylchloroisothiazolinone
and Methylisothiazolinone (MCI/MI) 37
Methyldibromoglutaronitrile 41
Neomycin Sulfate 83
Nickel Sulfate 7
Parabens 45
para-Phenylenediamine Free Base 111
Potassium Dichromate 11
Primin 95
Propylene Glycol 85
p-Tertiary-Butylphenol Formaldehyde Resin 113
Quaternium 15 (Dowicil 200) 23
Alphabetized Listing of Contents XVII
Sesquiterpene Lactone Mix 97
Thimerosal 47
Thiuram Mix 15
Tixocortol Pivalate 63
Tosylamide/Formaldehyde Resin 115
Urushiol 101
Wool Alcohols 89
Recommended Patch-test Concentrations
Allergen-patch- TRUE test
tape (μg/cm2)
Balsam of Peru 25 % pet. 800
Benzocaine 5 % pet.
Budesonide 0.01 % pet. 2
Cetylstearyl alcohol 20 % pet.
Clioquinol 5 % pet. 190 (mix)
Cobalt chloride 1 % pet. 20
Colophony 20 % pet. 1,200
Diazolidinyl Urea 2 % pet. 600
Epoxy resin 1 % pet. 50
Ethylenediamine dihydrochloride 1 % pet. 50
Formaldehyde 1 % aq. 180
Fragrance mix 8 % pet. 430
Hydrocortisone-17-butyrate 1 % ethanol 25
Imidazolidinyl urea 2 % pet. 600
Mercapto mix 1–2 % pet. 75
Mercaptobenzothiazole 1–2 % pet. 75
Methylchloroisothiazolinone 0.01–0.02 % aq. 4
and methylisothiazolinone
Methyldibromoglutaronitrile 0.05–0.3 % pet. 10
Neomycin sulfate 20 % pet. 230
Recommended patch-test concentrations XIX
Allergen-patch TRUE test
tape (μg/cm2)
Nickel sulfate 5 % pet. 200
Paraben mix 16 % pet. 1,000
para-Phenylenediamine free base 1 % pet. 90
Potassium dichromate 0.5 % pet. 23
Primin 0.01 % pet.
Propylene glycol 5 % pet., 20 % aq.
Not finally
stated
p-Tertiary-butylphenol 1 % pet. 45
formaldehyde resin
Quaternium 15 1 % pet. 100
Sesquiterpene lactone mix 0.1 % pet.
Thimerosal 0.1 % pet. 8
Thiuram mix 1 % pet. 25
Tixocortol pivalate 0.1 % pet. 20
Tosylamide/formaldehyde resin 10 % pet.
Urushiol 0.05–2.5 μg in 5 μl
acetone. Open test
Wool alcohols 30 % pet. 1,000
aq. aqueous, pet. in petrolatum.
Metals
