Acneiform Eruptions in Dermatology A Differential Diagnosis
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To Cori, Jake, and Chloe, whose bright smiles and unconditional love
inspire me every day. To my parents, without whose support I would not be
where I am today.
Joshua A. Zeichner, M.D.
Preface
An estimated 40–50 million people in the United States suffer from acne,
and up to 85 % of people experience acne at some point in their lives.
Dermatologists, primary care doctors, and pediatricians see these patients
every day in practice. It is important to treat the skin effectively not only to
reduce the risk of physical scarring but also to address the negative
psychosocial impact this disease carries. Improving the skin can improve
self-confidence, interpersonal relationships, and performance in school or at
work.
While the majority of acne patients seen in practice truly have run-of-
the-mill acne, not all “acne” is really acne vulgaris. It may be exception
rather than the rule for a patient to have a condition that mimics acne, but it
is our responsibility as health care providers to be up to date and educated
on acne’s broad differential diagnosis. If patients do not have any
comedonal lesions, if they have an atypical medical history, or if they are
not responding to traditional therapies, then alternative diagnoses should be
considered. Proper diagnosis will allow us to prescribe proper treatments
and ultimately improve clinical outcomes and patient satisfaction.
This book will help to provide a broad overview of acne vulgaris itself
as well as conditions that manifest with acneiform eruptions in the skin.
Joshua A. Zeichner
New York, NY, USA
Acknowledgment
We are all influenced by the people with whom we surround ourselves. I
have had the privilege of learning from the greatest minds in Dermatology,
who have shaped the person I am today. While I have had countless mentors
touch my career, I must take this opportunity to acknowledge one person in
particular. Dr. Mark Lebwohl is truly a mentor of mentors. He has taught
me not only how to be a good dermatologist, but also, more importantly,
how to be a great doctor, colleague, and teacher. This book would not have
been possible without his support, advice, and encouragement.
Contents
Part I Acne Vulgaris
1 Acne Pathophysiology
Shinjita Das and Rachel Reynolds
2 Clinical Presentation of Acne
Guy F. Webster
3 Topical Therapies for Acne
Mary-Margaret Kober, Whitney P. Bowe and Alan R. Shalita
4 Systemic Therapies for Acne
Marisa Kardos Garshick, Alexa Kimball and Lynn Drake
5 Laser and Light Based Therapies for Acne
Jeremy B. Green, Annelyse Ballin and Joely Kaufman
Part II Infectious Diseases Mimicking Acne Vulgaris
6 Bacterial Folliculitis
Jessica Gjede and Emmy Graber
7 Gram-Negative Folliculitis
Ani L. Tajirian and Leon H. Kircik
8 Hot-Tub Folliculitis
Paula S. Malhotra and Joseph F. Fowler Jr.
9 Malassezia Folliculitis
Patricia K. Farris and Andrea Murina
10 Tinea Barbae
Lauren Kole and Boni Elewski
11 Flat Warts
Ted Rosen and Sara Risner-Rumohr
12 Molluscum Contagiosum
Yvonne Clark and Lawrence F. Eichenfield
13 Herpes Simplex Virus
Rachel Gordon and Stephen Tyring
14 Varicella Zoster Virus
Rachel Gordon, Stephen Tyring, Whitney Lapolla and Rana Mays
Part III Variants of Acne Vulgaris
15 Acne Conglobata
Jonathan S. Weiss and Elijah Wilder
16 Acne Excoriée
Jillian Wong Millsop and John Y. M. Koo
17 Acne Fulminans
Alison Schram and Misha Rosenbach
18 Acne Mechanica
Zoe Diana Draelos
19 Cushing’s Syndrome
Nick Zilieris, Cheryl J. Gustafson and Steven R. Feldman
20 PAPA Syndrome
Fan Liu and Kanade Shinkai
21 Polycystic Ovary Syndrome
Joslyn Kirby
22 Pomade Acne
Oge Onwudiwe and Valerie D. Callender
23 Post-adolescent Female Acne
Gillian Heinecke and Diane Berson
24 SAPHO Syndrome
Caroline L. LaRosa and Andrea L. Zaenglein
Part IV Genetic Syndromes Mimicking Acne Vulgaris
25 Apert Syndrome
Yasser Albahrani and Joshua A. Zeichner
26 Birt-Hogg-Dubé Syndrome
Kristina Goldenberg and Gary Goldenberg
27 Brooke-Spiegler Syndrome
Bradley Glodny and Joshua A. Zeichner
28 Cowden Syndrome
Rita V. Linkner and Joshua A. Zeichner
29 Gardner Syndrome
Alexandra Golant and Joshua A. Zeichner
30 Gorlin Syndrome
Madelaine Haddican and James Spencer
31 Muir-Torre Syndrome
Adam J. Luber and Joshua A. Zeichner
32 Reed’s Syndrome
Kristen Pacific and Jason Emer
33 Tuberous Sclerosis
Omar Pacha and Adelaide Hebert
Part V Other Mimickers of Acne Vulgaris
34 Acne Scarring
Neal Bhatia, Consuelo Veronica David, Salar Hazany and
Aman Samrao
35 Eosinophilic Pustular Folliculitis
Joy Makdisi and Adam Friedman
36 Favre-Racouchot Syndrome
Silvina Pugliese, Andrea Smith, Rachel Epstein and Abel Torres
37 Hidradenitis Suppurativa
Deanna M. Sikorski and Kenneth J. Tomecki
38 Perioral Dermatitis
Bryan Gammon and Bethanee J. Schlosser
39 Photocontact Dermatitis
Nicholas Gulati and Emma Guttman-Yassky
40 Post-infl ammatory Pigment Alteration
Rajiv I. Nijhawan and Andrew F. Alexis
41 Pseudofolliculitis Barbae
Angela Lamb and Gregory N. Yañez
42 Pustular Psoriasis
Sebastian Bernardo and Mark Lebwohl
43 Rosacea
Joseph Bikowski
44 Rosacea Fulminans
Cristina Caridi and Joshua A. Zeichner
45 Sarcoidosis
Laura Thornsberry and Joseph English III
46 Seborrheic Dermatitis
Elizabeth Farhat and Linda Stein Gold
47 Steatocystoma Multiplex
Alejandra Vivas and Jonette Keri
48 Xanthomas
Libby Rhee and Mark Kaufmann
Part VI Pediatric Dermatoses Mimicking Acne
49 Periorifi cial Granulomatous Dermatitis
Jacquelyn Levin, James Del Rosso and Richard Miller
50 Keratosis Pilaris Atrophicans
Omar Pacha and Adelaide Hebert
51 Neonatal and Infantile Acne
Hilary Baldwin
52 Papular Granuloma Annulare
Rebecca Smith
53 Precocious Puberty and Acne
Maria Miyar and Moise L. Levy
Part VII Drug-Induced Acneiform Eruptions
54 Drug-Induced Acneiform Eruptions
Ha K. Do, Navid Ezra and Stephen E. Wolverton
Index
Contributors
Yasser Albahrani
Department of Dermatology, Mt. Sinai School of Medicine, New York, NY,
USA
Andrew F. Alexis
Department of Dermatology, St. Luke’s-Roosevelt Hospital Center, New
York, NY, USA
Hilary Baldwin
Department of Dermatology, SUNY Downstate School of Medicine,
Brooklyn, NY, USA
Annelyse Ballin
Private Practice, Dr. Brandt Dermatology Associates, Coral Gables, FL,
USA
Sebastian Bernardo
Department of Dermatology, Mt. Sinai School of Medicine, New York, NY,
USA
Diane Berson
Department of Dermatology, Weill Cornell Medical College, New York,
NY, USA
Neal Bhatia
Division of Dermatology, Harbor-UCLA Medical Center, Torrance, CA,
USA
Joseph Bikowski
Bikowski Skin Care Center, Sewickley, PA, USA
Whitney P. Bowe
Department of Dermatology, SUNY Downstate Medical Center, Brooklyn,
NY, USA
Valerie D. Callender
Callender Dermatology & Cosmetic Center, Glenn Dale, MD, USA
Cristina Caridi
Department of Dermatology, Mt. Sinai School of Medicine, New York, NY,
USA
Yvonne Clark
Department of Dermatology, Sharp Rees-Stealy, La Mesa, CA, USA
Shinjita Das
Department of Dermatology, Harvard Combined Dermatology Residency
Program, Boston, MA, USA
Consuelo Vera David
Division of Dermatology, Harbor-UCLA Medical Center, Torrance, CA,
USA
James Del Rosso
Touro University College of Osteopathic Medicine, Henderson, NV, USA
Ha K. Do
Department of Dermatology, Indiana University School of Medicine, New
York, NY, USA
Zoe Diana Draelos
Department of Dermatology, Duke University School of Medicine,
Durham, NC, USA
Lynn A. Drake
Department of Dermatology, Massachusetts General Hospital, Boston, MA,
USA
Lawrence F. Eichenfield
Division of Pediatric and Adolescent Dermatology, Rady Children’s
Hospital, San Diego, San Diego, CA, USA
Boni Elewski
Department of Dermatology, University of Alabama, Birmingham,
Birmingham, AL, USA
Jason Emer
Department of Dermatology, Mount Sinai School of Medicine, New York,
NY, USA
Joseph C. English III
Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA
Rachel Epstein
Department of Dermatology, Loma Linda University, Loma Linda, CA,
USA
Navid Ezra
Department of Dermatology, Indiana University School of Medicine, New
York, NY, USA
Elizabeth Farhat
Department of Dermatology, Henry Ford Health System, West Bloomfield,
MI, USA
Patricia K. Farris
Department of Dermatology, Old Metairie Dermatology, Metairie, LA,
USA
Steven R. Feldman
Department of Dermatology, Pathology, and Public Health Sciences, Wake
Forest University Baptist Medical Center, Winston-Salem, NC, USA
Joseph F. Fowler Jr.
Division of Dermatology, University of Louisville, Louisville, KY, USA
Adam Friedman
Department of Dermatology, Montefiore – Albert Einstein College of
Medicine, Bronx, NY, USA
Bryan Gammon
Department of Dermatology, Northwestern University, Chicago, IL, USA
Marisa Kardos Garshick
Department of Dermatology, Massachusetts General Hospital, Boston, MA,
USA
Jessica Gjede
Department of Dermatology, Boston Medical Center, Boston, MA, USA
Bradely Glodny
Department of Dermatology, Mt. Sinai, New York, NY, USA
Alexandra Golant
Department of Dermatology, The Mt. Sinai Hospital, New York, NY, USA
Linda Stein Gold
Department of Dermatology, Henry Ford Health System, West Bloomfield,
MI, USA
Gary Goldenberg
Department of Dermatology, The Mount Sinai Hospital, New York, NY,
USA
Kristina Goldenberg
Department of Dermatology, Mt. Sinai School of Medicine, New York, NY,
USA
Rachel Gordon
Department of Dermatology, The University of Texas Medical School at
Houston, Houston, TX, USA
Emmy Graber
Department of Dermatology, Boston Medical Center & Boston University
School of Medicine, Boston, MA, USA
Jeremy B. Green
Private Practice, Dr. Brandt Dermatology Associates, Coral Gables, FL,
USA
Nicholas Gulati
Laboratory for Investigative Dermatology, The Rockefeller University, New
York, NY, USA
Cheryl J. Gustafson
Department of Dermatology, Wake Forest University Baptist Medical
Center, Winston-Salem, NC, USA
Emma Guttman-Yassky
Department of Dermatology, Mount Sinai NY, New York, NY, USA
Madelaine Haddican
Department of Dermatology, Mount Sinai School of Medicine, New York,
NY, USA
Salar Hazany
Division of Dermatology, Harbor-UCLA Medical Center, Torrance, CA,
USA
Adelaide A. Hebert
Department of Dermatology, University of Texas Health Science Center,
Houston, Houston, TX, USA
Gillian Heinecke
Department of Dermatology, Mount Sinai, New York, NY, USA
Joely Kaufman
Private Practice, Dr. Brandt Dermatology Associates, Coral Gables, FL,
USA
Mark D. Kaufmann
Department of Dermatology, Icahn School of Medicine at Mt. Sinai, New
York, NY, USA
Jonette Keri
Department of Dermatology and Cutaneous Surgery, Veterans Hospital,
University of Miami, Miami, FL, USA
Alexa Kimball
Department of Dermatology, Massachusetts General Hospital, Boston, MA,
USA
Joslyn S. Kirby
Department of Dermatology, Penn State Hershey, Hershey, PA, USA
Leon H. Kircik
Department of Dermatology, Mt. Sinai School of Medicine, New York, NY,
USA
Indiana University School of Medicine, Indianapolis, IN, USA
Mary-Margaret Kober
Department of Dermatology, SUNY Downstate Medical Center, Brooklyn,
NY, USA
Lauren Kole
Department of Dermatology, University of Alabama, Birmingham,
Birmingham, AL, USA
John Y. M. Koo
Psoriasis and Skin Treatment Center, University of California San
Francisco, San Francisco, CA, USA
Angela Lamb
Department of Dermatology, Mount Sinai Hospital, New York, NY, USA
Whitney Lapolla
Department of Dermatology, The University of Texas at Houston, Houston,
TX, USA
Caroline L. LaRosa
Department of Dermatology and Pediatrics, Penn State/Milton S. Hershey
Medical Center, Hershey, PA, USA
Mark G. Lebwohl