Goodman and Gilman Manual of Pharmacology and
Therapeutics 2nd Edition
Visit the link below to download the full version of this book:
https://medipdf.com/product/goodman-and-gilman-manual-of-pharmacology-and-therap
eutics-2nd-edition/
Click Download Now
Copyright © 2014 by McGraw-Hill Education. All rights reserved.
Except as permitted under the United States Copyright Act of 1976,
no part of this publication may be reproduced or distributed in any
form or by any means, or stored in a data base or retrieval system,
without the prior written permission of the publisher.
ISBN: 978-0-07-181054-8
MHID: 0-07-181054-4
The material in this eBook also appears in the print version of this
title: ISBN: 978-0-07-176917-4, MHID: 0-07-176917-X.
eBook conversion by codeMantra
Version 1.0
All trademarks are trademarks of their respective owners. Rather
than put a trademark symbol after every occurrence of a
trademarked name, we use names in an editorial fashion only, and
to the benefit of the trademark owner, with no intention of
infringement of the trademark. Where such designations appear in
this book, they have been printed with initial caps.
McGraw-Hill Education eBooks are available at special quantity
discounts to use as premiums and sales promotions, or for use in
corporate training programs. To contact a representative please visit
the Contact Us page at www.mhprofessional.com.
TERMS OF USE
This is a copyrighted work and McGraw-Hill Education and its
licensors reserve all rights in and to the work. Use of this work is
subject to these terms. Except as permitted under the Copyright Act
of 1976 and the right to store and retrieve one copy of the work,
you may not decompile, disassemble, reverse engineer, reproduce,
modify, create derivative works based upon, transmit, distribute,
disseminate, sell, publish or sublicense the work or any part of it
without McGraw-Hill Education’s prior consent. You may use the
work for your own noncommercial and personal use; any other use
of the work is strictly prohibited. Your right to use the work may be
terminated if you fail to comply with these terms.
THE WORK IS PROVIDED “AS IS.” McGRAW-HILL
EDUCATION AND ITS LICENSORS MAKE NO
GUARANTEES OR WARRANTIES AS TO THE ACCURACY,
ADEQUACY OR COMPLETENESS OF OR RESULTS TO BE
OBTAINED FROM USING THE WORK, INCLUDING ANY
INFORMATION THAT CAN BE ACCESSED THROUGH THE
WORK VIA HYPERLINK OR OTHERWISE, AND EXPRESSLY
DISCLAIM ANY WARRANTY, EXPRESS OR IMPLIED,
INCLUDING BUT NOT LIMITED TO IMPLIED WARRANTIES
OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR
PURPOSE. McGraw-Hill Education and its licensors do not
warrant or guarantee that the functions contained in the work will
meet your requirements or that its operation will be uninterrupted
or error free. Neither McGraw-Hill Education nor its licensors shall
be liable to you or anyone else for any inaccuracy, error or
omission, regardless of cause, in the work or for any damages
resulting therefrom. McGraw-Hill Education has no responsibility
for the content of any information accessed through the work.
Under no circumstances shall McGraw-Hill Education and/or its
licensors be liable for any indirect, incidental, special, punitive,
consequential or similar damages that result from the use of or
inability to use the work, even if any of them has been advised of
the possibility of such damages. This limitation of liability shall
apply to any claim or cause whatsoever whether such claim or
cause arises in contract, tort or otherwise.
Contents
Preface
Section I
General Principles
1. Drug Invention and the Pharmaceutical Industry
2. Pharmacokinetics: The Dynamics of Drug Absorption,
Distribution, Metabolism, and Elimination
3. Pharmacodynamics: Molecular Mechanisms of Drug Action
4. Drug Toxicity and Poisoning
5. Membrane Transporters and Drug Response
6. Drug Metabolism
7. Pharmacogenetics
Section II
Neuropharmacology
8. Neurotransmission: The Autonomic and Somatic Motor
Nervous Systems
9. Muscarinic Receptor Agonists and Antagonists
10. Anticholinesterase Agents
11. Agents Acting at the Neuromuscular Junction and Autonomic
Ganglia
12. Adrenergic Agonists and Antagonists
13. 5-Hydroxytryptamine (Serotonin) and Dopamine
14. Neurotransmission and the Central Nervous System
15. Drug Therapy of Depression and Anxiety Disorders
16. Pharmacotherapy of Psychosis and Mania
17. Hypnotics and Sedatives
18. Opioids, Analgesia, and Pain Management
19. General Anesthetics and Therapeutic Gases
20. Local Anesthetics
21. Pharmacotherapy of the Epilepsies
22. Treatment of Central Nervous System Degenerative Disorders
23. Ethanol and Methanol
24. Drug Addiction
Section III
Modulation of Cardiovascular Function
25. Regulation of Renal Function and Vascular Volume
26. Renin and Angiotensin
27. Treatment of Myocardial Ischemia and Hypertension
28. Pharmacotherapy of Congestive Heart Failure
29. Anti-Arrhythmic Drugs
30. Blood Coagulation and Anticoagulant, Fibrinolytic, and
Antiplatelet Drugs
31. Drug Therapy for Hypercholesterolemia and Dyslipidemia
Section IV
Inflammation, Immunomodulation, and Hematopoiesis
32. Histamine, Bradykinin, and Their Antagonists
33. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating
Factor
34. Pharmacotherapy of Inflammation, Fever, Pain, and Gout
35. Immunosuppressants, Tolerogens, and Immunostimulants
36. Pulmonary Pharmacology
37. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins
Section V
Hormones and Hormone Antagonists
38. Introduction to Endocrinology: The Hypothalamic-Pituitary
Axis
39. Thyroid and Anti-Thyroid Drugs
40. Estrogens and Progestins
41. Androgens
42. Pharmacology of the Adrenal Cortex
43. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus
and Hypoglycemia
44. Agents Affecting Mineral Ion Homeostasis and Bone Turnover
Section VI
Drugs Affecting Gastrointestinal Function
45. Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and
Gastroesophageal Reflux Disease
46. Gastrointestinal Motility and Water Flux; Emesis; Biliary and
Pancreatic Disease
47. Pharmacotherapy of Inflammatory Bowel Disease
Section VII
Chemotherapy of Microbial Diseases
48. General Principles of Antimicrobial Therapy
49. Chemotherapy of Malaria
50. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis,
Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other
Protozoal Infections
51. Chemotherapy of Helminth Infections
52. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones,
and Agents for Urinary Tract Infections
53. Penicillins, Cephalosporins, and Other β-Lactam Antibiotics
54. Aminoglycosides
55. Protein Synthesis Inhibitors and Miscellaneous Antibacterial
Agents
56. Chemotherapy of Tuberculosis, Mycobacterium Avium
Complex Disease, and Leprosy
57. Antifungal Agents
58. Antiviral Agents (Nonretroviral)
59. Antiretroviral Agents and Treatment of HIV Infection
Section VIII
Chemotherapy of Neoplastic Diseases
60. General Principles of Cancer Chemotherapy
61. Cytotoxic Agents
62. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal
Antibodies, and Cytokines
63. Natural Products in Cancer Chemotherapy: Hormones and
Related Agents
Section IX
Special Systems Pharmacology
64. Ocular Pharmacology
65. Dermatological Pharmacology
66. Contraception and Pharmacotherapy of Obstetrical and
Gynecological Disorders
67. Environmental Toxicology: Carcinogens and Heavy Metals
Appendix I Principles of Prescription Order Writing and Patient
Compliance
Index
Preface to the Second Edition
This Manual derives from the 12th edition of Goodman &
Gilman’s The Pharmacological Basis of Therapeutics. The parent
text covers not just principles and mechanisms of action but also
details of clinical use and recent basic research that supports
therapeutic applications and points the way toward new therapies;
as a consequence of this thoroughness, the book is large and not in
the fashion of the shorter texts preferred by students of this era. To
make core material from G&G more accessible, we have abridged
the 12th edition of the parent text, trying to present the essentials of
mechanism and clinical use while omitting research data,
references, and the pharmacokinetic data of Appendix II, all of
which can be found at the G&G website on AccessMedicine.com
and AccessPharmacy.com, along with regular therapeutic updates
and mechanistic animations. We have also generally omitted the
structures of therapeutics agents, which are readily available on the
book’s website and on PubChem (pubchem.ncbi.nlm.nih.gov/). This
Manual of Pharmacology and Therapeutics is organized identically
to the parent text, using many of the same figures and tables; a
number of figures have been improved or added anew for this
edition.
Some realizations gained from editing the 12th edition and this
volume stand out:
• The invention of new classes of drugs has slowed to a trickle.
• Therapeutics has barely begun to capitalize on the information from the
Human Genome Project.
• The development of resistance to antimicrobial agents, mainly through
their overuse and misuse in agriculture and medicine, threatens to
return us to the pre-antibiotic era.
We have the ingenuity to correct these shortcomings if we can
muster the will and the research support to do so.
We thank the contributors and editors of the 12th edition of G&G,
Saloni Narang of Thomson Digital, Christie Naglieri and James
Shanahan of McGraw-Hill, and a long line of contributors and
editors who have worked on Goodman & Gilman over 12 editions.
It is a tribute to Louis Goodman and Alfred Gilman that their book
is alive and vigorous 72 years after the publication of the first
edition.
Randa Hilal-Dandan
Laurence Brunton
San Diego, California
St. Patrick’s Day, 2013
In Memoriam
Desmond R.H. Gourley (1922–2012)
Steven E. Mayer (1929–2010)
Section I
General Principles
