School of Bio Sciences and Technology

M.Sc. Bio Medical Genetics

Curriculum and Syllabus

(2023 – 2024 admitted students)
VISION STATEMENT OF VELLORE INSTITUTE OF TECHNOLOGY
 Transforming life through excellence in education and research.

MISSION STATEMENT OF VELLORE INSTITUTE OF TECHNOLOGY

 World class Education: Excellence in education, grounded in ethics and critical thinking,
for improvement of life.

 Cutting edge Research: An innovation ecosystem to extend knowledge and solve critical
problems.

 Impactful People: Happy, accountable, caring and effective workforce and students.

 Rewarding Co-creations: Active collaboration with national & international industries &
universities for productivity and economic development.

 Service to Society: Service to the region and world through knowledge and compassion.

Vision Statement of School of Bio Sciences and Technology (SBST)

 To nurture high-quality bioengineers and science graduates with the potential to innovate,
invent and disseminate knowledge for the benefit of society and environment

Mission Statement of School of Bio Sciences and Technology (SBST)

 To offer academic programs to impart knowledge skills to cater to the dynamic needs of the
bio sciences and the food industry

 To foster the spirit of innovation and creativity in the young minds in solving the

real-time problems arising in society and industry

 To instill confidence, ethics, values, and employability skills in the future citizens to focus
on the sustainable growth of the economy
 School of Bio Sciences and Technology (SBST)

Our Vision
To nurture high-quality bioengineers and science graduates with the potential to innovate, invent
and disseminate knowledge for the benefit of society and environment

Our Mission
 To offer academic programs to impart knowledge skills to cater to the dynamic needs of the
bio sciences and the food industry

 To foster the spirit of innovation and creativity in the young minds in solving the real-time
problems arising in society and industry

 To instill confidence, ethics, values, and employability skills in the future citizens to focus
on the sustainable growth of the economy
Mission of M.Sc., Bio Medical Genetics

 Apply knowledge of genetic principles and understand how they contribute to etiology,
clinical features, and disease expression

 Exhibit the knowledge of ethical legal, and social issues pertaining to genetic counselling
M.Sc Bio Medical Genetics

PEO Statements

PEO1: Excel in professional career and/or higher education by acquiring solid foundation in
science, mathematics and advanced technologies

PEO2: Develop and apply engineering solutions for solving contemporary, social and
human issues with realistic constraints suitable for the present need through the
use of modern tools.

PEO3: Exhibit professional and ethical standards, effective communication skills,

teamwork spirit, multidisciplinary and transdisciplinary approach for successful
careers and to be able to compete globally, function as leaders, as entrepreneurs,
and manage information efficiently and engage in lifelong learning

Programme Specific Outcomes (PSOs)

PSO Statement

1 Apply knowledge of genetic principles and understand how they contribute to etiology,
clinical features, and disease expression.

2 Exhibit the knowledge of ethical legal, and social issues pertaining to genetic counselling

3 Ability to independently carry out research and development work to solve the practical
problems
Category-wise Credit distribution

Category Credits

University core (UC) 29

Programme core (PC) 23

Programme elective (PE) 22

University elective (UE) 6

Total credits 80

Detailed curriculum

University Core

L T P J C
SL.No Course Code Course Title

1 ENG5003 English For Sciences and Technology 0 0 4 0 2

3 FRE5001 Francais fonctionnel-TH 2 0 0 0 2

4 GER5001 Deutsch fuer Anfaenger - TH 2 0 0 0 2

5 MSM5001 Biostatistics 2 0 2 0 3

6 STS 4001 Soft Skills 3 0 0 0 1

6 STS4002 Soft Skills 3 0 0 0 1

7 SET5001 SET Project ( I Semester) 0 0 0 0 2

8 SET5002 SET Project ( II Semester) 0 0 0 0 2

9 SET5003 SET Project ( III Semester) 0 0 0 0 2

10 RES5001 Research Methodology 2 0 0 0 2

11 BMG6099 Master’s Thesis 14

Programme Core
SL.N Course Pre
Course Title L T P J C
O Code requisite
1 BMG5001 Biochemistry 3 0 2 0 4 NIL
2 BMG5002 Principles of Genetics 3 0 0 0 3 NIL
3 BMG5003 Human Immunology 3 0 0 0 3 NIL
Clinical Cytogenetics and Prenatal
4 BMG6002 2 0 2 4 4 NIL
Diagnosis
5 BMG5004 Human Molecular Genetics 3 0 0 0 3 NIL
6 BMG5007 Developmental Genetics 3 0 0 0 3 NIL
7 BMG5008 Cancer Genetics 3 0 0 0 3 NIL

Programme Elective

SL. Course
Course Title L T P J C Pre requisite
NO Code
Human Anatomy and
1 BMG5005 2 0 0 4 3 NIL
Physiology
Advanced Analytical
2 BMG5006 3 0 0 0 3 NIL
Techniques
3 BMG5009 Genetics of Human Infertility 2 0 0 4 3 NIL
4 BMG5010 Radiation Genetics 2 0 0 4 3 NIL
5 BMG5011 Cognitive and Behavioral 2 0 0 4 3 NIL
 Genetics
6 BMG5012 Forensic Science 2 0 0 4 3 NIL
7 BMG5013 Stem Cell Biology 3 0 0 0 3 NIL
8 BMG5014 Environmental Genetics 3 0 2 0 4 NIL
Introduction to Human
9 BMG5015 3 0 0 0 3 NIL
Psychology*
10 BMG5016 Bioinformatics 2 0 2 4 4 NIL
11 BMG5017 Enzymology 3 0 0 0 3 NIL
12 BMG6001 Human Biochemical Genetics 2 0 0 4 3 NIL
13 BMG6003 Medical Biochemistry 3 0 0 0 3 NIL
14 BMG6004 Genetic Engineering 3 0 2 0 4 NIL
Clinical Cytogenetics and
15 BMG6005 Genetic Counseling * 2 0 0 4 3
Prenatal Diagnosis.
Ethical, Legal and Social Clinical Cytogenetics and
16 BMG6006 3 0 0 0 3
Issues in Genetic Counseling* Prenatal Diagnosis.
Clinical Cytogenetics and
17 BMG6007 Clinical rotation* 0 0 0 0 2
Prenatal Diagnosis.

University Elective

Course Pre
SL.NO Course Title L T P J C SL.NO
Code requisite
Any course offered to
1 M.Tech ( Subject to 0 0 0 0 6
CGPA
Conditions)/M.Sc
Programs.
Course code Course Title L T P J C
ENG5003 English for Science and Technology 0 0 4 0 2
(for MCA & M.Sc., programmes)
Pre-requisite Cleared EPT Syllabus version
v. 1.1
Course Objectives:
1. To enable students communicate effectively in social, academic and professional contexts
thereby
enhancing their interpersonal, managerial, problem-solving, and presentation skills.
2. To facilitate students develop their listening competency and critically evaluate and review
documentaries, talks and speeches.
3. To Assist students read and comprehend News Articles and Scientific Texts; effectively
interpret tables and graphs; write and proof-read official correspondences.

Expected Course Outcome:

1.Make effective presentations and display their interpersonal skills in academic and professional
contexts.
2.Emerge as good listeners and critically evaluate oral communication.
3.Excel in reading, comprehending and interpreting technical reports, texts and data.
4.Able to write effectively in English and also display their proof-reading abilities.
5.Face real interviews and handle personal and professional conflicts effectively.

Module:1 Career Goals 4hours

Short term and long term career goals
Activity: SWOT Analysis/ Comprehending speeches

Module:2 Interpersonal Skills 4 hours

Interpersonal Communication in/with Groups (Corporate Etiquette: Journey from Campus to
corporate)
Activity: Role Plays/Mime/Skit

Module:3 Listening Skills 4 hours

Listening to Documentary
Activity: Critically evaluate/Review a documentary/TED Talk

Module:4 Reading Skills 4hours

Skimming, Scanning, Intensive & Extensive reading
Activity: Reading News Papers/Magazines/Scientific Texts

Module:5 Report Writing 4hours

Language and mechanics of writing report
Activity: Writing a Report/Mini Project

Module:6 Study Skills 4hours

Summarizing the report
Activity: Abstract, Executive Summary, Digital Synopsis

Module:7 Interpreting skills 4hours

Interpret data in tables and graphs Activity: Transcoding

Module:8 Editing Skills 4hours

Proof Reading
Sequencing
Activity: Editing any given text

Module:9 Presentation Skills 4 hours

Oral Presentation using digital tools
Activity: Oral presentation on the given topic using appropriate non-verbal cues

Module:10 Group Discussion 4 hours

Intragroup interaction (avoid, accommodate, compete, compromise, collaborate)
Activity: Group discussion on a given topic

Module:11 Professional Skills 4 hours

Résumé Writing
Activity: Prepare an Electronic Résumé

Module:12 Skill-Gap Analysis 4 hours

Tailor your skills to suit the Job needs
Activity: Write a SoP for higher Studies/Purpose Statement for job

Module:13 Interview Skills 4 hours

Placement/Job Interview
Activity: Mock Interview

Module:14 Managerial Skills 4 hours

Official Meeting to organize events
Activity: Writing Agenda, Minutes of Meeting (video conferencing) and Organizing an event

Module:15 Problem Solving Skills 4 hours

Conflict Management & Decision Making
Activity: Case analysis of a challenging Scenario
 Total Lecture hours: 60 hours

Text Book(s)
1. Kuhnke, E. Communication Essentials For Dummies. (2015). First Edition. John Wiley &
Sons.
2. Hewings, M. Advanced Grammar in Use Book with Answers and CD-ROM: A Self-Study
Reference and Practice Book for Advanced Learners of English. (2013). Third Edition.
Cambridge University Press. UK.
Reference Books
1. Churches, R. Effective Classroom Communication Pocketbook. Management Pocketbooks.
(2015). First Edition. USA.
2. Wallwork, A. English for Writing Research Papers. (2016). Second Edition. Springer.
3. Wood, J. T. Communication in Our Lives. (2016). Cengage Learning. Boston. USA.
4. Anderson, C. TED Talks: The Official TED Guide to Public Speaking. (2016). First
Edition.Boston. Houghton Mifflin. New. York.
5. Zinsser, William. On writing well. HarperCollins Publishers. 2016. Thirtieth Edition. New
York.
6. Tebeaux, Elizabeth, and Sam Dragga. The essentials of Technical Communication. 2015. First
Edition Oxford University Press. USA.
Mode of Evaluation: Mini Project, Flipped Class Room, Lecture, PPT’s, Role play, Assignments
Class/Virtual Presentations, Report and beyond the classroom activities
List of Challenging Experiments (Indicative) CO:1,2,3,4,5
1. Setting short term and long term goals 2 hours
2. Mime/Skit/ Activities through VIT Community Radio 6 hours
3. Critically evaluate / review a documentary/ Activities through VIT 4 hours
Community Radio
4. Mini Project 10 hours
5. Digital Synopsis 4 hours
6. Case analysis of a challenging Scenario 4 hours
7. Intensive & Extensive reading of Scientific Texts 4 hours
8. Editing any given text 8 hours
9. Group discussion on a given topic / Activities through VIT 8 hours
Community Radio
10. Prepare a video résumé along with your video introduction and then 10 hours
create a website (in Google Sites/Webly/Wix) showcasing skills and
achievements.
Total Laboratory Hours 60 hours
Mode of evaluation: Mini Project, Flipped Class Room, Lecture, PPT’s, Role play, Assignments
Class/Virtual Presentations, Report and beyond the classroom activities
Recommended by Board of Studies 22-07-2017
Approved by Academic Council No. 47 Date 24.08.2017
Course code Course title L T P J C
FRE5001 Franicais Fonctionnel 2 0 0 0 2
Pre-requisite Syllabus version
v.1
Course Objectives:
The course gives students the necessary background to:
1. Demonstrate competence in reading, writing, and speaking basic French, including knowledge
of vocabulary (related to profession, emotions, food, workplace, sports/hobbies, classroom and
family).
2. Achieve proficiency in French culture oriented view point.

Expected Course Outcome:

The students will be able to
1. Remember the daily life communicative situations via personal pronouns, emphatic pronouns,
salutations, negations, interrogations etc.
2. Create communicative skill effectively in French language via regular / irregular verbs.
3. Demonstrate comprehension of the spoken / written language in translating simple sentences.
4. Understand and demonstrate the comprehension of some particular new range of unseen written
materials.
5. Demonstrate a clear understanding of the French culture through the language studied.

Module:1 Saluer, Se présenter, Etablir des contacts 9 hours

Les Salutations, Les nombres (1-100), Les jours de la semaine, Les mois de l’année, Les Pronoms
Sujets, Les Pronoms Toniques, La conjugaison des verbes réguliers, La conjugaison des verbes
irréguliers- avoir / être / aller / venir / faire etc.

Module:2 Présenter quelqu’un, Chercher un(e) 9 hours

correspondant(e), Demander des nouvelles
d’une personne.

La conjugaison des verbes Pronominaux, La Négation,

L’interrogation avec ‘Est-ce que ou sans Est-ce que’.

Module:3 Situer un objet ou un lieu, Poser des questions 9 hours

L’article (défini/ indéfini), Les prépositions (à/en/au/aux/sur/dans/avec etc.), L’article contracté,
Les heures en français, La Nationalité du Pays, L’adjectif (La Couleur, l’adjectif possessif,
l’adjectif démonstratif/ l’adjectif interrogatif (quel/quelles/quelle/quelles), L’accord des adjectifs
avec le nom, L’interrogation avec Comment/ Combien / Où etc.,

Module:4 Faire des achats, Comprendre un texte court, 8 hours

Demander et indiquer le chemin.
La traduction simple :(français-anglais / anglais –français)

Module:5 Trouver les questions, Répondre aux 7 hours

questions générales en français.
L’article Partitif, Mettez les phrases aux pluriels, Faites une phrase avec les mots donnés,
Exprimez les phrases données au Masculin ou Féminin, Associez les phrases.

Module:6 Comment ecrire un passage 9 hours

Décrivez :
La Famille /La Maison, /L’université /Les Loisirs/ La Vie quotidienne etc.

Module:7 Comment ecrire un dialogue 7 hours

Dialogue:
a) Réserver un billet de train
b) Entre deux amis qui se rencontrent au café
c) Parmi les membres de la famille
d) Entre le client et le médecin

Module:8 Invited Talk: Native speakers 2 hours

Total Lecture hours: 30 hours

Text Book(s)
1. Echo-1, Méthode de français, J. Girardet, J. Pécheur, Publisher CLE International, Paris 2010.
2 Echo-1, Cahier d’exercices, J. Girardet, J. Pécheur, Publisher CLE International, Paris 2010.
Reference Books
1. CONNEXIONS 1, Méthode de français, Régine Mérieux, Yves Loiseau,Les Éditions Didier,
2004.

2 CONNEXIONS 1, Le cahier d’exercices, Régine Mérieux, Yves Loiseau, Les Éditions

Didier, 2004.

3 ALTER EGO 1, Méthode de français, Annie Berthet, Catherine Hugo, Véronique M.

Kizirian, Béatrix Sampsonis, Monique Waendendries , Hachette livre 2006.

Mode of Evaluation: CAT / Assignment / Quiz / FAT

Recommended by Board of Studies 26.02.2016
Approved by Academic Council No.41 Date 17-06-2016
Course code Course title L T P J C

GER5001 Deutsch für Anfänger 2 0 0 0 2

Pre-requisite NIL Syllabus version

v.1
Course Objectives:
The course gives students the necessary background to:
1.Enable students to read and communicate in German in their day to day life
2.Become industry-ready
3.Make them understand the usage of grammar in the German Language.

Expected Course Outcome:

The students will be able to
1. Create the basics of German language in their day to day life.
2. Understand the conjugation of different forms of regular/irregular verbs.
3. Understand the rule to identify the gender of the Nouns and apply articles appropriately.
4. Apply the German language skill in writing corresponding letters, E-Mails etc.
5. Create the talent of translating passages from English-German and vice versa and To frame
simple dialogues based on given situations.

Module:1 3 hours
Einleitung, Begrüssungsformen, Landeskunde, Alphabet, Personalpronomen, Verb Konjugation,
Zahlen (1-100), W-fragen, Aussagesätze, Nomen – Singular und Plural
Lernziel:
Elementares Verständnis von Deutsch, Genus- Artikelwörter

Module:2 3 hours
Konjugation der Verben (regelmässig /unregelmässig) die Monate, die Wochentage, Hobbys,
Berufe, Jahreszeiten, Artikel, Zahlen (Hundert bis eine Million), Ja-/Nein- Frage, Imperativ mit
Sie
Lernziel :
Sätze schreiben, über Hobbys erzählen, über Berufe sprechen usw.
Module:3 4 hours
Possessivpronomen, Negation, Kasus- AkkusatitvundDativ (bestimmter, unbestimmterArtikel),
trennnbare verben, Modalverben, Adjektive, Uhrzeit, Präpositionen, Mahlzeiten, Lebensmittel,
Getränke
Lernziel :
Sätze mit Modalverben, Verwendung von Artikel, über Länder und Sprachen sprechen, über eine
Wohnung beschreiben.

Module:4 6 hours
Übersetzungen : (Deutsch – Englisch / Englisch – Deutsch)
Lernziel :
Grammatik – Wortschatz - Übung

Module:5 5 hours
Leseverständnis,Mindmap machen,Korrespondenz- Briefe, Postkarten, E-Mail
Lernziel :
Wortschatzbildung und aktiver Sprach gebrauch

Module:6 . 3 hours
Aufsätze :
Meine Universität, Das Essen, mein Freund oder meine Freundin, meine Familie, ein Fest in
Deutschland usw

Module:7 4 hours
Dialoge:
a) Gespräche mit Familienmitgliedern, Am Bahnhof,
b) Gespräche beim Einkaufen ; in einem Supermarkt ; in einer Buchhandlung ;
c) in einem Hotel - an der Rezeption ;ein Termin beim Arzt.
Treffen im Cafe

Module:8 2 hours
Guest Lectures/Native Speakers / Feinheiten der deutschen Sprache, Basisinformation über die
deutschsprachigen Länder
Total Lecture hours: 30 hours

Text Book(s)
1. Studio d A1 Deutsch als Fremdsprache, Hermann Funk, Christina Kuhn, Silke
Demme : 2012
Reference Books
1 Netzwerk Deutsch als Fremdsprache A1, Stefanie Dengler, Paul Rusch, Helen Schmtiz, Tanja
Sieber, 2013
2 Lagune ,Hartmut Aufderstrasse, Jutta Müller, Thomas Storz, 2012.
3 Deutsche SprachlehrefürAUsländer, Heinz Griesbach, Dora Schulz, 2011
4 ThemenAktuell 1, HartmurtAufderstrasse, Heiko Bock, MechthildGerdes, Jutta Müller und
Helmut Müller, 2010
www.goethe.de
wirtschaftsdeutsch.de
hueber.de
klett-sprachen.de
 www.deutschtraning.org

Mode of Evaluation: CAT / Assignment / Quiz / FAT

Recommended by Board of Studies 04.03.2016
Approved by Academic Council 41 Date 17.06.2016

MSM BIOSTATISTICS L T P J C

5001 2 0 2 0 3
Pre-requisite NIL Syllabus version
1.1
Course Objectives:
1. Understand the concepts behind collection and presentation of data
2. Understand the measures of central tendency and dispersion along with related analysis
3. Interpret and analyse data using statistical tools and design experiments

Expected Course Outcome:

1. Construct tables and graphs for data presentation
2. Explain measures of central tendency and dispersion along with predicting probability features of
experiments.
3. Discuss the correlation between different types of data along with related variables.
4. Test hypothesis and carry out related statistical tests including that of significance.
5. Formulate designs for experiments.
6. Analyse and interpret practically, the data acquired in biological experiments, by using statistical
methods.

Module:1 Descriptive methods 5 hours

Frequency Distribution, Characteristics of a Frequency Distribution, Tabular and Graphical
Presentation of Data: Line Graphs, Bar Charts, Histograms

Module:2 Measures of central tendency 5 hours

Arithmetic Mean, Median, Mode, Selection of the Appropriate Measure of Central Tendency,
Geometric Mean, Harmonic Mean

Module:3 Measures of dispersion ‐ 3 hours

Range, quartile Deviation, Mean Deviation, Variance and Standard Deviation, Skewness and
Kurtosis.
 Module:4 Probability 3 hours

Probability Definition, Rules for Calculating Probabilities, Normal Distribution.

Module:5 Correlation and Regression 3 hours

Correlation , Karl Pearson correlation, Rank correlation, regression analysis

Module:6 Data analysis and interpretation 5 hours

Tests of hypothesis, Tests of significance, student’ s t- test, Non‐parametric test: chi‐square

test, Goodness of fit, Analysis of variance. F-test

Module:7 Experimental Design 3 hours

Designed Experiments ‐ Principles of experimental design, Blocking and Extraneous
Variables. Completely Randomized Design, Randomized block design

Module:8 Contemporary issues: 3 hours

Industrial Expert lecture

Total Lecture hours: 30 hours

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar

Text Book(s)
1. Wayne W. Daniel, Chad L. Cross,2012, 10th edition, Biostatistics: A Foundation for
Analysis in the Health Sciences, Wiley Sciences Publisher

Reference Books
1. Gupta S.P., 2010, 5th Edition, Statistical Methods, Sultan chand & Sons.
List of Challenging Experiments (Indicative)
2 Hours
1 Determination of frequency distribution for raw data for population

2 Hours
2 Estimation of mean ,median and mode

2 Hours
3 Estimation of SD
2 Hours
4 Estimation of variability

2 Hours
5 Estimation of correlation coefficient
2 Hours
6 Estimation of regression analysis
 2 Hours
7 Hypotesis testing

2 Hours
8 Chi-square test

2 Hours
9 Challenging research problems on t test

2 Hours
10 Challenging research problems on Estimation of one way ANOVA

2 Hours
11 Challenging research problems on Estimation of two way ANOVA
2 Hours
12 Challenging research problems on Designs of experiments

3 Hours
13 Challenging research problems on Determination of frequency distribution
for raw data for population
3 Hours
14 Challenging research problems on. Estimation of mean ,median and mode
Total Laboratory Hours 30 Hours
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar

Recommended by Board of Studies 03-08-2017

Approved by Academic Council No. 46 Date 24-08-2017
Course code Course title L T P J C
STS 4001 Essentials of Business Etiquette and problem solving 3 0 0 0 1
Pre-requisite None Syllabus version

Course Objectives:
 To develop the students’ logical thinking skills
 To learn the strategies of solving quantitative ability problems
 To enrich the verbal ability of the students
 To enhance critical thinking and innovative skills

Expected Course Outcome:

 Enabling students to use relevant aptitude and appropriate language to express themselves
 To communicate the message to the target audience clearly
 The students will be able to be proficient in solving quantitative aptitude and verbal ability
questions of various examinations effortlessly

Module:1 Business Etiquette: Social and Cultural 9 hours

Etiquette and Writing Company Blogs and
Internal Communications and Planning and
Writing press release and meeting notes

Value, Manners, Customs, Language, Tradition, Building a blog, Developing brand message,
FAQs', Assessing Competition, Open and objective Communication, Two way dialogue,
Understanding the audience, Identifying, Gathering Information, Analysis, Determining, selecting
plan, Progress check, Types of planning, Write a short, catchy headline, Get to the Point –
summarize your subject in the first paragraph., Body – Make it relevant to your audience,

Module:2 Study skills – Time management skills 3 hours

Prioritization, Procrastination, Scheduling, Multitasking, Monitoring, working under pressure and

adhering to deadlines
Module:3 Presentation skills – Preparing presentation 7 hours
and Organizing materials and Maintaining
and preparing visual aids and Dealing with
questions

10 Tips to prepare PowerPoint presentation, Outlining the content, Passing the Elevator Test, Blue
sky thinking, Introduction , body and conclusion, Use of Font, Use of Color, Strategic
presentation, Importance and types of visual aids, Animation to captivate your audience, Design of
posters, Setting out the ground rules, Dealing with interruptions, Staying in control of the
questions, Handling difficult questions

Module:4 Quantitative Ability -L1 – Number 11 hours

properties and Averages and Progressions
and Percentages and Ratios

Number of factors, Factorials, Remainder Theorem, Unit digit position, Tens digit position,
Averages, Weighted Average, Arithmetic Progression, Geometric Progression, Harmonic
Progression, Increase & Decrease or successive increase, Types of ratios and proportions

Module:5 Reasoning Ability-L1 – Analytical 8 hours

Reasoning

Data Arrangement (Linear and circular & Cross Variable Relationship), Blood Relations,
Ordering/ranking/grouping, Puzzle test, Selection Decision table

Module:6 Verbal Ability-L1 – Vocabulary Building 7 hours

Synonyms & Antonyms, One-word substitutes, Word Pairs, Spellings, Idioms, Sentence
completion, Analogies

Total Lecture hours: 45 hours

Reference Books
1. Kerry Patterson, Joseph Grenny, Ron McMillan, Al Switzler (2001) Crucial Conversations:
Tools for Talking When Stakes are High. Bangalore. McGraw‐Hill Contemporary
2. Dale Carnegie, (1936) How to Win Friends and Influence People. New York. Gallery
Books
3. Scott Peck. M (1978) Road Less Travelled. New York City. M. Scott Peck.
4. FACE (2016) Aptipedia Aptitude Encyclopedia. Delhi. Wiley publications
5. ETHNUS (2013) Aptimithra. Bangalore. McGraw-Hill Education Pvt. Ltd.
Websites:
1. www.chalkstreet.com
2. www.skillsyouneed.com
3. www.mindtools.com
4. www.thebalance.com
5. www.eguru.ooo
Mode of Evaluation: FAT, Assignments, Projects, Case studies, Role plays,
3 Assessments with Term End FAT (Computer Based Test)

Course code Course title L T P J C

STS 4002 Preparing for Industry 3 0 0 0 1
Pre-requisite None Syllabus version
1
Course  To challenge students to explore their problem-solving skills
Objectives:  To develop essential skills to tackle advance quantitative and verbal
ability questions
 To have working knowledge of communicating in English

Expected Course  Enabling students to simplify, evaluate, analyze and use functions and
Outcome: expressions to simulate real situations to be industry ready.
 The students will be able to interact confidently and use decision
making models effectively
 The students will be able to be proficient in solving quantitative
aptitude and verbal ability questions of various examinations
effortlessly

Module:1 Interview skills – Types of interview and Techniques toa 3 hours

face remote interviews and Mock Interview

Structured and unstructured interview orientation, Closed questions and hypothetical questions,
Interviewers' perspective, Questions to ask/not ask during an interview, Video interview¸
Recorded feedback, Phone interview preparation, Tips to customize preparation for personal
interview, Practice rounds

Module:2 Resume skills – Resume Template and Use of power 2 hours

verbs and Types of resume and Customizing resume
Structure of a standard resume, Content, color, font, Introduction to Power verbs and Write up,
Quiz on types of resume, Frequent mistakes in customizing resume, Layout - Understanding
different company's requirement, Digitizing career portfolio
Module:3 Emotional Intelligence - L1 – Transactional Analysis 12 hours
and Brain storming and Psychometric Analysis and
Rebus Puzzles/Problem Solving
Introduction, Contracting, ego states, Life positions, Individual Brainstorming, Group
Brainstorming, Stepladder Technique, Brain writing, Crawford's Slip writing approach, Reverse
brainstorming, Star bursting, Charlette procedure, Round robin brainstorming, Skill Test,
Personality Test, More than one answer, Unique ways

Module:4 Quantitative Ability-L3 – Permutation-Combinations 14 hours

and Probability and Geometry and mensuration and
Trigonometry and Logarithms and Functions and
Quadratic Equations and Set Theory
Counting, Grouping, Linear Arrangement, Circular Arrangements, Conditional Probability,
Independent and Dependent Events, Properties of Polygon, 2D & 3D Figures, Area & Volumes,
Heights and distances, Simple trigonometric functions, Introduction to logarithms, Basic rules of
logarithms, Introduction to functions, Basic rules of functions, Understanding Quadratic
Equations, Rules & probabilities of Quadratic Equations, Basic concepts of Venn Diagram

Module:5 Reasoning ability-L3 – Logical reasoning and Data 7 hours

Analysis and Interpretation

Syllogisms, Binary logic, Sequential output tracing, Crypto arithmetic, Data Sufficiency, Data
interpretation-Advanced, Interpretation tables, pie charts & bar chats

Module:6 Verbal Ability-L3 – Comprehension and Logic 7 hours

Reading comprehension, Para Jumbles, Critical Reasoning (a) Premise and Conclusion, (b)
Assumption & Inference, (c) Strengthening & Weakening an Argument

Total Lecture hours: 45 hours

References Michael Farra and JIST Editors(2011) Quick Resume & Cover Letter
Book: Write and Use an Effective Resume in Just One Day. Saint
Paul, Minnesota. Jist Works
 Daniel Flage Ph.D(2003) The Art of Questioning: An Introduction to
Critical Thinking. London. Pearson
 FACE(2016) Aptipedia Aptitude Encyclopedia.Delhi. Wiley
publications
Mode of Evaluation: FAT, Assignments, Projects, Case studies, Role plays,
3 Assessments with Term End FAT (Computer Based Test)
 RES5001 Research Methodology L T P J C

2 0 0 0 2

Pre-requisite Nil Syllabus version

v. 1.0
Course Objectives:
1. Impart skills to develop a research topic and design
2. Define a purpose statement, a research question or hypothesis, and a research objective
3. Analyze the data and arrive at a valid conclusion
4. Compile and present research findings
Expected Course Outcome:
1. Explain the basic aspects of research and its ethics
2. Outline research problems, their types and objectives
3. Formulate good research designs and carry out statistically relevant sampling
4. Collect, collate, analyze and interpret data systematically.
5. Experiment with animals ethically
6. Make use of literature and other search engines judiciously for research purposes

Module:1 Introduction and Foundation of Research 2 hours

Meaning, Objectives, Motivation, Utility for research. Concept of theory, empiricism, deductive
and inductive theory. Characteristics of scientific method –Understanding the language of
research.

Module:2 Problem identification and formulation 4 hours

Scientific Research: Problem, Definition, Objectives, Types, Purposes and components of

Research problem
 Module:3 Research Design 4 hours

Concept and Importance in Research : Features of a good research design, Exploratory

Research Design and Descriptive Research Designs

Module:4 Sampling 6 hours

Sampling methods, Merits and Demerits. Observation methods, Sampling Errors (Type I and
Type II). Determining size of the sample. Experimental Design: Concept of Independent &
Dependent variables.

Module:5 Data analysis and Reporting 6 hours

Fundamentals of Statistical Analysis and Inference, Multivariate methods, Concepts of

Correlation and Regression; Research Reports: Structure, Components, Types and Layout of
Research report and articles, Writing and interpreting research results, Figures and Graphs

Module:6 Animal handling 2 hours

guidelines-animal ethical committee, animal models, various routes of drug administrations,
LD50, ED50

Module:7 Use of encyclopedias and tools in research 4 hours

Research Guides, Handbook, Academic Databases for Biological Science Discipline.

Methods to search required information effectively.

Module:8 Contemporary issues: 2 hours

Total Lecture hours: 30 hours

Text Book(s)
1. Catherine Dawson, Introduction to research methods : a practical guide for anyone
undertaking a research project, Oxford : How To Books, Reprint 2010

2. Julius S. Bendat, Allan G. Piersol, Random Data: Analysis and Measurement Procedures, 4th
Edition, ISBN: 978-1-118-21082-6, 640 pages, September 2011
3. Research in Medical and Biological Sciences, 1st Edition, From Planning and Preparation to
Grant Application and Publication, Editos: Petter Laake Haakon Benestad Bjorn Olsen,
ISBN: 9780128001547, Academic Press, March 2015
Reference Books
1. John Creswell, Research Design: Qualitative, Quantitative, and Mixed Methods
Approaches, Fourth Edition (March 14, 2013)
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies 03.08.2017
Approved by Academic Council No.46 Date 24-08-2017
 Course Code Title L T P J C
MSM6099 Master’s Thesis 0 0 0 0 14
Pre-requisite As per the academic regulations Syllabus version
1.0
Course Objectives:
To provide sufficient hands-on learning experience related to the area of specialization with a
focus on research orientation

Expected Course Outcome:

1. Formulate specific problem statements for ill-defined real life problems with reasonable
assumptions and constraints.
2. Perform literature search and / or patent search in the area of interest.
3. Design and Conduct experiments
4. Perform error analysis / benchmarking / costing
5. Synthesise the results and arrive at scientific conclusions
6. Document the results in the form of technical report / presentation

Contents
1. Can be a theoretical analysis, modeling & simulation, experimentation & analysis,
prototype design, correlation and analysis of data, software development, applied research
and any other related activities.

2. Project can be for one or two semesters based on the completion of required number of
credits as per the academic regulations.

3. Should be individual work.

4. Carried out inside or outside the university, in any relevant industry or research institution.
 5. Publications in the peer reviewed journals / International Conferences will be an added
advantage

Mode of Evaluation: Periodic reviews, Presentation, Final oral viva, Poster submission
Recommended by Board of Studies 04.03.2016
Approved by Academic Council 40th AC Date 18.03.2016

Course Code Title L T P J C

BMG5001 BIOCHEMISTRY 3 0 2 0 4
Pre-requisite NIL Syllabus version
1.1

Course objectives (CoB):

1. Able to demonstrate fundamental biochemical principles, such as the structure/function of
biomolecules and the regulation of biological/biochemical processes
2. Define the major pathways of intermediary metabolism of biomolecules, and discuss their
bioenergetics, physiological adaptation, metabolic and main hormonal regulation, localization
and cellular compartmentalization.
3. Correlate the metabolic activity of molecules with their function

Expected Course Outcomes (CO):

1. Demonstrate an understanding of the chemistry, structure and function of biological molecules
2. Explain biological mechanisms, such as the processes and control of bioenergetics and
metabolism, as chemical reactions
3. Solve the biochemical processes that underlie the relationship between proteins and other
macromolecules
4. Discuss how disruptions in intermediary metabolism may lead to disease, and illustrate with
selected examples
5. Build an ability to employ critical thinking and scientific inquiry
6. Demonstrate critical thinking skills to solve problems relating to chemistry and/or Biochemistry

Module:1 Carbohydrates 6 hours

Classification, structure, properties and function; Aminoacids -classification, structure and function.
Abnormalities of carbohydrate metabolism

Module:2 Proteins 6 hours

Classification, Structure, properties and function; Protein metabolism, Higher orders of structure;
Myoglobin and Hemoglobin

Module:3 Lipids 6 hours

Classification, structure and function; Fatty acid biosynthesis, oxidation, cholesterol biosynthesis
Nucleotides–classification, structure and function

Module:4 Catabolism of carbohydrates 7 hours

Glycolysis, TCA cycle Oxidative phosphorylation, HMP-shunt, gluconeogenesis. glycogenesis,
Glycogenolysis

Module:5 Aminoacid metabolism 6 hours

Essential aminoacid, sources, Biosynthesis of nonessential amino acids, Urea cycle

Module:6 Metabolism of purines and pyrimidines 6 hours

Denovo and salvage pathway of biosynthesis and break down of purines and pyrimidines.

Module:7 Energy metabolism 6 hours

Biological oxidation, high energy compounds, electron transport chain and oxidative
phosphorylation.

Module:8 Contemporary issues: 2 hours

Industry expert lecture

Total Lecture hours: 45 hours

Mode of Evaluation: Digital Assignments, Continuous Assessment Tests
and Final assessment test.
Text Book(s)
1. Nelson, D.L. and M.M.Cox.. Lehninger’s Principles of Biochemistry, 2011,SixthEdition,
WH Freeman, New York.
2 Victor W. Rodwell (Author), David Bender (Author), Kathleen M. Botham (Author), Peter J.
Kennelly. 2011. Harpers Illustrated Biochemistry, 30th Edition, McGraw-Hill companies,
Inc. USA
Reference Books
1. Christopher K. Mathews (Author), Kensal E. Van Holde (Author), Dean R. Appling (Author),
Spencer J. Anthony-Cahill (Author). 2012. Biochemistry, 4th Edition. Prentice
List of Challenging Experiments
1. Estimation of blood glucose 2 Hours
2. Estimation of blood cholesterol 2 Hours

3. Estimation of uric acid in blood 2 Hours

4. Estimation of Urea 4 Hours

5. Estimation of serum total protein 4 Hours

6 Estimation of DNA 2 Hours

7 Leukocyte isolation from peripheral blood 2 Hours

 8 Estimation of Arylsulphatase activity from the isolated leukocytes 4 Hours

9 Isolation of Glycosaminoglycans (GAGs) from Urine. 4 Hours

10 Thin layer chromatography of the isolated GAG 4 Hours

Total Laboratory Hours 30 hours

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

Course code Course title L T P J C

BMG5002 PRINCIPLES OF GENETICS 3 0 0 0 3
Pre-requisite NIL Syllabus version
1.1

Course Objectives (CoB):

The course is aimed
1. To compare the fundamental principles of classical and molecular genetics.
2. To summarize the basics of Mendelian and molecular genetics.
3. To interpret the basic mathematical principles relevant to genetics.

Expected Course Outcome (CO):

1. Apply the knowledge to learn the concepts of genetics at the molecular, microbial and
societal level.
2. Summarize the different heredity patterns and family history importance for heredity risks.
3. Outline the genomic structure, how DNA, genes, and chromosomes are related to one another
and how genetic changes are connected to genetic diseases.
4. Compare the relationship between phenotype and genotype in human genetic traits.
5. Make use of the scientific method to generate new knowledge and to solve problems,
regarding human heredity.
6. Relate real-life situations and one’s life the principles of human heredity

Module:1 Mendelian Genetics 9 hours

Mendel’s experiments, monohybrid and dihybrid crosses, back cross, test cross, genetic ratios,
Molecular basis of Mendelian genetics, Mendelian Inheritance, Law of Segregation, Independent
Assortment. Epistasis, Incomplete dominance, Multiple alleles, Lethal genes.

Module:2 Non-Mendelian inheritance 4 hours

Patterns of Inheritance- Non-Mendelian inheritance. Human Genetics - Inheritance patterns and
Pedigrees. Pedigree symbols and analysis.

Module:3 Genome Organization 8 hours

Eukaryotic genome structure and function – Chromosomal theory, the topography of the
chromosomes set, Chromosome number, size, centromeres, the position of nucleolar organizers.
Heterochromatinpatterns,the 3-Dstructureof t h e chromosome, role of his toneprotein in packaging
sequence, organization, repetitive sequences. Mitosis and Meiosis, Comparison with the prokaryotic
genome.

Module:4 Linkage and Mapping 6 hours

Linkage and chromosome mapping: Linkage and recombination, linkage maps, linkage mapping with
molecular markers.DNA testing, DNA tests for identity and relationships including forensic
applications.

Module:5 Microbial Genetics 4 hours

DNA as a genetic material – experiments of Griffith, Hershey, Chase, and Mcleod. Gene transfer in
Bacteria, Bacterial conjugation – fertility factor, HFR strain, interrupted mating experiments.

Module:6 Molecular mechanism of bacterial gene 4 hours

mapping
Transformation. Transduction – specialized transduction, generalized transduction and chromosome
mapping.

Module:7 PopulationGeneticsand Behavioural 8 hours

Genetics
Hardy – Weinberg law, Factors affecting Hardy-Weinberg law: mutation, recombination,migration,
assortative mating, and selection. Non-random mating in the human population, inbreeding coefficient.
Behavioural Genetics- Behaviour and genome, Genes and criminality, Intelligence, genes and the
environment. Molecular research in intelligence.

Module:8 Contemporary issues: 2 hours

Lecture by Industrial Expert

Total Lecture hours: 45 hours

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar

Text Book(s)
1. Griffiths AJF, Wessler SR, Lewontin RC and Carroll SB (2015). An Introduction to genetic
analysis. 11th ed. W.H Freeman.
Reference Books
1. David L. Rimoin, Reed E. Pyeritz, Bruce Korf (2013). Emery and Rimoin's Essential Medical
Genetics. Elsevier
2. Hartl, D.L. et al. (2012). Genetics: Analysis of Genes and Genomes, 8th ed., Jones
and Bartlett Publishers.
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017
 Course code Course title L T P J C
BMG5003 HUMAN IMMUNOLOGY 3 0 0 0 3
Pre-requisite NIL Syllabus version
1.1
Course Objectives (CoB):
1. Differentiate the function the various cells and tissues of the human immune system.
2. Compare the physiological and pathological functions of the immune system in disease andorgan
transplantation.
3. Evaluate how the components of immune system work together to achieve a state of health and well
being

Expected Course Outcome (CO):

1. Explain the foundation of the defense mechanisms of the human body.
2. Distinguish various cell types involved in immune responses and their associated functions.
3. Describe and discuss the basis of complex genetic events that contribute to immunological responses
4. Interpret and examine the pathobiology of infections, and the interaction of pathogens with the
immune system
5. Demonstrate a comprehensive understanding of basic immunological principles involved in host
graft compatibility and other immune disorders.
6. Translate the basic knowledge of the immune system to further appraise and develop understanding
of medicine (vaccines) and related research topics in human immunology.
Module: 1 Introduction to Immunology 6 hours
Overview of Immune system. Cells and organs of the immune system. Basic Principles of Immunity,
Immunogens and antigens, Immunoglobulin classes, structure and function.

Module: 2 Organization and expression of 6 hours

Immunoglobulin genes
Multigene organization of immunoglobulin genes, variable and constant region genes, generating
antibody diversity, class switching among constant region genes.

Module: 3 General organization and inheritance of MHC 6 hours

MHC molecules and genes, cellular distribution of MHC, regulation of MHC expression.

Module: 4 Immunohaematology & Immunity in Health & 8 hours

Disease
Blood group system; ABO blood groups, Genetics of ABO blood groups and Rh factor, Rh
Incompatibility. Immune response to infectious diseases, AIDS and other Immunodeficiencies. Primary
and secondary deficiencies, Inherited Immunodeficiency diseases.

Module: 5 Transplantation 6 hours

Types of grafts, Immunological basis of graft rejection, Clinical manifestation of graft rejection, graft
versus host reaction.
Module:6 Hypersensitivity 6 hours
Overview and Types. Autoimmunity-Organ specific and systemic autoimmune diseases. Tumor
Immunology- Tumor antigens, immune response to tumor antigens and tumor immunotherapy.

Module:7 Vaccines 5 hours

Vaccine types, recent developments in vaccine production, vaccine failures, challenges in vaccine
production. Human monoclonal antibodies, Monoclonal antibodies production and their applications.

Module: 8 Contemporary issues: 2 hours

Latest advances in immunology. (By Industry experts).
Total Lecture hours: 45 hours
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Text Book(s)
1 Abbas, Abul K., Andrew Lichtman and Pillai. Cellular and Molecular Immunology.2014, 8th
.
ed. Philadelphia, PA: Saunders,. ISBN: 978032322275
2 Peter Parham. The Immune System. 4th Ed Garland Science. Taylor and Francis. 2014.
 ISBN 9780815345275

Reference Books
1 Lauren Sompayrac. How the Immune System Works, 5th Edition, Wiley Blackwell, 2016,
.
ISBN-13:978-1118997772.
2 Kenneth Murphy. Janeway’s Immunobiology. 8th New York, Garland Science, 2011. ISBN:
9780815342434

Mode of Evaluation: CAT / FAT / Assignment

Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

Course code Course title L T PJ C

BMG 6002 CLINICAL CYTOGENETICS AND PRENATAL 2 0 2 4 4

DIAGNOSIS
Pre-requisite Principles of Genetics Syllabus version

1.1
Course Objectives:
1. To analyze the cause of human genetic disorders using different cytogenetic techniques.
2. To illustrate the importance of prenatal diagnosis and genetic testing.
3. To elaborate on the ethical issues in clinical genetics research and genetic counseling

Expected Course Outcome:

1. Have knowledge on the application of the cytogenetic techniques for clinical
classification of the genetic disorders.
2. Analyze the cause of genetic disorders.
3. Relate the importance of new genetics with clinical practice
4. Translate various aspects of genetic knowledge to society.
5. Design /develop an idea for identifying the cause or solution for the genetic disorder
6. Identify the cause and interpret the clinical conditions

Module:1 Cytogenetics Technology and Nomenclature 5 hours

An international system for human cytogenetic nomenclature, cytogenetic technology,
Differential and selective banding techniques, high-resolution banding. Chromosome mapping -
somatic cell hybridization, FISH technique, and its clinical application. The techniques: CGH,
CGH array, M- FISH and their applications. Microscopy (Light, TEM, SEM) and imaging,
computer-assisted image processing systems, flow cytometer, PCC.
Module:2 Aneuploidy in Human 4 hours
Abnormalities of Chromosome Number- polyploidy, aneuploidy. Clinical cases of Aneuploidy –
Autosomal aneuploid syndromes- trisomy 21, trisomy 18, trisomy 13. Sex chromosome aneuploid
syndromes- Turner, Klinefelter, Triple X, XYY. Factors causing aneuploidy, non-disjunction, X
inactivation.

Module:3 Structural chromosomal aberrations in Human 5 hours

Types of structural chromosomal aberrations - Duplication, deletion, translocation, reciprocal

translocation, Robertsonian translocation, microdeletion, ring chromosome, inversion,
isochromosome. Clinical cases.

Module:4 Genomic Imprinting 4 hours

The imprinting phenomenon and its genetic syndromes. Uniparental disomy (UPD).

Module:5 Prenatal diagnosis 4 hours

Chromosome Abnormalities and Pregnancy Loss, prenatal diagnosis techniques - amniocentesis,
chorionic villus sampling, cordocentesis. Non-invasive techniques. Preimplantation genetic
diagnosis and in vitro fertilization

Module:6 Genetic counseling 3 hours

Population screening, carrier detection and genetic counseling. Types of Genetic counseling,
Genetic testing, consanguinity in the human population.

Module:7 Genetics and Society, Ethical issues in Genetic 3 hours

research
Future of genetics: Science & society. Ethical issues and related problems. The application of new
genetics to clinical practice, Bioethics and human population genetic research, Reproductive rights

Module:8 Contemporary issues: 2 hours

Industry expert lecture

Total Lecture hours: 30 hours

Text Book(s)
1. Lynn Jorde, John Carey, and Michael Bamshad (2015) Medical Genetics, 5th Edition,
Elsevier
Reference Books
1. David L. Rimoin, Reed E. Pyeritz, Bruce Korf (2013). Emery and Rimoin's Essential
Medical Genetics Elsevier
2. Emery, A.E.H. and Rimoin, D.L. (2010). Principles and Practices of Medical Genetics.
Churchill Livingstone.
3. Peter Turnpenny, and Sian Ellard (2010) Emery's Elements of Medical Genetics, 14th edition
ISBN 0702029173 / 9780702029172 Churchill Livingstone.
4. ICMR Guidelines-Ethics, Prenatal diagnosis

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar

List of Challenging Experiments (Indicative)
1. Laboratory Safety and Microscopy for Cytogenetic study. 2 hours
2. Human Leukocyte Culture. 4 hours
3. Chromosomes staining and identification. 4 hours
4. Human chromosome karyotyping. 4 hours
5. Different Banding Techniques 4 hours
6. Pedigree Analysis. 4 hours
7. Use of Karyotyping software. 4 hours
8. Cytogenetic test report 4 hours
Total Laboratory Hours 30 hours
Mode of Evaluation: CAT / FAT / Assignment
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

Course code Course title L T P J C

BMG 5004 HUMAN MOLECULAR GENETICS 3 0 0 0 3
Pre-requisite NIL Syllabus
version
1.1
Course Objectives:
1. The objective of this course is to introduce the graduates of biological sciences to the principle
of molecular genetics and its application in medicine.
2. Familiarization of students with the experimental approaches used in molecular biology.
3. The student will acquire knowledge, how natural polymorphism and genetic variation can give
rise to mutant genes and how these genetic errors are inherited.
Expected Course Outcome:
1. Apply logical analysis in the assessment of relationship between the human molecular genetics
and modern medicine.

2. Attain a basic conceptual knowledge how gene expression is regulated at different levels, how
tissue-specific expression is achieved and exemplify how gene expression can be manipulated
and studied experimentally

3. Explain concepts such as gene control element and DNA repair defects.

4. Will be able to critically think, analyse and evaluate issues related to molecular genetics
5. Describe the importance of recent discoveries and the applications and potential of molecular
biology associated with these new technologies.

6. Apply the principles and techniques of molecular biology which prepares students for further
education and/or employment in teaching and basic research.

Module:1 General organization of the human genome 7 hours

Organization of nuclear and mitochondrial genomes; Distribution of human genes - Coding
and Non coding genes. Repetitive DNA with special reference to satellite DNAs and
interspersed repeated DNAs, Transposable elements, LINES, SINES, Alu family and their
importance in
human genome

Module:2 Transcription 4 hours

Initiation, regulation of initiation, elongation and termination, post transcriptional modification.

Module:3 Translation 5 hours

Amino acid activation, mechanism of initiation, elongation, termination and post
translation
Modification

Module:4 Control of gene expression in human cells 6 hours

Control of gene expression by binding of trans-acting protein factors to cis-acting regulatory
sequences in DNA and RNA. DNA repair mechanism. DNA repair defects and the underlying
diseases

Module:5 Dynamics of Repeat sequences 7 hours

Genetic mechanisms which results in sequence exchanges between repeats. Pathogenic
mutations, the pathogenic potential of repeated sequences. Simple mutation, Gain of
function
(GOFA) and loss of function mutation (LOFA) and their association with different inherited
human disorder

Module:6 Genes and diseases 6 hours

Principles and strategies in identifying disease genes, position- independent strategies for
identifying disease genes, positional cloning. Applications of mapping in normal and disease
genome analysis

Module:7 Human genome project 8 hours

The ground – breaking importance of genome projects. Background and organization of

the Human Genome Project, how the human genome was mapped and sequenced.
Advances in sequencing technology, Genetic mapping: Linkage analysis (RFLP/MS/SNP);
Applications of mapping in normal and disease genome analysis.

Module:8 Contemporary issues: 2 hours

Expert lectures from Industry or Hospitals

Total Lecture hours: 45 hours

 Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar

Text Book(s)
1. Tom Strachan and Andrew P. Read. John, Human Molecular Genetics, 2010, 4th Edition.
Garland Publishing London and New York
Reference Books
1. T A Brown , Introduction to Genetics: A Molecular Approach, 2012, Garland Science
publisher
2. Tom Trachan, Human Molecular Genetics by , Andrew Read , (2010), 4th edition, Garland
and Science publisher

Mode of Evaluation: CAT / FAT / Assignment

Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

Course code Course title LT P J C

BMG5007 DEVELOPMENTAL GENETICS 30 0 0 3

Pre-requisite NIL Syllabus version

1.1
Course Objectives (CoB):
1. This advanced course concerns the genes and mechanisms responsible for building
multicellular organisms.
2. To impart knowledge regarding basic concepts of differentiation and growth, differential gene
expression as well as cytoplasmic determinants to the students.

3. To introduce students to the developmental processes that lead to the establishment of the body
plan of vertebrates and the corresponding cellular and genetic mechanisms.

Expected Course Outcome (CO):

At the end of the course the student should be able to
1. Discuss the critical contributions of the sperm and the egg to the zygote, and how structure
informs function.
2. Apply critical thinking and logical analysis in assessment of embryonic developmental events
including fate map, germ layers development, extra-embryonic membranes, embryo implantation
and significance of placental formation
3. Attain a basic conceptual knowledge how gene expression is regulated at different levels, how
tissue-specific expression is achieved and exemplify how gene expression can be manipulated
and studied experimentally
4. Describe experiments that would help to distinguish between when a cell has become specified
 and when its fate has become determined.
5. Explain and compare different principles of sex determination occurs during embryo
development and
6. Students aware about modern implications of developmental biology by impaired knowledge
regarding teratogens.
Module:1 Germ line 5 hours
Germ plasm and determination of the primordial germ cells, Germ cell migration, Structure of the
Gametes.
Module:2 Early embryonic development 6 hours
Recognition of egg and sperm, Gamete fusion and the prevention of polyspermy, Activation of
egg metabolism, Fusion of the genetic material

Module:3 Cleavage and Gastrulation 5 hours

Patterns of embryonic cleavage, Cleavage and gastrulation in amphibians. Cleavage and
gastrulation in humans, molecular mechanism of cleavage.

Module:4 The genetic core of development 7 hours

Differential gene transcription, methylation pattern and the control of transcription.
Transcriptional regulation of an entire chromosome: Dosage compensation. Differential RNA
processing, control of gene expression at the level of translation.

Module:5 The genetics of axis specification in 6 hours

Drosophila
Embryogenesis in Drosophila, Early Drosophila development, genes involved in origins of
anterior- posterior polarity and dorsal-ventral polarity.

Module:6 Cell differentiation and late embryonic 8 hours

development
Basic principles – Cell fate, fate map, developmental hierarchy, autonomous, conditional and
syncytial specification. Mechanisms of cellular determination (endocrine, paracrine, juxtacrine),
Neurulation, Myogenesis and tetrapod limb development

Module:7 Sex determination, Environmental regulation 6 hours

of animal development
Chromosomal sex determination in mammals, Chromosomal Sex determination in Drosophila,
Environmental sex determination. Environmental regulation of normal development,
Environmental disruption of normal development.

Module:8 Contemporary issues: 2 hours

Expert Lecture from industry or hospitals

Total Lecture hours: 45 hours

Text Book(s)
1. Scott F.Gilbert (2013) Developmental Biology, 10th edition, Sinauer Associates, Inc,
Publishers.
Reference Books
1. Lewis Wolpert, Cheryll Tickle, Alfonso Martinez Arias, Principles of Development , 2015,
5th edition, Oxford University Press.
 2. Jonathan M. W. Slack , Essential Developmental Biology, 2012, 3rd Edition, Wiley-
Blackwell publisher.
3. Sally Moody , Principles of Developmental Genetics , 2014. 2nd Edition, Academic
Press
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar

Recommended by Board of Studies 03-08-2017

Approved by Academic Council No. 46 Date 24-08-2017

Course code Course title LT P J C

BMG 5008 CANCER GENETICS 3 0 0 0 3

Pre-requisite NIL Syllabus version
1.1
Course Objectives (CoB):
1. To outline the genetic basic of cancer
2. To explain the mechanism of carcinogenesis and metastatic process
3. To define the genetic instability, involvement of cancer stem cells and treatment strategies for
cancer

Expected Course Outcome (CO):

1. Summarize the molecular basis of cancer
2. Relate the oncogene activation, tumor suppressor gene inactivation and cell cycle dysregulation
in carcinogenesis
3. Discuss how the cancer cells evade apoptosis
4. Extend their knowledge in signaling pathways, angiogenesis and metastasis processes
5. Explain the stem cell theory of cancer, origin of cancer stem cells
6. Relate the signaling pathways with the diagnostic methods and treatment approaches for cancer
Module:1 Hall marks of cancer 6 hours CO: 1
Cancer gene theory- activation and suppression, cancer and mutagenesis. Causes for onset of
genetic variation and cancer genes and alterations. Viruses (as causative agents).
Module:2 Oncogene activation, Tumour suppressor 6 hours CO: 2
gene inactivation and Cell cycle Dysregulation
Activated oncogene, Tumour suppressor gene inactivation and cancer gene pathways. Cell cycle
dysregulation – Cancer gene pathways converge on cell cycle regulators, Cyclins and cyclin-
dependent kinases; Cell Cycle Checkpoints (deficient)

Module:3 Evading Apoptosis and Telomere 6 hours CO: 3

dysregulation
Inactivation of apoptotic pathways, caspases Bcl-2 Protein Family; IAPs; Endogenous inhibitors
of IAPs. Telomeres, Hayflick limit, Telomerase Activation and Immortality, Alternative
Lengthening of Telomere (ALT) pathway in cancer.

Module:4 Angiogenesis and Metastasis 6 hours CO: 4

Angiogenesis – Angiogenesis, mechanism and role in tumour; Metastasis – Overview of
metastasis – Seed and soil theory and beyond; epithelial to mesenchymal transition, signalling
pathways in metastasis.

Module:5 Genetic Instability and cancer 6 hours CO: 5

Chromosomal Instability (CIN), Microsatellite Instability (MSI), DNA repair dysregulation and
genomic instability in cancer. Epigenetics- DNA methylation, histone covalent modifications and
their interplay in normal and cancer cells, An epigenetic role of RNA in cancer. Cancer
susceptibility syndromes.

Module:6 Cancer stem cells 6 hours CO: 5

The stem cell theory of cancer, origin of cancer stem cells, markers of cancer stem cells.

Module:7 Cancer Diagnosis, Cancer genetics and 7 hours CO: 6

therapeutics
Conventional and new diagnostic techniques, molecular screening and detection. Conventional
therapy, Gene therapy, Immunotherapy, Hormone therapy, multi-targeted therapy (allele-specific,
antibody-mediated inhibition of RTKs, personalized cancer therapy), patient-derived xenografts
(PDXs), clonal evolution and cancer resistance.
Module:8 Contemporary issues 2 hours
Industrial Expert lecture
Total Lecture hours: 45 hours
Text Book(s)
1. Robert Weinberg, The Biology of Cancer, 2013, 2nd Edition –. Edition– 2nd
ISBN:9780815342205, Garland science publishers.
Reference Books
1. Bunz, Fred , Principles of Cancer Genetics., 2015, 2nd edition, Springer
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017
 Course code Course title L T P J C

BMG 5005 HUMAN ANATOMY AND PHYSIOLOGY 2 0 0 4 3

Pre-requisite NIL Syllabus version
1.1
Course Objectives (CoB):
1. To make the students to learn the anatomical and medical terminology.
2. To Understand the functions of different organ systems in the human body.
3. To understand the physiological basis for the diseases and treatment.

Expected Course Outcome (CO):

1. Familiar with the medical terminology and discuss with health professionals.
2. Describe the functions of blood.
3. Acquire knowledge about digestive and excretory systems.
4. Compare the functioning of endocrine and reproductive systems
5. Relate the mechanics of respiratory and cardiovascular systems
6. Attain a basic conceptual knowledge of brain and nervous system.

Module:1 Basic Anatomy & Concepts of systems in 3 hours

human body
Anatomical terminology, RBC, WBC and platelets. ABO Blood grouping.

Module:2 Nervous system 4 hours

Structure and classification of nervous. reflex action. Parts of the brain, CSF.

Module:3 Digestive systems 4 hours

Structure of alimentary canal, secretions in digestive tract, digestion and absorption of food
materials, functions of liver.

Module:4 Excretory systems 4 hours

Structure of the kidney, formation of urine, functions of the kidneys.

Module:5 Endocrine 3 hours

Concepts of endocrine organs and hormones, types of hormones

Module:6 Reproductive system 5 hours

Structure of reproductive organs of male and female, Sex hormones and their functions.

Module:7 Circulatory systems and Respiratory system 5 hours

Structure of heart, circulation through arteries, capillaries and veins, factors maintaining B.P.,
ECG, Structure of respiratory tract, gaseous exchange in the lungs, mechanics of respiration, lung
volumes.

Module:8 Contemporary issues: 2 hours

Industry Expert Lecture

Total Lecture hours: 30 hours

Text Book(s)
1. Ross and Wilson Anatomy and Physiology in Health and Illness: Janet S. Ross, Kathleen J
W Wilson, Anne Waugh,Allison Grant: Books, 12th Edition, 2014, IRL press (Oxford
University press, USA)
Principles of Anatomy and Physiology by Gerard J. Tortora, John Wiley & Sons; 14th
2.
Edition edition (2014)
Reference Books
1. Frederic H. Martini, Judi L. Nath, Edwin F. Bartholomew , Fundamentals of Anatomy &
Physiology, 2012, 10 Edition, Pearson Publishers.
2. Elaine N. Marieb , Human Anatomy & Physiology, 2014, Pearson Publishers.

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar

Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017
Course code Course title L T P J C

BMG 5006 Advanced Analytical Techniques 3 0 0 0 3

Pre-requisite Nil Syllabus version
1.1
Course Objectives (CoB):
1. To recall methods of solution preparation and buffer concepts.
2. To explaining the principle, instrumentation and applications of different analytical instruments
3. To make use of analytical instruments for estimation of biomolecules

Expected Course Outcome (CO):

1. Define the concepts of solution formulations.
2. Explain the principle behind different instrumental methods of analyses.
3. Relate the instrumental parts with their specific roles.
4. Discuss the role of these instruments in applications related to molecular analyses.
5. Select the correct technique for specific biomolecular evaluations.
6. Experiment with different instruments for molecular separations and estimations.

Module:1 Electrochemical Techniques 6 hours

Buffers, importance of pH, Dissociation constant HH equations, Electro chemical cells; Clark
oxygen electrode; biosensors- types and applications.

Module:2 Centrifugation 6 hours

Basic principle of sedimentation, centrifugation techniques, types of centrifuges and their uses.

Module:3 Chromatographic Techniques 6 hours

Adsorption and partition chromatography-column, thin layer, paper, ion-exchange, Affinity and
Gas Chromatography; High performance liquid chromatography (HPLC) and HPTLC.

Module:4 Microscopy 6 hours

 Basic principles of microscopy, types of microscopy, light microscope, dark field microscopy,
fluorescence microscopy, concepts of electron microscopy (EM), types of EM, SEM, TEM.

Module:5 Immunochemical Techniques 6 hours

Principles and applications of immunodiffusion, immunoelectrophoresis, RIA, ELISA, avidin-
biotin assays, immunofluorescence, western blotting for identifying protein and antibody.

Module:6 Spectroscopic techniques 6 hours

Theory and application of UV-VIS, IR, NMR, MS, Fluorescence, Atomic absorption
spectroscopy and X-ray diffraction.

Module:7 Radio isotopic techniques 7 hours

Introduction to radioisotopes, their uses, radioactive counters, autoradiography, Positron Emission
Tomography (PET). Safety aspects of radioactivity.
Electrophoretic techniques: Isoelectric focussing, agarose gel electrophoresis, 2-dimensional gel
electrophoresis, 3-dimensional gel electrophoresis, PAGE.

Module:8 Contemporary issues: Industrial Expert 2 hours

Lecture
Total Lecture hours: 45 hours

Text Book(s)
1. 1.Wilson.K and Walker 2010. Principles and Techniques of Practical Biochemistry, 7th edition
Cambridge, University Press, London.
Reference Books
1. 1. Sawhney, S.K. and Singh R.( 2010) Introductory practical biochemistry, Narosa Publisher
2. Wilson and Goulding (2010). A Biological guide to principles and techniques of practical
biochemistry.
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies 3. 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017
 Course code Course title L T P J C
BMG5009 GENETICS OF HUMAN INFERTILITY 2 0 0 4 3
Pre-requisite NIL Syllabus version
1.1
Course Objectives (CoB):
1. To outline about human fertility, infertility, and associated genetic disorders.
2. To relate the causes and etiology of reproductive genetic disorders
3. To develop knowledge about the different types of assisted reproductive technologies in infertility
treatment.

Expected Course Outcome (CO):

1. Infer the Embryonic development of the reproductive system.
2. Relate that certain reproductive hormones, conditions or diseases can have genetic causes.
3. Classify the types of male and female infertility disorders in human.

4. Summarize the role of prenatal screening and testing in pregnancy management and care and the
options available when a fetal abnormality is detected.

5. Utilize the applications of assisted reproductive technologies in infertility treatment.

6. Explain how reproductive genetic diseases influence both individual and family as a society.

Module:1 Human Reproductive System 5 hours

Embryonic development of the female and male reproductive system, Reproductive system of
women and men, Oogenesis, Spermatogenesis.

Module:2 Reproductive Hormones 4 hours

Reproductive hormones- Estrogen, Follicle Stimulating Hormone, Gonadotropin-Releasing
Hormone, Human Chorionic Gonadotropin Hormone, Luteinizing Hormone, Oxytocin,
Progesterone, Prolactin, Testosterone.
Module:3 Female infertility 5 hours
The Genetics and types of female Infertility, amenorrhea, abnormal uterine bleeding, reproductive
tract abnormalities (acquired and developmental), androgen disorders, recurrent abortion, fertility
after cancer treatment.

Module:4 Male infertility 4 hours

The Genetics and types of male Infertility, meiotic errors, and male infertility, environmental
influences on male infertility, cryptorchidism. Clinical evaluation of male infertility, Y-
Chromosome microdeletions.

Module:5 Application of Assisted Reproductive 4 hours

Technologies in Infertility
Diagnosis- Prenatal diagnosis- amniocentesis, chorionic villus sampling, Preimplantation Genetic
Diagnosis (PGD). Treatment – Assisted Reproductive Technologies (ART) –IVF, ICSI, GIFT and
ZIFT, Recent advances in Artificial Reproductive Techniques.

Module:6 Reproductive Genetic counseling 4 hours

When and who can utilize Prenatal diagnosis, Sperm count management, Prenatal Testing &
Eugenics. Ethical dilemmas in PGD and ART. Preconception and prenatal assessment of genetic
risk and counseling.

Module:7 Socioeconomic problems 2 hours

Usefulness of genetic tests and their risks, benefits, and impact on society. Socioeconomic
problems, the status of infertility in developed and developing countries.

Module:8 Contemporary issues: 2 hours

Industry expert lecture

Total Lecture hours: 30 hours

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Project:
Text Book(s)
1. Björn Glantz and Klas Edquist, Hauppauge, N.Y., Male and Female Infertility: Genetic
Causes, Hormonal Treatments and Health Effects (Human Reproductive System--
Anatomy, Roles, and Disorders), 2011. Nova Science Publishers.
Reference Books
1 Lipshultz, Larry I., Stuart S. Howards, and Craig S. Niederberger, eds. Infertility in the Male. ,
. 2012, 4th ed. Cambridge: Cambridge University Press.
2 Rizk, Botros R. M. B., et al., eds. Infertility and Assisted Reproduction. 2010, 2nd ed.
Cambridge: Cambridge University Press,
Mode of Evaluation: CAT / FAT / Assignment
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017
Course code Course title L T P J C
BMG5010 Radiation Genetics 2 0 0 4 3
Pre-requisite NIL Syllabus version
v. xx.xx
Course Objectives (CoB):
1. To interpret the effects of radiation exposure on biological systems and medical exposure levels
2. To apply the methods for measuring, monitoring radiation and radio-protection
3. To assess radiation carcinogenesis and appraise about clinical radiobiology

Expected Course Outcome (CO):

1. Outline the basic concepts in radiation physics, chemistry and biological aspects of radiation
2. Elaborate the mechanisms and consequences of radiation-induced injury and radiation pathogenesis
3. Interpret the effects of radiation in cancer
4. Explain DNA damage, repair and application of biodosimetry techniques
5. Discuss the recent advances in radiation biology and application of diagnostic techniques in
radiobiology/cancer therapy
6. Identify the biomarkers for monitoring radiation exposed population or in carcinogenesis

Module:1 Radiation Physics and Radiation Chemistry 5 hours CO: 1

Internal and external sources of radiation, types of radiation and their properties. Ionization and excitation,
Interaction of radiation with matter. Direct and indirect effects of radiation. Units of radiation
measurement.

Module:2 Cellular responses to radiation 5 hours CO: 1

Radiolysis of water and radical formation. Cell survival curve (concepts of D0, D37, shoulder,
extrapolation number). Factors affecting survival- RBE, oxygen effect, sensitizers and protectors. Cell
cycle stage and radiation sensitivity

Module:3 Radiation Induced Injury 4 hours CO: 2

Law of Bergonie and Tribondeau. Stochastic Effect, Deterministic effect, Bystander effects. Dose
fractionation, Radiotherapy. Radiation cataractogenesis

Module:4 Radiation pathology 4 hours CO: 2

Somatic effects of whole body radiation exposure. Effect on the immune response. Radiation syndromes:
Bone marrow, Gastrointestinal and Cerebrovascular (central nervous system) syndromes.

Module:5 Radiation carcinogenesis 4 hours CO: 3

Long term effects of radiation. Radiation carcinogenesis. Risk estimates for radiation induced cancer.
Genetic effects of radiation.

Module:6 Radiation dosimetry 3 hours CO: 4

Radiation protection, ICRP, Radon, DNA damage and chromosome aberration. Molecular techniques in
radiation biology.

Module:7 Diagnostic Radiobiology 3 hours CO: 5

Clinical applications of radiation biology. The radiation sensitive syndromes (XP, FA).Treatment of
radiation accident victims. Recent advances in radiation Genetics

Module:8 Contemporary issues: 2 hours CO: 6

Industry Expert lecture

Total Lecture hours: 30 hours

Text Book(s)
1 Lippincott, Williams and Wilkins Hall, E.J. and Giaccia, A.J. Radiobiology for the Radiologist,
2012, (7th edition). Philadelphia, Publishers
2 Friedberg, E.C., Walker, G.C., and Siede, W, DNA Repair and Mutagenesis,2011, ASM Press
.
Reference Books
1. Umadevi. P, Nagarathnam. A and Satish Rao. B.S., Introduction to radiation biology.2011, B.I.
Churchill Livingstone, Pvt. Ltd., New Delhi.
Shirley Lehnert Biomolecular Action of Ionizing Radiation,2011, Taylor and Francis.
2.

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar

Mode of Evaluation: CAT / FAT / Assignment
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

Course code Course title L T P J C

BMG5011 COGNITIVE AND BEHAVIOURAL GENETICS 2 0 0 4 3
Pre-requisite NIL Syllabus version

Course Objectives (CoB):

1. To understand the aspects of cognition, language, emotion, personality, and behaviour in
genetic disorders
2. To estimate the risk factors for psychological disorders and variation in behavioural and
personality traits.
3. To analyse neurogenetic disorder using molecular genetics

Expected Course Outcome (CO):

1. Outline the basics of neurobiology and neurogenetics
2. Identify appropriate techniques to analyse the neurogenetic disorder
3. Determine the gene-environment interaction in humans
4. Illustrate the importance of genetic factors in the etiology (causes) of mental disorders
5. Analyze the clinical condition and recommend for clinical management
6. Apply the knowledge from recent advances in neurosciences

Module:1 Organ and Hormone function 4 hours CO: 1

Over view of human brain, neurons, mind - structure and function, Hormone and behavior
Module:2 Neurogenetics 4 hours CO: 1
Cognitive and behavioral phenotypes, Neural basis of behavior, Nature and nurture forms of
behavior. Genes, environment and genesis of psychopathology

Module:3 Major techniques in behavioral genetics 4 hours CO: 2

Discoveries of behavioral genetics Quantitative genetics – Family, twin and adoption studies.
Gene mutations, Huntington’s Disease, a single gene autosomal dominant mutation.

Module:4 Environmental and Genetic Context 4 hours CO: 3

Genomic, cellular and local environment, Impulsive behavior – positive and negative impulsive
traits, Intelligence.

Module:5 Genetics of mental disorders 3 hours CO: 4

Genetics of Language- Heritability of normal variation and pathologies of language. Specific
Language Impairment. Dyslexia, Developmental language delay, Stuttering.

Module:6 Neuro Disorders 4 hours CO: 4

Mood disorders – Bipolar disorders, manic depressive illness and alcoholism.

Module:7 Genetics of childhood disorders 5 hours CO: 4,5

Autistic spectral disorders, psychotic disorders – schizophrenia. Clinical applications- Implications
for diagnosis and treatment, Genetic counseling and testing. Social and ethical concomitants of
cognitive and behavioral genetics: eugenics, social Darwinism, race.

Module:8 Contemporary issues: 2 hours CO: 6

Industry expert lecture

Total Lecture hours: 30 hours

Text Book(s)
1. Plomin, R., DeFries, J.C., McClearn, G.E., & McGuffin, P 2010. Behavioral Genetics. 5th
ed. New York: Worth Publishers
Bryan Kolb; Ian Q Whishaw; G Campbell Teskey 2016. An Introduction to Brain and
2. Behavior. 5th edition Worth Publishers, New York
Reference Books
1. Nuffield Council on Bioethics, Genetics of Human Behavior, 2010, ISBN- 190438403X
2. Peter Mc Guffin, M.J.Owen, I.Gottesman Psychiatric genetics and genomics,2011. Oxford
University Press

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar

Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

Course code Course title L T PJ C

BMG5012 FORENSIC SCIENCE 2 0 0 4 3
Pre-requisite NIL Syllabus
version
1.1
Course Objectives (CoB):
1. To emphasize the importance of scientific methods in crime detection.
2. To disseminate information on the advancements in the field of forensic science.
3. To highlight the importance of forensic science for perseverance of the society.

Expected Course Outcome (CO):

1. Helping students discover the field of forensics and its related departments
2. Demonstrate competency in the collection, processing, analyses, and evaluation of evidence.
3. Discuss the principle of crime scene investigation, including the recognition, collection,
identification, preservation, and documentation of physical evidence.
4. Demonstrate an understanding of the scientific method and the use of problem-solving within
the field of forensic science.
5. Identify the role of the forensic scientist and physical evidence within the criminal justice
system.
6. Able to document and orally describe crime scenes, physical evidence, and scientific
processes.
7. Identify and examine current and emerging concepts and practices within the forensic science
field.
Module:1 Forensic Science, Development and 3 hours CO: 1
Significance
History and Significance, Experts involved and procedures in crime scene investigative, Forensic
laboratories: National and Global laboratories, Body farms, Recent advances in Forensic Science.

Module:2 Crime Investigation Protocol and 3 hours CO: 2

Instrumentation
Evidences: Physical Evidence, procedures in collection, documentation, and Chain of Custody,
Instrumentation in Forensic Analysis.

Module:3 Fingerprinting in Forensic Science 3 hours CO: 3

Principle, Types, Fingerprint lifting techniques and Documentation, Fingerprint Recorders:
Biometric system in detecting individual variation, Optical, Capacitance-based and other types of
fingerprint recorders.

Module:4 Document Analysis, Impression Based 4 hours CO: 4

Evidences
Impression based evidence: Principle, Tool markings, Tire, Footwear markings and associated
databases, Hand writing analysis, Question documents, Polymers and fibers.

Module:5 Ballistics Principles and Study in Crime 4 hours CO: 5

Analysis
Types, application, procedures: internal, external and terminal ballistics, and identification of
firearms, databases in ballistic analysis.

Module:6 Pathology, Toxicology and DNA 6 hours CO: 6

fingerprinting in Forensics
Analysis of blood, saliva, semen at crime scene, Blood Splatter- Origin of impact studies,
Abusive Drug types, CSA- schedules, Poisons and analysis. Time of death analysis;
Entomology and pathology in death analysis, Bite-mark analysis, Forensic Medicine.
DNA fingerprinting: RFLP and PCR (VNTR, STR-CODIS) based profiling.

Module:7 Digital media and Information Science in 5 hours CO: 7

Forensic Sciences
Photographic Applications: SLR-camera, Digital camera, CCTV in forensic analysis, Camera
techniques for evidence visualization, Forensic Facial Reconstruction. Cyber Forensics:
Computer, Mobile phone data analysis, Ethical hacking, drones, remote surveillance in forensic
investigations, and Corporate crimes. Deception detection tests (DDT): polygraph, narco-
analysis and brain-mapping. Forensic and Legal proceedings in India: Legal proceedings in
forensics, CSI in India, and Case study

Module:8 Contemporary issues: 2 hours CO: 7

Industry Expert lecture

Total Lecture hours: 30 hours

Text Book(s)
1. Criminalistics: An Introduction to Forensic Science, 11/E, Richard Saferstein, 2015,ISBN-
10:0133458822 ISBN-13: 9780133458824, • Prentice Hall
Reference Books
 1. Forensic DNA Typing, , Biology, Technology, and Genetics of STR Markers, J Butler,
2010, 3rd Edition , Imprint: Academic Press, eBook ISBN : 9780080470610, Print Book
ISBN : 9780121479527, Pages: 688
Introduction to Criminalistics: The Foundation of Forensic Science, 2010, by Barry
2. A.J. Fisher, William J. Tilstone, Catherine Woytowicz, Elsevier Academic Press
USA,.
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 49 Date 24-08-2017

Course code Course title L T PJ C

BMG5013 STEM CELL BIOLOGY 3 0 00 3

Pre-requisite NIL Syllabus version
1.1
Course Objectives (CoB):
1. To elaborate upon the fundamental and conceptual aspects of stem cell biology
2. To dissect the mechanistic aspects
3. To interpret technical information in peer-reviewed papers

Expected Course Outcome (CO):

1. Able to recall and demonstrate proficiency in the theoretical aspects of the subject
(mechanistic/basic and applied aspects)
2. Discuss latest techniques in stem cell culture
3. Compare and distinguish the principle and the latest methodologies used in stem cell
research (identification, localization, lineage tracing and differentiation potential)
4. Improve their technical writing skills; make presentations and design experiments

Module:1 Introduction to cell & Stem cell Biology 6 hours CO: 1

General definitions. Overview of stem cell isolation methods, overview of cell cycle,
proliferation, differentiation and transdifferentiation (cell Vs stem cell). Overview of
Quiescence,Self-renewal and Pluripotency; types of stem cell (primate Vs mouse Vs human);
politics and ethics.

Module:2 Stem cell niche, epigenetics & Signal 6 hours CO:2

Transduction pathways
Niche – localization, molecular aspects. Epigenetics – classification and analysis of factors
regulating stem cell fate, latest methods for dissecting the mechanisms. Integration of signal
transduction pathways.
Module:3 Stem cell Invertebrate Model Systems 6 hours CO: 3
Stem cell systems in sponge, immortal hydra, basal flatworm, ascidians – latest methods and
techniques.

Module:4 Stem cell in Vertebrate Systems 5 hours CO: 3

Stem cell in amphibian and mouse. Similarities and differences between mouse and human
embryonic stem cell/epiblast stem cell –latest methods and techniques.

Module:5 Keratinocyte and hair follicle stem cells 6 hours CO: 3

Identification, localization and tracing; regenerative potential-latest methods and techniques.

Module:6 Mesenchymal Stem cell 7 hours CO: 3

Immunomodulatory role/ therapeutic/ engraftment potential, proliferation and differentiation
protocols- latest methods and techniques.

Module:7 Hematopoietic Stem cells 7 hours CO:3

HSCs –subpopulations and the niche. Reconstitution experiments, HSCs in therapy –success
stories. Induced Pluripotent Stem cells (iPSCs) - Production methods Disease Modeling; iPSC in
therapy. Overview of regenerative science.

Module:8 Contemporary issues 2 hours CO: 4

Industry Expert Lecture

Total Lecture 45 hours

hours:
Text Book(s)
1. Essentials of Stem Cell Biology. 3rd edition. (2014). Elsevier Inc. Academic Press USA.
2. Stem Cell Biology & Regenerative Medicine. From Molecular Embryology to Tissue
Engineering (2011). Appasani K. & Appasani R.K. Humana Press.
Reference Books
1. Stem Book. http://www.stembook.org/. (2013) Massachusetts General Hospital. Boston,
USA.
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar

Recommended by Board of Studies 03-08-2017

Approved by Academic Council No. 46 Date 24-08-2017
Course code Course title LT P J C

BMG5014 ENVIRONMENTAL GENETICS 3 0 2 0 4

Pre-requisite Nil Syllabus version
1.1
Course Objectives (CoB):
1. The objective of this course is to introduce the graduate about the chemical basis of
heredity.
2. To acquire knowledge about mutagenesis, mutagens, carcinogenesis and teratogens.
3. To develop, implement, monitor and maintain environmental strategies that will promote
sustainable development.

Expected Course Outcome (CO):

1. Describe the roles of genes and the environment in the determination of phenotype.

2. Analyse the sources of mutagenic, carcinogenic, and teratogenic chemicals in the environment
and identify their known effects.
3. Plan and carry out experiments in animal models to evaluate the risk of mutagens and teratogens
which can be responsible for inherited and acquired ailment or conditions, such as cancer
4. Recognize and evaluate the different types of toxicity in the environment that causes health
and environmental hazards.
5. Understand and explain the importance of molecular approaches in Environmental Genetics.
6. Utilize quantitative knowledge and skills and modern tools and technologies to asses,
analyse, plan, and implement environmental management systems

Module:1 Environment and mutations 6 hours

Emerging global environmental health problems. Modification of mutagenic damage,
antimutagenesis and desmutagenesis.

Module:2 Risk analysis of Biomarkers 6 hours

Biomarkers and risk analysis, mutagenesis and carcinogenesis, Procedures for assessment of
genotoxicity.
Module:3 Mammalian systems for mutagenicity 7 hours
assessment
Mouse- cytogenetic procedures and techniques to assess gene mutations. Fibroblasts and chinese
hamster cells in culture- Unscheduled DNA synthesis, Chromosomal aberrations, Sister chromatid
exchanges, gene mutation- HGPRT and TK

Module:4 Evaluation of mutagens 6 hours

Interrelationship between mutagenesis and Carcinogenesis- Tests for evaluation. Xenobiotics
metabolism.

Module:5 Teratogens 6 hours

Mouse as a test system – congenital anomalies- teratogens in comparison with mutagens and
carcinogens- birth defects in humans.

Module:6 Structural defects of DNA 6 hours

DNA mutagen adducts and altered DNA conformation- DNA repair defects in humans.

Module:7 Biomonitoring of human population 6 hours

Chromosomal analysis, Sperm morphology analysis. Nutritional Toxicants - Toxicology and
Epidemiology of human exposure to pesticides and food toxicants.

Module:8 Contemporary issues: 2 hours

Expert Lecture from Industry or Hospital

Total Lecture hours: 45 hours

Text Book(s)
1. Chemical Mutagens- Principles and methods for their detection, Plenum Press, 2011. New
York,
2. Hand Book of Epigenetics: The New Molecular and Medical Genetics. 2011, Academic
Press UK
Reference Books
1. Handbook of Mutagenicity test procedures, Kilbey et al., 2011 (ed.) Elsevier, Amsterdam,
2. Venite, S and Parry, J.M , Mutagenicity testing- A practical approach,. 2011. IRL Press,
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar

List of Challenging Experiments (Indicative)

1. Analysis of induced chromosome aberration in Leukocyte Culture by 2 hours
Chemical mutagens.
2. Analysis of induced chromosome aberration in Leukocyte Culture by 2 hours
radiation
3. Sister chromatid exchange analysis. 2 hours
4. Micronucleus test. 2 hours
5. Sperm abnormality Analysis 3 hours
6. Chromosome Preparation from Mouse bone marrow. 3 hours
7. DNA damage analysis. 3 hours
8. DNA fragmentation 3 hours
Total Laboratory Hours 30 hours
Mode of Evaluation: Continuous assessment Test/ Assignment/ Quiz/ Final Assessment test.
 Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

Course code Course title LT P J C

BMG5015 INTRODUCTION TO HUMAN PSYCHOLOGY 3 0 0 0 3
Pre-requisite Nil Syllabus version
1.1
Course Objectives (CoB):
1. To introduce the students to the subject of psychology, nature, scope and schools of
psychology.
2. To familiarize the methods used in psychology and to facilitate their knowledge about
causes of behavior.
3. To provide the knowledge of basic concepts in psychology

Expected Course Outcome (CO):

1. Use scientific reasoning to interpret psychological phenomena
2. Engage in innovative and integrative thinking and problem solving
3. Interpret, design, and conduct basic psychological research
4. Student will be able to work effectively in teams
5. Communicate better and understand the diversity of human behaviour.
6. To have a more open sense of mind towards the people suffering from various psychological
issues and disorder in the society and be a good citizen

Module:1 Introduction and Methods 6 hours

Science of Psychology, Behaviorism, Humanism, Sensation and perception, Emotion, Cognitive
abilities and Intelligence.

Module:2 Physiological Psychology 6 hours

Relationship between behavior and physiological processes, Neurophysiological processes, Study
of human behavior.
Module:3 Therapeutic Approaches 6 hours
Psychodynamic therapies, Indigenous therapies, Bio-feedback therapy, Fostering mental health.

Module:4 Counselling Psychology 6 hours

Basic Counseling skills, Counselor self-care, Integrative therapies Common Factors, Positive
Psychology, Family Systems therapy, Behavior therapies, Client centered therapy, Cognitive
therapies.

Module:5 Rehabilitation Psychology 7 hours

Primary, secondary and tertiary prevention programmes - role of psychologists, Organizing of
services for rehabilitation of physically, mentally and socially challenged persons including old
persons, Rehabilitation of persons suffering from substance abuse, juvenile delinquency, criminal
behavior, Rehabilitation of victims of violence, Rehabilitation of HIV/AIDS victims.

Module:6 Social Psychology 6 hours

Issues of discrimination, Management of diversity, Glass ceiling effect, Self-fulfilling prophesy,
Arousing community consciousness and action for handling social problems, Group decision
making and leadership for social change, Effective strategies for social change, Women and
Indian society.

Module:7 Applications-I 6 hours

Distance learning through IT and mass media, Entrepreneurship through e-commerce;
Psychological consequences of recent developments in Information Technology, Achievement
motivation and economic development. Applications- II: Motivating and training people for
entrepreneurship and economic development, Consumer rights and consumer awareness,
Population psychology.

Module:8 Contemporary issues: 2 hours

Industry Expert Lecture

Total Lecture hours: 45 hours

Text Book(s)
1. Clifford T. Morgan, Richard A. King, John R. Weisz, John Schopler- Introduction to
Psychology, 7th Edition, 2010 ,Tata Mcgraw Hill Edition-.

Reference Books
1. Edward E. Smith, Susan Nolen, Hoeksema, Barba Fredickson, Geoffer R Lottus Introduction
to Psychology, 14th Edition , 2011, Atkinson and Hilgar’s-
Shelley E. Taylor, Letitia Anne Peplan, David O. Sears, Social Psychology-12th Edition
2.
2011, Pearsons Eduction,.
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017
 Course code Course title L T P J C
BMG5016 Bioinformatics 2 0 2 4 4
Pre-requisite Nil Syllabus version
1.1
Course Objectives:
1. To introduce the basic concepts, methods and tools employed in Bioinformatics.
2. To solve biological problems using bioinformatics tools
3. To utilize the wide variety of tools, servers, biological databases.

Expected Course Outcome

1. Apply knowledge of the basic concepts of biology, computer science and mathematics
2. Use the information in computer modelling
3. Appraise structure-function relationships, database queries
4. Reach rapidly the frontier of bioinformatics.
5. Formulate biological big data to unlock the next big biotech discovery.

Module:1 Biological Database 4 hours

NCBI, EMBL, Uniprot, PDB and other biological databases, File Formats - sequence formats,
Scope and application of Bioinformatics
Module:2 Sequence Alignment techniques 4 hours
Introduction to Sequences alignments - Dot plot and Dynamic Programming – Local alignment
smith waterman algorithm – Global alignment - Needleman-wunsch - (algorithm and example)

Module:3 Scoring Matrices and Multiple sequence 4 hours

alignment
Gap penalty, types, substitution scoring matrices, multiple sequence alignment – Clustal W
algorithm - Feng Doolittle algorithm, star method, applications

Module:4 Heuristic methods 4 hours

Similarity Searches on Sequence Databases - Heuristic Sequence Alignment -BLAST and its
types, FASTA – Algorithms -Sensitivity, specificity, applications

Module:5 Genome annotation 4 hours

Principles of Genome annotations, Annotation tools and resources, Comparative Genomics-
Patterns and mechanisms in genome evolution Next Generation Sequencing (NGS).

Module:6 Molecular Phylogenetics 3 hours

Tree construction– Distance based method, Character-Based Methods- Maximum parsimony
method, Maximum likelihood- Phylogenetic Tree Evaluation – Jack-knifing and Bootstrapping -
applications

Module:7 Molecular modelling and In silico Drug 5 hours

design
Protein secondary structure prediction – 3D structure Prediction – Homology Modelling,
Threading, tools for structure prediction Ligand based Drug design, Target based drug design,
Virtual screening, SBDD, docking, QSAR, ADME prediction.

Module:8 Contemporary issues 2 hours

Industrial Expert lecture

Total Lecture hours: 30 hours

Practical
1 Retrieval and analysis of Nucleotide sequence from primary nucleotide database
 2 Hrs
2 Exploring Protein sequence from protein database 2 Hrs
3 Annotation of Protein structure from structure database 2 Hrs
4
Access of secondary biological data from various Biological database 2 Hrs
5 Pairwise alignment using dot plot (Virtual mode) 2 Hrs
6 Pairwise alignment using dynamic programming 2 Hrs
7 Heuristic Sequence Alignment using BLAST/ FASTA 4 Hrs
8 Multiple sequence alignment (Virtual mode) 2 Hrs
9 Construction of Phylogenetic tree 2 Hrs
10 Gene prediction analysis 2 Hrs
11 Prediction of secondary structure of protein. 4 Hrs
12 Visualization of protein Structure 4 Hrs
Total hours 30 Hrs
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Project: “J Component”
Text Books:
1. Bioinformatics- a Practical Guide to the Analysis of Genes and Proteins by
Baxevanis, A.D. and Francis Ouellellette, B.F., Wiley India Pvt Ltd. 2009
2. Bioinformatics: Sequence and Genome Analysis by Mount D., Cold Spring
Harbor Laboratory Press, New York. 2004.
Reference Books:
1. Introduction to bioinformatics by Teresa K. Attwood, David J. Parry-Smith,
Pearson Education. 1999.
2. Bios Instant Notes in Bioinformatics by Hodgman, Andrew and David R.
Westhead, Taylor and Francis, 2007.
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017
Course code Course title L T P J C
BMG5017 ENZYMOLOGY 3 0 0 0 3
Pre-requisite NIL Syllabus version
1.1
Course objectives (CoB):
1. To introduce students to various theoretical and practical aspects of enzymology
2. To stimulate their interest in learning the structure, function and kinetics of enzyme and their
role as catalyst and regulator of cell metabolism.
3. To serve as foundation for more advanced enzymology courses.
Expected Course Outcome (CO):
1. Compare various classes of enzyme and their functions in the cell;
2. Importance of co-enzyme or cofactor in enzyme catalyzed reaction
3. Distinguish between equilibrium and steady state kinetics
4. Extend role of enzymes as clinical markers
5. Demonstrate isolation and purification of enzymes
6. Elaborate various applications of enzymes in industry

Module:1 Introduction to enzymes 6 hours

Biochemical importance, properties, structure, active site features, organisation- multienzyme
complex, isoenzymes, classification and nomenclature.

Module 2 Fundamentals of Enzyme Kinetics 6 hours

Activation energy, Reaction co-ordinate diagram, MM kinetics-kinetic constants - Km , Kcat,
Line weaver Burk plot, Factors influencing enzyme activity.
Module:3 Enzyme inhibitors as drugs 6 hours
Enzyme inhibition, types-reversible & irreversible, enzyme inhibitors as drugs for various
diseases.

Module:4 Enzyme catalysis and regulation 6 hours

Acid base catalysis, covalent catalysis, metal ion catalysis, proximity effect RNase, chymotrypsin,
carbonic anhydrase. Enzyme regulation – covalent modification, allosteric regulation with
examples

Module:5 Enzyme extraction & purification 6 hours

Enzyme sources, intracellular & extracellular enzymes- isolation methods, purification &
characterization of industrial enzymes

Module:6 Clinical enzymology 6 hours

Importance of enzymes in various disorders: LDH and isoenzymes, CPK, AST, ALT, ALP, ACP,
GPD, Amylase, Lipase, GGT, enzyme based biosensors. Enzymes in therapy-asparaginase,
urokinase, lactamase, uricase.

Module:7 Enzymes assays & Industrial applications 7 hours

Measurement of enzyme activity, units, types – direct, indirect, role of enzymes as analytical
agents in coupled assays. Immobilized enzymes & its applications. Applications of enzyme
technology: Recent developments in enzymatic assays. Industrial production & applications of
enzymes. Enzyme engineering, synzymes and applications.

Module:8 Contemporary issues: 2 hours

Industry Expert Lecture

Total Lecture hours: 45 hours

Text Book(s)
1. Trevor palmer and Philip Boner, Enzymes: Biochemistry, Biotechnology and Clinical
Chemistry, 2011
Reference Books
 1. Martin F. Chaplin, Christopher Bucke, Enzyme Technology , 2010. ISBN/ASIN:
0521348846. ISBN-13: 9780521348843 Cambridge University Press
Nicholas Price and Lewis Stevens , Fundamentals of Enzymology, Cell and Molecular
2.
Biology of Catalytic Proteins. 2012, 3rd Edition, Oxford University Press.
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies 03-08-2017
Approved by Academic Council 46 Date 24-08-2017

Course code Course title LT P J C

BMG6001 HUMAN BIOCHEMICAL GENETICS 20 0 4 3
Pre-requisite NIL Syllabus version
1.1
Course Objectives (CoB):
1. To gain knowledge on the basic principles of metabolic pathways
2. To identify the changes in metabolic pathways in various biochemical disorders
3. To introduce them the genetics of metabolic pathways and associated abnormalities

Expected Course Outcome (CO):

1. Acquire knowledge on molecular basis of human genetic diseases
2. Identify the inborn errors of amino acid metabolism and interpret the genetics of metabolic
syndrome
3. Catogorise hemoglobinopathies and its prevalence in India storage disorders
4. Develop knowledge on the genetics of storage disorders such as lysosomal, mucopolysaccharides
and lipids
5. Relate the types of muscular dystrophies and associated biochemical abnormalities
6. Compare the genetic defect with the metabolic diseases.

Module:1 Introduction to Biochemical disorders 2 hours

Biochemical and molecular basis of human genetic diseases.

Module:2 Disorders of Amino Acid Metabolism 4 hours

PKU, Alkaptonuria, Homocystinuria, Albinism.
 Module:3 Genetics of Metabolic Syndromes 5 hours
Galactosemia, Diabetes, Lactic acidosis, G-6 PD deficiency and glycogen storage disorders. Lesch
Nyhan syndrome, Gout and pseudogout.

Module:4 Haemoglobinopathies 4 hours

Classification, globin gene structure and mutation, biochemistry of Thalassaemia, Sickle cell
anemia and other haemoglobin variants. Haemoglobinopathies in India.

Module:5 Storage Disorders 4 hours

Classification of lysosomal storage disorders. Molecular Genetics of Mucopolysaccharidoses and
Lipidosis

Module:6 Muscular Dystrophies 4 hours

Muscular dystrophies - Duchenne muscular dystrophy, Becker muscular dystrophy, Distal
muscular dystrophy, Emery– Dreifuss muscular dystrophy, Myotonic muscular dystrophy,
Limb-girdle muscular dystrophy, Cystic fibrosis.

Module:7 Biochemical diagnosis 5 hours

New born screening and population screening for biochemical disorders. Genetic registries and
prevention of inherited metabolic disorders. Metabolism and Metabolic Disease Resources on the
Web. Biochemical disease management: Clinical Management of Inborn Errors of Metabolism,
Metabolic Disorders and Counseling Issues.

Module:8 Contemporary issues: 2hours

Industry Expert Lecture

Total Lecture hours: 30 hours

Text Book(s)
1. Lee B and Scalia F Inborn Errors of Metabolism From Neonatal Screening to Metabolic
Pathways, 2014, Oxford Monographs on Medical Genetics.
Reference Books
1. T.M. Devlin, 2010. Textbook of Biochemistry with clinical correlations (7th edn.). D.J.
2. A.E.H. Emery and D.L. Rimoin 2013. Principles and Practice of Medial Genetics, Vol. II,
Churchill, Livingston, Chap.99
3.
Alan E. H. Emery, Francesco Muntoni, and Rosaline C. M. Quinlivan 2015 Duchenne
Muscular Dystrophy Fourth Edition, Oxford
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar

Recommended by Board of Studies 03-08-2017

Approved by Academic Council No. 46 Date 24-08-2017
Course code Course title L T P J C

BMG6003 MEDICAL BIOCHEMISTRY 3 0 0 0 3

Pre-requisite Nil Syllabus version

1.1
Course Objectives (CoB):
1. To provide a breadth of knowledge, from basic principles to the latest
cutting-edge developments in biochemistry, and develop analysis skills to understand
biochemical data.
2. To demonstrate clinical disorders, the biochemical consequences of
particular disease process and the response to therapy.
3. To develop skills for understanding the clinical case studies with the help
of interpretation of laboratory results.
Expected Course Outcome (CO):
1.Interpret the metabolic effects following influence on individual reaction steps by clinical or
genetic variation.
2.Categorize the changes in the metabolism for common diseases.
3.Competently perform a series of fundamental biochemical techniques.
4.Solve laboratory calculations for biomedical applications.
5.Evaluate different choices of methods for biochemical laboratory work, and to plan, and to
evaluate experiments.
6.Outline the ethical and security issues in biomedical work.
7.To develop a competent knowledge on latest advancements in Medical Biochemistry.
Module:1 Methods for collection, handling and analysis 6 hours
of clinical samples
Blood, urine CSF, bile, biopsy specimens- Biochemical investigations and quality control, normal
values and interpretation of results.

Module:2 Disorders of carbohydrate metabolism 6 hours

Diabetes mellitus - acute and chronic complications, laboratory diagnosis and monitoring -
Glycated Hb, Glucose tolerance test.

Module:3 Disorders of Lipid metabolism 6 hours

 Dyslipidemia - Hypo and hyperlipoproteinemias, Fatty liver, familial hypercholesterolemia,
Cholesterol level in blood and therosclerosis. Lipoidsis and xanthomatoses.

Module:4 Liver function tests & interpretation 6 hours

Classifications of liver function tests- tests based on abnormal bile pigment metabolism, excretory
function tests.

Module:5 Renal function tests & interpretation 6 hours

Tests based on renal plasma flow, tubular function, glomerular filtration rate. Urea and insulin
clearance tests.

Module:6 Gastric function tests & interpretation 6 hours

Fractional test meal analysis, tubeless gastric analysis , stimulation tests

Module:7 Thyroid functioning tests and Recent 7 hours

advances in biochemical diagnosis
Hyper and hypothyroidism tests measuring blood levels of thyroid hormone, immunological tests
for thyroid function.

Module:8 Contemporary issues: Industry Expert Lecture 2 hours

Total Lecture hours: 45 hours

Text Book(s)
1. Chatterjea M. N, Rana Shinde, Textbook Of Medical Biochemistry, 2012, 8th Edition,
JAYPEE publication, INDIA
Reference Books
1. Allan Gaw, Michael Murphy, Rajeev Srivastava, Robert A. Cowan, Denis St. J. O'Reilly,
Clinical Biochemistry: An Illustrated Colour Text, 2013, 5th Edition, Elsevier Health
publication - UK
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017
 Course code Course title L T P J C
BMG 6004 GENETIC ENGINEERING 3 0 2 0 4
Pre-requisite NIL Syllabus version
1.1
Course Objectives (CoB):
1. Expose tools and strategies used in genetic engineering.
2. Acquire knowledge about the concept of genetic engineering including the techniques,
applications and limitations.
3. Understand the applications of genetic engineering from academic and industrial perspective.
Expected Course Outcome (CO):
1. Describe the function of the most common enzymes and vectors used in genetic engineering.
2. Attain a basic conceptual knowledge on different molecular techniques and when they would
be applied
3. Explain which biological hosts are the best choice for producing a certain protein and why
4. Clone the gene of interest theoretically and manipulate the gene to be expressed in different
host.
5. Hypothesize how concepts in genetic engineering could be applied in their field of research
6. Proficiency in designing and conducting experiments involving genetic manipulation.
Module:1 Manipulation of DNA 7 hours
Manipulation of DNA: Restriction and modification enzymes, ligase, linker, adaptors,
homopolymer tailing, Reverse transcriptase, Taq polymerase, DNA polymerase.

Module:2 Cloning vectors 7 hours

Characteristics of cloning and expression vectors based on plasmid, bacteriophage – lambda, M13
and Yeast.
Module:3 Blotting techniques 4 hours
Southern, Northern and Western blotting; Dot and reverse blot.

Module:4 Techniques in Genetic engineering 8 hours

PCR- basic reaction and types of PCR; DNA sequencing, Next generation sequencing,
Microarray-based comparative genomic hybridization.

Module:5 Transformation and cloning strategies 6 hours

Methods for gene transfer –chemical and physical methods. Cloning in Yeast, B. subtilis;
Genomic and cDNA Libraries.

Module:6 Reporter genes and Screening of 3 hours

recombinants
GFP, CAT, luciferase, colony hybridization, plaque lift techniques.

Module:7 Applications of r-DNA technology 8 hours

Applications of r-DNA technology: Nucleic acid sequences as diagnostic tools- SNPs, VNTR,
Genetic changes for over production of biomolecules such as insulin, interferon and growth
hormones, Hazards and safety aspects of Genetic Engineering.

Module:8 Contemporary issues: Industry Expert Lecture 2 hours

Total Lecture hours: 45 hours

Text Book(s)
1. Primrose SB and Old. Principles of Gene manipulation Blackwell Scientific Publications,
2015
Reference Books
1. Terence A. Brown. Gene cloning and DNA analysis: an introduction, Wiley-Blackwell,2013
2 M. R. Green, J. Sambrook. Molecular Cloning: A Laboratory Manual (Cold Spring Harbor,
ed. 4, 2012).
3 M. Wink. An Introduction to Molecular Biotechnology: Molecular Fundamentals, Methods
and Applications in Modern Biotechnology (Wiley, ed. 2, 2011)
List of Challenging Experiments (Indicative)
1. Genomic DNA isolation from human sample and analysis 3 hours
2. Plasmid DNA Isolation and analysis 3 hours
3. Competent cell preparation 3 hours
4. Transformation and antibiotic selection or Blue white selection method 3 hours
5. Restriction digestion 3 hours
6. Ligation 3 hours
7. Polymerase chain reaction 3 hours
8. GFP Cloning 3 hours
9. Elution of DNA from agarose gel 3 hours
10. Non- Denaturing Poly Acrylamide Gel Electrophoresis 3 hours
Total Laboratory Hours 30 hours
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies 03-08-2017

Approved by Academic Council No. 46 Date 24-08-2017

 Course code Course title LT P J C
BMG6005 GENETIC COUNSELING 2 0 0 4 3
Pre-requisite Clinical Cytogenetics and Prenatal Diagnosis Syllabus version
1.1

Course Objectives (CoB):

1. To develop strong foundational knowledge and skills in genetic counseling encompassing
medical genetics; psychological and ethical issues; and familial and social implications of
genetic contributions to health and human disease.
2. To build basic knowledge around the genetics of clinic and genetic guidance to be able to be
aware of when and how patients should be referred further to genetic investigations.
3. To extend the knowledge of different psychosocial and ethical aspects in connection with genetic
guidance.

Expected Course Outcome (CO):

1. Analyze the various aspects of genetic counseling and the significance of genetic testing and
screening procedure.
2. Discuss how genetic diseases influence both individual and family as a society.
3. Infer the knowledge around the genetics of clinic and genetic guidance to be able to be aware of
when and how patients should be referred further to genetic investigations.
4. Summarize the advanced knowledge of medical genetics and genomics; community genetics and
genomics; clinical practice and genetic counseling skills; ethical, legal and social issues of genetic
medicine.
5. Elaborate the different genetic counseling process and the impact on families from a cultural,
ethical and psychosocial perspective.
6. Identify the potential for ethical challenges in emerging new genetic technologies.
Module:1 Introduction of Genetic Counseling 4 hours
History and development of genetic counseling. Counseling Theory, Counseling Techniques, Lab
genetic counseling. Group Dynamics: Theory and Application

Module:2 Invasive prenatal diagnostic techniques 4 hours

Indications for prenatal diagnosis, Techniques: amniocentesis, chorionic villus sampling,
cordocentesis, placentocentesis. Comparative advantages, disadvantages and their importance for
preventing chromosomal and gene abnormalities. Pseudomosaicism and Confined placental
mosaicism.

Module:3 Noninvasive and Less invasive prenatal 4 hours

diagnostic techniques.
Noninvasive - Ultrasound, Embryoscopy, MRI, Less invasive - Prenatal screening for Down’s
syndrome and neural tube defect, Maternal screening (MSAFP patterns, triple test), detection of
fetal blood cells and ffDNA in maternal blood. Preimplantation genetic diagnosis

Module:4 Pediatric genetic counseling 4 hours

Diagnosis, management and genetic counseling for newborn multifactorial birth defects, multiple
congenital anomalies, developmental delay, mental retardation, clinical syndromes, and single
gene disorders; chromosome anomalies, neurological diseases, teratogenic effects, deformations
and disruptions in the pediatric population.

Module:5 Reproductive genetic counseling 4 hours

Normal and abnormal human embryonic development with emphasis on congenital
malformations and birth defect syndromes. Role of teratogens in embryogenesis. Preconception
and prenatal assessment of genetic risk and counseling. Reproductive Endocrinology and
Infertility; female and male infertility; new reproductive technologies

Module:6 Cancer genetic counseling 4 hours

Overview of medical oncology with an emphasis on familial and hereditary cancer. Genetic cancer
risk assessment, clinical variability of cancer syndromes, diagnostic and presymptomatic
molecular testing in hereditary cancer families; the indications, benefits and potential harm of
testing. The application of contemporary genetics to cancer syndromes and sporadic cancer
genetics evaluation and counseling.

Module:7 Adult genetic counseling and Psychological 4 hours

aspects of genetic counseling:
The genetic basis of psychiatric disorders and the relevance to clinical practice. Adult genetic
counseling - diagnosis, management, and genetic counseling of individuals with adult-onset
genetic disease, mental retardation and single gene disorders of the adult population, adult
neurometabolic and neurologic disorders, Psychology of women, psychology of pregnancy,
psychology of the family (family dynamics, therapy), mourning process, loss, influence of a
handicapped child on the family, psychological aspects of infertility, adoption, use of
psychodynamic theory of development
Module:8 Contemporary issues: 2 hours
Industry expert lecture
Total Lecture hours: 30 hours
Project: “J Component”
Text Book(s)
1. Uhlmann WR, Schuette JL, Yashar B (2011). A Guide to Genetic Counseling. ISBN-10:
0470179651, ISBN-13: 978-0470179659, Wiley-Blackwell; 2 edition
Reference Books
 1. Corey, Gerald. (2013). Theory and practice of counseling and psychotherapy (8th ed.).
Belmont, CA: Brooks/Cole (ISBN: 978-0840028549).
2. Patricia McCarthy Veach, Bonnie S. LeRoy, Dianne M. Bartels (2011). Facilitating the
Genetic Counseling Process: A Practice Manual. Springer, ISBN: 0387003304,
9780387003306
3. Gladding, S. and Newsome, D. (2010) Clinical Mental Health Counseling in Community and
Agency Settings (4rd Edition), NJ, Pearson
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

Course code Course title L T P J C

BMG6006 ETHICAL, LEGAL AND SOCIAL ISSUES IN 3 0 0 0 3
GENETIC COUNSELING
Pre-requisite Clinical Cytogenetics and Prenatal Diagnosis Syllabus version

Course Objectives:
1. To apply public health genetics within the context of law, ethics, and policy.
2. To extend health services, environmental health, law, ethics, and socio-cultural aspects of
public health genetics
3. To evaluate genetic principles and genomic technologies in diagnosis, screening, and
interventions for disease prevention and health promotion programs
Expected Course Outcome:
1. Summarize fundamentals of public health genetics
2. Address ethical and legal implications in the use of genetic information and technologies in
public health
3. Identify gene interactions, environmental factors, behaviors, and race in health and disease
4. Importance of ethical concepts
5. Analysis of psycho-social aspects and clinical application of genomic technology
6. Interpret the concept of ELSI in genetic counseling
Module:1 Public health Genetics 8 hours
Historical perspectives on Public Health Genetics and ELSI. Eugenics, Newborn screening
programs, special considerations in genetic testing children and adolescents, the nature and
mission of genetic counseling, misattributed paternity and issues in DTC genetic testing.
Community involvement in public health genetics.

Module:2 Ethics in Genetic counseling 6 hours

Ethics and development. Ethical theories in the clinical, professional. Organizational and political-
economic fields of action in health care. Professional codes of ethics. Bioethics - ethical theories
and standards by health care professionals.

Module:3 Bioethical principles and their applications 8 hours

Case management and genetic counseling, different types of ethical dilemmas and alternative
ways of handling them morally. Issues include euthanasia, assisted suicide, truth-telling,
confidentiality, research ethics, abortion, genetic counseling, surrogate motherhood, the uses of
new reproductive technologies, and justice with respect to care.

Module:4 Global Health and Ethics 6 hours

Ethical issues in global health, fundamental ethical issues about health prospects of population-
the natural world, the global economy, war and international aid. Ethical issues about trade in
human organs, infectious diseases, human migration, sustainable development, malnutrition, and
care of the elderly, health inequalities within and between countries, nutrition, war, environmental
degradation.

Module:5 Genetics and racial disparities 4 hours

Identifying racial and ethnic differences in genetic risk factors. Using genetics to address health
disparities. Ethical, legal, and social issues involved in using genetics to address

Module:6 Ethical concepts 3 hours

Related to responsibility, need, autonomy, community, human rights, and global justice.
Genetic discrimination and genetic exceptionalism

Module:7 Psychosocial Aspects of Genetic 8 hours

Counseling
Exploration of the impact of genetic knowledge/conditions on the individual and family. Human
development and the theoretical underpinnings of various counseling models and psychotherapy,
related to genetic counseling. Specific techniques of the counseling process, including the
rationale for the technique, the timing of the technique and the evaluation of the technique. The
biopsychosocial assessment, with an appreciation of the function of race, gender, social class and
sexual orientation in human behavior. Contemporary Issues in Genetics and Society - Genetics
and law - human subject research and the limits, regulations, protection of vulnerable populations,
research on children, role of the IRB in the review of human subjects research, bio banking,
research on stored tissues and data, the Human Genome Diversity Project. Commercialization of
genetic research and genetic patents; gene transfer research. The future of Genetics: science and
society. Genomic advances in personal and professional life.

Module:8 Contemporary issues: Industry expert lecture 2 hours

Total Lecture hours: 45 hours

Text Book(s)
1. Uhlmann WR, Schuette JL, Yashar B (2009). A Guide to Genetic Counseling. ISBN-10:
0470179651, ISBN-13: 978-0470179659, Wiley-Blackwell; 2 edition.
Reference Books
1. Francis S. Collins , The Language of Life: DNA and the Revolution in Personalized
Medicine.2011, Harper Perenial Publishers.
David L. Rimoin, Reed E. Pyeritz, Bruce Korf (2013). Emery and Rimoin's Essential Medical
2. Genetics Elsevier.
ICMR Guidelines-Ethics, Prenatal diagnosis
3.
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017
Course code Course title L T P J C
BMG6007 Clinical Rotation 0 0 0 8 2
Pre-requisite Clinical Cytogenetics and Prenatal Diagnosis Syllabus version

Course Objectives:
1. To observe in a variety of genetic counseling settings to begin to integrate academic knowledge
into clinical settings.
2. To understand the medical and psychosocial implications of genetic disorders

Expected Course Outcome:

1. Elaborate on the various aspects of genetic counseling and its influence in genetic testing
2. Summarize the clinical practice and genetic counseling skills; ethical, legal and social issues of
genetic medicine

Module:1 Clinical training for atleast 12 weeks 100 hours

1. First year – First semester end – December (4 weeks)

2. First year – Second semester end – June (4 weeks)

3. Second year – Third semester end – December (4 weeks)

4. Specialty Clinics and clinical genetic settings – Pediatric hemato-oncology, Speech, hearing and

language, Child development (Pediatrics), Neonatology, Urology, Obstetrics and Gynaecology,

Human Genetics, Pathology, Radiology, SMART, Clinical psychology and Genetic Diagnostics.

5. Students will submit a write-up of their observations at the end of the program
6. Attendance will be taken for the students for the duration of the program

Mode of Evaluation:
1. An oral defense and research project to be completed
2. Supervision with Program faculty
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017