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Medicinal Chemistry 1 PYQS

The document outlines various topics in medicinal chemistry, including drug metabolism, structure-activity relationships (SAR), and the synthesis and mechanisms of action of several drugs. It covers different units focusing on bio transformation, beta blockers, antipsychotics, NSAIDs, and anesthetics, detailing their classifications, uses, and chemical structures. The content is structured into questions for examination preparation, emphasizing the importance of understanding drug action and synthesis.

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chahatjaiswal677
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71 views4 pages

Medicinal Chemistry 1 PYQS

The document outlines various topics in medicinal chemistry, including drug metabolism, structure-activity relationships (SAR), and the synthesis and mechanisms of action of several drugs. It covers different units focusing on bio transformation, beta blockers, antipsychotics, NSAIDs, and anesthetics, detailing their classifications, uses, and chemical structures. The content is structured into questions for examination preparation, emphasizing the importance of understanding drug action and synthesis.

Uploaded by

chahatjaiswal677
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Medicinal chemistry 1 PYQS

UNIT 1
10 Marks
1. Define bio transformation? Explain principles of drug
metabolism including phase 1 & phase 2 pathways.
2. Explain Bioisosterism , types and their role in drug delivery with
suitable example.
3. Explain about various physicochemical parameters that affect
drug action.
7 Marks
1. Steriochemistry contributes towards biological action of drug.
Explain with example.
2. Describe geometrical isomerism in relation to affect the
biological activity.
3. Compare Phase 1 & phase 2 metabolism and various factors
affecting drug metabolism.

UNIT 2
10 Marks
1. Discuss the Structure activity relationship (SAR) of beta
blocker and write Mechanism of action, Synthesis of
propranolol.
7 Marks
1. Write Synthesis, Mechanism of action and use of Ipratropium
bromide.
2. Define adrenergic blocker. Explain SAR and use of Beta
blocker.
3. Discuss in detail about indirect acting sympathomimetic
agents.
4. Outline the classification and SAR of Sympathomimetic.
5. Give uses, mechanism & synthesis of Carbachol.
6. Give biosynthesis of propranolol and discuss SAR of
catecholamines.

UNIT 3
10 Marks
1. Write the chemical structure, Mechanism of Action, Synthesis
and use of carbachol and Procyclidine.
7 Marks
1. Give use, Mechanism of action and synthesis of Neostigmine
and salbutamol.
2. Write a note on cholinesterase inhibitors.
3. Illustrate Mechanism of action, synthesis and use of
Dicyclomine hydrochloride, Carbachol.
UNIT 4
10 Marks
1. Write classification, Mechanism of action and SAR of
Antipsychotics with suitable example.
2. Classify sedative and hypnotics. Outline synthesis,
mechanism of action and use of diazepam.
7 Marks
1. Discuss SAR of phenothiazine.
2. Classify anticonvulsant and give synthesis of phenytoin.
3. Discuss SAR of barbiturate with example.
4. Write a note on medicinal chemistry of barbiturate.
5. Explain SAR of Succinimide. Write mechanism of action &
synthesis of ethosuccimide.
6. Write synthesis, mechanism of action and use of
Chlorpromazine hydrochloride and carbamazepine.

UNIT 5
10 Marks
1. Classify NSAIDs. Give synthesis of Ibuprofen.
2. Classify narcotics analgesics. Write SAR of morphine
analogues in detail.
UNIT 7
1. Classify anti inflammatory agent. Discuss the mode of action
and synthesis of Ibuprofen.
2. Classify general anaesthetic. Give synthesis of halothane.
3. Discuss the SAR of morphine analogues. Write mechanism of
action and synthesis of Fentanyl.
4. Write short note on dissociative anaesthetic.
5. Write chemical structure and use of :- Indomethacin, Valproic
acid, phenacetin, meperidine hydrochloride, sulindac.

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