Pharmacokinetics & Biopharmaceutics
Faculty of Pharmacy
Department of Pharmaceutics
Spring 2025
Practical Exam
Course Title : Pharmacokinetics&Biopharmaceutics Time : 60 min.
Course code : Marks : 30 marks
Instructor :
Name : ……………………………………................. ID No. : ……………………
Question I
Directions: Complete the following statements with the appropriate answers
in the given space only:
1) A drug with a Vd = 7 L is given to a patient through IV. The following table
shows some samples which are taken from the patient.:
a- What is the reaction order?, Calculate the
elimination rate constant
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b- find the time at which the conc. decreases by 10% ?
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c- Find the amount of drug in the body after 90 minutes?
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d- What is the [𝐴𝑈𝐶]!"
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Pharmacokinetics & Biopharmaceutics
e- Give the equation for the line that best fits the data with drawing ?
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2) Cocaine is known to follow one-compartment model. After 20 mg is
administered as a single IV bolus dose, the following data were observed:
a- Calculate the elimination rate constant
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b- Calculate the elimination half life
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c- Find the amount remaining after 2 hours
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3) Give reason : in urinary excretion rate method we plot against midpoint
of time but not time ?
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4) IV dose of 300 mg was given to a normal adult:
a- Draw and calculate the 𝒕𝟏/𝟐 Time (hr) Du (mg)
b- Calculate K 2 83.3
c- Calculate 𝑲𝒆 4 49.2
d- Calculate the 𝑪𝒍𝑻 if you know that the Vld
6 28.4
of this patient is 7L
e- If this drug was given orally, Calculate the 8 16.4
absolute bioavailability of this drug if you 10 9.7
know that 𝑫𝒖& 𝒐𝒓𝒂𝒍 = 𝟏𝟗𝟎𝒎𝒈 12 5.6
18 6.3
24 1.3
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Pharmacokinetics & Biopharmaceutics
5) Mention assumptions of two compartment open mpdel:
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2- ………………………………………………….………………….
3- ……………………………………………………………………..
6) 3 drug products of the same drug were given to 8 adults (75 kg). Plasma
samples were collected, and the following data were obtained:
Drug product Dose (mg) 𝐀𝐔𝐂 (mg.hr/L)
Oral tablet 250 88
Oral Solution 200 87.1
IV bolus injection 50 39.8
a- Find the absolute bioavailability of the tablet drug. Will the drug be
completely absorbed from this tablet
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b- Find %RB of the Tablet compared to the solution
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Pharmacokinetics & Biopharmaceutics
7) A new drug whose Vd is 30 L is given to a patient , and the total
clearance is 600 ml/min.
a- what is the t1⁄2?
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b- What will be the new t1⁄2 if there’s a partial renal failure which
leads to a new total clearance of 75 ml/min only
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8) A patient was infused with a drug at a rate of 60 mg/hr. the infusion is
stopped after 12 hours from starting it. (t1⁄2 = 8 hr , Vd = 20 L) a)
- What is the concentration of a drug in the body at 2 hours after
cessation of the infusion?
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Pharmacokinetics & Biopharmaceutics
9) From the following figure answer the following questions:
a- Symbol represent that
IV bolus dose is = optimum 𝐃𝐋 A
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b- which sybmol represent that the iv bolus
is not effective ? C
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c- Which symbol may represent toxic dose?
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10) A single 450mg IV dose of an antibiotic is given to a young man (85
kg), Vd is 20% of body weight, t1/2 is 140 min, If the (AUC) for oral
dose of 600 mg of the same drug is 90 mg.hr/L.
Calculate the % Absolute bioavailability
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Pharmacokinetics & Biopharmaceutics
Question II
Choose the correct answer:
1) It’s the study of the rate of ADME processes ( absorption,
distribution, metabolism, Excretion )
a- Biopharmaceutics
b- Pharmacodynamics
c- Pharmacokinetics
d- a and b
2) Which of the following graphs represent the first oreder
reaction kinetic on semi-log paper presentation :
a- b–
c- d-
3) One compartment IV bolus dose following assumptions except:
a- The body acts as one compartment
b- Concentration is inversely proportional to dose
c- Distribution is instantaneous
d- Elimination follows first order kinetic
4) If the drug is completely excreted unchanged in urine (as in
case of hepatic failure)
a- K < 𝑲𝒆
b- 𝑫𝑶
𝑩 = 𝑫𝒖
$
c- K > 𝑲𝒆
d- 𝑫𝑶
𝑩 not equal 𝑫𝒖
$
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5) Which of the following is true on two compartment open model:
a- 𝜶 < 𝜷 b- 𝜶 > 𝜷 c- K > 𝜷 d- b and c
6) A single 250mg IV dose of an antibiotic is given to a young
man (75 kg), Vd is 10% of body weight, t1/2 is 120 min, If the
(AUC) for oral dose of 300 mg of the same drug is 90 mg.hr/L.
Calculate the % Absolute bioavailability:
a- 84% b- 93% c- 67% d- 78%
7) Possible renal excretion mechanism when Drug is Completely
reabsorbed
a- Cl ratio < 1
b- Cl ratio = 0
c- Cl ratio = 1
d- Cl ratio > 1
8) In IV infusion, the concentration of steady state once reached
after:
a- 4 t1⁄2 b- 5 t1⁄2 c- 10 t1⁄2 d- 2 t1⁄2
9) if the following figure represesnt
on the loading dose with infusion,
which of the following is correct:
a- IV bolus dose that is Lower than the
optimum 𝐃𝐋
b- IV bolus dose that is higher than
the optimum 𝐃𝐋
c- IV bolus dose that’s equal to the
optimum 𝐃𝐋
d- None the above
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10)A patient 70 kg is given an IV bolus dose (1 mg/kg) with IV
infusion rate of 0.2 mg/kg/hr. The goal was to immediately
achieve a therapeutic Level of 10 μg/ml. it was also revealed
that 4 hours post-infusion the Css declined to 5 μg/ml. What is
the total body clearance of the drug
a- 4.1 L/hr b- 2.4 L/hr c- 1.4 L/hr d-5.6L/hr
1 2 3 4 5
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Pharmacokinetics & Biopharmaceutics
Question III
Choose the correct answer ( true ) or ( false ) :
1) Pharmacokinetic is the study of the relationship between the
physicochemical properties of the drug & dosage form and the route
of administration on the rate and extent of drug absorption. ( )
2) In calculation of K from urine data, Urine samples should be
collected for more than 5 t1⁄2 ( )
3) Brand product is drug product that marketed under a different
name after the patent has expired. ( )
4) RB is comparing bioavailability of a test product to the
bioavailability of a reference standard product ( )
5) Possible renal excretion mechanism when Drug is Filtered only
(GFR) is Cl ratio = 1 ( )
6) Drugs are given by I.V infusion at constant infusion rate (first order)
to maintain the level of drug in the body constant. ( )
1 2 3 4 5
Best withes
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